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WO2008011625A3 - Dispositifs à micro-aiguille(s) et procédés d'administration de médicament ou de retrait de fluide - Google Patents

Dispositifs à micro-aiguille(s) et procédés d'administration de médicament ou de retrait de fluide Download PDF

Info

Publication number
WO2008011625A3
WO2008011625A3 PCT/US2007/074123 US2007074123W WO2008011625A3 WO 2008011625 A3 WO2008011625 A3 WO 2008011625A3 US 2007074123 W US2007074123 W US 2007074123W WO 2008011625 A3 WO2008011625 A3 WO 2008011625A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
microneedle devices
drug delivery
drug
base substrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/074123
Other languages
English (en)
Other versions
WO2008011625A2 (fr
Inventor
Mark R Prausnitz
Jeong Woo Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgia Tech Research Corp
Original Assignee
Georgia Tech Research Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgia Tech Research Corp filed Critical Georgia Tech Research Corp
Publication of WO2008011625A2 publication Critical patent/WO2008011625A2/fr
Publication of WO2008011625A3 publication Critical patent/WO2008011625A3/fr
Priority to US12/357,195 priority Critical patent/US20090182306A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
    • B81C1/00111—Tips, pillars, i.e. raised structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/05—Microfluidics
    • B81B2201/055—Microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C2201/00—Manufacture or treatment of microstructural devices or systems
    • B81C2201/03—Processes for manufacturing substrate-free structures
    • B81C2201/034—Moulding

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

L'invention concerne des dispositifs à micro-aiguille(s) et des procédés de fabrication et d'utilisation de ceux-ci. Dans un mode de réalisation, l'invention concerne un dispositif permettant la libération prolongée d'un médicament à travers ou dans une barrière biologique telle que la peau. Ce dispositif peut comporter un substrat de base comprenant un médicament dispersé dans une matière de matrice, et une ou plusieurs micro-aiguilles s'étendant à partir du substrat de base, la ou les micro-aiguilles comportant une matière soluble ou gonflable dans l'eau, matière grâce à laquelle la ou les micro-aiguilles se dissolvent ou gonflent après avoir été introduites dans la barrière biologique, permettant ainsi le passage du médicament du substrat de base dans la barrière biologique.
PCT/US2007/074123 2006-07-21 2007-07-23 Dispositifs à micro-aiguille(s) et procédés d'administration de médicament ou de retrait de fluide Ceased WO2008011625A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/357,195 US20090182306A1 (en) 2006-07-21 2009-01-21 Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83247906P 2006-07-21 2006-07-21
US60/832,479 2006-07-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/357,195 Continuation-In-Part US20090182306A1 (en) 2006-07-21 2009-01-21 Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal

Publications (2)

Publication Number Publication Date
WO2008011625A2 WO2008011625A2 (fr) 2008-01-24
WO2008011625A3 true WO2008011625A3 (fr) 2008-12-04

Family

ID=38957686

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/074123 Ceased WO2008011625A2 (fr) 2006-07-21 2007-07-23 Dispositifs à micro-aiguille(s) et procédés d'administration de médicament ou de retrait de fluide

Country Status (1)

Country Link
WO (1) WO2008011625A2 (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
EP1893130A4 (fr) 2005-06-17 2015-08-26 Georgia Tech Res Inst Microstructures revetues et procede de fabrication de celles-ci
US7699819B2 (en) 2006-02-21 2010-04-20 The Hong Kong University Of Science And Technology Molecular sieve and zeolite microneedles and preparation thereof
AU2008209537B2 (en) 2007-01-22 2013-01-31 Corium Pharma Solutions, Inc. Applicators for microneedle arrays
EP2664323B1 (fr) 2007-04-16 2020-07-29 Corium, Inc. Actif comprenant des réseaux de micro-aiguilles coulés en solution
AU2014200648B2 (en) * 2007-04-16 2015-09-24 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
CN101808588B (zh) 2007-09-28 2012-12-19 贝尔法斯特女王大学 递送装置及方法
WO2009048607A1 (fr) 2007-10-10 2009-04-16 Corium International, Inc. Distribution de vaccin par l'intermédiaire de réseaux de micro-aiguilles
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
WO2009079712A1 (fr) 2007-12-24 2009-07-02 The University Of Queensland Procédé d'application
CN102007066B (zh) 2008-02-07 2013-06-26 昆士兰大学 贴片制造
US8398397B2 (en) 2008-03-12 2013-03-19 Ultradent Products, Inc. Dental intraligamentary injection needles and related methods of manufacture
ES2687258T3 (es) * 2008-05-21 2018-10-24 Theraject, Inc. Procedimiento de fabricación de conjuntos de microagujas
US9387000B2 (en) 2008-05-23 2016-07-12 The University Of Queensland Analyte detection using a needle projection patch
CA2739876A1 (fr) * 2008-10-07 2010-04-15 Tuo Jin Micro-aiguilles polymeres a transition de phase
AU2009329806A1 (en) * 2008-12-22 2010-07-01 The University Of Queensland Patch production
JP6327852B2 (ja) 2010-05-04 2018-05-23 コリウム インターナショナル， インコーポレイテッド 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
JP5770055B2 (ja) * 2010-09-29 2015-08-26 富士フイルム株式会社 針状アレイ経皮吸収シートの製造方法
GB201107642D0 (en) * 2011-05-09 2011-06-22 Univ Cork Method
US11179553B2 (en) 2011-10-12 2021-11-23 Vaxxas Pty Limited Delivery device
CN105073178B (zh) 2012-12-21 2019-07-30 考里安国际公司 用于治疗剂递送的微阵列及其使用方法
JP2016506780A (ja) * 2013-01-21 2016-03-07 ブキョン ファ−ム カンパニ− リミテッド マイクロニードル及びその製造用モールドならびにその製造方法
JP6487899B2 (ja) 2013-03-12 2019-03-20 コリウム インターナショナル， インコーポレイテッド 微小突起アプリケータ
CA2903583C (fr) 2013-03-15 2021-12-28 Corium International, Inc. Micro-reseau pour administrer un agent therapeutique, procedes d'utilisation et procedes de fabrication
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
BR112015022625B1 (pt) 2013-03-15 2023-01-31 Corium, Inc Aparelho de microestrutura para entrega de agente terapêutico
AU2014237357B2 (en) 2013-03-15 2019-11-28 Corium Pharma Solutions, Inc. Multiple impact microprojection applicators and methods of use
JP6608382B2 (ja) 2014-02-26 2019-11-20 ルマ セラピューティクス，インク． 紫外光治療装置及び方法
WO2015151516A1 (fr) * 2014-04-03 2015-10-08 凸版印刷株式会社 Instrument d'injection ponction
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
WO2016123665A1 (fr) 2015-02-02 2016-08-11 Vaxxas Pty Limited Applicateur à réseau de microprojections et procédé
CA2983289C (fr) * 2015-04-21 2023-10-03 North Carolina State University Systeme de distribution d'insuline repondant au glucose au moyen de nanocomposites sensibles a l'hypoxie
WO2017004067A1 (fr) 2015-06-29 2017-01-05 Corium International, Inc. Micro-réseau pour l'administration d'un agent thérapeutique, procédés d'utilisation, et procédés de fabrication
WO2017045031A1 (fr) 2015-09-18 2017-03-23 Vaxxas Pty Limited Réseaux de micro-saillies comportant des micro-saillies ayant des profils à surface élevée
CA2999538A1 (fr) 2015-09-28 2017-04-06 Vaxxas Pty Limited Reseau de microsaillies ayant des proprietes de penetration de la peau ameliorees et procedes associes
WO2017124028A1 (fr) * 2016-01-13 2017-07-20 The General Hospital Corporation Dba Massachusetts General Hospital Systèmes et procédés permettant d'éliminer les particules exogènes de la peau d'un patient
JP2019511343A (ja) 2016-02-09 2019-04-25 ルマ セラピューティクス, インク.Luma Therapeutics, Inc. 光線療法による乾癬処置の方法と組成物と装置
WO2018176102A1 (fr) 2017-03-31 2018-10-04 Vaxxas Pty Limited Dispositif et procédé de revêtement de surfaces
CA3065371A1 (fr) 2017-06-13 2018-12-20 Vaxxas Pty Limited Controle de la qualite de revetements de substrats
US11464957B2 (en) 2017-08-04 2022-10-11 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP)
CN108837238B (zh) * 2018-07-13 2023-09-01 江苏省人民医院（南京医科大学第一附属医院） 一种玻尿酸注射针
CN111588689B (zh) * 2020-06-20 2023-08-11 温州医科大学 一种角膜微创可溶性微针贴片及其制备方法与应用
US20220105029A1 (en) * 2020-10-07 2022-04-07 The Board Of Trustees Of The University Of Arkansas Biodegradable chitosan microneedle patch for transdermal delivery for livestock pain management
EP4291282A4 (fr) * 2021-02-11 2025-04-16 10X Technology LLC Procédé et appareil de fabrication de micro-aiguille cassante
WO2022183122A1 (fr) * 2021-02-27 2022-09-01 The Brigham And Women's Hospital, Inc. Compositions de micro-aiguilles et méthodes d'administration les utilisant

Citations (2)

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US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US20020177839A1 (en) * 2001-04-20 2002-11-28 Cormier Michel J. N. Microprojection array having a beneficial agent containing coating

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US20020177839A1 (en) * 2001-04-20 2002-11-28 Cormier Michel J. N. Microprojection array having a beneficial agent containing coating

Also Published As

Publication number Publication date
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