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WO2008011625A3 - Microneedle devices and methods of drug delivery or fluid withdrawal - Google Patents

Microneedle devices and methods of drug delivery or fluid withdrawal Download PDF

Info

Publication number
WO2008011625A3
WO2008011625A3 PCT/US2007/074123 US2007074123W WO2008011625A3 WO 2008011625 A3 WO2008011625 A3 WO 2008011625A3 US 2007074123 W US2007074123 W US 2007074123W WO 2008011625 A3 WO2008011625 A3 WO 2008011625A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
microneedle devices
drug delivery
drug
base substrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/074123
Other languages
French (fr)
Other versions
WO2008011625A2 (en
Inventor
Mark R Prausnitz
Jeong Woo Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgia Tech Research Corp
Original Assignee
Georgia Tech Research Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgia Tech Research Corp filed Critical Georgia Tech Research Corp
Publication of WO2008011625A2 publication Critical patent/WO2008011625A2/en
Publication of WO2008011625A3 publication Critical patent/WO2008011625A3/en
Priority to US12/357,195 priority Critical patent/US20090182306A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
    • B81C1/00111—Tips, pillars, i.e. raised structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/05—Microfluidics
    • B81B2201/055—Microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C2201/00—Manufacture or treatment of microstructural devices or systems
    • B81C2201/03—Processes for manufacturing substrate-free structures
    • B81C2201/034—Moulding

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

Microneedle devices and methods of manufacture and use thereof are provided. In one embodiment, a device is provided for sustained delivery of drug across or into a biological barrier, such as skin. The device may include a base substrate which comprises a drug dispersed in a matrix material; and one or more microneedles extending from the base substrate, wherein the one or more microneedles comprise a water-soluble or water-swellable material, wherein the one or more microneedles will dissolve or swell following insertion into the biological barrier, providing a transport pathway for the drug to pass from the base substrate into the biological barrier.
PCT/US2007/074123 2006-07-21 2007-07-23 Microneedle devices and methods of drug delivery or fluid withdrawal Ceased WO2008011625A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/357,195 US20090182306A1 (en) 2006-07-21 2009-01-21 Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83247906P 2006-07-21 2006-07-21
US60/832,479 2006-07-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/357,195 Continuation-In-Part US20090182306A1 (en) 2006-07-21 2009-01-21 Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal

Publications (2)

Publication Number Publication Date
WO2008011625A2 WO2008011625A2 (en) 2008-01-24
WO2008011625A3 true WO2008011625A3 (en) 2008-12-04

Family

ID=38957686

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/074123 Ceased WO2008011625A2 (en) 2006-07-21 2007-07-23 Microneedle devices and methods of drug delivery or fluid withdrawal

Country Status (1)

Country Link
WO (1) WO2008011625A2 (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
EP1893130A4 (en) 2005-06-17 2015-08-26 Georgia Tech Res Inst Coated microstructures and method of manufacture thereof
US7699819B2 (en) 2006-02-21 2010-04-20 The Hong Kong University Of Science And Technology Molecular sieve and zeolite microneedles and preparation thereof
AU2008209537B2 (en) 2007-01-22 2013-01-31 Corium Pharma Solutions, Inc. Applicators for microneedle arrays
EP2664323B1 (en) 2007-04-16 2020-07-29 Corium, Inc. Solvent-cast microneedle arrays containing active
AU2014200648B2 (en) * 2007-04-16 2015-09-24 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
CN101808588B (en) 2007-09-28 2012-12-19 贝尔法斯特女王大学 Delivery device and method
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
WO2009079712A1 (en) 2007-12-24 2009-07-02 The University Of Queensland Coating method
CN102007066B (en) 2008-02-07 2013-06-26 昆士兰大学 Chip manufacturing
US8398397B2 (en) 2008-03-12 2013-03-19 Ultradent Products, Inc. Dental intraligamentary injection needles and related methods of manufacture
ES2687258T3 (en) * 2008-05-21 2018-10-24 Theraject, Inc. Manufacturing procedure of microneedle assemblies
US9387000B2 (en) 2008-05-23 2016-07-12 The University Of Queensland Analyte detection using a needle projection patch
CA2739876A1 (en) * 2008-10-07 2010-04-15 Tuo Jin Phase-transition polymeric microneedles
AU2009329806A1 (en) * 2008-12-22 2010-07-01 The University Of Queensland Patch production
JP6327852B2 (en) 2010-05-04 2018-05-23 コリウム インターナショナル， インコーポレイテッド Methods and devices for transdermal delivery of parathyroid hormone using microprojection arrays
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
JP5770055B2 (en) * 2010-09-29 2015-08-26 富士フイルム株式会社 Method for manufacturing needle-like array transdermal absorption sheet
GB201107642D0 (en) * 2011-05-09 2011-06-22 Univ Cork Method
US11179553B2 (en) 2011-10-12 2021-11-23 Vaxxas Pty Limited Delivery device
CN105073178B (en) 2012-12-21 2019-07-30 考里安国际公司 Microarray and its application method for therapeutic agent delivering
JP2016506780A (en) * 2013-01-21 2016-03-07 ブキョン ファ−ム カンパニ− リミテッド Microneedle, mold for manufacturing the same, and method for manufacturing the same
JP6487899B2 (en) 2013-03-12 2019-03-20 コリウム インターナショナル， インコーポレイテッド Microprojection applicator
CA2903583C (en) 2013-03-15 2021-12-28 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
BR112015022625B1 (en) 2013-03-15 2023-01-31 Corium, Inc MICROSTRUCTURE DEVICE FOR DELIVERY OF THERAPEUTIC AGENT
AU2014237357B2 (en) 2013-03-15 2019-11-28 Corium Pharma Solutions, Inc. Multiple impact microprojection applicators and methods of use
JP6608382B2 (en) 2014-02-26 2019-11-20 ルマ セラピューティクス，インク． Ultraviolet light treatment apparatus and method
WO2015151516A1 (en) * 2014-04-03 2015-10-08 凸版印刷株式会社 Puncture injection instrument
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
WO2016123665A1 (en) 2015-02-02 2016-08-11 Vaxxas Pty Limited Microprojection array applicator and method
CA2983289C (en) * 2015-04-21 2023-10-03 North Carolina State University Glucose-responsive insulin delivery system using hypoxia-sensitive nanocomposites
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
CA2999538A1 (en) 2015-09-28 2017-04-06 Vaxxas Pty Limited Microprojection arrays with enhanced skin penetrating properties and methods thereof
WO2017124028A1 (en) * 2016-01-13 2017-07-20 The General Hospital Corporation Dba Massachusetts General Hospital Systems and methods for removing exogenous particles from the skin of a patient
JP2019511343A (en) 2016-02-09 2019-04-25 ルマ セラピューティクス, インク.Luma Therapeutics, Inc. Methods, compositions and devices for treating psoriasis with phototherapy
WO2018176102A1 (en) 2017-03-31 2018-10-04 Vaxxas Pty Limited Device and method for coating surfaces
CA3065371A1 (en) 2017-06-13 2018-12-20 Vaxxas Pty Limited Quality control of substrate coatings
US11464957B2 (en) 2017-08-04 2022-10-11 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP)
CN108837238B (en) * 2018-07-13 2023-09-01 江苏省人民医院（南京医科大学第一附属医院） Hyaluronic acid injection needle
CN111588689B (en) * 2020-06-20 2023-08-11 温州医科大学 A kind of corneal minimally invasive dissolvable microneedle patch and its preparation method and application
US20220105029A1 (en) * 2020-10-07 2022-04-07 The Board Of Trustees Of The University Of Arkansas Biodegradable chitosan microneedle patch for transdermal delivery for livestock pain management
EP4291282A4 (en) * 2021-02-11 2025-04-16 10X Technology LLC METHOD AND DEVICE FOR PRODUCING A BRITTLE MICRONEEDLE
WO2022183122A1 (en) * 2021-02-27 2022-09-01 The Brigham And Women's Hospital, Inc. Microneedle compositions and methods of delivery using the same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US20020177839A1 (en) * 2001-04-20 2002-11-28 Cormier Michel J. N. Microprojection array having a beneficial agent containing coating

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US20020177839A1 (en) * 2001-04-20 2002-11-28 Cormier Michel J. N. Microprojection array having a beneficial agent containing coating

Also Published As

Publication number Publication date
WO2008011625A2 (en) 2008-01-24

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