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WO2008114817A1 - 新規なアデニン化合物 - Google Patents

新規なアデニン化合物 Download PDF

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Publication number
WO2008114817A1
WO2008114817A1 PCT/JP2008/055078 JP2008055078W WO2008114817A1 WO 2008114817 A1 WO2008114817 A1 WO 2008114817A1 JP 2008055078 W JP2008055078 W JP 2008055078W WO 2008114817 A1 WO2008114817 A1 WO 2008114817A1
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WO
WIPO (PCT)
Prior art keywords
group
substituted
single bond
unsubstituted
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/055078
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English (en)
French (fr)
Inventor
Yoshiaki Isobe
Tomoaki Nakamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
AstraZeneca AB
Original Assignee
Sumitomo Dainippon Pharma Co Ltd
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39765921&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2008114817(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to NZ579744A priority Critical patent/NZ579744A/en
Application filed by Sumitomo Dainippon Pharma Co Ltd, AstraZeneca AB filed Critical Sumitomo Dainippon Pharma Co Ltd
Priority to JP2009505235A priority patent/JPWO2008114817A1/ja
Priority to CN200880016120A priority patent/CN101679433A/zh
Priority to AU2008227500A priority patent/AU2008227500A1/en
Priority to CA002680397A priority patent/CA2680397A1/en
Priority to EP08738671A priority patent/EP2133353A4/en
Priority to US12/532,007 priority patent/US20100093998A1/en
Priority to MX2009010024A priority patent/MX2009010024A/es
Priority to BRPI0809134-0A priority patent/BRPI0809134A2/pt
Publication of WO2008114817A1 publication Critical patent/WO2008114817A1/ja
Priority to IL200831A priority patent/IL200831A0/en
Anticipated expiration legal-status Critical
Priority to US12/905,012 priority patent/US20110028715A1/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
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    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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    • C—CHEMISTRY; METALLURGY
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    • C07D473/00—Heterocyclic compounds containing purine ring systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

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  • Life Sciences & Earth Sciences (AREA)
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Abstract

　本発明は、医薬として有用な、式（Ｉ）： ［式中、Ａは、置換又は無置換の、芳香族炭素環又は芳香族炭素環を表し、Ｌ1およびＬ2は独立して、単結合又は直鎖もしくは分枝のアルキレン等を表し、Ｒ1は、ハロゲン原子であるか、又は置換もしくは無置換の、アルキル基、アルケニル基、アルキニル基、シクロアルキル基、アリール基もしくはヘテロアリール基を表し、Ｒ2及びＲ3は独立して、水素原子であるか、又は置換もしくは無置換の、アルキル基、アルケニル基、アルキニル基、シクロアルキル基、飽和へテロ環基、アリール基もしくはヘテロアリール基を表わすか、あるいはＲ2は、Ｌ2又はＲ3と一緒になって置換もしくは無置換の４～８員の含窒素飽和へテロ環を形成してもよく、Ｘは、酸素原子、硫黄原子、ＳＯ、ＳＯ2、ＮＲ7、ＮＲ7ＣＯ（Ｒ7は水素原子又はアルキル基を表す）又は単結合を表す（但し、Ｒ1がハロゲン原子を表す場合には、Ｘは単結合である）］で表されるアデニン化合物、又はその薬学上許容される塩を提供する。
PCT/JP2008/055078 2007-03-20 2008-03-19 新規なアデニン化合物 Ceased WO2008114817A1 (ja)

Priority Applications (11)

Application Number Priority Date Filing Date Title
US12/532,007 US20100093998A1 (en) 2007-03-20 2008-03-19 Novel adenine compound
EP08738671A EP2133353A4 (en) 2007-03-20 2008-03-19 NEW ADENINE COMPOUND
JP2009505235A JPWO2008114817A1 (ja) 2007-03-20 2008-03-19 新規なアデニン化合物
CN200880016120A CN101679433A (zh) 2007-03-20 2008-03-19 新型腺嘌呤化合物
AU2008227500A AU2008227500A1 (en) 2007-03-20 2008-03-19 Novel adenine compound
CA002680397A CA2680397A1 (en) 2007-03-20 2008-03-19 Novel adenine compound
MX2009010024A MX2009010024A (es) 2007-03-20 2008-03-19 Nuevo compuesto de adenina.
NZ579744A NZ579744A (en) 2007-03-20 2008-03-19 Adenine derivatives as TLR7 modulators
BRPI0809134-0A BRPI0809134A2 (pt) 2007-03-20 2008-03-19 Composto de adenina 31/14 a61p 31/16 a61p 31/18 a61p 31/20 a61p 31/22 a61p 33/02 a61p 35/00 a61p 35/02 a61p 35/04 a61p 37/00 a61p 37/02 a61p 37/08 a61p 43/00 c07d 473/16 c07d 473/18
IL200831A IL200831A0 (en) 2007-03-20 2009-09-09 Novel adenine compounds
US12/905,012 US20110028715A1 (en) 2007-03-20 2010-10-14 Novel adenine compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007071713 2007-03-20
JP2007-071713 2007-03-20

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/905,012 Continuation US20110028715A1 (en) 2007-03-20 2010-10-14 Novel adenine compound

Publications (1)

Publication Number Publication Date
WO2008114817A1 true WO2008114817A1 (ja) 2008-09-25

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/055078 Ceased WO2008114817A1 (ja) 2007-03-20 2008-03-19 新規なアデニン化合物

Country Status (21)

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US (2) US20100093998A1 (ja)
EP (1) EP2133353A4 (ja)
JP (1) JPWO2008114817A1 (ja)
KR (1) KR20090125774A (ja)
CN (1) CN101679433A (ja)
AR (1) AR065784A1 (ja)
AU (1) AU2008227500A1 (ja)
BR (1) BRPI0809134A2 (ja)
CA (1) CA2680397A1 (ja)
CL (1) CL2008000789A1 (ja)
CO (1) CO6220972A2 (ja)
EC (1) ECSP099638A (ja)
IL (1) IL200831A0 (ja)
MX (1) MX2009010024A (ja)
NZ (1) NZ579744A (ja)
PE (1) PE20081887A1 (ja)
RU (1) RU2009138471A (ja)
TW (1) TW200902018A (ja)
UY (1) UY30966A1 (ja)
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AR065784A1 (es) 2009-07-01
AU2008227500A1 (en) 2008-09-25
PE20081887A1 (es) 2009-01-16
IL200831A0 (en) 2010-05-17
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KR20090125774A (ko) 2009-12-07
EP2133353A4 (en) 2011-08-31
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BRPI0809134A2 (pt) 2014-08-26
RU2009138471A (ru) 2011-04-27
JPWO2008114817A1 (ja) 2010-07-08
TW200902018A (en) 2009-01-16
US20100093998A1 (en) 2010-04-15
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NZ579744A (en) 2012-06-29
UY30966A1 (es) 2008-10-31
EP2133353A1 (en) 2009-12-16
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CA2680397A1 (en) 2008-09-25
US20110028715A1 (en) 2011-02-03

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