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WO2007046867A3 - Derives de piperidine et leurs utilisations comme agents therapeutiques - Google Patents

Derives de piperidine et leurs utilisations comme agents therapeutiques Download PDF

Info

Publication number
WO2007046867A3
WO2007046867A3 PCT/US2006/019354 US2006019354W WO2007046867A3 WO 2007046867 A3 WO2007046867 A3 WO 2007046867A3 US 2006019354 W US2006019354 W US 2006019354W WO 2007046867 A3 WO2007046867 A3 WO 2007046867A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic agents
piperidine derivatives
mammal
formula
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/019354
Other languages
English (en)
Other versions
WO2007046867A2 (fr
Inventor
Vishnumurthy Kodumuru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xenon Pharmaceuticals Inc
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of WO2007046867A2 publication Critical patent/WO2007046867A2/fr
Publication of WO2007046867A3 publication Critical patent/WO2007046867A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

L'invention concerne des procédés permettant de traiter une maladie ou un état médié par SCD chez un mammifère, de préférence un humain, qui consistent à administrer au mammifère concerné un composé de formule (I), dans laquelle K, K, L, M, W, V, R2, R3 et R5 sont tels que définis dans le descriptif. L'invention concerne également des compositions pharmaceutiques comprenant les composés de formule (I).
PCT/US2006/019354 2005-05-19 2006-05-19 Derives de piperidine et leurs utilisations comme agents therapeutiques Ceased WO2007046867A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68295205P 2005-05-19 2005-05-19
US60/682,952 2005-05-19

Publications (2)

Publication Number Publication Date
WO2007046867A2 WO2007046867A2 (fr) 2007-04-26
WO2007046867A3 true WO2007046867A3 (fr) 2007-07-05

Family

ID=37885399

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/019354 Ceased WO2007046867A2 (fr) 2005-05-19 2006-05-19 Derives de piperidine et leurs utilisations comme agents therapeutiques

Country Status (1)

Country Link
WO (1) WO2007046867A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2666193A1 (fr) 2006-08-08 2008-02-14 Sanofi-Aventis Imidazolidin-2,4-dione arylaminoaryl-alkyl-substituee, son procede de fabrication, medicament contenant ce compose et son utilisation
US8314138B2 (en) 2006-08-24 2012-11-20 Novartis Ag Pyrazole derivative as SCD1 inhibitors for the treatment of diabetes
GB0722077D0 (en) 2007-11-09 2007-12-19 Smithkline Beecham Corp Compounds
EP2310372B1 (fr) 2008-07-09 2012-05-23 Sanofi Composés hétérocycliques, leur procédé de préparation, médicaments les contenant et leur utilisation
WO2010068601A1 (fr) 2008-12-08 2010-06-17 Sanofi-Aventis Hydrate de fluoroglycoside hétéroaromatique cristallin, ses procédés de fabrication, ses procédés d'utilisation et compositions pharmaceutiques le contenant
JP5597210B2 (ja) 2009-02-17 2014-10-01 メルク カナダ インコーポレイテッド ステアロイル−補酵素ａデルタ−９デサチュラーゼの阻害剤として有用な新規スピロ化合物
EP2459568A4 (fr) 2009-07-28 2013-02-27 Merck Frosst Canada Ltd Nouveaux composés spiro utiles en tant qu'inhibiteurs de la stéaroyl-coenzyme a delta-9 désaturase
WO2011023754A1 (fr) 2009-08-26 2011-03-03 Sanofi-Aventis Nouveaux hydrates de fluoroglycoside hétéroaromatiques cristallins, substances pharmaceutiques comprenant ces composés et leur utilisation
KR20120080226A (ko) * 2009-10-01 2012-07-16 제논 파마슈티칼스 인크. 스테아로일-ｃｏａ 탈포화화효소를 조절하는 피라졸 유도체
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120052A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés d'oxathiazine substitués par des carbocycles ou des hétérocycles, leur procédé de préparation, médicaments contenant ces composés et leur utilisation
WO2012120055A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
BR112014008590A2 (pt) 2011-10-15 2017-10-24 Genentech Inc métodos de uso de antagonistas de scd1
MX2014014174A (es) 2012-05-22 2015-07-06 Hoffmann La Roche Inhibidores selectivos de celulas no diferenciadas.
SG10202110874TA (en) 2016-06-07 2021-11-29 Jacobio Pharmaceuticals Co Ltd Novel heterocyclic derivatives useful as shp2 inhibitors
MA49013A (fr) 2017-03-23 2021-05-05 Jacobio Pharmaceuticals Co Ltd Nouveaux dérivés hétérocycliques utiles en tant qu'inhibiteurs de shp2
US20210393623A1 (en) 2018-09-26 2021-12-23 Jacobio Pharmaceuticals Co., Ltd. Novel Heterocyclic Derivatives Useful as SHP2 Inhibitors

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0398427A1 (fr) * 1989-05-15 1990-11-22 Janssen Pharmaceutica N.V. Pyridazine-amines antirhinovirales
EP0435381A1 (fr) * 1989-12-26 1991-07-03 Janssen Pharmaceutica N.V. Pyridazinamines antipicornavirales
EP0537696A1 (fr) * 1991-10-18 1993-04-21 Dr. Karl Thomae GmbH Dérivés hétérocycliques biarylés, médicaments contenant ces composés et procédé pour leur préparation
WO1997026258A1 (fr) * 1996-01-15 1997-07-24 Janssen Pharmaceutica N.V. Pyridazinamines inhibant l'angiogenese
WO2002000661A1 (fr) * 2000-06-26 2002-01-03 Pfizer Products Inc. Composes pyrrolo[2,3-d]pyrimidine en tant qu'agents immunosuppresseurs
WO2003022809A2 (fr) * 2001-09-13 2003-03-20 Smithkline Beecham P.L.C. Nouveaux composes
WO2005011657A2 (fr) * 2003-07-30 2005-02-10 Xenon Pharmaceuticals Inc. Derives de piperazine et utilisation comme agents therapeutiques
WO2006012226A2 (fr) * 2004-06-24 2006-02-02 Incyte Corporation Piperidines a substitution n et utilisation de ces dernieres en tant que substances pharmaceutiques
WO2006020598A2 (fr) * 2004-08-10 2006-02-23 Incyte Corporation Composes amido et leur utilisation comme produits pharmaceutiques
WO2006034338A1 (fr) * 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Derives heterocycliques et leur utilisation en tant que modulateurs de stearoyle-coa desaturase
EP1647553A1 (fr) * 2003-07-17 2006-04-19 Astellas Pharma Inc. Derive 2-acylaminothiazole ou sel de celui-ci
WO2006052913A1 (fr) * 2004-11-04 2006-05-18 Vertex Pharmaceuticals Incorporated PYRAZOLO[1,5-a]PYRIMIDINES UTILES EN TANT QU’INHIBITEURS DE PROTEINES KINASES

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0398427A1 (fr) * 1989-05-15 1990-11-22 Janssen Pharmaceutica N.V. Pyridazine-amines antirhinovirales
EP0435381A1 (fr) * 1989-12-26 1991-07-03 Janssen Pharmaceutica N.V. Pyridazinamines antipicornavirales
EP0537696A1 (fr) * 1991-10-18 1993-04-21 Dr. Karl Thomae GmbH Dérivés hétérocycliques biarylés, médicaments contenant ces composés et procédé pour leur préparation
WO1997026258A1 (fr) * 1996-01-15 1997-07-24 Janssen Pharmaceutica N.V. Pyridazinamines inhibant l'angiogenese
WO2002000661A1 (fr) * 2000-06-26 2002-01-03 Pfizer Products Inc. Composes pyrrolo[2,3-d]pyrimidine en tant qu'agents immunosuppresseurs
WO2003022809A2 (fr) * 2001-09-13 2003-03-20 Smithkline Beecham P.L.C. Nouveaux composes
EP1647553A1 (fr) * 2003-07-17 2006-04-19 Astellas Pharma Inc. Derive 2-acylaminothiazole ou sel de celui-ci
WO2005011657A2 (fr) * 2003-07-30 2005-02-10 Xenon Pharmaceuticals Inc. Derives de piperazine et utilisation comme agents therapeutiques
WO2006012226A2 (fr) * 2004-06-24 2006-02-02 Incyte Corporation Piperidines a substitution n et utilisation de ces dernieres en tant que substances pharmaceutiques
WO2006020598A2 (fr) * 2004-08-10 2006-02-23 Incyte Corporation Composes amido et leur utilisation comme produits pharmaceutiques
WO2006034338A1 (fr) * 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Derives heterocycliques et leur utilisation en tant que modulateurs de stearoyle-coa desaturase
WO2006052913A1 (fr) * 2004-11-04 2006-05-18 Vertex Pharmaceuticals Incorporated PYRAZOLO[1,5-a]PYRIMIDINES UTILES EN TANT QU’INHIBITEURS DE PROTEINES KINASES

Also Published As

Publication number Publication date
WO2007046867A2 (fr) 2007-04-26

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