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WO2006125819A3 - Forme medicamenteuse orale, microparticulaire, anti-mesusage - Google Patents

Forme medicamenteuse orale, microparticulaire, anti-mesusage Download PDF

Info

Publication number
WO2006125819A3
WO2006125819A3 PCT/EP2006/062623 EP2006062623W WO2006125819A3 WO 2006125819 A3 WO2006125819 A3 WO 2006125819A3 EP 2006062623 W EP2006062623 W EP 2006062623W WO 2006125819 A3 WO2006125819 A3 WO 2006125819A3
Authority
WO
WIPO (PCT)
Prior art keywords
analgesic
misuse
oral
analgesics
drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2006/062623
Other languages
English (en)
Other versions
WO2006125819A2 (fr
Inventor
Florence Guimberteau
Gerard Soula
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Flamel Technologies SA
Original Assignee
Flamel Technologies SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flamel Technologies SA filed Critical Flamel Technologies SA
Publication of WO2006125819A2 publication Critical patent/WO2006125819A2/fr
Anticipated expiration legal-status Critical
Publication of WO2006125819A3 publication Critical patent/WO2006125819A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)

Abstract

Le domaine de la présente invention est celui des médicaments oraux analgésiques, microparticulaires solides. L'invention est de fournir de nouveaux médicaments analgésiques permettant à la fois la prévention du mésusage et de l'addiction à certains analgésiques et/ou le contrôle de la variabilité de la concentration plasmatique et/ou la facilitation de l'administration orale ; et/ou l'association de analgésiques entre eux et/ou avec un ou plusieurs principes actifs dans une même forme orale. Le médicament selon l'invention comprend (i) des moyens anti-mésusage et une pluralité de microcapsules à libération modifiée d'analgésique(s), de diamètre moyen compris entre 50 et 600 µm, (ii) au moins 100 microcapsules par dose ; ce médicament pouvant être administré en une ou deux fois par jour à des fins analgésiques.
PCT/EP2006/062623 2005-05-24 2006-05-24 Forme medicamenteuse orale, microparticulaire, anti-mesusage Ceased WO2006125819A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0551344 2005-05-24
FR0551344A FR2889810A1 (fr) 2005-05-24 2005-05-24 Forme medicamenteuse orale, microparticulaire, anti-mesurage

Publications (2)

Publication Number Publication Date
WO2006125819A2 WO2006125819A2 (fr) 2006-11-30
WO2006125819A3 true WO2006125819A3 (fr) 2008-03-06

Family

ID=35414911

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/062623 Ceased WO2006125819A2 (fr) 2005-05-24 2006-05-24 Forme medicamenteuse orale, microparticulaire, anti-mesusage

Country Status (3)

Country Link
US (1) US20070264326A1 (fr)
FR (1) FR2889810A1 (fr)
WO (1) WO2006125819A2 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040253310A1 (en) 2001-09-21 2004-12-16 Gina Fischer Morphine polymer release system
WO2003024429A1 (fr) 2001-09-21 2003-03-27 Egalet A/S Systeme de liberation a base de polymere
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
JP4732696B2 (ja) 2002-04-09 2011-07-27 フラメル・テクノロジー 活性成分の改変された放出のための、マイクロカプセルの水性懸濁液形態での経口医薬品製剤
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
EP2301526B1 (fr) 2003-03-26 2016-03-23 Egalet Ltd. Système de libération contrôlée de morphine
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
WO2006133733A1 (fr) 2005-06-13 2006-12-21 Flamel Technologies Forme posologique orale comportant un systeme anti-abus
FR2892937B1 (fr) * 2005-11-10 2013-04-05 Flamel Tech Sa Forme pharmaceutique orale microparticulaire anti-mesusage
US8652529B2 (en) 2005-11-10 2014-02-18 Flamel Technologies Anti-misuse microparticulate oral pharmaceutical form
EP1810678A1 (fr) * 2006-01-19 2007-07-25 Holger Lars Hermann Utilisation de morphine et naloxone pour la substitution de médicaments
FR2897267A1 (fr) * 2006-02-16 2007-08-17 Flamel Technologies Sa Formes pharmaceutiques multimicroparticulaires pour administration per os
CA2687192C (fr) 2007-06-04 2015-11-24 Egalet A/S Compositions pharmaceutiques a liberation controlee pour un effet prolonge
BRPI0821732A2 (pt) * 2007-12-17 2015-06-16 Labopharm Inc Formulações de liberação controlada , forma de dosagem sólida, e, uso da formulação de liberação controlada
JP5667575B2 (ja) 2008-12-16 2015-02-12 パラディン ラブス インコーポレーテッド 誤用を防止する放出制御製剤
NZ594207A (en) 2009-02-06 2013-03-28 Egalet Ltd Immediate release composition resistant to abuse by intake of alcohol
NZ603579A (en) 2009-06-24 2014-02-28 Egalet Ltd Controlled release formulations
PL2997965T3 (pl) 2009-07-22 2019-06-28 Grünenthal GmbH Odporna na manipulacje postać dawkowania opioidów wrażliwych na utlenianie
FR2959935B1 (fr) * 2010-05-14 2013-02-08 Ethypharm Sa Forme pharmaceutique orale alcoolo-resistante
US9877925B2 (en) 2010-05-14 2018-01-30 Ethypharm Alcohol-resistant oral pharmaceutical form
LT2736497T (lt) 2011-07-29 2017-11-10 Grünenthal GmbH Sugadinimui atspari tabletė, pasižyminti greitu vaisto atpalaidavimu
US10201502B2 (en) 2011-07-29 2019-02-12 Gruenenthal Gmbh Tamper-resistant tablet providing immediate drug release
WO2013055670A2 (fr) * 2011-10-11 2013-04-18 Kraft Foods Global Brands Llc Composition d'édulcorant encapsulé, son procédé de préparation et gomme à mâcher comprenant la composition
MX2014015880A (es) 2012-07-06 2015-08-05 Egalet Ltd Composiciones farmaceuticas disuasivas de abuso para liberacion controlada.
CA2913209A1 (fr) * 2013-05-29 2014-12-04 Grunenthal Gmbh Forme dosifiee inviolable a profil de liberation bimodale
KR20160031526A (ko) 2013-07-12 2016-03-22 그뤼넨탈 게엠베하 에틸렌-비닐 아세테이트 중합체를 함유하는 템퍼 내성 투여형
JP6480936B2 (ja) 2013-11-26 2019-03-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング クライオミリングによる粉末状医薬組成物の調製
US10842750B2 (en) 2015-09-10 2020-11-24 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations
US20220409539A1 (en) * 2019-12-30 2022-12-29 Fraunhofer Usa Inc. Particles for multi-dose delivery
CN113425683B (zh) * 2021-08-19 2022-09-20 谢彩华 一种三氮脒缓释注射剂及其制备方法

Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5656295A (en) * 1991-11-27 1997-08-12 Euro-Celtique, S.A. Controlled release oxycodone compositions
WO2003013476A1 (fr) * 2001-08-06 2003-02-20 Euro-Celtique S.A. Compositions et procedes servant a empecher la surconsommation d'opioides
WO2003013479A1 (fr) * 2001-08-06 2003-02-20 Euro-Celtique S.A. Compositions et methodes destinees a prevenir l'abus d'opioides
US20030068276A1 (en) * 2001-09-17 2003-04-10 Lyn Hughes Dosage forms
WO2003030878A2 (fr) * 2001-10-09 2003-04-17 Flamel Technologies Forme galenique orale microparticulaire
FR2837100A1 (fr) * 2002-03-18 2003-09-19 Flamel Tech Sa Comprimes a bases de microcapsules a liberation modifiee
WO2003084518A2 (fr) * 2002-04-09 2003-10-16 Flamel Technologies Suspension orale de microcapsules de principes actifs
WO2004004693A1 (fr) * 2002-07-05 2004-01-15 Collgegium Pharmaceutical Compositions pharmaceutiques empechant la consommation abusive d'opioides et d'autres drogues
WO2004010983A2 (fr) * 2002-07-26 2004-02-05 Flamel Technologies Formulation pharmaceutique orale sous forme d'une pluralite de microcapsules permettant la liberation prolongee de principe(s) actif(s) peu soluble(s)
WO2004026262A2 (fr) * 2002-09-23 2004-04-01 Verion, Inc. Compositions pharmaceutiques n'induisant pas l'abus
WO2004037259A1 (fr) * 2002-10-25 2004-05-06 Grünenthal GmbH Forme galenique protegee contre un usage detourne
US20040092542A1 (en) * 2000-02-08 2004-05-13 Benjamin Oshlack Tamper-resistant oral opioid agonist formulations
US20040126428A1 (en) * 2001-11-02 2004-07-01 Lyn Hughes Pharmaceutical formulation including a resinate and an aversive agent
WO2004100894A2 (fr) * 2003-05-12 2004-11-25 Shire Laboratories, Inc. Formulations de medicament presentant un potentiel d'abus reduit
WO2005016314A1 (fr) * 2003-08-06 2005-02-24 Grünenthal GmbH Forme galenique empechant un usage detourne
WO2005016313A1 (fr) * 2003-08-06 2005-02-24 Grünenthal GmbH Forme de preparation securisee contre un emploi abusif
WO2005063214A1 (fr) * 2003-12-24 2005-07-14 Grünenthal GmbH Procede de fabrication d'une forme d'administration securisee contre tout usage detourne

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
US3980766A (en) * 1973-08-13 1976-09-14 West Laboratories, Inc. Orally administered drug composition for therapy in the treatment of narcotic drug addiction
IL103224A (en) * 1992-09-18 1998-08-16 Teva Pharma Stabilized pharmaceutical compositions containing derivatives of vitamins d2 and d3
AU755790B2 (en) * 1997-12-22 2002-12-19 Euro-Celtique S.A. A method of preventing abuse of opioid dosage forms
FR2811571B1 (fr) * 2000-07-11 2002-10-11 Flamel Tech Sa Composition pharmaceutique orale, permettant la liberation controlee et l'absorption prolongee d'un principe actif
WO2006035416A2 (fr) * 2004-09-27 2006-04-06 Sigmoid Biotechnologies Limited Formulations comprenant des minicapsules

Patent Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5656295A (en) * 1991-11-27 1997-08-12 Euro-Celtique, S.A. Controlled release oxycodone compositions
US20040092542A1 (en) * 2000-02-08 2004-05-13 Benjamin Oshlack Tamper-resistant oral opioid agonist formulations
WO2003013476A1 (fr) * 2001-08-06 2003-02-20 Euro-Celtique S.A. Compositions et procedes servant a empecher la surconsommation d'opioides
WO2003013479A1 (fr) * 2001-08-06 2003-02-20 Euro-Celtique S.A. Compositions et methodes destinees a prevenir l'abus d'opioides
US20030068276A1 (en) * 2001-09-17 2003-04-10 Lyn Hughes Dosage forms
WO2003030878A2 (fr) * 2001-10-09 2003-04-17 Flamel Technologies Forme galenique orale microparticulaire
US20040126428A1 (en) * 2001-11-02 2004-07-01 Lyn Hughes Pharmaceutical formulation including a resinate and an aversive agent
FR2837100A1 (fr) * 2002-03-18 2003-09-19 Flamel Tech Sa Comprimes a bases de microcapsules a liberation modifiee
WO2003084518A2 (fr) * 2002-04-09 2003-10-16 Flamel Technologies Suspension orale de microcapsules de principes actifs
WO2004004693A1 (fr) * 2002-07-05 2004-01-15 Collgegium Pharmaceutical Compositions pharmaceutiques empechant la consommation abusive d'opioides et d'autres drogues
WO2004010983A2 (fr) * 2002-07-26 2004-02-05 Flamel Technologies Formulation pharmaceutique orale sous forme d'une pluralite de microcapsules permettant la liberation prolongee de principe(s) actif(s) peu soluble(s)
WO2004026262A2 (fr) * 2002-09-23 2004-04-01 Verion, Inc. Compositions pharmaceutiques n'induisant pas l'abus
WO2004037259A1 (fr) * 2002-10-25 2004-05-06 Grünenthal GmbH Forme galenique protegee contre un usage detourne
WO2004100894A2 (fr) * 2003-05-12 2004-11-25 Shire Laboratories, Inc. Formulations de medicament presentant un potentiel d'abus reduit
WO2005016314A1 (fr) * 2003-08-06 2005-02-24 Grünenthal GmbH Forme galenique empechant un usage detourne
WO2005016313A1 (fr) * 2003-08-06 2005-02-24 Grünenthal GmbH Forme de preparation securisee contre un emploi abusif
WO2005063214A1 (fr) * 2003-12-24 2005-07-14 Grünenthal GmbH Procede de fabrication d'une forme d'administration securisee contre tout usage detourne

Also Published As

Publication number Publication date
FR2889810A1 (fr) 2007-02-23
US20070264326A1 (en) 2007-11-15
WO2006125819A2 (fr) 2006-11-30

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