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WO2006035300A3 - Procede de preparation de meropenem - Google Patents

Procede de preparation de meropenem Download PDF

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Publication number
WO2006035300A3
WO2006035300A3 PCT/IB2005/002889 IB2005002889W WO2006035300A3 WO 2006035300 A3 WO2006035300 A3 WO 2006035300A3 IB 2005002889 W IB2005002889 W IB 2005002889W WO 2006035300 A3 WO2006035300 A3 WO 2006035300A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
meropenem
present
provides
invention further
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2005/002889
Other languages
English (en)
Other versions
WO2006035300A2 (fr
Inventor
Neera Tewari
Hashim Nizar Poovanathi Meeran
Bishwa Prakash Rai
Avinash Sheshrao Mane
Yatendra Kumar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ranbaxy Laboratories Ltd
Original Assignee
Ranbaxy Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Laboratories Ltd filed Critical Ranbaxy Laboratories Ltd
Publication of WO2006035300A2 publication Critical patent/WO2006035300A2/fr
Publication of WO2006035300A3 publication Critical patent/WO2006035300A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un procédé monotope de préparation de meropenem. L'invention concerne également un procédé de préparation de trihydrate de meropenem trihydrate.
PCT/IB2005/002889 2004-09-30 2005-09-28 Procede de preparation de meropenem Ceased WO2006035300A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN1896DE2004 2004-09-30
IN1895DE2004 2004-09-30
IN1896/DEL/2004 2004-09-30
IN1895/DEL/2004 2004-09-30

Publications (2)

Publication Number Publication Date
WO2006035300A2 WO2006035300A2 (fr) 2006-04-06
WO2006035300A3 true WO2006035300A3 (fr) 2006-08-31

Family

ID=35510909

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/002889 Ceased WO2006035300A2 (fr) 2004-09-30 2005-09-28 Procede de preparation de meropenem

Country Status (1)

Country Link
WO (1) WO2006035300A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8097719B2 (en) 2008-07-15 2012-01-17 Genesen Labs Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1934221A4 (fr) * 2005-09-15 2011-10-26 Orchid Chemicals & Pharm Ltd Procede ameliore de preparation d'un antibiotique beta-lactame
US20100240886A1 (en) * 2006-03-28 2010-09-23 Kaneka Corporation Process for producing carbapenem compound
KR100869165B1 (ko) 2007-09-13 2008-11-19 조동옥 메로페넴의 개선된 제조방법
EP2098525A1 (fr) * 2008-02-26 2009-09-09 Savior Lifetec Corporation Composé de carbapenem cristallin et son procédé de production
CN101348486B (zh) * 2008-08-29 2010-09-29 深圳市海滨制药有限公司 一种美罗培南的制备方法
JP5656881B2 (ja) * 2009-03-13 2015-01-21 ダエウン ファーマシューティカル カンパニー リミテッド 亜鉛粉末を用いるメロペネムの改善された製造方法
CN101875665B (zh) * 2009-04-30 2013-02-06 石药集团中奇制药技术（石家庄）有限公司 一种厄他培南中间体、含其的组合物及其制备方法
KR101142757B1 (ko) * 2009-12-03 2012-05-08 (주)하이텍팜 메로페넴 삼수화물의 제조방법
US8318716B2 (en) 2009-12-31 2012-11-27 Kbp Biosciences Co., Ltd. Carbapenem derivatives
CN101891742B (zh) * 2010-07-20 2012-06-27 深圳市海滨制药有限公司 美罗培南三水合物结晶的制备方法
CN101914098B (zh) * 2010-07-20 2012-08-15 深圳市海滨制药有限公司 美罗培南三水合物结晶的制备方法
CN102153554A (zh) * 2010-09-21 2011-08-17 重庆天地药业有限责任公司 一种制备美罗培南的方法
US9000150B2 (en) 2010-10-22 2015-04-07 Ranbaxy Laboratories Limited Process for the preparation of pure meropenem trihydrate
CN102532140B (zh) * 2010-12-21 2015-03-11 北大方正集团有限公司 一种美罗培南三水合物的制备方法
CN102250096B (zh) * 2011-09-05 2016-04-06 江西华邦药业有限公司 一种美罗培南的制备方法
CN102372715A (zh) * 2011-12-07 2012-03-14 凯莱英医药集团（天津）股份有限公司 一种制备美罗培南的方法
KR102144777B1 (ko) 2013-06-19 2020-08-18 제이더블유중외제약 주식회사 결정형 메로페넴 삼수화물의 제조방법
CN105194436A (zh) * 2015-10-26 2015-12-30 张刚 一种用于消除阑尾脓肿的外敷药物
CN111992205B (zh) * 2020-09-07 2023-06-16 西安凯立新材料股份有限公司 一种一锅法制备美罗培南用催化剂的方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0169410A1 (fr) * 1984-07-02 1986-01-29 Merck & Co. Inc. Carbapénèmes ayant en position 2 un substituant quaternisé pyridine alkylthio ou alkylénethio, compositions les contenant et leurs combinaisons avec des inhibiteurs de DHP
US4888344A (en) * 1986-07-30 1989-12-19 Sumitomo Pharmaceuticals Company, Limited Carbapenem compound in crystalline form, and its production and use
US5122604A (en) * 1983-05-09 1992-06-16 Sumitomo Pharmaceuticals Co., Ltd. β-lactam compounds
US5140030A (en) * 1985-06-10 1992-08-18 Merck 2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids
US20020128283A1 (en) * 2000-07-13 2002-09-12 American Home Products Corporation Process improvement in the preparation of (4R, 5S, 6S)-3-[[(2R,3R)-2-[[[(S)-2-amino-3-methyl-1-oxobutyl]amino]methyl]tetrahydro-3-furanyl]thio]-6-[(R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
WO2002094828A1 (fr) * 2001-05-18 2002-11-28 Ranbaxy Laboratories Limited Procede relatif a l'elaboration d'imipenem
WO2005118586A1 (fr) * 2004-06-02 2005-12-15 Sandoz Ag Intermediaire de meropenem sous forme cristalline

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5122604A (en) * 1983-05-09 1992-06-16 Sumitomo Pharmaceuticals Co., Ltd. β-lactam compounds
EP0169410A1 (fr) * 1984-07-02 1986-01-29 Merck & Co. Inc. Carbapénèmes ayant en position 2 un substituant quaternisé pyridine alkylthio ou alkylénethio, compositions les contenant et leurs combinaisons avec des inhibiteurs de DHP
US5140030A (en) * 1985-06-10 1992-08-18 Merck 2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids
US4888344A (en) * 1986-07-30 1989-12-19 Sumitomo Pharmaceuticals Company, Limited Carbapenem compound in crystalline form, and its production and use
US20020128283A1 (en) * 2000-07-13 2002-09-12 American Home Products Corporation Process improvement in the preparation of (4R, 5S, 6S)-3-[[(2R,3R)-2-[[[(S)-2-amino-3-methyl-1-oxobutyl]amino]methyl]tetrahydro-3-furanyl]thio]-6-[(R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
WO2002094828A1 (fr) * 2001-05-18 2002-11-28 Ranbaxy Laboratories Limited Procede relatif a l'elaboration d'imipenem
WO2005118586A1 (fr) * 2004-06-02 2005-12-15 Sandoz Ag Intermediaire de meropenem sous forme cristalline

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8097719B2 (en) 2008-07-15 2012-01-17 Genesen Labs Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem

Also Published As

Publication number Publication date
WO2006035300A2 (fr) 2006-04-06

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