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WO2006034822A8 - Neue substituierte thiophencarbonsäureamide, deren herstellung und deren verwendung als arzneimittel - Google Patents

Neue substituierte thiophencarbonsäureamide, deren herstellung und deren verwendung als arzneimittel

Info

Publication number
WO2006034822A8
WO2006034822A8 PCT/EP2005/010307 EP2005010307W WO2006034822A8 WO 2006034822 A8 WO2006034822 A8 WO 2006034822A8 EP 2005010307 W EP2005010307 W EP 2005010307W WO 2006034822 A8 WO2006034822 A8 WO 2006034822A8
Authority
WO
WIPO (PCT)
Prior art keywords
acid amides
novel substituted
medicaments
production
thiophencarboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2005/010307
Other languages
English (en)
French (fr)
Other versions
WO2006034822A1 (de
Inventor
Henning Priepke
Kai Gerlach
Roland Pfau
Wolfgang Wienen
Annette Schuler-Metz
Herbert Nar
Sandra Handschuh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim International GmbH
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH, Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim International GmbH
Priority to EP05788511A priority Critical patent/EP1797080A1/de
Priority to CA002581580A priority patent/CA2581580A1/en
Priority to JP2007533923A priority patent/JP2008514665A/ja
Publication of WO2006034822A1 publication Critical patent/WO2006034822A1/de
Publication of WO2006034822A8 publication Critical patent/WO2006034822A8/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Gegenstand der vorliegenden Erfindung sind neue substituierte Thiophen-2-carbonsäureamide der allgemeinen Formel (I), in der A, Ar und R1 bis R5 wie in Anspruch 1 definiert sind, deren Tautomere, deren Enantiomere, deren Diastereomere, deren Gemische und deren Salze, insbesondere deren physiologisch verträgliche Salze mit anorganischen oder organischen Säuren oder Basen, welche wertvolle Eigenschaften aufweisen.
PCT/EP2005/010307 2004-09-29 2005-09-23 Neue substituierte thiophencarbonsäureamide, deren herstellung und deren verwendung als arzneimittel Ceased WO2006034822A1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP05788511A EP1797080A1 (de) 2004-09-29 2005-09-23 Neue substituierte thiophencarbonsäureamide, deren herstellung und deren verwendung als arzneimittel
CA002581580A CA2581580A1 (en) 2004-09-29 2005-09-23 Novel substituted thiophencarboxylic acid amides, production thereof and use thereof as medicaments
JP2007533923A JP2008514665A (ja) 2004-09-29 2005-09-23 新規置換チオフェンカルボン酸アミド、それらの製造方法及び薬剤としてのそれらの使用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004047840A DE102004047840A1 (de) 2004-09-29 2004-09-29 Neue substituierte Thiophencarbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel
DE102004047840.6 2004-09-29

Publications (2)

Publication Number Publication Date
WO2006034822A1 WO2006034822A1 (de) 2006-04-06
WO2006034822A8 true WO2006034822A8 (de) 2006-06-15

Family

ID=35385703

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/010307 Ceased WO2006034822A1 (de) 2004-09-29 2005-09-23 Neue substituierte thiophencarbonsäureamide, deren herstellung und deren verwendung als arzneimittel

Country Status (6)

Country Link
US (1) US7563786B2 (de)
EP (1) EP1797080A1 (de)
JP (1) JP2008514665A (de)
CA (1) CA2581580A1 (de)
DE (1) DE102004047840A1 (de)
WO (1) WO2006034822A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1748997A1 (de) * 2004-05-13 2007-02-07 Boehringer Ingelheim International Gmbh Substituierte thiophen-2-carbonsäureamide, deren herstellung und deren verwendung als arzneimittel
PE20070171A1 (es) * 2005-06-30 2007-03-08 Boehringer Ingelheim Int GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa
PE20081834A1 (es) * 2006-12-31 2009-01-16 Boehringer Ingelheim Int Proceso para la sintesis de derivados de acido 3-amino-tetrahidrofuran-3-carboxilico y uso de los mismos como medicamentos
EP2220079A2 (de) 2007-11-15 2010-08-25 Boehringer Ingelheim International GmbH Substituierte amide sowie ihre herstellung und verwendung als medikamente
CA2731097A1 (en) 2008-07-15 2010-01-21 Novartis Ag Organic compounds
ES2528948T3 (es) 2009-09-21 2015-02-13 Chemocentryx, Inc. Derivados de pirrolidinona carboxamida como moduladores de quemerina-R (ChemR23)
US8912221B2 (en) * 2010-12-27 2014-12-16 Hoffmann-La Roche Inc. Biaryl amide derivatives
CN105294669B (zh) * 2014-10-24 2019-01-22 山东凯森制药有限公司 一种第十因子抑制剂及其制备方法和应用
EP3078378B1 (de) 2015-04-08 2020-06-24 Vaiomer Verwendung von faktor-xa-inhibitoren zur regulierung von glykämie
JP7502564B2 (ja) 2020-11-06 2024-06-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ２－［（チオフェン－２－イル）ホルムアミド］－ｎ－（フェニル）－２－メチルプロパンアミド誘導体及びその医薬としての使用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19962924A1 (de) * 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
GB0030305D0 (en) * 2000-12-13 2001-01-24 Lilly Co Eli Compounds
JP4266092B2 (ja) * 2001-10-09 2009-05-20 第一三共株式会社 ジアミン誘導体
EP1558606A4 (de) * 2002-10-02 2008-05-07 Bristol Myers Squibb Co LACTAMHALTIGE DIAMINOALKYLVERBINDUNGEN,BETA-AMINOSûUREN, ALPHA-AMINOSûUREN UND DERIVATE DAVON ALSFAKTOR-XA-INHIBITOREN
DE10254336A1 (de) 2002-11-21 2004-06-03 Merck Patent Gmbh Carbonsäureamide

Also Published As

Publication number Publication date
US20060069082A1 (en) 2006-03-30
US7563786B2 (en) 2009-07-21
DE102004047840A1 (de) 2006-03-30
CA2581580A1 (en) 2006-04-06
EP1797080A1 (de) 2007-06-20
WO2006034822A1 (de) 2006-04-06
JP2008514665A (ja) 2008-05-08

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