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PE20081834A1 - Proceso para la sintesis de derivados de acido 3-amino-tetrahidrofuran-3-carboxilico y uso de los mismos como medicamentos - Google Patents

Proceso para la sintesis de derivados de acido 3-amino-tetrahidrofuran-3-carboxilico y uso de los mismos como medicamentos

Info

Publication number
PE20081834A1
PE20081834A1 PE2007001815A PE2007001815A PE20081834A1 PE 20081834 A1 PE20081834 A1 PE 20081834A1 PE 2007001815 A PE2007001815 A PE 2007001815A PE 2007001815 A PE2007001815 A PE 2007001815A PE 20081834 A1 PE20081834 A1 PE 20081834A1
Authority
PE
Peru
Prior art keywords
synthesis
amino
acid
tetrahidrofuran
medicines
Prior art date
Application number
PE2007001815A
Other languages
English (en)
Inventor
Zhengxu Han
Dhileepkumar Krishnamurthy
Chris H Senanayake
Wenjun Tang
Yibo Xu
Nathan K Yee
Kai Gerlach
Burkhard Matthes
Herbert Nar
Roland Pfau
Henning Priepke
Annette Schuler-Metz
Peter Sieger
Wolfgang Wienen
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20081834A1 publication Critical patent/PE20081834A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE REFIERE A PROCESO PAR LA SINTESIS DE DERIVADOS DEL ACIDO 3-AMINO-TETRAHIDROFURANO DE FORMULA (I), EN DONDE D ES UN SISTEMA DE ANILLO BICICLICO DE FORMULA (II), EN DONDE K1 Y K4 SON INDEPENDIENTEMENTE -CH2, -CHR7a, -CR7b7c O -C(O); CADA R2 Y R3 SON INDEPENDIENTEMENTE -CH2, -CHR8a, -CR8b8c O -C(O); X ES NR1; A1 ES N O CR10; A2 ES N O CR11; A3 ES N O CR12; R3 ES H O ALQUILO(C1-C3); M ES TIOFENO QUE ESTA UNIDO AL CARBONILO DE (I), EN LA POSICION 2 Y ESTA SUSTITUIDO EN LA POSICION 5 CON R2 Y OPCIONALMENTE TAMBIEN CON R6. SON SELECCIONADOS AMIDAS DEL ACIDO (S)-3-[(5-BROMO-TIOFEN-2-IL)-CARBONILAMINO]-N-(3-METIL-2,3,4,5-TETRAHIDRO-1H-BENZO[d]AZEPIN-7-IL)-TETRAHIDROFURANO-3-CARBOXILICO, N-{3-[4-(5-CIANIMIN-[1,4]OXAZEPAN-4-IL)-FENILCARBAMOIL]-TETRAHIDROFURANO-3-IL}-AMIDA DEL ACIDO (S)-5-CLORO-TIOFENO-2-CARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS PRESENTAN UN EFECTO INHIBIDOR SOBRE EL FACTOR Xa E INHIBIDOR SOBRE SERIN PROTEASAS PRESENTANDO ACTIVIDAD ANTITROMBOTICA
PE2007001815A 2006-12-31 2007-12-14 Proceso para la sintesis de derivados de acido 3-amino-tetrahidrofuran-3-carboxilico y uso de los mismos como medicamentos PE20081834A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US88293706P 2006-12-31 2006-12-31

Publications (1)

Publication Number Publication Date
PE20081834A1 true PE20081834A1 (es) 2009-01-16

Family

ID=39253961

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001815A PE20081834A1 (es) 2006-12-31 2007-12-14 Proceso para la sintesis de derivados de acido 3-amino-tetrahidrofuran-3-carboxilico y uso de los mismos como medicamentos

Country Status (23)

Country Link
US (2) US20100317848A1 (es)
EP (1) EP2114909A2 (es)
JP (1) JP2010514729A (es)
KR (1) KR20090097208A (es)
CN (1) CN101573346B (es)
AR (1) AR064708A1 (es)
AU (1) AU2007341335A1 (es)
BR (1) BRPI0720748A2 (es)
CA (1) CA2674168A1 (es)
CL (1) CL2007003875A1 (es)
EA (1) EA200900797A1 (es)
EC (1) ECSP099406A (es)
MA (1) MA31116B1 (es)
MY (1) MY148769A (es)
NO (1) NO20091782L (es)
NZ (1) NZ578715A (es)
PE (1) PE20081834A1 (es)
TN (1) TN2009000276A1 (es)
TW (1) TW200846345A (es)
UA (1) UA96973C2 (es)
UY (1) UY30851A1 (es)
WO (1) WO2008080891A2 (es)
ZA (1) ZA200902451B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20070171A1 (es) 2005-06-30 2007-03-08 Boehringer Ingelheim Int GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa
EP2220079A2 (en) 2007-11-15 2010-08-25 Boehringer Ingelheim International GmbH Substituted amides, manufacturing and use thereof as medicaments
EP2497489A1 (en) 2011-03-09 2012-09-12 CSL Behring GmbH Factor XII inhibitors for the treatment of silent brain ischemia and ischemia of other organs
PL2683397T3 (pl) * 2011-03-09 2018-01-31 Csl Behring Gmbh Inhibitory czynnika XII do podawania w zabiegach medycznych obejmujących kontakt z powierzchniami sztucznymi
US9096579B2 (en) 2012-04-20 2015-08-04 Boehringer Ingelheim International Gmbh Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
WO2014060575A2 (en) * 2012-10-19 2014-04-24 Medichem S.A. Process for the enantioselective synthesis of a tetrahydrobenzazepine compound
RU2520134C1 (ru) * 2013-02-27 2014-06-20 Общество с ограниченной ответственностью "Авионко" (ООО "Авионко") Замещенные (r)-3-(4-метилкарбамоил-3-фторфениламино)-тетрагидро-фуран-3-енкарбоновые кислоты и их эфиры, способ их получения и применения
JP6636334B2 (ja) 2013-03-08 2020-01-29 ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー 遠隔虚血再灌流傷害の治療および予防
EP2999692A1 (en) * 2013-05-20 2016-03-30 LEK Pharmaceuticals d.d. Novel synthetic processes to 8-chloro-3-benzo[d]azepine via friedel-crafts alkylation of olefin
CN104530029B (zh) * 2014-12-09 2017-04-12 广东东阳光药业有限公司 作为Xa因子抑制剂的杂环化合物及其使用方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06013213A (es) 2004-05-13 2007-02-08 Boehringer Ingelheim Int Nuevas amidas sustituidas del acido tiofencarboxilico, su obtencion y su uso como medicamentos.
EP1748997A1 (de) * 2004-05-13 2007-02-07 Boehringer Ingelheim International Gmbh Substituierte thiophen-2-carbonsäureamide, deren herstellung und deren verwendung als arzneimittel
WO2005111014A1 (de) 2004-05-13 2005-11-24 Boehringer Ingelheim International Gmbh Substituierte thiophencarbonsäureamide, deren herstellung und deren verwendung als arzneimittel
DE102004047840A1 (de) 2004-09-29 2006-03-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue substituierte Thiophencarbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel
PE20070171A1 (es) * 2005-06-30 2007-03-08 Boehringer Ingelheim Int GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa

Also Published As

Publication number Publication date
EA200900797A1 (ru) 2009-12-30
JP2010514729A (ja) 2010-05-06
CN101573346A (zh) 2009-11-04
UA96973C2 (ru) 2011-12-26
NZ578715A (en) 2012-06-29
UY30851A1 (es) 2008-07-31
ECSP099406A (es) 2009-07-31
MY148769A (en) 2013-05-31
TN2009000276A1 (fr) 2010-10-18
CA2674168A1 (en) 2008-07-10
TW200846345A (en) 2008-12-01
EP2114909A2 (en) 2009-11-11
US20130005962A1 (en) 2013-01-03
AR064708A1 (es) 2009-04-22
CL2007003875A1 (es) 2008-04-18
WO2008080891A3 (en) 2008-10-02
US20100317848A1 (en) 2010-12-16
BRPI0720748A2 (pt) 2015-05-19
CN101573346B (zh) 2013-01-09
WO2008080891A2 (en) 2008-07-10
ZA200902451B (en) 2010-05-26
AU2007341335A1 (en) 2008-07-10
NO20091782L (no) 2009-06-10
KR20090097208A (ko) 2009-09-15
MA31116B1 (fr) 2010-01-04

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