[go: up one dir, main page]

WO2006031388A3 - Dentritic polymers, crosslinked gels, and their uses in orthopedic applications - Google Patents

Dentritic polymers, crosslinked gels, and their uses in orthopedic applications Download PDF

Info

Publication number
WO2006031388A3
WO2006031388A3 PCT/US2005/029915 US2005029915W WO2006031388A3 WO 2006031388 A3 WO2006031388 A3 WO 2006031388A3 US 2005029915 W US2005029915 W US 2005029915W WO 2006031388 A3 WO2006031388 A3 WO 2006031388A3
Authority
WO
WIPO (PCT)
Prior art keywords
capped
compound
dendritic
isocysteine
cysteine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/029915
Other languages
French (fr)
Other versions
WO2006031388A2 (en
Inventor
Mark W Grinstaff
Michael A Carnahan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hyperbranch Medical Technology Inc
Original Assignee
Hyperbranch Medical Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hyperbranch Medical Technology Inc filed Critical Hyperbranch Medical Technology Inc
Publication of WO2006031388A2 publication Critical patent/WO2006031388A2/en
Publication of WO2006031388A3 publication Critical patent/WO2006031388A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The present invention provides compositions, kits, and methods for repairing cartilaginous tissue. Certain methods of the invention utilize dendritic macromolecules formed by treating a dendritic compound with light or a linking compound. In certain instances, the dendritic compounds have a lysine, cysteine, isocysteine residue or other nucleophilic group attached to their peripheries. Addition of a compound containing two or more electrophilic groups, such as aldehydes, activated esters, or acrylates, to the lysine-capped, cysteine-capped, or isocysteine-capped dendrimers produces a polymeric compound that can repair a cartilage defect.
PCT/US2005/029915 2004-08-20 2005-08-22 Dentritic polymers, crosslinked gels, and their uses in orthopedic applications Ceased WO2006031388A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US60350204P 2004-08-20 2004-08-20
US60/603,502 2004-08-20
US60409704P 2004-08-23 2004-08-23
US60/604,097 2004-08-23

Publications (2)

Publication Number Publication Date
WO2006031388A2 WO2006031388A2 (en) 2006-03-23
WO2006031388A3 true WO2006031388A3 (en) 2006-10-12

Family

ID=36060499

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/029915 Ceased WO2006031388A2 (en) 2004-08-20 2005-08-22 Dentritic polymers, crosslinked gels, and their uses in orthopedic applications

Country Status (1)

Country Link
WO (1) WO2006031388A2 (en)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7943573B2 (en) 2008-02-07 2011-05-17 Biomimetic Therapeutics, Inc. Methods for treatment of distraction osteogenesis using PDGF
US8106008B2 (en) 2006-11-03 2012-01-31 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures
US8114841B2 (en) 2004-10-14 2012-02-14 Biomimetic Therapeutics, Inc. Maxillofacial bone augmentation using rhPDGF-BB and a biocompatible matrix
US8492335B2 (en) 2010-02-22 2013-07-23 Biomimetic Therapeutics, Llc Platelet-derived growth factor compositions and methods for the treatment of tendinopathies
US8563027B2 (en) 2009-02-12 2013-10-22 Incept, Llc Drug delivery through hydrogel plugs
US8870954B2 (en) 2008-09-09 2014-10-28 Biomimetic Therapeutics, Llc Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
US8905963B2 (en) 2010-08-05 2014-12-09 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US8986730B2 (en) 2004-11-05 2015-03-24 Incept, Llc Methods for sealing a vascular puncture
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
US9370485B2 (en) 2007-07-09 2016-06-21 Incept, Llc Hydrogel polymeric compositions and methods
US9417238B2 (en) 2009-01-29 2016-08-16 Forsight Vision4, Inc. Posterior segment drug delivery
US9474756B2 (en) 2014-08-08 2016-10-25 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
US9492315B2 (en) 2010-08-05 2016-11-15 Forsight Vision4, Inc. Implantable therapeutic device
US9526654B2 (en) 2013-03-28 2016-12-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
US9642891B2 (en) 2006-06-30 2017-05-09 Biomimetic Therapeutics, Llc Compositions and methods for treating rotator cuff injuries
US10258566B2 (en) 2004-10-14 2019-04-16 Biomimetic Therapeutics, Llc Compositions and methods for treating bone

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
WO2007048672A1 (en) 2005-10-25 2007-05-03 Evonik Degussa Gmbh Preparations containing hyperbranched polymers
DE102005051334A1 (en) * 2005-10-25 2007-06-21 Degussa Gmbh Preparation, useful e.g. as a hardening agent and catalyst, and in cosmetics and medicines, comprises a low-molecular substance and a hyperbranched polymer having a hydrophilic core containing polyester unit and hydrophobic terminal group
WO2007082061A2 (en) 2006-01-11 2007-07-19 Hyperbranch Medical Technology, Inc. Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices
US8262608B2 (en) 2007-01-25 2012-09-11 Hyperbranch Medical Technology, Inc. Applicators for multiple component formulations and the like, and methods of use thereof
US7862538B2 (en) 2008-02-04 2011-01-04 Incept Llc Surgical delivery system for medical sealant
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
US9463004B2 (en) 2009-05-04 2016-10-11 Incept, Llc. Biomaterials for track and puncture closure
WO2011084465A2 (en) 2009-12-15 2011-07-14 Incept, Llc Implants and biodegradable fiducial markers
US10166142B2 (en) 2010-01-29 2019-01-01 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
CN103153316B (en) 2010-08-05 2015-08-19 弗赛特影像4股份有限公司 Combination drug delivery methods and devices
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
US20140031769A1 (en) 2010-11-19 2014-01-30 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
WO2013003620A2 (en) 2011-06-28 2013-01-03 Forsight Vision4, Inc. Diagnostic methods and apparatus
WO2013040247A2 (en) 2011-09-16 2013-03-21 Forsight Vision4, Inc. Fluid exchange apparatus and methods
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
KR20190090048A (en) 2011-12-05 2019-07-31 인셉트, 엘엘씨 Medical organogel processes and compositions
US10010448B2 (en) 2012-02-03 2018-07-03 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
CA2905496A1 (en) 2013-03-14 2014-09-25 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
RU2695563C2 (en) 2014-07-15 2019-07-24 Форсайт Вижн4, Инк. Method and device for eye implant delivery
US10550187B2 (en) 2014-10-24 2020-02-04 Incept, Llc Extra luminal scaffold
AU2015346450B2 (en) 2014-11-10 2020-01-30 Forsight Vision4, Inc. Expandable drug delivery devices and method of use
EP3229779B1 (en) 2014-12-10 2021-02-03 Incept, LLC Hydrogel drug delivery implants
WO2016183296A1 (en) 2015-05-12 2016-11-17 Incept, Llc Drug delivery from hydrogels
MX2018006234A (en) 2015-11-20 2018-08-14 Forsight Vision4 Inc Porous structures for extended release drug delivery devices.
US10420724B2 (en) 2015-11-25 2019-09-24 Incept, Llc Shape changing drug delivery devices and methods
MX2018012021A (en) 2016-04-05 2019-01-24 Forsight Vision4 Inc Implantable ocular drug delivery devices.
CN109982683A (en) 2016-09-23 2019-07-05 因赛普特有限责任公司 Drug delivery storage cavern in anterior chamber
AU2018372806B2 (en) 2017-11-21 2024-05-30 Forsight Vision4, Inc. Fluid exchange apparatus for expandable port delivery system and methods of use
CN117001995A (en) 2018-04-06 2023-11-07 聚合-医药有限公司 Methods and compositions for photopolymerizable additive manufacturing
EP3781384A4 (en) 2018-04-19 2022-01-26 Poly-Med Inc. MACROMERS AND COMPOSITIONS FOR PHOTOCURING PROCESSES
CA3202843A1 (en) * 2020-12-22 2022-06-30 Russell J. Stewart In situ solidifying injectable compositions with transient contrast agents and methods of making and using thereof
EP4312983A4 (en) 2021-03-30 2025-01-22 Tulavi Therapeutics, Inc. METHODS AND COMPOSITIONS FOR NERVE ABLATION
USD1033637S1 (en) 2022-01-24 2024-07-02 Forsight Vision4, Inc. Fluid exchange device

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6642363B1 (en) * 1996-09-19 2003-11-04 The Regents Of The University Of Michigan Polymers containing polysaccharides such as alginates or modified alginates

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6642363B1 (en) * 1996-09-19 2003-11-04 The Regents Of The University Of Michigan Polymers containing polysaccharides such as alginates or modified alginates

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8114841B2 (en) 2004-10-14 2012-02-14 Biomimetic Therapeutics, Inc. Maxillofacial bone augmentation using rhPDGF-BB and a biocompatible matrix
US10258566B2 (en) 2004-10-14 2019-04-16 Biomimetic Therapeutics, Llc Compositions and methods for treating bone
US9386969B2 (en) 2004-11-05 2016-07-12 Incept, Llc Methods for sealing a vascular puncture
US8986730B2 (en) 2004-11-05 2015-03-24 Incept, Llc Methods for sealing a vascular puncture
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
US9642891B2 (en) 2006-06-30 2017-05-09 Biomimetic Therapeutics, Llc Compositions and methods for treating rotator cuff injuries
US11058801B2 (en) 2006-06-30 2021-07-13 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
US10456450B2 (en) 2006-06-30 2019-10-29 Biomimetic Therapeutics, Llc Compositions and methods for treating rotator cuff injuries
US8106008B2 (en) 2006-11-03 2012-01-31 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures
US9370485B2 (en) 2007-07-09 2016-06-21 Incept, Llc Hydrogel polymeric compositions and methods
US8349796B2 (en) 2008-02-07 2013-01-08 Biomimetic Therapeutics Inc. Methods for treatment of distraction osteogenesis using PDGF
US7943573B2 (en) 2008-02-07 2011-05-17 Biomimetic Therapeutics, Inc. Methods for treatment of distraction osteogenesis using PDGF
US8870954B2 (en) 2008-09-09 2014-10-28 Biomimetic Therapeutics, Llc Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
US11135341B2 (en) 2008-09-09 2021-10-05 Biomimetic Therapeutics, Llc Platelet-derived growth factor composition and methods for the treatment of tendon and ligament injuries
US9417238B2 (en) 2009-01-29 2016-08-16 Forsight Vision4, Inc. Posterior segment drug delivery
US8563027B2 (en) 2009-02-12 2013-10-22 Incept, Llc Drug delivery through hydrogel plugs
US8492335B2 (en) 2010-02-22 2013-07-23 Biomimetic Therapeutics, Llc Platelet-derived growth factor compositions and methods for the treatment of tendinopathies
US9492315B2 (en) 2010-08-05 2016-11-15 Forsight Vision4, Inc. Implantable therapeutic device
US9033911B2 (en) 2010-08-05 2015-05-19 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US8905963B2 (en) 2010-08-05 2014-12-09 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US9526654B2 (en) 2013-03-28 2016-12-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
US9474756B2 (en) 2014-08-08 2016-10-25 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof

Also Published As

Publication number Publication date
WO2006031388A2 (en) 2006-03-23

Similar Documents

Publication Publication Date Title
WO2006031388A3 (en) Dentritic polymers, crosslinked gels, and their uses in orthopedic applications
WO2006031358A3 (en) Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses
RU2009111261A (en) COMPOSITIONS FOR THE TREATMENT OF HAIR, INCLUDING POLYMERS, HAVING AN EQUITY FOR HAIR
WO2007082061A3 (en) Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices
ZA200804109B (en) Malodor reducing compositions and methods
DE602004006892D1 (en) ANION-BONDING POLYMERS AND ITS USES
TW200606580A (en) A chemically amplified positive resist composition, (meth)acrylate derivative and a process for producing the same
AU2008222967A8 (en) Cross-linking of antioxidant-containing polymers
EA200970819A1 (en) THYOURETHANE COMPOSITIONS AND METHODS OF OBTAINING AND APPLICATION OF THE INDICATED COMPOSITIONS
EP2273512A3 (en) Conjugated polymers comprising triarylamine-arylenevinylene units, synthesis and use of the same
WO2007086904A3 (en) Compositions for use in identification of adenoviruses
MX2010000920A (en) Thermoreversibly crosslinked bitumen/polymer composition.
WO2009051373A3 (en) Methacrylic copolymer, method for preparing the same and methacrylic resin composition using thereof
BRPI0509765A (en) polymers with h-bridge forming features
ATE521373T1 (en) BONE CEMENT COMPOSITION
DE502008002831D1 (en) AQUEOUS DISPERSIONS CONTAINING AT LEAST ONE OLD OF A (METH) ACRYLATE SEGMENT
DE50105082D1 (en) NETWORKED WATER-SOURCE POLYMERISATE AND METHOD FOR THE PRODUCTION THEREOF
BRPI0707404A8 (en) METHOD FOR THE PURIFICATION OF A RESORBIBLE POLYMER FROM RESIDUAL MONOMERS
MX2010000917A (en) Graft polymer and thermoreversibly cross-linked bitumen composition comprising said graft polymer.
BR0212902A (en) Shock Resistant Polymer Modified Compositions
ATE532804T1 (en) NEW RHEOLOGICAL MODIFIERS FOR MODIFYING THE RHEOLOGICAL BEHAVIOR OF COATING COMPOSITIONS
EA200800594A1 (en) POLYMERIC COMPOSITIONS AND METHODS OF MANUFACTURE AND APPLICATION OF POLYMERIC COMPOSITIONS
TW200505990A (en) Chemical composition and method of polymerisation thereof for use on vehicle bodywork repair
DE60209795D1 (en) COMPOSITIONS CONTAINING END-GROUP-POLYALKYLENE GLYCOLS
BR0303105A (en) Method for improving the processability of a matrix resin and polymer composition

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase