WO2006006270A1 - Alleviator for falling-off of hair - Google Patents

Abstract

[PROBLEMS] To provide an alleviator for the falling-off of hair which is highly safe, can be taken or administered daily, and is effective in alleviating the falling-off of hair. [MEANS FOR SOLVING PROBLEMS] Bitter melon treated with heating or an extract thereof functions to lower the neutral-fat content in the blood and is used as an active ingredient for an alleviator for the falling-off of hair.

Description

 Specification

 Hair loss improving agent

 Technical field

 [0001] The present invention relates to a hair loss improving agent that effectively improves hair loss symptoms. Furthermore, this invention relates to the foodstuff or pharmaceutical composition containing the said hair loss improving agent.

 Background art

 [0002] Sebaceous gland strength of the scalp Secreted sebum imparts appropriate oil, suppleness and strength to the hair, and also plays a role in suppressing the entry of foreign substances into the scalp and the release of moisture from the scalp. . However, it is known that if excessive sebum is secreted into the scalp, the sebum will block the pores, which may cause or worsen hair loss symptoms!

 [0003] Conventionally, various hair restorers have been used for the prevention and treatment of alopecia! Conventional hair restoration agents generally contain ingredients that contribute to blood circulation promotion, cleansing, anti-inflammatory, sterilization, cell activation, and the like. However, the ingredients used in conventional hair restorers do not have the effect of suppressing the excessive secretion of sebum to the scalp or are weak, so that a sufficient hair-growth effect cannot be obtained. There is. Against the background of such conventional technology, it is desired to develop a hair loss improving agent that suppresses the accumulation of sebum in pores and can effectively prevent the occurrence of hair loss symptoms and bad hair.

 [0004] On the other hand, it has been known that an extract of Nigauri has a hair follicle cell proliferation activity and can be used as a hair restorer (see Patent Document 1). In addition, it has been reported that pulverized Nigauri and its extract have an effect of improving lipid metabolism (Patent Literature).

2). However, it is known that the components extracted from Nigauri have no effect on reducing the amount of blood neutral fat that causes sebum secretion in the scalp (see paragraph 0036 of Patent Document 2). [0046] However, even if it is ingested as food or the like, a sufficient hair loss improving effect cannot be expected. In addition, it is not known how the heat-treated product of Nigauri affects the improvement of hair loss.

 Patent Document 1: Japanese Patent Laid-Open No. 2002-212050

Patent Document 2: JP 2002-278804 A Disclosure of the invention

 Problems to be solved by the invention

 [0005] An object of the present invention is to provide a hair loss improving agent that is highly safe and can be taken or administered on a daily basis and is effective in improving hair loss. Furthermore, an object of the present invention is to provide foods and pharmaceuticals containing the hair loss improving agent.

 Means for solving the problem

 [0006] The inventors of the present invention have intensively studied to solve the above-described problems. As a result, the scalp has a heat-treated product of two gourds, in particular, a heat-treated product after drying the gourd. It has been found that it suppresses the secretion of sebum and prevents or treats hair loss. The present invention has been developed based on further studies and further studies.

 [0007] That is, the present invention provides the following inventions:

 Item 1. A hair loss-improving agent comprising a heat-treated two-gauri product or an extract thereof as an active ingredient.

 Item 2. The hair loss improving agent according to Item 1, wherein the two-gauri heat-treated product is obtained by heating after drying -gouli.

 Item 3. A hair loss improving food comprising the hair loss improving agent according to Item 1 or 2.

 Item 4. The food for improving hair loss according to Item 3, which is in the form of a powder, tablet, capsule, syrup, jelly, or beverage.

 Item 5. A pharmaceutical product or quasi-drug for hair loss improvement comprising the hair loss improving agent according to Item 1 or 2.

 [0008] The present invention is described in detail below. In the hair loss improving agent of the present invention, a two-gauri heat-treated product is used as an active ingredient.

[0009] Nigauri is a plant belonging to the cucurbitaceae family and has the scientific name Momordica charantia.

 Known as Shishi, it is native to tropical Asia, and is often cultivated in the offshore and Kyushu regions in Japan.

. Nigauri is also known as Goya Ralishi. The gourd used in the present invention may be a wild species or an improved variety!

[0010] As the raw material of the heat-treated 2-gauri product that is the active ingredient of the present invention, a fruit portion of 2-gauri is used. The fruit part includes fruit skin, fruit pulp, fruit juice, cotton, seeds, etc., but any of these parts may be used as a raw material for the two-gauri heat-treated product. Preferably, from the fruit part An edible part excluding seeds and cotton, more preferably pulp.

 [0011] The two-gauri heat-treated product can be obtained by chopping or crushing two-gauri as necessary, for example, by heating at 40 to 120 ° C for about 1 to 60 minutes. The heating method is not particularly limited, but a roasting method is preferable.

 [0012] Preferably, the -gouli heat-treated product is obtained by heating two-gauri after drying. Hereinafter, a method for preparing a gourd heat-treated product by drying and heating two gourds will be described. In the preparation of heat-treated cucumbers, it is subjected to a step of drying the two gauli prior to the heat treatment of the gauri, but before the drying step, the two gaulis are chopped or crushed to an appropriate size. It is desirable to keep it. From the viewpoint of efficiently performing drying and heating, it is desirable to cut the two gourd into pieces of about 120 mm, preferably about 5-8 mm. The dry weight of bigauri may be carried out until the weight is reduced to 120%, preferably 5-12% of the weight before drying. The drying method and conditions are not particularly limited, and a drying method known or commonly used in the art may be employed. Specific examples of the drying method include a method of drying by applying hot air of about 40 to 120 ° C, and a method of drying for 15 to 15 days, preferably about 3 days in the sun. The dried bigauri is then subjected to a heat treatment (for example, roasting treatment). The calorific heat condition is appropriately adjusted according to the heating temperature and the heating time. The heating temperature is usually set to 40-120 ° C, preferably 60-120 ° C. In addition, the heating time varies depending on the heating temperature and cannot be specified uniformly, but is usually 1 to 60 minutes, preferably about 3 to 15 minutes. The heating method is not particularly limited, and an example of a suitable heating method is a method of frying under the above temperature conditions. The said heat processing can be implemented using a roasting machine etc., for example. By performing such heat treatment, a two-gauri heat-treated product is prepared. The -gouli heat-treated product is usually reduced to a weight of 1-10%, preferably 5-7% of the weight of the -gouli before drying.

[0013] In the present invention, as an active ingredient of the hair loss improving agent, the ability to use the -gauri heat-treated product obtained by the above method as it is, and further, an extract of the -gauri-heat-treated product may be used. [0014] An extract of a heat-treated 2-gauli product can be obtained by extracting the heat-treated 2-gauli product with an extraction solvent at room temperature or under heating. Examples of the extraction solvent include water; an organic solvent; or a mixed solution of water and an organic solvent. Examples of the organic solvent used for extraction include methanol, ethanol, isopropanol, propylene glycol, 1,3-butylene glycol, acetone, ethyl acetate, chloroform, pentane, hexane, heptane, etc. A combination of more than one species can be mentioned. The extraction solvent is preferably water; a lower alcohol such as methanol, ethanol or isopropanol; or a mixture of water and a lower alcohol, more preferably water, ethanol or a mixture of water and ethanol (5-50). A water-weight ethanol solution); particularly preferably water. The above water includes warm water and hot water.

 [0015] The extract of the two-gauri heat-treated product used for the hair loss improving agent may be the extract obtained by the above-described extraction treatment as it is, or the extract liquid solids may be removed. It may be. If necessary, it may be further concentrated by vacuum distillation or the like, or may be dried by a drying treatment such as vacuum drying or freeze drying.

 [0016] The amount or dose of the hair loss improving agent of the present invention varies depending on the age and sex of the subject, the degree of hair loss symptoms, the expected effect, etc., and cannot be uniformly defined, but per adult day As an example, the amount of hair loss improver (converted to the dry weight of the two-gauri heat-treated product) is 0.1-4 g, preferably 0.3-2 g, more preferably 0.7-2 g. The quantity is illustrated.

 [0017] The hair loss-improving agent of the present invention can also be provided as a food product for improving hair loss by blending it in foods, or it can be prepared in the form of an internal medicine or quasi-drug and used for improving skin hair loss. Or as a quasi-drug.

[0018] Preferably, the above-mentioned food for improving hair loss includes health functional foods (nutrient functional foods and foods for specific health), so-called health foods, nutritional supplements or special-purpose foods (food for the sick, etc.). Can do. Examples of the form include powders, tablets, capsules, syrups, jelly forms and the like. In addition, since the extract of the two gourd heat-treated product obtained using water as an extraction solvent can be used as it is, the extract itself, or its concentrated or diluted solution can be used as a beverage form food. . [0019] In the above-mentioned food for improving hair loss, the ratio of the hair loss improving agent to be blended may be appropriately set according to the intake amount of the agent per day, the form of food, the expected effect, etc. Good.

 [0020] The shape of the pharmaceutical product or quasi-drug for improving hair loss is not particularly limited as long as the effect of the present invention is not hindered. Examples of the form of the pharmaceutical or quasi drug include tablets, powders, granules, capsules, pills, troches, liquids, extracts and the like. The drug or quasi-drug is formulated with a pharmaceutically acceptable carrier or carrier, but if necessary, a binder, a disintegrant, a lubricant, a wetting agent, a buffer, a preservative. In addition, it may optionally contain pharmaceutically acceptable additives such as fragrances.

 [0021] The ratio of the hair loss improving agent contained in the above-mentioned pharmaceutical product or quasi-drug for improving hair loss is the dosage of the agent per day, the age and sex of the subject, the form of the pharmaceutical product or quasi-drug, It can be set as appropriate according to the expected effect.

 The hair loss improving agent of the present invention is useful as an edible hair restorer because it can prevent or treat hair loss by preventing the accumulation of sebum in the pores when taken or applied orally. It is. Moreover, the hair loss improving agent of the present invention is suitable for the ability to be effective against hair loss symptoms caused by any factor, particularly for the prevention or treatment of seborrheic alopecia.

 [0023] The hair loss improving agent of the present invention may be used in combination with other hair growth agents that are applied transdermally or taken orally, and this may cause the effect of improving hair loss more remarkably.

 The invention's effect

 [0024] According to the hair loss improving agent of the present invention, it is possible to effectively suppress the accumulation of sebum in the pores, thus effectively preventing the occurrence of hair loss and symptom illness, and healthy scalp and hair. It is possible to maintain a stable state.

 [0025] Further, the hair loss improving agent of the present invention can be conventionally used as a raw material for foods-it is prepared as a raw material, and thus is taken or administered daily as a highly safe food or an internal medicine. It is possible.

[0026] Furthermore, the two-gauri heat-treated product obtained by drying and heating two-gauri does not have the bitterness peculiar to two-gauri and does not adversely affect the taste. Can be used without being limited to the type of medicine or the shape of the pharmaceutical or pharmaceutical composition, preventing hair loss Alternatively, it is possible to provide a wide variety of means for treatment.

 Brief Description of Drawings

 [0027] [Fig. 1] A photograph of the condition of the scalp before ingesting the subject's grilled meat during the test of Test Example 1.

 [Fig. 2] A photograph of the condition of the scalp 2 hours after ingestion of the subject's grilled meat during the test of Test Example 1.

 FIG. 3 is a photograph of the condition of the scalp before ingesting the subject's grilled meat during the control test in Test Example 1.

 FIG. 4 is a photograph of the condition of the scalp taken 2 hours after ingesting the subject's grilled meat during the control test in Test Example 1.

 BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, the present invention will be described with reference to examples, but the present invention is not limited to these examples.

 Example 1

 It is known that hair loss symptoms can be improved by preventing the accumulation of sebum in the pores. In addition, the amount of sebum secreted into the scalp (hair) is correlated with the amount of sebum secreted in the forehead. Therefore, by confirming the amount of sebum secreted in the scalp (hair part) and measuring the amount of sebum secreted in the forehead, what effect is exerted on the improvement of hair loss due to the treatment of two-gauri heat treatment? Evaluation was performed.

[0029] <Preparation of two-gauri heat-treated product>

 After removing the seeds and cotton from the fruit part of the bigauri, it was chopped to about 5-8 mm. Chopped-gouli lOOOOg was dried in a hot air dryer with hot air at 40-120 ° C until the weight was 120 g. Next, using a direct fire roaster, the iron plate temperature was gradually raised from 70 ° C. to 110 ° C. for 15 minutes and fried to obtain 60 g of a two-gauri heat-treated product.

[0030] The -gowry heat-treated product thus obtained was added to boiling water immediately after boiling, and allowed to stand for 1 minute, and extracted to 100 g of the extract solution so that the -gowri-heat-treated product was 0.2 g. Thereafter, an extract from which solid residue was removed by filtration was used as a test sample. [0031] <Evaluation of the degree of sebum accumulation in the scalp (hair) and measurement of the amount of sebum secreted in the forehead>

 The degree of sebum accumulation in the scalp (hair) was evaluated by subjects who took the test sample under the conditions shown in Table 1 below, and the amount of sebum secreted in the forehead was measured. Specifically, first, the degree of sebum accumulation in the subject's scalp (hair) was confirmed by visual and photography, and oil blotting paper (trade name “Cosmetics Planet Oil Blotting Paper”, Orbit Co., Ltd.) 100% natural hemp) was used to fully absorb the subject's forehead sebum. Immediately thereafter, about 300 g of grilled meat was ingested. Two hours after the disclosure of grilled meat intake, the degree of sebum accumulation on the subject's scalp (hair) was confirmed visually and by photography, and the oil on the left half of the subject's left forehead was sufficiently removed using oil blotting paper. Sucked up. In addition, 4 hours after the disclosure of grilled meat intake, the degree of sebum accumulation in the scalp (hair) of the subject was confirmed again visually, and the oil on the right half of the forehead of the subject was sufficiently removed using a blotting paper. Sucked up. For a picture of the scalp, set the 3D Digital Finescope V C1000 (made by OMRON Corporation), set the low-magnification zoom lens VC-M20Z (made by OMRON Corporation), and then attach the contact adapter for VC-M20Z to the lens tip. Photographed by mounting and magnifying 80x.

 The sebum amount after 2 and 4 hours of ingestion of yakiniku was calculated according to the following formula.

[0032] [Equation 1] Sebum Amount (g) (Weight of Oil Blotting Paper after Absorbing Sebum) (g)

 1 (weight of oil blotting paper before absorbing sebum) (g)

[0033] [Table 1]

[0034] <Result> Figure 14 shows the results of confirming the degree of sebum accumulation in the scalp by photography. Fig. 1 shows the condition of the scalp before ingestion of the grilled meat of one subject in the test of Test Example 1; Fig. 2 shows the condition of the scalp 2 hours after ingestion of the subject's grilled meat in the test of Test Example 1; Fig. 4 shows the condition of the scalp before ingestion of the subject's grilled meat during the control test of Test Example 1; Fig. 4 shows the condition of the scalp after 2 hours of ingestion of the subject's grilled meat during the control test of Test Example 1. It is a photograph. As shown in these photographs (Fig. 1-14), it is confirmed that the accumulation of sebum in the hair roots of the scalp can be remarkably suppressed by ingesting the extract of the two-gauri heat-treated product 2 hours after ingestion of the roast meat. It was done.

 [0035] Similarly, as a result of visual evaluation of the degree of sebum accumulation in the scalp (hair part), in both Test Examples 1 and 2, control was obtained by ingesting an extract of the two-gauri heat-treated product. In contrast, it was confirmed that the accumulation of sebum in the scalp (hair part) was suppressed 2 hours and 4 hours after ingestion of grilled meat.

 [0036] Table 2 shows the results obtained for the amount of sebum secreted in the forehead. In Table 2, the rate of decrease in sebum secretion means the ratio (%) of the amount of sebum decreased relative to the amount of sebum in the control. As a result, it was confirmed that the amount of sebum secreted in the forehead was reduced by ingesting the extract of the two-gauri heat-treated product. In particular, from the results of Test Example 2, it was confirmed that the amount of sebum secreted could be effectively suppressed by daily intake of the extract of the heat-treated two gourd.

 [0037] From the above results, the heat treatment product or extract thereof has the effect of suppressing the sebum secretion to the scalp and preventing the accumulation of sebum in the pores, resulting in hair loss symptoms. It became clear that it was useful for improvement.

 [0038] [Table 2]

# The sebum amount and the decrease rate of sebum secretion in Test Examples 1 and 2 show the average values of the results of all subjects. [0039] Example 2 (capsule)

 Gelatin 5g heated to 40-60 ° C was gradually added with stirring to dissolve. The mixed solution was degassed under reduced pressure, and then appropriate amounts of titanium oxide and pigment were added and further mixed. Then, after filling into a capsule-type bottle, it was dried until the moisture content was 15-18% by weight, and the body part of the capsule was prepared by the method described in Example 1 and filled with 200 mg of a gourd heat-treated product. Then, the cap part was bonded to prepare a capsule containing the two-gauri heat-treated product.

 [0040] Implementation 13 (Micro Capsenore)

 To 10 g of purified water heated to 40 ° C, 5 g of gelatin was gradually added with stirring and mixed and dissolved. Thereafter, 200 mg of a gourd heat-treated product prepared by the method described in Example 1, titanium oxide, glycerin and a dye were added in appropriate amounts and mixed to obtain a capsule. The capsule was then cooled and dehydrated until the water content was 15-18% by weight and further dried until the water content was 8.2 to 16% by weight. Then, it filtered and the microcapsule containing a two-gauri heat-processed material was prepared.

 [0041] Example 4 (cookies)

 First, while stirring 70 g of unsalted butter, 80 g of sugar (granulated sugar) was gradually added thereto. After adding one loose egg to this, 2 g of the galley-heat-treated product prepared by the method described in Example 1 was added and further stirred. At the stage of sufficient mixing, 200 g of uniformly powdered flour was added and stirred at a low speed, and then lumped together. After sleeping in a low temperature room for about 30 minutes, it was uniformly stretched to a thickness of about 1 cm and extracted with a circular mold having a diameter of 5 cm. Next, the cut cookie dough was arranged on a top plate and heated in an oven preheated at 170 ° C. for 12-15 minutes to obtain a cookie containing a two-gauri heat-treated product.

 [0042] Example 5 (soft drink)

 A soft drink having the following composition was prepared.

 [0043] (wt%)

 Digauri heat-treated extract (prepared by the method described in Example 1) 0.5

 Fructose dextrose liquid sugar 6.0

Sodium quenate 0.6 L Asconolevic acid 3.0

 Dredging

Total 100% by weight Example 6 (jelly)

 According to a conventional method, a jelly having the following composition was prepared.

 (% By weight) Extract from Nigauri heat-treated product (prepared by the method described in Example 1) Gelatin 1. 1 Sugar 22.0

 L Tartaric acid 0.1 Sodium citrate 0.1 0.1 Quenic acid 0.1

 S.

100% by weight

Claims

The scope of the claims  [1] A hair loss-improving agent comprising a heat-treated two-gauri product or an extract thereof as an active ingredient. [2] The hair loss improving agent according to claim 1, wherein the two-gauri heat-treated product is obtained by drying and heating two-gauri.  [3] A food for improving hair loss, comprising the hair loss improving agent according to claim 1 or 2. [4] A pharmaceutical product or quasi-drug for hair loss improvement, comprising the hair loss improving agent according to claim 1 or 2.