JP2002080385A - Metal deposition inhibitor - Google Patents
Metal deposition inhibitorInfo
- Publication number
- JP2002080385A JP2002080385A JP2001067281A JP2001067281A JP2002080385A JP 2002080385 A JP2002080385 A JP 2002080385A JP 2001067281 A JP2001067281 A JP 2001067281A JP 2001067281 A JP2001067281 A JP 2001067281A JP 2002080385 A JP2002080385 A JP 2002080385A
- Authority
- JP
- Japan
- Prior art keywords
- metal deposition
- deposition inhibitor
- metal
- plant
- product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Abstract
(57)【要約】
【課題】 手軽に常用することができ、かつ、効果的に
金属中毒を予防、緩和、治療することのできる、安全性
の高い金属沈着抑制剤を提供する。
【解決手段】 有効成分としてセリ科植物の加工物とト
レハロース及び／又はマルチトールとを含む金属沈着抑
制剤を提供することにより解決する。(57) [Problem] To provide a highly safe metal deposition inhibitor which can be easily used regularly and can effectively prevent, alleviate and treat metal poisoning. SOLUTION: The problem is solved by providing a metal deposition inhibitor containing a processed product of a Umbelliferae plant and trehalose and / or maltitol as active ingredients.
Description
【０００１】[0001]
【発明の属する技術分野】この発明は、新規な金属沈着
抑制剤、より詳細には、有効成分としてセリ科植物の加
工物とトレハロース及び／又はマルチトールとを含む金
属沈着抑制剤に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel metal deposition inhibitor, and more particularly to a metal deposition inhibitor containing a processed product of a Umbelliferae plant and trehalose and / or maltitol as active ingredients. .
【０００２】[0002]
【従来の技術】生体に対して有毒な金属ないしは金属化
合物が何らかの原因で生体内に侵入すると、その生体の
恒常性が障害を受ける場合がある。このような障害を金
属中毒という。金属中毒を惹き起こす金属としては、例
えば、鉛、砒素、水銀、金などの重金属があり、これら
の金属は消化器系、呼吸器系、皮膚などを介して生体に
侵入すると臓器などの局所に沈着し、これにより、金属
の種類やその侵入経路などによって、骨・造血組織障
害、消化器障害、呼吸器障害、循環器障害をはじめとす
る諸種の障害が惹き起こされることとなる。2. Description of the Related Art When a metal or metal compound toxic to a living body enters the living body for some reason, homeostasis of the living body may be impaired. Such an obstacle is called metal poisoning. Metals that cause metal poisoning include, for example, heavy metals such as lead, arsenic, mercury, and gold.When these metals enter the living body through the digestive system, respiratory system, skin, etc. This causes various kinds of disorders including bone / hematopoietic tissue disorders, digestive organ disorders, respiratory disorders, circulatory disorders, etc., depending on the type of metal and its entry route.
【０００３】このような金属中毒に対しては、現代の医
学をもってしても特効薬といえるものはほとんどない。
金属中毒の種類によってはエチレンジアミン四酢酸や
１，２−ジチオグリセロールなどのキレート剤が奏効す
る場合もあるけれども、これら自身が毒性を示す場合も
あり、医師による厳密な処方の下においてもなお安易に
利用できないのが現状である。以上のことから、金属中
毒に関しては、十分な予防措置をとることが最も有効で
あり、最も肝心であるといわれている。[0003] With regard to such metal poisoning, there is almost no silver bullet even in modern medicine.
Depending on the type of metal poisoning, chelating agents such as ethylenediaminetetraacetic acid and 1,2-dithioglycerol may be effective, but these may themselves exhibit toxicity, which makes it easy even under strict prescription by a doctor. It is currently unavailable. Based on the above, it is said that taking sufficient preventive measures is the most effective and the most important for metal poisoning.
【０００４】[0004]
【発明が解決しようとする課題】斯かる状況に鑑み、こ
の発明の課題は、手軽に常用することができ、かつ、効
果的に金属中毒を予防、緩和、治療することのできる、
安全性の高い金属沈着抑制剤とその用途を提供すること
にある。DISCLOSURE OF THE INVENTION In view of such circumstances, an object of the present invention is to provide a method which can be easily used regularly and which can effectively prevent, reduce and treat metal poisoning.
An object of the present invention is to provide a highly safe metal deposition inhibitor and its use.
【０００５】[0005]
【課題を解決するための手段】上記の課題を解決するた
め、本発明者等は、東洋で古来より生薬として利用され
てきた植物を中心として、生体での金属の沈着を抑制す
る作用（以下、「金属沈着抑制作用」という。）を有す
るものを広く検索した。その結果、中国パセリをはじめ
とするセリ科植物に比較的顕著な金属沈着抑制作用が確
認された。しかしながら、セリ科植物は、それを摂取す
るヒトによっては風味・呈味の点で奇異な印象を受ける
場合があるために手軽に常用できるとはいい難く、ま
た、生の植物体そのままの形態では、一度に摂取できる
量が限られるなどのことから、必ずしも十分に所期の作
用を発揮できないという問題があることが判明した。そ
こで本発明者等は、セリ科植物を加工した上で他の成分
を配合することによりこれらの問題が解決できるか否か
について、種々の糖質を中心として広く検討したとこ
ろ、非還元性糖質の一種であるトレハロース及び／又は
マルチトールをセリ科植物の加工物と配合するときに
は、上記の課題が解決できるばかりではなく、全く意外
なことに、その本来の金属沈着抑制作用が顕著に増強さ
れるという独自の知見を得た。この発明は、以上の本発
明者等による独自の知見に基づいて為されたものであ
る。Means for Solving the Problems In order to solve the above-mentioned problems, the present inventors have studied the action of inhibiting metal deposition in living organisms, mainly on plants that have been used as crude drugs in the Orient since ancient times (hereinafter, referred to as “plants”). , "Metal deposition inhibiting action"). As a result, relatively remarkable metal deposition inhibitory action was confirmed for Chinese Parsley and other Umbelliferae plants. However, the Umbelliferae plant may be strangely impressive in terms of flavor and taste depending on the person who consumes it, so it is difficult to say that it can be easily used regularly. However, since the amount that can be taken at one time is limited, it has been found that there is a problem that the desired action cannot always be sufficiently exerted. Accordingly, the present inventors have studied extensively, mainly on various carbohydrates, whether or not these problems can be solved by blending other components after processing a Umbelliferae plant. When trehalose and / or maltitol, which is one of the qualities, are blended with a processed product of a Umbelliferae plant, not only the above-mentioned problem can be solved, but also, surprisingly, its original effect of suppressing metal deposition is significantly enhanced. I got the unique knowledge that it will be. The present invention has been made based on the above-described unique findings of the present inventors.
【０００６】すなわち、この発明は、有効成分としてセ
リ科植物の加工物とトレハロース及び／又はマルチトー
ルとを含む金属沈着抑制剤を提供することにより上記の
課題を解決するものである。That is, the present invention solves the above-mentioned problems by providing a metal deposition inhibitor containing a processed product of a Umbelliferae plant and trehalose and / or maltitol as active ingredients.
【０００７】[0007]
【発明の実施の形態】この発明は、有効成分としてセリ
科植物の加工物とトレハロース及び／又はマルチトール
とを含む金属沈着抑制剤を提供するものである。この発
明でいう「金属沈着抑制作用」とは、ヒトを含む哺乳類
の生体内での金属の沈着に対する抑制作用を意味する。
詳細には、生体外から何らかの原因で生体内に侵入し
た、有機化合物ならびに無機化合物の形態を含む金属
の、生体内での沈着の過程を抑制する作用、生体内で沈
着した該金属を生体からの除去もしくは排出を促進する
作用などが挙げられる。この発明の金属沈着抑制剤はこ
れらの作用の少なくともひとつを示す。金属沈着抑制作
用は、例えば、後記実験例に詳述するような動物実験に
より確認することができる。BEST MODE FOR CARRYING OUT THE INVENTION The present invention provides a metal deposition inhibitor containing a processed product of a Umbelliferae plant and trehalose and / or maltitol as active ingredients. As used herein, the term "metal deposition inhibitory effect" means an inhibitory effect on metal deposition in living organisms of mammals including humans.
In detail, the metal which has entered into the living body from outside the living body for some reason, including the form of the organic compound and the inorganic compound, suppresses the process of deposition in the living body, the metal deposited in the living body from the living body And the action of promoting the removal or discharge. The metal deposition inhibitor of the present invention exhibits at least one of these effects. The effect of suppressing metal deposition can be confirmed, for example, by an animal experiment as described in detail in the following experimental examples.
【０００８】この発明で利用できるセリ科植物は、生物
分類上セリ科に属し、その全体又は一部からの加工物を
ヒトへの経口的又は経皮的に適用することが許容され、
かつ、該加工物が本来的に生体における金属の沈着に対
する抑制作用を示すものであるかぎり、属、種や、利用
する部位に特に制限はない。詳細には、中国パセリ（英
名：コリアンダー、分類：コエンドロ属。以下同様に括
弧内に英名、分類の順に示す。なお、中国パセリは、欧
米においては、その葉部がシラントロと呼称される場合
がある。また、日本においては、葉部、乾燥子実等部位
を問わずコエンドロと呼称される場合がある。）、アニ
ス（アニス、アニス属）、アメリカボウフウ（パースニ
ップ、アメリカボウフウ属）、ディル（ディル、イノン
ド属）、ウイキョウ（フェンネル、ウイキョウ属）、パ
セリ（パセリ、オランダセリ属）、ヒメウイキョウ（キ
ャラウェイ、キャラウェイ属）、クミン（クミン、クミ
ン属）、セリ（ウォーター・ドロップワート、セリ
属）、ニンジン（キャロット、ニンジン属）、ミツバ
（ジャパニーズ・ドロップワート、ミツバ属）などが挙
げられる。この発明で利用できるセリ科植物の部位とし
ては、例えば、葉、茎、花弁、子実、根などが挙げられ
る。以上のような植物のうち、中国パセリの葉を含む地
上部は、金属沈着抑制作用が本来的に比較的顕著である
上、トレハロース及び／又はマルチトールと混合したと
きその作用が特に著しく高まるので、この発明の実施に
とりわけ有用である。The Umbelliferae plant which can be used in the present invention belongs to the Umbelliferae in terms of biological classification, and it is permissible to apply a processed product from the whole or a part thereof to humans orally or percutaneously,
In addition, there is no particular limitation on the genus, species, and site to be used as long as the processed product inherently exhibits an inhibitory effect on metal deposition in a living body. In detail, Chinese parsley (English name: coriander, classification: genus Cilantro. Similarly, the English name and classification are shown in parentheses in the following order. In Europe and the United States, Chinese parsley leaves may be called silantro. Also, in Japan, it may be referred to as cilantro irrespective of parts such as leaves and dried grains, etc.), anise (anis, genus Anise), U.S. americana (parsnip, U.S. americana), dill ( Dill, Inondo, Fennel (Fennel, Fennel), Parsley (Parsley, Holland Seri), Hime Fennel (Caraway, Caraway), Cumin (Cumin, Cumin), Seri (Water Drop Wort, Seri) Genus), carrot (carrot, carrot genus), honey bee (Japanese drop wort, honey genus) It is below. Examples of parts of the Umbelliferae plant that can be used in the present invention include leaves, stems, petals, grains, roots, and the like. Among the above plants, the above-ground parts including Chinese parsley leaves have a relatively remarkable metal deposition inhibitory effect, and their effects are particularly remarkably enhanced when mixed with trehalose and / or maltitol. Are particularly useful in the practice of this invention.
【０００９】本発明の実施においては、上記のようなセ
リ科植物を、例えば、細断、破砕、磨砕、加熱、蒸煮、
粉砕、乾燥、圧搾、発酵、抽出などから選ばれる、必要
に応じて適宜組み合わせて実施される処理を施して得ら
れる加工物を利用することができる。抽出物をセリ科植
物の加工物として利用する場合、メタノール、エタノー
ル、プロパノール、イソプロパノール、ブタノールなど
のアルコール類、酢酸エチル、酢酸ゲラニル、桂皮酸エ
チルなどのエステル類をはじめとする有機溶媒ならび
に、水などから選ばれる適宜の抽出溶媒を用いて抽出し
て得られる抽出物はいずれも有利に利用できる。これら
の抽出物間で金属沈着抑制作用を相互に比較すると、エ
タノールなどの低級アルコールや酢酸エチルなどの低級
エステルによる抽出物は比較的強い作用を示すので、該
加工物として抽出物を用いる場合にはこれらのいずれか
の抽出物が特に有用である。また、抽出物は、抽出され
たそのままの形態でも、また、濃縮、希釈、乾燥、溶解
等の適宜の工程を経た上でもいずれも有利に利用できる
けれども、抽出溶媒として、ヒトへの経口的又は経皮的
適用が許容されないか又は許容し難いものを利用する場
合には、抽出物は、用いた溶媒をエバポレーター等によ
り留去した後に用いるのが望ましい。In the practice of the present invention, the above-mentioned Umbelliferae plants are, for example, shredded, crushed, ground, heated, steamed,
A processed product obtained by performing a treatment selected from crushing, drying, squeezing, fermentation, extraction and the like, which is appropriately combined as necessary, can be used. When the extract is used as a processed product of a Umbelliferae plant, organic solvents such as alcohols such as methanol, ethanol, propanol, isopropanol and butanol, esters such as ethyl acetate, geranyl acetate and ethyl cinnamate, and water Any extract obtained by extraction with an appropriate extraction solvent selected from the above can be advantageously used. Comparing the metal deposition inhibiting action between these extracts, an extract by a lower alcohol such as ethanol or a lower ester such as ethyl acetate shows a relatively strong action, so that when the extract is used as the processed product, Especially useful are extracts of any of these. In addition, the extract may be used in the form of the extract as it is, or after being subjected to appropriate steps such as concentration, dilution, drying, and dissolution. In the case of using a substance which is unacceptable or unacceptable for percutaneous application, it is desirable to use the extract after distilling off the solvent used with an evaporator or the like.
【００１０】この発明でいうトレハロースとは、２分子
のグルコースが還元性基同士でα，α結合してなる非還
元性二糖を意味する。この発明で用いるトレハロース
は、このように定義される化合物であって、上記のセリ
科植物と配合したときにこの発明の課題を解決する効果
を発揮するものである限り、性状、純度、調製方法は特
定のものに限定されない。The term trehalose as used in the present invention means a non-reducing disaccharide in which two molecules of glucose are α-α-linked with each other by reducing groups. Trehalose used in the present invention is a compound defined as described above, as long as it exhibits the effect of solving the problem of the present invention when combined with the above-mentioned Umbelliferae, properties, purity, and preparation method Is not limited to a specific one.
【００１１】トレハロースは種々の方法で調製すること
ができる。例えば、特開平７−１４３８７６号公報、特
開平７−２１３２８３号公報、特開平７−３２２８８３
号公報、特開平７−２９８８８０号公報、特開平８−６
６１８７号公報、特開平８−６６１８８号公報、特開平
８−３３６３８８号公報及び特開平８−８４５８６号公
報のいずれかに開示された非還元性糖質生成酵素及びト
レハロース遊離酵素を澱粉部分加水分解物に作用させる
方法が好適である。この方法によるときには、廉価な材
料である澱粉からトレハロースが好収量で得られる特徴
がある。ちなみに、斯かる方法により調製されたトレハ
ロースの市販品としては、含水結晶トレハロース（商品
名『トレハ』、株式会社林原商事販売）や、トレハロー
ス含有シロップ（商品名『トレハスター』、株式会社林
原商事販売）などがあり、これらはこの発明に有利に利
用できる。また、例えば、特開平７−１７０９７７号公
報、特開平８−２６３号公報、特開平８−１４９９８０
号公報のいずれかに記載されたマルトース・トレハロー
ス変換酵素を作用させるか、あるいは、公知のマルトー
ス・ホスホリラーゼ及びトレハロース・ホスホリラーゼ
を組合せて作用させることによってもトレハロースは得
ることができる。さらにまた、後述するように、トレハ
ロースとマルチトールとを併用する場合には、特開平８
−７３４８２号公報に記載された、トレハロースとマル
トースとの混合物を水素添加して得られる両糖質の混合
物を利用することも随意である。トレハロースの無水物
は、上記のようにして調製又は入手される含水結晶トレ
ハロースを、例えば、７０℃乃至１６０℃の範囲の温度
で常圧乾燥又は減圧乾燥、より望ましくは、８０℃乃至
１００℃の範囲の温度で減圧乾燥するか、あるいは、水
分１０％未満の高濃度トレハロース高含有液を助晶缶に
とり、種晶共存下で５０乃至１６０℃、望ましくは８０
乃至１４０℃の範囲で攪拌しつつ無水結晶トレハロース
を含有するマスキットを製造し、これを比較的高温乾燥
条件下で、例えば、ブロック粉砕、流動造粒、噴霧乾燥
などの方法で晶出、粉末化することにより調製すること
ができる。Trehalose can be prepared by various methods. For example, JP-A-7-143876, JP-A-7-213283, JP-A-7-322883
JP, JP-A-7-298880, JP-A-8-6
No. 6187, JP-A-8-66188, JP-A-8-336388 and JP-A-8-84586 dissolve the non-reducing saccharide-forming enzyme and trehalose-releasing enzyme in starch by partial hydrolysis. A method of acting on an object is preferable. This method is characterized in that trehalose can be obtained in good yield from starch, which is an inexpensive material. Incidentally, commercially available trehalose prepared by such a method includes hydrated crystalline trehalose (trade name “Treha”, sold by Hayashibara Shoji Co., Ltd.) and trehalose-containing syrup (trade name “Trehastar”, sold by Hayashibara Shoji Co., Ltd.) ), Which can be advantageously used in the present invention. Also, for example, JP-A-7-170977, JP-A-8-263, and JP-A-8-149980
The trehalose can be obtained by reacting the maltose / trehalose converting enzyme described in any of the above publications, or by combining a known maltose phosphorylase and trehalose phosphorylase. Furthermore, as described later, when trehalose and maltitol are used in combination,
It is optional to use a mixture of both saccharides obtained by hydrogenating a mixture of trehalose and maltose described in -73482. Anhydrous trehalose can be obtained by drying water-containing crystalline trehalose prepared or obtained as described above, for example, under normal pressure or reduced pressure drying at a temperature in the range of 70 ° C to 160 ° C, more preferably 80 ° C to 100 ° C. Dry under reduced pressure at a temperature in the range, or place a high-concentration trehalose-rich liquid having a water content of less than 10% in an auxiliary crystal can, and coexist with a seed crystal at 50 to 160 ° C, preferably 80 ° C.
A mass kit containing anhydrous crystalline trehalose is manufactured with stirring at a temperature in the range of ~ 140 ° C. Can be prepared.
【００１２】この発明でいうマルチトールとは、グルコ
ースがα−１，４結合してなる二糖であるマルトースの
還元体を意味する。この発明で用いるマルチトールは、
このように定義される化合物であって、上記のセリ科植
物と配合したときにこの発明の課題を解決する効果を発
揮するものである限り、性状、純度、調製方法は特定の
ものに限定されない。例えば、同じ特許出願人による特
公昭４７−１３６９９号公報に開示された方法により得
られるシラップ状のマルチトールや、特公昭６３−２４
３９号公報に開示された方法により得られる無水結晶マ
ルチトールは適宜この発明において有利に利用できる。
また、市販の無水結晶マルチトール（商品名『粉末マビ
ット』、株式会社林原商事販売）や、マルチトール含有
シロップ（商品名『マビット』、株式会社林原商事販
売）もこの発明においては有利に利用できる。The term maltitol used in the present invention means a reduced form of maltose, which is a disaccharide composed of α-1,4 linked glucose. Maltitol used in the present invention is:
Properties, purity, and preparation methods are not limited to specific ones as long as the compound thus defined exhibits the effect of solving the problem of the present invention when combined with the above-mentioned Umbelliferae. . For example, syrup-shaped maltitol obtained by the method disclosed in Japanese Patent Publication No. 47-13699 by the same applicant, and Japanese Patent Publication No. Sho 63-24
The anhydrous crystalline maltitol obtained by the method disclosed in Japanese Patent Publication No. 39 can be suitably and advantageously used in the present invention.
Also, commercially available anhydrous crystalline maltitol (trade name “powder mavit”, sold by Hayashibara Shoji Co., Ltd.) and maltitol-containing syrup (trade name “Mabit”, sold by Hayashibara Shoji Co., Ltd.) can be advantageously used in the present invention. .
【００１３】この発明の金属沈着抑制剤におけるセリ科
植物とトレハロース及び／又はマルチトール（以下、こ
の発明で用いるトレハロース及び／又はマルチトール
を、単に「当該糖質」という場合がある。）との配合割
合は、これらの成分を配合して利用する際にこの発明の
課題を解決する効果を発揮するものであるかぎり特に制
限はない。例えば、当該糖質の添加によりセリ科植物の
加工物による金属沈着抑制作用をより顕著に増強すると
いう観点からは、セリ科植物の加工物の固形分１重量部
に対して、当該糖質を無水物換算で、通常、０．１重量
部以上、望ましくは、１重量部以上とするのが好適であ
る。当該金属沈着抑制剤を経口摂取する際の風味ならび
に呈味の観点からは当該糖質の配合割合は高い程好まし
いけれども、良好な風味・呈味を達成するとともに、比
較的少ない摂取量で顕著な金属沈着抑制作用を引き出す
ためには、セリ科植物の加工物の固形分１重量部に対し
て、当該糖質を無水物換算で、通常、２００重量部以
下、望ましくは、１００重量部以下の範囲が好適であ
る。[0013] In the metal deposition inhibitor of the present invention, a plant belonging to the Umbelliferae family and trehalose and / or maltitol (hereinafter, trehalose and / or maltitol used in the present invention may be simply referred to as “the sugar”). The blending ratio is not particularly limited as long as the components solve the problem of the present invention when used by blending these components. For example, from the viewpoint that the addition of the carbohydrate further remarkably enhances the metal deposition inhibitory effect of the processed product of a Umbelliferae plant, the sugar is added to 1 part by weight of the solid content of the processed product of a Umbelliferous plant. It is usually 0.1 part by weight or more, preferably 1 part by weight or more in terms of anhydride. From the viewpoint of flavor and taste when the metal deposition inhibitor is orally ingested, the higher the blending ratio of the saccharide, the better, but it achieves good flavor and taste and is remarkable with a relatively small intake. In order to bring out the metal deposition inhibiting action, the sugar is usually not more than 200 parts by weight, preferably not more than 100 parts by weight, based on 1 part by weight of the solid matter of the processed product of the Umbelliferae plant, in terms of anhydride. A range is preferred.
【００１４】以上のようなこの発明の金属沈着抑制剤に
抗酸化剤をさらに添加すると、対象とする金属によって
は、その生体での沈着抑制作用がさらに増強される場合
がある。この発明で用いる抗酸化剤は特定の種類に限定
されないけれども、当該金属沈着抑制剤をヒトを含む哺
乳類のための食用として利用する場合には、食品分野で
通常用いられるものから選択するのが望ましい。食品分
野で通常用いられる抗酸化剤としては、具体的には、フ
ラボノイド、ポリフェノール、ビタミンＥ、ビタミンＣ
などが挙げられる。フラボノイドとしては、より詳細に
は、ルチン、ヘスペリジン、ナリンジン、ケルセチン
や、これらのそれぞれにグルコース又はその重合体など
の糖類が結合してなる糖転移ルチン、糖転移ヘスペリジ
ン、糖転移ナリンジン、糖転移ケルセチンなどが挙げら
れる。ポリフェノールとしては、より詳細には、カテキ
ン、没食子酸などや、これらのポリフェノールを含有す
る、プロポリスならびにプロポリスエキスなどが挙げら
れる。さらに、植物抽出物であるエンジュ抽出物、ロー
ズマリー抽出物、ユーカリ抽出物などもこの発明におい
ては抗酸化剤として有利に利用できる。これらの抗酸化
剤の当該金属沈着抑制剤における含量は特に制限がない
けれども、当該金属沈着抑制剤の経口摂取が想定される
場合には、呈味・風味への影響を考慮して、食品分野で
通常用いられる配合割合以下で用いるのが望ましい。When an antioxidant is further added to the metal deposition inhibitor of the present invention as described above, the action of inhibiting the deposition in a living body may be further enhanced depending on the target metal. Although the antioxidant used in the present invention is not limited to a specific type, when the metal deposition inhibitor is used as food for mammals including humans, it is preferable to select from those normally used in the food field. . Specific examples of antioxidants commonly used in the food field include flavonoids, polyphenols, vitamin E, and vitamin C.
And the like. As the flavonoids, more specifically, rutin, hesperidin, naringin, quercetin, and glycosylated rutin, glycosylated hesperidin, glycosylated heparsin, glycosylated naringin, glycosylated quercetin, each of which is linked to a saccharide such as glucose or a polymer thereof. And the like. More specifically, examples of the polyphenol include catechin, gallic acid, and the like, and propolis and propolis extract containing these polyphenols. In addition, plant extracts, such as an extract of red pepper, an extract of rosemary, and an extract of eucalyptus, can also be advantageously used as an antioxidant in the present invention. The content of these antioxidants in the metal deposition inhibitor is not particularly limited. However, when it is assumed that the metal deposition inhibitor is to be taken orally, the effect on the taste and flavor should be taken into consideration. It is desirable to use the compounding ratio below the amount normally used.
【００１５】この発明の金属沈着抑制剤には、さらに必
要に応じて、乳化剤、賦形剤、ｐＨ調節剤、香料、香辛
料、色素、ビタミン、アミノ酸等の上記で述べた以外の
成分をさらに含有させることも有利に実施できる。当該
金属沈着抑制剤におけるこれらの成分の含有量は、この
発明の金属沈着抑制剤による効果を妨げない限り特に制
限はなく、例えば、この発明の金属沈着抑制剤の利用分
野、詳細には、食品分野、化粧品分野、医薬品分野など
において添加剤として利用される個々の成分ならびにそ
の配合割合は、本発明においても有利に適用できる。The metal deposition inhibitor of the present invention may further contain, if necessary, components other than those described above, such as emulsifiers, excipients, pH regulators, spices, spices, pigments, vitamins and amino acids. Can also be advantageously implemented. The content of these components in the metal deposition inhibitor is not particularly limited as long as the effect of the metal deposition inhibitor of the present invention is not hindered.For example, the field of application of the metal deposition inhibitor of the present invention, The individual components used as additives in the field, cosmetics field, pharmaceutical field, and the like, and the mixing ratio thereof can be advantageously applied also in the present invention.
【００１６】以上のような成分を含むこの発明の金属沈
着抑制剤の形態には特に制限はなく、固体、半固体、液
体もしくはそれらの混成体のいずれか、例えば、粉末、
顆粒、タブレット、ゲル、ペースト、乳液、溶液などか
ら選ばれる所望の形態で提供することができる。以上の
ようなこの発明の金属沈着抑制剤は、セリ科植物の加工
物を、固形分重量換算で、通常、０．０１％乃至９９．
９％、望ましくは、０．０５％乃至９０％、さらに望ま
しくは、０．１％乃至８０％の範囲で含有する。The form of the metal deposition inhibitor of the present invention containing the above components is not particularly limited, and may be any of solid, semi-solid, liquid or a hybrid thereof, for example, powder,
It can be provided in a desired form selected from granules, tablets, gels, pastes, emulsions, solutions and the like. The metal deposition inhibitor of the present invention as described above can be used to treat a processed product of a Umbelliferae plant in an amount of usually 0.01% to 99.
The content is 9%, preferably 0.05% to 90%, and more preferably 0.1% to 80%.
【００１７】以上のように構成されるこの発明の金属沈
着抑制剤は、セリ科植物が本来有している金属沈着抑制
作用と比較してより顕著に該作用を発揮する。この発明
の金属沈着抑制剤が生体における沈着の抑制効果を示す
金属としては、例えば、鉛、砒素、アンチモン、クロ
ム、金、水銀、マンガン、ベリリウム、亜鉛、カドミウ
ムや、これらの化合物、例えば、以上のような金属のい
ずれかを含む無機又は有機化合物などが挙げられる。以
上のような金属が、呼吸器系、消化器系、皮膚粘膜など
を介して生体内に侵入して局所的に沈着すると、その生
体の恒常性が障害をうけた状態、いわゆる中毒症状を呈
する場合がある。このような中毒は一般に金属中毒と呼
ばれている。金属中毒においては、生体に侵入する金属
の種類や金属の侵入経路の違いなどによって様々な臓器
に諸種の障害が現れる。例えば、鉛や砒素による骨・造
血組織の障害、鉛による循環器の障害、砒素、鉛または
アンチモンによる消化器の障害、水銀、マンガン又は有
機鉛による神経系の障害、砒素、クロム又は金による皮
膚粘膜の障害、水銀による腎障害、ベリリウム、亜鉛又
はマンガンによる呼吸器系の障害、クロム又はカドミウ
ムによる全身に亙る機能障害が挙げられる。以上のよう
な金属中毒のうち、この発明の金属沈着抑制剤は、鉛中
毒、砒素中毒、水銀中毒の予防、緩和、治療効果を特に
顕著に発揮し、障害の部位としては、骨・造血系組織の
障害に対して特に顕著に予防、緩和、治療効果を発揮す
る特徴がある。また、特開平１０−６７６７２号公報に
は、感染症や癌などの諸疾患においては、水銀、鉛、ア
ルミニウムなどの金属が沈着する場合があること、そし
て、このような金属沈着を伴う疾患に対して、中国パセ
リをはじめとするセリ科植物が、該金属沈着の抑制を介
して、あるいは、該金属沈着の抑制を伴って予防、緩
和、治療効果を発揮することが記載されている。この発
明の金属沈着抑制剤は、以上説明した作用故に、種々の
疾患に伴って起こる生体内での金属の沈着の抑制と、金
属の沈着を伴う諸疾患の予防、緩和、治療効果を、セリ
科植物単独の場合に比べてより顕著に発揮する。したが
ってこの発明の金属沈着抑制剤は、それ自体で、ウイル
スや微生物の感染に伴う諸症状の緩和剤や、癌における
諸症状の緩和剤として、また、以上のような緩和剤の有
効成分のひとつとしてとりわけ有用である。以上のよう
なこの発明の金属沈着抑制剤の有効な摂取量は、セリ科
植物ならびに加工物の種類や、当該金属沈着抑制剤の摂
取方法、対象疾患の種類や症状などにもよるけれども、
セリ科植物の加工物の固形分重量として、経口摂取する
場合には、体重１ｋｇ当り、通常、０．００１ｍｇ乃至
２ｇ、望ましくは、０．０１ｍｇ乃至１ｇの範囲であ
り、経皮摂取する場合には、通常、０．０００１ｍｇ乃
至２００ｍｇ、望ましくは、０．００１ｍｇ乃至１００
ｍｇの範囲である。The metal deposition inhibitor of the present invention constituted as described above exerts its action more remarkably than the metal deposition inhibitory action inherently present in Umbelliferae plants. Examples of the metal in which the metal deposition inhibitor of the present invention exhibits the effect of inhibiting deposition in a living body include, for example, lead, arsenic, antimony, chromium, gold, mercury, manganese, beryllium, zinc, cadmium, and these compounds. And inorganic or organic compounds containing any of the above metals. When such metals enter the living body through the respiratory system, digestive system, skin mucous membranes, etc. and locally deposit, the homeostasis of the living body is impaired, so-called toxic symptoms are exhibited. There are cases. Such poisoning is commonly referred to as metal poisoning. In metal poisoning, various kinds of disorders appear in various organs depending on the types of metals that invade living bodies and the differences in metal intrusion routes. For example, damage to bones and hematopoietic tissues by lead and arsenic, damage to the circulatory system by lead, damage to the digestive system by arsenic, lead or antimony, damage to the nervous system by mercury, manganese or organic lead, skin by arsenic, chromium or gold Mucosal damage, renal damage due to mercury, respiratory damage due to beryllium, zinc or manganese, systemic dysfunction due to chromium or cadmium. Among the metal poisoning described above, the metal deposition inhibitor of the present invention exerts particularly remarkable preventive, alleviating, and therapeutic effects on lead poisoning, arsenic poisoning, and mercury poisoning. It has the characteristic of exerting remarkable preventive, palliative and therapeutic effects on tissue disorders. Japanese Patent Application Laid-Open No. H10-67672 discloses that in various diseases such as infectious diseases and cancer, metals such as mercury, lead, and aluminum may be deposited. On the other hand, it is described that Umbelliferae plants such as Chinese parsley exert preventive, palliative and therapeutic effects through the suppression of the metal deposition or with the suppression of the metal deposition. The metal deposition inhibitor of the present invention, due to the above-described effects, suppresses metal deposition in vivo due to various diseases and prevents, alleviates and cures various diseases accompanied by metal deposition. It exerts more remarkably compared to the case of the family plant alone. Therefore, the metal deposition inhibitor of the present invention itself can be used as a relieving agent for various symptoms associated with the infection of a virus or a microorganism, or as a relieving agent for various symptoms in cancer, and as one of the active ingredients of the above relieving agent. Is particularly useful as The effective intake of the metal deposition inhibitor of the present invention as described above depends on the type of the Umbelliferae plant and the processed product, the method of ingesting the metal deposition inhibitor, the type and symptom of the target disease, and the like.
As a solid weight of a processed product of a plant of the Umbelliferae, when taken orally, it is usually within a range of 0.001 mg to 2 g, preferably 0.01 mg to 1 g per 1 kg of body weight. Is usually 0.0001 mg to 200 mg, preferably 0.001 mg to 100 mg
mg range.
【００１８】以上のような特徴を有するこの発明の金属
沈着抑制剤はその形状に応じて、それ自体で経口的及び
／又は経皮的に摂取して利用することができ、斯かる利
用により、その生体内において金属の沈着を抑制する作
用を発揮するので、当該金属沈着抑制剤は、生体での金
属沈着を抑制したり、金属中毒を予防又は緩和するため
の食品、健康食品、病院食、飲料、皮膚外用剤などとし
て有利に利用できる。また、この発明の金属沈着抑制剤
は、金属中毒を予防、緩和又は治療するための医薬品に
配合する有効成分としてや、そのような医薬品の作用を
強化するための添加物などとしても有用である。さらに
また、当該金属沈着抑制剤は、通常一般の食品、健康食
品、化粧品などに金属沈着抑制作用を付与するための配
合素材としても利用できる。この発明の金属沈着抑制剤
を配合して利用できる食品としては、例えば、アイスク
リーム、アイスキャンデー、シャーベットなどの氷菓、
氷蜜などのシロップ、バタークリーム、カスタードクリ
ーム、フラワーペースト、ピーナッツペースト、フルー
ツペーストなどのスプレッド及びペースト、チョコレー
ト、ゼリー、キャンディー、グミゼリー、キャラメル、
チューインガム、プリン、シュークリーム、スポンジケ
ーキなどの洋菓子、ジャム、マーマレード、シロップ
漬、糖菓などの加工果実ないしは加工野菜、まんじゅ
う、ういろう、あん、羊羮、水羊羮、カステラ、飴玉な
どの和菓子、醤油、粉末醤油、味噌、粉末味噌、マヨネ
ーズ、ドレッシング、食酢、三杯酢、テーブルシュガ
ー、コーヒーシュガーなどの調味料などが挙げられる。
当該金属沈着抑制剤を配合して利用できる飲料として
は、例えば、合成酒、醸造酒、果実酒、洋酒などの酒
類、ジュース、ミネラル飲料、炭酸飲料、乳酸飲料、乳
酸菌飲料、スポーツドリンク、ドリンク剤、茶、紅茶、
ウーロン茶、コーヒー、ココアなどの清涼飲料などが挙
げられる。当該金属沈着抑制剤を配合して利用できる化
粧品としては、例えば、ローション、乳液、クリーム又
はペーストの形態の、基礎化粧品、洗浄用化粧品、入浴
用化粧品、頭髪化粧品、口腔用化粧品、日焼け・日焼け
止め化粧品、メイクアップ化粧品、発毛剤、育毛剤など
が挙げられる。以上のようなこの発明の金属沈着抑制剤
を添加せしめてなる、食品、化粧品、医薬品などの組成
物は、固形分重量換算で、セリ科植物の加工物を、通
常、０．００００１％乃至２０％、望ましくは、０．０
００１％乃至１０％、より望ましくは、０．００１％乃
至２％の範囲で含有する。The metal deposition inhibitor of the present invention having the above characteristics can be taken orally and / or percutaneously by itself depending on its shape, and can be used. Since it exerts an action of suppressing metal deposition in the living body, the metal deposition inhibitor suppresses metal deposition in the living body, food for preventing or alleviating metal poisoning, health food, hospital food, It can be advantageously used as a beverage, an external preparation for skin and the like. Further, the metal deposition inhibitor of the present invention is also useful as an active ingredient to be added to a drug for preventing, alleviating or treating metal poisoning, or as an additive for enhancing the action of such a drug. . Furthermore, the metal deposition inhibitor can also be used as a compound material for imparting a metal deposition inhibitory action to ordinary foods, health foods, cosmetics, and the like. Foods that can be used in combination with the metal deposition inhibitor of the present invention include, for example, ice cream, ice candy, ice confectionery such as sherbet,
Spreads and pastes such as syrup such as honey, butter cream, custard cream, flower paste, peanut paste, fruit paste, chocolate, jelly, candy, gummy jelly, caramel,
Western confectionery such as chewing gum, pudding, cream puff, sponge cake, processed fruits or processed vegetables such as jam, marmalade, syrup pickles, confectionery, Japanese confectionery such as steamed buns, cucumber, candy, etc., soy sauce And seasonings such as powdered soy sauce, miso, powdered miso, mayonnaise, dressing, vinegar, three tablespoons vinegar, table sugar, coffee sugar and the like.
Examples of beverages that can be used by incorporating the metal deposition inhibitor include, for example, alcoholic beverages such as synthetic liquor, brewed liquor, fruit liquor, and Western liquor, juices, mineral beverages, carbonated beverages, lactic acid beverages, lactic acid beverages, sports drinks, and drinks. , Tea, tea,
Soft drinks such as oolong tea, coffee, and cocoa are included. Examples of cosmetics that can be used by blending the metal deposition inhibitor include, for example, lotions, emulsions, creams or pastes, basic cosmetics, cleaning cosmetics, bath cosmetics, hair cosmetics, oral cosmetics, sunscreens and sunscreens Cosmetics, make-up cosmetics, hair growth agents, hair restorers, and the like. Compositions such as foods, cosmetics, and pharmaceuticals, to which the metal deposition inhibitor of the present invention is added as described above, are usually obtained by converting a processed product of a Umbelliferae plant in terms of solids content from 0.00001% to 20%. %, Preferably 0.0
001% to 10%, more preferably 0.001% to 2%.
【００１９】以下、実験例、実施例及び臨床例に基づい
て本発明をより詳細に説明する。Hereinafter, the present invention will be described in more detail based on experimental examples, examples and clinical examples.
【００２０】[0020]
【実験例１】〈マウス生体での金属沈着に対するセリ科
植物加工物による抑制作用〉[Experimental Example 1] <Inhibition of metal deposition in the living body of mice by a processed plant of the Umbelliferae>
【００２１】[0021]
【実験例１−１】〈セリ科植物加工物の調製〉収穫した
中国パセリの全草より根を除去し、これを水洗し、水切
りした後、ブレンダーを用いて細断（ミンチ）した。細
断した中国パセリを遠心濾過分離器（回転数１５００ｒ
ｐｍ）を用いて１５０メッシュのフィルターを通して濾
過した。濾液を回収し、１２１℃で１０分間処理し、室
温にまで放冷して、中国パセリ加工物（搾汁）を得た。
該加工物の固形分含量は６０ｍｇ／ｍｌであった。[Experimental example 1-1] <Preparation of a processed product of Apiaceae plant> The roots of the harvested Chinese parsley were removed from the whole plant, washed with water, drained, and then minced using a blender. The shredded Chinese parsley is centrifuged through a centrifugal separator (rotation speed 1500r
pm) through a 150 mesh filter. The filtrate was collected, treated at 121 ° C. for 10 minutes, and allowed to cool to room temperature to obtain a processed Chinese parsley (squeezed juice).
The solids content of the processed product was 60 mg / ml.
【００２２】[0022]
【実験例１−２】〈マウス生体での金属沈着に対するセ
リ科植物加工物の抑制作用〉７週齢の雄性ＩＣＲマウス
（チャールズ・リバー・ジャパン社販売）を、慣用の餌
料と水を自由摂取させながら温度制御した条件下で７日
間飼育した（７日間の飼育を終了した日を「第０日」と
表示する）。マウスを各８匹ごとの３群に分け、第１日
以降第３２日までの間、全ての群のマウスに１．８３ｍ
ｇ／ｌの酢酸鉛（ＩＩ）・三水和物水溶液（鉛濃度とし
ては１０００ｐｐｍ）と慣用の餌料とを自由摂取させ
た。第１群のマウスに対しては、第８日以降第３２日ま
での間、実験例１−１の方法で調製した中国パセリ加工
物を、１日２回、１週間当り計１０回の頻度で、１匹１
回当り２００μｌの用量で、胃ゾンデを用いて投与した
（試験群１）。第２群のマウスに対しては、実験例１−
１の方法で調製した中国パセリ加工物の精製水による１
００倍希釈物を、試験群１と同様のスケジュール及び方
法で投与した（試験群２）。第３群のマウスに対して
は、中国パセリ加工物を与えずに第３２日まで飼育した
（対照群）。この期間中、各群ごとにマウスによる鉛水
溶液の摂取量の１日当たりの平均値を調べたところ、い
ずれも液量として７乃至８ｍｌ／匹／日であり、群間で
差は認められなかった。[Experimental example 1-2] <Inhibitory effect of processed plant of the Umbelliferae on metal deposition in living body of mouse> A 7-week-old male ICR mouse (available from Charles River Japan Co., Ltd.) is allowed free access to conventional food and water. The animals were bred for 7 days under temperature-controlled conditions (the day when breeding was completed for 7 days is indicated as "day 0"). The mice were divided into three groups of eight animals each, and from day 1 to day 32, 1.83 m for all groups of mice.
g / l of lead (II) acetate / trihydrate aqueous solution (lead concentration: 1000 ppm) and a conventional feed were freely ingested. For the mice of the first group, the processed Chinese parsley prepared by the method of Experimental Example 1-1 was used twice a day for a total of 10 times per week from day 8 to day 32. And one per animal
A 200 μl dose was administered using a gastric probe (test group 1). For the second group of mice, Experimental Example 1-
Purified water of processed Chinese parsley prepared by method 1
The 00-fold dilution was administered according to the same schedule and method as Test Group 1 (Test Group 2). The mice of the third group were bred until day 32 without the processed Chinese parsley (control group). During this period, the average daily intake amount of the aqueous lead solution by the mice was examined for each group, and the average amount was 7 to 8 ml / animal / day as a liquid volume, and no difference was observed between the groups. .
【００２３】第３３日に、全ての群のマウスより、左大
腿骨を常法により摘出した。摘出した個々の大腿骨は、
精秤した後、強酸を用いる常法にしたがって湿式灰化
し、１０ｍｌの溶液とした。この溶液を通常の原子吸光
分析法に供し、得られた分析値より各大腿骨における鉛
含量を求めた。結果を表１に示す。On the 33rd day, the left femur was excised from the mice of all groups by a conventional method. The individual femurs removed
After precise weighing, wet ash was performed according to a conventional method using a strong acid to obtain a 10 ml solution. This solution was subjected to ordinary atomic absorption spectrometry, and the lead content in each femur was determined from the obtained analysis values. Table 1 shows the results.
【００２４】[0024]
【表１】 [Table 1]
【００２５】表１に示すとおり、対照群で約３５０ｐｐ
ｍであった大腿骨における鉛含量は、中国パセリ加工物
の投与により、その投与量に依存して著しく低下した。
この結果は、中国パセリ加工物が、中毒を惹き起こす金
属のひとつである鉛の生体での沈着を抑制する作用を本
来的に有していることを示している。As shown in Table 1, in the control group, about 350 pp
m, the lead content in the femur was significantly reduced by the administration of Chinese parsley processed food in a dose-dependent manner.
This result indicates that the processed Chinese parsley naturally has the effect of suppressing the deposition of lead, one of the metals that cause poisoning, in vivo.
【００２６】[0026]
【実験例２】〈セリ科植物加工物による金属沈着抑制作
用を増強する糖質〉トレハロース（無水結晶）、マルチ
トール（無水結晶）、ネオトレハロース、キシリトー
ル、スクロース、マルトース、デキストリン（ＤＥ２
５）、プルラン（いずれも試薬級の市販品）のいずれか
を含む濃度６０ｍｇ／ｍｌの水溶液を調製した。これら
の糖質水溶液のいずれかと実験例１−１の方法で得た中
国パセリ加工物とを体積比で等量ずつ混合し、それぞれ
異なる糖質を含む８種類の被験試料を準備した。[Experimental Example 2] <Saccharide that enhances the metal deposition inhibitory action of processed products of Umbelliferae> Trehalose (anhydrous crystals), maltitol (anhydrous crystals), neotrehalose, xylitol, sucrose, maltose, dextrin (DE2)
5) A 60 mg / ml aqueous solution containing either pullulan (all of which are reagent grade commercial products) was prepared. Either of these aqueous saccharide solutions and the processed Chinese parsley product obtained by the method of Experimental Example 1-1 were mixed in an equal volume ratio to prepare eight kinds of test samples each containing a different saccharide.
【００２７】実験例１−２における試験群１で用いた中
国パセリ加工物に代えて上記で準備した８種類の被験試
料のいずれかを用い、その投与量を１匹１回当たり４０
０μｌとし、１群当たりの構成を４匹としたこと以外は
実験例１−２の試験群１にしたがって、被験試料をマウ
スに投与した。また、同じく１群４匹の構成で、実験例
１−２における試験群１と対照群と同様の処置も実施し
た。全スケジュールを終了後、実験例１−２にしたがっ
て各マウスより大腿骨を摘出し、それぞれの鉛含量を求
めた。各群の平均値を算出し、対照群における値を１０
０とした場合の試験群１ならびに被験試料投与群におけ
る値の相対値を求めた。結果を表２に示す。In place of the processed Chinese parsley product used in Test Group 1 in Experimental Example 1-2, any of the eight test samples prepared above was used, and the dose was 40 times per animal.
The test sample was administered to mice according to Test Group 1 of Experimental Example 1-2 except that the volume was set to 0 μl and the composition per group was set to 4. In addition, the same treatment as that of the test group 1 and the control group in Experimental Example 1-2 was also performed with a configuration of 4 animals per group. After completing the entire schedule, the femur was excised from each mouse according to Experimental Example 1-2, and the lead content of each was determined. The average value of each group was calculated, and the value in the control group was calculated as 10
The relative values of the values in the test group 1 and the test sample administration group when 0 was set were determined. Table 2 shows the results.
【００２８】[0028]
【表２】 [Table 2]
【００２９】表２に示すとおり、試験群１における鉛含
量は、実験例１−２と同様に対照群の約７０％であっ
た。一方、被験試料投与群は添加した糖質の種類によっ
てそれぞれ異なる値を示した。トレハロース又はマルチ
トールを添加して投与した場合には、試験群１より明ら
かに低い値であったのに対して、それ以外の糖質を添加
して投与した場合には、試験群１と同等かあるいは寧ろ
悪化する場合も認められた。なお、データは割愛するけ
れども、本実験例で用いた糖質をそれぞれ単独でマウス
に投与した場合には金属沈着抑制作用は確認されなかっ
た。以上の結果は、セリ科植物が本来的に発揮する金属
沈着抑制作用は、トレハロース及びマルチトールにより
顕著に増強されることを示している。As shown in Table 2, the lead content in Test Group 1 was about 70% of that in the control group, as in Experimental Example 1-2. On the other hand, the test sample administration groups showed different values depending on the type of added saccharide. When trehalose or maltitol was administered, the value was clearly lower than that in test group 1, whereas when other saccharides were added, the value was equivalent to test group 1. Or worse. In addition, although the data are omitted, when the carbohydrates used in the present experimental example were each administered alone to mice, no metal deposition inhibitory action was confirmed. The above results indicate that the metal deposition inhibitory action inherently exhibited by the Umbelliferae plant is significantly enhanced by trehalose and maltitol.
【００３０】[0030]
【実験例３】〈セリ科植物加工物による金属沈着抑制作
用を増強するトレハロースの有効量〉濃度２００、６
０、２０、６又は２ｍｇ／ｍｌでトレハロース（無水結
晶）を含む水溶液を調製し、これらの水溶液のいずれか
と実験例１−１の方法で得た中国パセリ加工物とを体積
比で等量ずつ混合し、トレハロース濃度のそれぞれ異な
る５種類の被験試料を準備した。[Experimental Example 3] <Effective amount of trehalose that enhances the metal deposition inhibitory effect of processed products of Umbelliferae> Concentrations 200 and 6
Aqueous solutions containing trehalose (anhydrous crystals) at 0, 20, 6 or 2 mg / ml are prepared, and each of these aqueous solutions and the Chinese parsley processed product obtained by the method of Experimental Example 1-1 are equal in volume ratio. After mixing, five types of test samples having different trehalose concentrations were prepared.
【００３１】実験例１−２における試験群１で用いた中
国パセリ加工物に代えて上記で準備した５種類の被験試
料のいずれかを用い、その投与量を１匹１回当たり４０
０μｌとし、１群当たりの構成を４匹としたこと以外は
実験例１−２の試験群１にしたがって、被験試料をマウ
スに投与した。また、同じく１群４匹の構成で、実験例
１−２における試験群１と対照群と同様の処置も実施し
た。全スケジュールを終了後、実験１−２にしたがって
各マウスより大腿骨を摘出し、それぞれの鉛含量を求め
た。各群の平均値を算出し、対照群における値を１００
とした場合の対照群ならびに被験試料投与群における値
の相対値を求めた。結果を表３に示す。In place of the processed Chinese parsley product used in Test Group 1 in Experimental Example 1-2, one of the five test samples prepared above was used, and the dose was 40 per animal.
The test sample was administered to mice according to Test Group 1 of Experimental Example 1-2 except that the volume was set to 0 μl and the composition per group was set to 4. In addition, the same treatment as that of the test group 1 and the control group in Experimental Example 1-2 was also performed with a configuration of 4 animals per group. After completing the entire schedule, the femur was excised from each mouse according to Experiment 1-2, and the lead content of each was determined. The average value of each group was calculated, and the value in the control group was 100
, The relative values of the values in the control group and the test sample administration group were determined. Table 3 shows the results.
【００３２】[0032]
【表３】 [Table 3]
【００３３】表３に示すとおり、用量が０．４ｍｇ／匹
／回となるようにトレハロースを配合した被験試料では
中国パセリ加工物による金属沈着抑制作用に大きな変化
はなかったものの、トレハロースを、その用量が１．２
ｍｇ／匹／回以上となるように配合した場合には中国パ
セリ加工物による金属沈着抑制作用が顕著に増強され、
用量１２ｍｇ／匹／回以上となるように配合した場合に
その増強のレベルはほぼ最大に達した。以上の結果は、
セリ科植物加工物による金属沈着抑制作用をトレハロー
スの添加により増強するためには、該加工物の固形分量
に対してトレハロースが無水物換算で重量比で、１／１
０量以上が望ましく、等量以上あれば十分であることを
示している。なお、データは割愛するけれども、マルチ
トールを用いて同様の実験を行ったところ、同様の傾向
が認められた。As shown in Table 3, the test sample containing trehalose at a dose of 0.4 mg / animal / dose showed no significant change in the metal deposition-inhibiting action of the processed Chinese parsley, but trehalose was added to the test sample. Dose is 1.2
When it is blended so as to be not less than mg / animal / time, the metal deposition suppressing effect of the processed Chinese parsley is remarkably enhanced,
When formulated at doses of 12 mg / animal / dose or higher, the level of enhancement almost reached a maximum. The above results
In order to enhance the metal deposition inhibitory effect of the processed plant of the Umbelliferae by the addition of trehalose, the weight ratio of trehalose to the solid content of the processed product in terms of an anhydride is 1/1,
It is shown that 0 or more is desirable, and an equivalent or more is sufficient. In addition, although the data is omitted, when the same experiment was performed using maltitol, the same tendency was recognized.
【００３４】また、パネルテストにより、本実験例で用
いた被験試料はいずれも良好な呈味を示し、これらのう
ち、増強された金属沈着抑制作用を示したもの、とりわ
け、中国パセリ加工物と等量以上のトレハロース又はマ
ルチトールを含むものほど特に良好な呈味を示すことを
パネルテストにより確認した。したがって、セリ科植物
加工物の固形分重量に対して、無水物換算で重量比で等
量以上のトレハロース及び／又はマルチトールとを含む
組成物は、とりわけ顕著な金属沈着抑制作用を示すこと
に加えて、その呈味がとりわけ優れているという特長を
有しているといえる。According to the panel test, all of the test samples used in the present experimental example exhibited a good taste. Among them, those exhibiting enhanced metal deposition inhibiting action, in particular, processed parsley with Chinese parsley Panel tests confirmed that those containing trehalose or maltitol in equal amounts or more showed particularly good taste. Therefore, a composition containing trehalose and / or maltitol in an equivalent amount or more by weight in terms of anhydride with respect to the weight of the solid matter of a processed plant of the Umbelliferae has a particularly remarkable metal deposition inhibiting effect. In addition, it can be said that it has the feature that the taste is particularly excellent.
【００３５】[0035]
【実施例１】〈金属沈着抑制剤〉収穫した中国パセリの
全草より根を除去し、これを水洗し、水切りした。この
中国パセリ（湿重量で１００重量部）をブレンダーを用
いて細断（ミンチ）した。細断した中国パセリを遠心濾
過分離器（回転数３０００ｒｐｍ）を用いて３００メッ
シュのフィルターを通して濾過し、濾液を回収した。回
収した濾液の全量（８２重量部）を直火にかけて煮詰
め、濃縮液を得た。濃縮液の全量（３２重量部）を１２
１℃で１０分間処理し、室温にまで放冷した後、４℃で
一晩静置した。この液を０．４２ｍｍメッシュの篩を通
し、通過液中になお残存する不溶物をブレンダーを用い
て分散し、この液を回収して３０重量部の中国パセリ加
工物を得た。この加工物の固形分含量は約６％（ｗ／
ｗ）であった。この加工物の全量に７重量部の含水結晶
トレハロース（商品名『トレハ』、株式会社林原商事販
売）を添加し、十分に溶解させ、液状の金属沈着抑制剤
を得た。Example 1 <Metal Deposition Inhibitor> Roots were removed from the whole plant of harvested Chinese parsley, which was washed with water and drained. The Chinese parsley (100 parts by weight in wet weight) was minced using a blender. The shredded Chinese parsley was filtered through a 300-mesh filter using a centrifugal filter separator (3,000 rpm), and the filtrate was collected. The whole amount (82 parts by weight) of the collected filtrate was boiled down over an open fire to obtain a concentrated solution. 12 parts by weight of the concentrate
The mixture was treated at 1 ° C. for 10 minutes, allowed to cool to room temperature, and allowed to stand at 4 ° C. overnight. This solution was passed through a 0.42 mm mesh sieve, and the insoluble matter remaining in the passing solution was dispersed using a blender. This solution was recovered to obtain 30 parts by weight of a processed Chinese parsley product. The solids content of the processed product is about 6% (w /
w). 7 parts by weight of hydrated crystalline trehalose (trade name “Treha”, sold by Hayashibara Shoji Co., Ltd.) was added to the entire amount of the processed product and sufficiently dissolved to obtain a liquid metal deposition inhibitor.
【００３６】本品は、顕著な金属沈着抑制作用を示す
上、中国パセリ本来の臭みが顕著に改善されているの
で、金属中毒の予防、緩和もしくは治療のための経口摂
取用の金属値着抑制剤として、食品分野や医薬品分野な
どで有利に利用できる。This product has a remarkable inhibitory effect on metal deposition and a remarkable improvement in the odor inherent in Chinese parsley. Therefore, it inhibits metal deposition for oral ingestion for preventing, alleviating or treating metal poisoning. As an agent, it can be advantageously used in the food and pharmaceutical fields.
【００３７】[0037]
【実施例２】〈金属沈着抑制剤〉根を除去し、水洗し、
水切りした、湿重量として１００重量部の中国パセリよ
り、実施例１の方法で３０重量部の中国パセリ加工物を
調製した。この加工物の全量に６重量部の無水結晶マル
チトール（商品名『粉末マビット』、株式会社林原商事
販売）を添加し、十分に溶解し、液状の金属沈着抑制剤
を得た。Example 2 <Metal Deposition Inhibitor> Root was removed, washed with water,
30 parts by weight of processed Chinese parsley was prepared by the method of Example 1 from 100 parts by weight of wet parsley Chinese parsley. 6 parts by weight of anhydrous crystalline maltitol (trade name “powder mavit”, sold by Hayashibara Shoji Co., Ltd.) was added to the whole amount of the processed product and sufficiently dissolved to obtain a liquid metal deposition inhibitor.
【００３８】本品は、顕著な金属沈着抑制作用を示す
上、中国パセリ本来の臭みが顕著に改善されているの
で、金属中毒の予防、緩和もしくは治療のための経口摂
取用の金属沈着抑制剤として、食品分野や医薬品分野な
どで有利に利用できる。The product has a remarkable inhibitory effect on metal deposition and a remarkably improved odor inherent in Chinese parsley. Therefore, a metal deposition inhibitor for oral ingestion for preventing, alleviating or treating metal poisoning. It can be advantageously used in the food and pharmaceutical fields.
【００３９】[0039]
【実施例３】〈金属沈着抑制剤〉根を除去し、水洗し、
水切りした、湿重量として１００重量部の中国パセリよ
り、実施例１の方法により、３０重量部の中国パセリ加
工物を調製した。この加工物の全量に２０８重量部の無
水結晶マルチトール（商品名『粉末マビット』、株式会
社林原商事販売）を添加し、８０℃に加温した条件下で
造粒器を用いて十分に混合・乾燥させた。造粒器より乾
燥後の混合物を回収し（２０５重量部）、室温で一晩静
置した後、混合器を用いて４重量部のシュガーエステル
と十分に混合した。得られた混合物（２０９重量部）を
打錠器を用いて、１錠の大きさが直径６ｍｍ、厚さ６．
３ｍｍのタブレット状の金属沈着抑制剤を得た。Example 3 <Metal deposition inhibitor> The roots were removed, washed with water,
According to the method of Example 1, 30 parts by weight of a processed Chinese parsley was prepared from 100 parts by weight of wet parsley Chinese parsley. 208 parts by weight of anhydrous crystalline maltitol (trade name “Powder Mavit”, sold by Hayashibara Shoji Co., Ltd.) was added to the entire amount of the processed product, and thoroughly mixed using a granulator under the condition of heating to 80 ° C. -It was dried. The dried mixture was recovered from the granulator (205 parts by weight), allowed to stand at room temperature overnight, and then thoroughly mixed with 4 parts by weight of a sugar ester using a mixer. Using a tableting machine, the obtained mixture (209 parts by weight) was 6 tablets in diameter and 6 mm in thickness.
A 3 mm tablet-shaped metal deposition inhibitor was obtained.
【００４０】本品は、顕著な金属沈着抑制作用を示す
上、中国パセリ本来の臭みが顕著に改善されているの
で、金属中毒の予防、緩和もしくは治療のための経口摂
取用の金属沈着抑制剤として、食品分野や医薬品分野な
どで有利に利用できる。This product has a remarkable inhibitory effect on metal deposition and a remarkably improved odor inherent in Chinese parsley. Therefore, a metal deposition inhibitor for oral ingestion for preventing, alleviating or treating metal poisoning. It can be advantageously used in the food and pharmaceutical fields.
【００４１】[0041]
【実施例４】〈金属沈着抑制剤〉含水結晶トレハロース
（商品名『トレハ』、株式会社林原商事販売）を、ジャ
ケット付き回転式真空乾燥機を用いて、温度９０℃、気
圧−３００乃至−３５０ｍｍＨｇの条件下で７時間処理
した。その後、温度を常温に、気圧を常圧に戻して内容
物を回収し、無水トレハロースを得た。Example 4 <Metal Deposition Inhibitor> Hydrous crystalline trehalose (trade name “Treha”, sold by Hayashibara Shoji Co., Ltd.) was used at a temperature of 90 ° C. and a pressure of −300 to −350 mmHg using a rotary vacuum dryer equipped with a jacket. For 7 hours. Thereafter, the temperature was returned to normal temperature and the atmospheric pressure was returned to normal pressure, and the contents were collected to obtain anhydrous trehalose.
【００４２】根を除去し、水洗し、水切りした、湿重量
として１００重量部の中国パセリより、実施例１の方法
により、３０重量部の中国パセリ加工物を調製した。こ
の加工物の全量に２００重量部の上記で得た無水トレハ
ロースと１０重量部の糖転移ヘスペリジン（商品名『α
ＧヘスペリジンＰＡ』、株式会社林原商事販売）とを添
加し、６０℃に加温した条件下で造粒器を用いて十分に
混合・乾燥させた。造粒器より乾燥後の混合物を回収し
（２２５重量部）、室温で一晩静置した後、混合器を用
いて４重量部のシュガーエステルと十分に混合した。得
られた混合物（２２９．５重量部）を打錠器を用いて、
１錠の大きさが直径６ｍｍ、厚さ６．３ｍｍのタブレッ
ト状の金属沈着抑制剤を得た。From the roots removed, washed and drained, 30 parts by weight of processed Chinese parsley was prepared by the method of Example 1 from 100 parts by weight of Chinese parsley as a wet weight. 200 parts by weight of the anhydrous trehalose obtained above and 10 parts by weight of transglycosylated hesperidin (trade name “α
G Hesperidin PA ”, sold by Hayashibara Shoji Co., Ltd.) and thoroughly mixed and dried using a granulator under the condition of heating to 60 ° C. The dried mixture was recovered from the granulator (225 parts by weight), allowed to stand at room temperature overnight, and then thoroughly mixed with 4 parts by weight of a sugar ester using a mixer. Using a tableting machine, the obtained mixture (229.5 parts by weight) was used.
A tablet-shaped metal deposition inhibitor having a tablet size of 6 mm in diameter and 6.3 mm in thickness was obtained.
【００４３】本品は、顕著な金属沈着抑制作用を示す
上、中国パセリ本来の臭みが顕著に改善されているの
で、金属中毒の予防、緩和もしくは治療のための経口摂
取用の金属沈着抑制剤として食品分野や医薬品分野など
で有利に利用できる。This product has a remarkable inhibitory effect on metal deposition and a remarkably improved odor inherent in Chinese parsley. Therefore, a metal deposition inhibitor for oral ingestion for preventing, alleviating or treating metal poisoning. It can be advantageously used in the food and pharmaceutical fields.
【００４４】[0044]
【実施例５】〈金属沈着抑制剤〉微粉状の含水ケイ酸ア
ルミニウム５５０重量部、ほう酸５０重量部、濃グリセ
リン４００重量部、カンフル４重量部、ハッカ油０．５
重量部、無水結晶マルチトール（商品名『粉末マビッ
ト』、株式会社林原商事販売）１０重量部、及び実施例
１による金属沈着抑制剤６０重量部を耐熱容器に入れ、
湯浴中で十分に混合し、ゲル状の金属沈着抑制剤を得
た。Example 5 <Metal deposition inhibitor> 550 parts by weight of finely powdered hydrated aluminum silicate, 50 parts by weight of boric acid, 400 parts by weight of concentrated glycerin, 4 parts by weight of camphor, and 0.5 minutes of peppermint oil
10 parts by weight of anhydrous crystalline maltitol (trade name “powder mavit”, sold by Hayashibara Corporation) and 60 parts by weight of the metal deposition inhibitor according to Example 1 were placed in a heat-resistant container.
The mixture was sufficiently mixed in a hot water bath to obtain a gel-like metal deposition inhibitor.
【００４５】本品は、通常の温湿布に準じて皮膚に貼付
して利用することができるので、金属中毒を予防、緩和
もしくは治療するためのパップ剤などとして、医薬品分
野をはじめとする諸種の分野で有利に利用できる。This product can be used by applying it to the skin in the same manner as a normal hot compress, so that it can be used as a poultice for preventing, alleviating or treating metal poisoning, in various fields including the pharmaceutical field. It can be used advantageously in the field.
【００４６】[0046]
【実施例６】〈清涼飲料〉実施例１による金属沈着抑制
剤１２０ｇ、異性化糖６０ｇ、クエン酸０．５ｇ及びＬ
−アスコルビン酸０．５ｇに水を加えて全量を１ｋｇと
して、金属沈着抑制剤を含んでなる清涼飲料を調製し
た。本品は、まろやかな甘味と適度の苦味に加え、さわ
やかな風味を呈する嗜好性に優れた製品である。本品に
は金属沈着抑制作用が付与されているので、本品は、金
属中毒から生体を守るための健康食品ないしは健康補助
食品として有用である。Example 6 <Soft drink> 120 g of metal deposition inhibitor according to Example 1, 60 g of isomerized sugar, 0.5 g of citric acid and L
Water was added to 0.5 g of ascorbic acid to make the total amount 1 kg, and a soft drink containing a metal deposition inhibitor was prepared. This product is a product with excellent taste that exhibits a refreshing flavor in addition to a mild sweetness and a moderate bitterness. Since the product has an effect of inhibiting metal deposition, the product is useful as a health food or health supplement for protecting a living body from metal poisoning.
【００４７】[0047]
【実施例７】〈チューインガム〉実施例３の方法で調製
した、中国パセリ加工物、マルチトール及びシュガーエ
ステルを配合した打錠前の混合物の２重量部に、グルコ
ース６重量部及び、柔らかくなる程度に加熱溶融したガ
ムベース２重量部を加えて混合し、さらに適量のハッカ
香料を混合した後、常法にしたがってロールにより練り
合わせ、成形することによって、金属沈着抑制剤を含ん
でなるチューインガムを製造した。本品は、まろやかな
甘味と適度の苦味に加え、さわやかな風味を呈するテク
スチャーに優れた製品である。本品には金属沈着抑制作
用が付与されているので、本品は、金属中毒から生体を
守るための健康食品ないしは健康補助食品として有用で
ある。Example 7 <Chewing gum> 2 parts by weight of the mixture before tableting prepared with the Chinese parsley processed product, maltitol and sugar ester prepared by the method of Example 3, 6 parts by weight of glucose, and 2 parts by weight of the heated and melted gum base were added and mixed, and an appropriate amount of the mint flavor was further mixed. Then, the mixture was kneaded with a roll according to a conventional method and molded to produce a chewing gum containing a metal deposition inhibitor. This product has excellent texture with a refreshing flavor in addition to mild sweetness and moderate bitterness. Since the product has an effect of inhibiting metal deposition, the product is useful as a health food or health supplement for protecting a living body from metal poisoning.
【００４８】[0048]
【臨床例１】数年に亙って肩、肘、手首、指の関節に痛
みを日常的に覚え続けている４７歳の女性を検査したと
ころ、単純ヘルペスによる感染が確認された。また、こ
の女性の血液と尿を検査したところ、水銀の量が健常者
における範囲を逸脱しており、生体内で金属沈着がおこ
っている疑いがもたれた。[Clinical Example 1] Examination of a 47-year-old woman who has routinely remembered pain in her shoulders, elbows, wrists and finger joints for several years has revealed an infection caused by herpes simplex. Examination of the woman's blood and urine also revealed that the amount of mercury was out of range for healthy subjects, suggesting that metal deposition had occurred in vivo.
【００４９】この女性に、実施例３の方法で得た金属沈
着抑制剤を１回あたり２錠、１日あたり４回の用量で連
日経口投与する治療を開始した。治療を開始してから２
日後に痛みの緩和が認められはじめ、１０日後にはそれ
ぞれの関節における痛みは全体に亙って顕著に緩和され
た。この経口投与を１４日間続け、その後、血液と尿に
おける水銀の量を検査したところ、健常者における範囲
内にあることが確認された。The female was started to be treated orally daily with the metal deposition inhibitor obtained by the method of Example 3 at a dose of 2 tablets at a time, 4 times a day. 2 after starting treatment
Pain relief began to appear after days, and after 10 days, the pain in each joint was significantly alleviated throughout. This oral administration was continued for 14 days, after which the amount of mercury in blood and urine was examined and found to be within the range for healthy subjects.
【００５０】この臨床例は、この発明の金属沈着抑制剤
が、患者の生体内での金属沈着の抑制を介して、あるい
は、該抑制を伴って、単純ヘルペスの感染に伴う患者に
おける諸症状を緩和したことを示している。This clinical example shows that the metal deposition inhibitor of the present invention is effective in suppressing various symptoms in a patient associated with herpes simplex infection through, or together with, the suppression of metal deposition in the living body of the patient. This indicates that it has eased.
【００５１】[0051]
【臨床例２】約１ヶ月前より背部と肩部に強い痛みを覚
えはじめた４２歳の女性を検査したところ、単純ヘルペ
スによる感染が確認された。また、この女性の血液と尿
を検査したところ、水銀の量が健常者における範囲を逸
脱しており、生体内で金属沈着がおこっている疑いがも
たれた。[Clinical Example 2] An examination of a 42-year-old woman who had started to feel severe pain in her back and shoulders about one month ago confirmed that herpes simplex infection was present. Examination of the woman's blood and urine also revealed that the amount of mercury was out of range for healthy subjects, suggesting that metal deposition had occurred in vivo.
【００５２】この女性に、実施例４の方法で得た金属沈
着抑制剤を１回あたり２錠、１日あたり３回の用量で連
日経口投与する治療を開始した。治療を開始してから２
日後に痛みの緩和が認められはじめ、５日後には両部位
の痛みは顕著に緩和された。この経口投与を１４日間続
け、その後、血液と尿における水銀の量を検査したとこ
ろ、健常者における範囲内にあることが確認された。The woman was started to be treated orally daily with the metal deposition inhibitor obtained by the method of Example 4 at a dose of 2 tablets at a time, 3 times a day. 2 after starting treatment
Pain relief began to be observed after 5 days, and after 5 days, the pain at both sites was remarkably reduced. This oral administration was continued for 14 days, after which the amount of mercury in blood and urine was examined and found to be within the range for healthy subjects.
【００５３】この臨床例は、この発明の金属沈着抑制剤
が、患者の生体内での金属沈着の抑制を介して、あるい
は、該抑制を伴って、単純ヘルペスの感染に伴う患者に
おける諸症状を緩和したことを示している。This clinical example shows that the metal deposition inhibitor of the present invention is useful for suppressing various metal symptoms in a patient associated with herpes simplex infection through or together with the suppression of metal deposition in the living body of the patient. This indicates that it has eased.
【００５４】[0054]
【発明の効果】以上説明したとおり、この発明は、セリ
科植物の加工物にトレハロース及び／又はマルチトール
を添加すると、該加工物が本来示す金属沈着抑制作用が
顕著に増強されるという本発明者等による全く独自の知
見に基づくものである。本発明が提供する金属沈着抑制
剤は、顕著な金属沈着抑制作用を示す上、安全性高く、
日常的に常用できるので、それ自体で金属中毒の予防、
緩和もしくは治療の効果を発揮する食品、化粧品、医薬
品などとして、また、食品や化粧品などに斯かる作用を
付与するための配合素材などとして有利に利用できる。As described above, according to the present invention, when trehalose and / or maltitol are added to a processed product of a Umbelliferae plant, the metal deposition inhibiting action originally exhibited by the processed product is significantly enhanced. It is based on completely original knowledge of the people. The metal deposition inhibitor provided by the present invention exhibits a remarkable metal deposition inhibitory action, and is highly safe.
Can be used on a daily basis, preventing metal poisoning by itself,
It can be advantageously used as foods, cosmetics, pharmaceuticals, etc. that exhibit a relaxing or therapeutic effect, and as compounding materials for imparting such effects to foods, cosmetics, etc.
【００５５】本発明は、斯くも顕著な作用効果を奏する
発明であり、斯界に貢献すること誠に多大な意義のある
発明である。The present invention is an invention having such remarkable functions and effects, and is an invention having a great significance to contribute to the art.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ テーマコート゛(参考） Ａ２３Ｌ 2/38 Ａ２３Ｌ 2/38 Ｚ ４Ｃ０８８ Ａ６１Ｋ 7/00 Ｆ Ａ６１Ｋ 7/00 Ｋ 31/7016 31/7016 Ａ６１Ｐ 31/04 Ａ６１Ｐ 31/04 39/02 39/02 Ａ２３Ｌ 2/00 Ｆ Ｆターム(参考） 4B014 GB13 GG09 GL10 4B017 LC03 LG15 LK12 4B018 MD29 MD32 MD61 ME14 4C083 AA111 AA112 AD191 AD192 CC01 EE03 4C086 AA01 AA02 EA01 MA03 MA04 NA05 ZC37 ZC54 ZC75 4C088 AB40 BA08 BA09 BA10 CA05 CA06 CA07 CA11 MA08 NA05 ZC37 ZC54 ZC75 ──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. 7 Identification symbol FI theme coat ゛ (Reference) A23L 2/38 A23L 2/38 Z 4C088 A61K 7/00 F A61K 7/00 K 31/7016 31/7016 A61P 31/04 A61P 31/04 39/02 39/02 A23L 2/00 FF term (reference) 4B014 GB13 GG09 GL10 4B017 LC03 LG15 LK12 4B018 MD29 MD32 MD61 ME14 4C083 AA111 AA112 AD191 AD192 CC01 EE03 4C086 AA01 AA02 EA01 MA03 MA03 ZC37 ZC54 ZC75 4C088 AB40 BA08 BA09 BA10 CA05 CA06 CA07 CA11 MA08 NA05 ZC37 ZC54 ZC75
Claims (12)
レハロース及び／又はマルチトールとを含む金属沈着抑
制剤。1. A metal deposition inhibitor comprising a processed product of a Umbelliferae plant and trehalose and / or maltitol as active ingredients.
求項１に記載の金属沈着抑制剤。2. The metal deposition inhibitor according to claim 1, wherein the Umbelliferae is a plant of the genus Cilantro.
パセリである請求項２に記載の金属沈着抑制剤。3. The metal deposition inhibitor according to claim 2, wherein the Apiaceae plant is Chinese parsley belonging to the genus Cilantro.
破砕物、細断物、粉末化物、搾汁、乾燥物又は抽出物で
ある請求項１、２又は３に記載の金属沈着抑制剤。4. The metal deposition according to claim 1, wherein the processed product of a plant of the Umbelliferae is a crushed product, a shredded product, a powdered product, a squeezed product, a dried product or an extract of the above-ground part of the plant. Inhibitors.
の生体での沈着を抑制する請求項１乃至４のいずれかに
記載の金属沈着抑制剤。5. The metal deposition inhibitor according to claim 1, which suppresses the deposition of an organic compound or an inorganic compound containing a heavy metal in a living body.
５に記載の金属沈着抑制剤。6. The metal deposition inhibitor according to claim 5, wherein the heavy metal is lead, arsenic or mercury.
毒を予防、緩和又は治療する効果を発揮する請求項１乃
至６のいずれかに記載の金属沈着抑制剤。7. The metal deposition inhibitor according to claim 1, which, when ingested, exhibits an effect of preventing, alleviating or treating metal poisoning in the living body.
毒である請求項７に記載の金属沈着抑制剤。8. The metal deposition inhibitor according to claim 7, wherein the metal poisoning is lead poisoning, arsenic poisoning or mercury poisoning.
沈着抑制剤を含有する組成物。9. A composition containing the metal deposition inhibitor according to claim 1.
ース及び／又はマルチトールを含有する組成物。10. A composition containing trehalose and / or maltitol together with a processed product of a Umbelliferae plant.
９又は１０に記載の組成物。11. The composition according to claim 9, which is a food, a cosmetic, or a pharmaceutical.
属沈着抑制剤を有効成分とする、ウイルス又は微生物の
感染に伴う諸症状の緩和剤。12. An agent for alleviating various symptoms associated with virus or microbial infection, comprising the metal deposition inhibitor according to claim 1 as an active ingredient.
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| JP2001067281A JP4982648B2 (en) | 2000-06-27 | 2001-03-09 | Metal deposition inhibitor |
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| JP2000-193349 | 2000-06-27 | ||
| JP2000193349 | 2000-06-27 | ||
| JP2000193349 | 2000-06-27 | ||
| JP2001067281A JP4982648B2 (en) | 2000-06-27 | 2001-03-09 | Metal deposition inhibitor |
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| JP2002080385A true JP2002080385A (en) | 2002-03-19 |
| JP2002080385A5 JP2002080385A5 (en) | 2008-04-17 |
| JP4982648B2 JP4982648B2 (en) | 2012-07-25 |
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| JP2001067281A Expired - Lifetime JP4982648B2 (en) | 2000-06-27 | 2001-03-09 | Metal deposition inhibitor |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005261245A (en) * | 2004-03-17 | 2005-09-29 | Japan Science & Technology Agency | Animal feed |
| WO2005112667A1 (en) * | 2004-05-20 | 2005-12-01 | Takashi Omori | Health food |
| JP2017043617A (en) * | 2015-08-27 | 2017-03-02 | 日本新薬株式会社 | Muscle activator |
| JP2018076250A (en) * | 2016-11-08 | 2018-05-17 | 株式会社にしはらグループ | Composition for treating, preventing and/or reducing heavy metal-induced cell damage |
| CN114376935A (en) * | 2022-01-11 | 2022-04-22 | 英国纽歌芬生物科技国际集团控股有限公司 | Composition containing phytochelatin and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1067672A (en) * | 1996-03-01 | 1998-03-10 | Omura Yoshiaki | Treatment of various resistant infection, cancer, other disease which has infection in case in which metal is deposited in pathological area |
| JP2000050807A (en) * | 1998-04-28 | 2000-02-22 | Hayashibara Biochem Lab Inc | High moisture and high hardness hard candy and method for producing the same |
-
2001
- 2001-03-09 JP JP2001067281A patent/JP4982648B2/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1067672A (en) * | 1996-03-01 | 1998-03-10 | Omura Yoshiaki | Treatment of various resistant infection, cancer, other disease which has infection in case in which metal is deposited in pathological area |
| JP2000050807A (en) * | 1998-04-28 | 2000-02-22 | Hayashibara Biochem Lab Inc | High moisture and high hardness hard candy and method for producing the same |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005261245A (en) * | 2004-03-17 | 2005-09-29 | Japan Science & Technology Agency | Animal feed |
| WO2005112667A1 (en) * | 2004-05-20 | 2005-12-01 | Takashi Omori | Health food |
| JPWO2005112667A1 (en) * | 2004-05-20 | 2008-03-27 | 隆史 大森 | healthy food |
| JP2017043617A (en) * | 2015-08-27 | 2017-03-02 | 日本新薬株式会社 | Muscle activator |
| JP2018076250A (en) * | 2016-11-08 | 2018-05-17 | 株式会社にしはらグループ | Composition for treating, preventing and/or reducing heavy metal-induced cell damage |
| CN114376935A (en) * | 2022-01-11 | 2022-04-22 | 英国纽歌芬生物科技国际集团控股有限公司 | Composition containing phytochelatin and application thereof |
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|---|---|
| JP4982648B2 (en) | 2012-07-25 |
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