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WO2006046108A3 - Diagnostic de l'infertilite masculine par dosage de l'inhibiteur de la voie du facteur tissulaire - Google Patents

Diagnostic de l'infertilite masculine par dosage de l'inhibiteur de la voie du facteur tissulaire Download PDF

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Publication number
WO2006046108A3
WO2006046108A3 PCT/IB2005/003172 IB2005003172W WO2006046108A3 WO 2006046108 A3 WO2006046108 A3 WO 2006046108A3 IB 2005003172 W IB2005003172 W IB 2005003172W WO 2006046108 A3 WO2006046108 A3 WO 2006046108A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue factor
tfpi
pathway inhibitor
diagnosis
factor pathway
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2005/003172
Other languages
English (en)
Other versions
WO2006046108A2 (fr
Inventor
Bashir Lwaleed
Alan Cooper
Robert Greenfield
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
American Diagnostica Inc
Original Assignee
American Diagnostica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Diagnostica Inc filed Critical American Diagnostica Inc
Publication of WO2006046108A2 publication Critical patent/WO2006046108A2/fr
Publication of WO2006046108A3 publication Critical patent/WO2006046108A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8114—Kunitz type inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/367—Infertility, e.g. sperm disorder, ovulatory dysfunction

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Le sperme humain contient du facteur tissulaire (TF, Thromboplastine, CD142) et un inhibiteur naturel de la voie dépendante du TF, l'inhibiteur de la voie du facteur tissulaire (TFPI), présent dans le plasma séminal, le sperme sélectionné par migration ascendante (swim-up) et les prostasomes. On a constaté que les taux de TFPI étaient significativement plus élevés chez les hommes normaux que chez les sujets présentant une hypofertilité (p<0,01), ou chez les sujets vasectomisés (p<0,001). La présente invention concerne une méthode de diagnostic pratiquée in vitro, consistant à obtenir un échantillon de sperme d'un sujet mâle et à mesurer le taux de TFPI qu'il contient. Ce taux est ensuite comparé à un niveau de référence. Une valeur mesurée se situant en dessous du niveau de référence indique un faible niveau de fécondité chez le sujet. Une trousse de matériel permettant la mise en oeuvre de cette méthode de diagnostic est également décrite.
PCT/IB2005/003172 2004-10-26 2005-10-24 Diagnostic de l'infertilite masculine par dosage de l'inhibiteur de la voie du facteur tissulaire Ceased WO2006046108A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62216604P 2004-10-26 2004-10-26
US60/622,166 2004-10-26

Publications (2)

Publication Number Publication Date
WO2006046108A2 WO2006046108A2 (fr) 2006-05-04
WO2006046108A3 true WO2006046108A3 (fr) 2006-07-20

Family

ID=36228150

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/003172 Ceased WO2006046108A2 (fr) 2004-10-26 2005-10-24 Diagnostic de l'infertilite masculine par dosage de l'inhibiteur de la voie du facteur tissulaire

Country Status (1)

Country Link
WO (1) WO2006046108A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008053503B4 (de) 2008-10-28 2011-04-28 Justus-Liebig-Universität Giessen Immunologischer Test zum Nachweis von Autoantikörpern gegen testikuläre Antigene
US8669871B2 (en) 2009-11-13 2014-03-11 University Of Central Florida Research Foundation, Inc. Implementation of on-off passive wireless surface acoustic wave sensor using coding and switching techniques
US9040464B2 (en) 2010-08-16 2015-05-26 Mount Sinai Hosptial Markers of the male urogenital tract

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030187200A1 (en) * 1997-01-31 2003-10-02 Human Genome Sciences, Inc. Tissue factor pathway inhibitor-3

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030187200A1 (en) * 1997-01-31 2003-10-02 Human Genome Sciences, Inc. Tissue factor pathway inhibitor-3

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
THYZEL E.: "Decreased TFPI Levels in Seminal Plasma of Infertile Men", CLINICAL CHEMISTRY, vol. 49, no. 6, SUPPLEMENT, June 2003 (2003-06-01), pages A3 - A4, XP008070468 *
THYZEL E.: "Quantification of Tissue Factor Pathway Inhibitor in Human Seminal Plasma and in Human Follicular Fluid", THROMBOSIS RESEARCH, vol. 109, no. 5-6, 15 March 2003 (2003-03-15), pages 329 - 332, XP003001708 *

Also Published As

Publication number Publication date
WO2006046108A2 (fr) 2006-05-04

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