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WO2005123034A3 - Systemes de microparticules pour l'administration par voie orale de substances bioactives - Google Patents

Systemes de microparticules pour l'administration par voie orale de substances bioactives Download PDF

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Publication number
WO2005123034A3
WO2005123034A3 PCT/IT2005/000353 IT2005000353W WO2005123034A3 WO 2005123034 A3 WO2005123034 A3 WO 2005123034A3 IT 2005000353 W IT2005000353 W IT 2005000353W WO 2005123034 A3 WO2005123034 A3 WO 2005123034A3
Authority
WO
WIPO (PCT)
Prior art keywords
biologically active
active substances
microparticulate systems
gastroresistant
oral administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IT2005/000353
Other languages
English (en)
Other versions
WO2005123034A2 (fr
WO2005123034A8 (fr
Inventor
Daniele Vigo
Vincenzo Russo
Massimo Faustini
Mario Francesco Pace
Eleonora Munari
Maria Luisa Torre
Ubaldo Conte
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universita degli Studi di Pavia
Universita degli Studi di Milano
Original Assignee
Universita degli Studi di Pavia
Universita degli Studi di Milano
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universita degli Studi di Pavia, Universita degli Studi di Milano filed Critical Universita degli Studi di Pavia
Priority to EP05760593A priority Critical patent/EP1778192A2/fr
Publication of WO2005123034A2 publication Critical patent/WO2005123034A2/fr
Publication of WO2005123034A8 publication Critical patent/WO2005123034A8/fr
Publication of WO2005123034A3 publication Critical patent/WO2005123034A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne des systèmes de microparticules constitués d'une matrice polymère gastrorésistante, biocompatible et biodégradable contenant un polymère gastrorésistant et entérosoluble, un cryoprotecteur ou un lyoprotecteur, un sel de métal divalent ou trivalent d'un polymère biocompatible et biodégradable présentant des groupes acides et des substances bioactives. Lesdits systèmes de microparticules gastrorésistants sont utilisés pour l'administration, de préférence par voie orale, de substances bioactives à des espèces animales. La composition spéciale de ces systèmes à microparticules permet la protection desdites substances bioactives contre la dégradation par les protéases et l'acide gastrique, permettant leur libération dans l'intestin où leur action peut avoir lieu.
PCT/IT2005/000353 2004-06-22 2005-06-20 Systemes de microparticules pour l'administration par voie orale de substances bioactives Ceased WO2005123034A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05760593A EP1778192A2 (fr) 2004-06-22 2005-06-20 Systemes de microparticules pour l'administration par voie orale de substances bioactives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2004A001255 2004-06-22
ITMI20041255 ITMI20041255A1 (it) 2004-06-22 2004-06-22 Sistemi microparticellari per somministrazione orale di sostanze biologicamente attive

Publications (3)

Publication Number Publication Date
WO2005123034A2 WO2005123034A2 (fr) 2005-12-29
WO2005123034A8 WO2005123034A8 (fr) 2006-03-30
WO2005123034A3 true WO2005123034A3 (fr) 2006-09-14

Family

ID=35510243

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2005/000353 Ceased WO2005123034A2 (fr) 2004-06-22 2005-06-20 Systemes de microparticules pour l'administration par voie orale de substances bioactives

Country Status (3)

Country Link
EP (1) EP1778192A2 (fr)
IT (1) ITMI20041255A1 (fr)
WO (1) WO2005123034A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2222315B1 (fr) * 2007-12-21 2013-04-24 Inspiration Biopharmaceuticals, Inc. Formulations stabilisées de facteur ix contenant du tréhalose
JP5724108B2 (ja) 2009-04-22 2015-05-27 メドスキン ソリューションズ ドクター ズベラック アーゲーＭｅｄＳｋｉｎ Ｓｏｌｕｔｉｏｎｓ Ｄｒ．Ｓｕｗｅｌａｃｋ ＡＧ 凍結乾燥組成物
GB201102865D0 (en) 2011-02-18 2011-04-06 Danisco Feed additive composition
WO2012110776A2 (fr) 2011-02-18 2012-08-23 Dupont Nutrition Biosciences Aps Composition d'additif alimentaire
GB201102857D0 (en) 2011-02-18 2011-04-06 Danisco Feed additive composition
GB201213801D0 (en) 2012-08-03 2012-09-12 Dupont Nutrition Biosci Aps Feed additive composition
BR112015002449B1 (pt) 2012-08-03 2021-07-06 Dupont Nutrition Biosciences Aps composição aditiva para ração compreendendo pelo menos dois micro-organismos vivos alimentados diretamente (dfm) e método de aperfeiçoamento do desempenho gastrointestinal
US20160243154A1 (en) * 2013-10-23 2016-08-25 Donald W. Jessup Hyaluronic acid formulation
CN108366582A (zh) 2015-11-09 2018-08-03 杜邦营养生物科学有限公司 饲料添加剂组合物
EP3397278A1 (fr) 2015-12-29 2018-11-07 Intervet International B.V. Vaccin contre la coccidiose
CN113115952A (zh) * 2021-05-27 2021-07-16 江苏恒康生物科技有限公司 一种含微晶球的耐胃酸爆珠及其制备方法
US11833224B1 (en) 2023-02-08 2023-12-05 Leuvian Llc Lyoprotectant compositions and uses thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0290229A1 (fr) * 1987-05-08 1988-11-09 Smith Kline & French Laboratories Limited Compositions pharmaceutiques
US5230901A (en) * 1988-03-23 1993-07-27 Knoll Ag Sustained release tablet of a mixture of alginates and polyacrylates
US5695781A (en) * 1995-03-01 1997-12-09 Hallmark Pharmaceuticals, Inc. Sustained release formulation containing three different types of polymers
WO1999039698A1 (fr) * 1998-02-04 1999-08-12 Duramed Pharmaceuticals, Inc. Formulation a liberation prolongee
US6103269A (en) * 1992-01-17 2000-08-15 Alfatec-Pharma Gmbh Solid bodies containing active substances and a structure consisting of hydrophilic macromolecules, plus a method of producing such bodies

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0290229A1 (fr) * 1987-05-08 1988-11-09 Smith Kline & French Laboratories Limited Compositions pharmaceutiques
US5230901A (en) * 1988-03-23 1993-07-27 Knoll Ag Sustained release tablet of a mixture of alginates and polyacrylates
US6103269A (en) * 1992-01-17 2000-08-15 Alfatec-Pharma Gmbh Solid bodies containing active substances and a structure consisting of hydrophilic macromolecules, plus a method of producing such bodies
US5695781A (en) * 1995-03-01 1997-12-09 Hallmark Pharmaceuticals, Inc. Sustained release formulation containing three different types of polymers
WO1999039698A1 (fr) * 1998-02-04 1999-08-12 Duramed Pharmaceuticals, Inc. Formulation a liberation prolongee

Also Published As

Publication number Publication date
EP1778192A2 (fr) 2007-05-02
ITMI20041255A1 (it) 2004-09-22
WO2005123034A2 (fr) 2005-12-29
WO2005123034A8 (fr) 2006-03-30

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