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WO2005123034A3 - Microparticulate systems for the oral administration of biologically active substances - Google Patents

Microparticulate systems for the oral administration of biologically active substances Download PDF

Info

Publication number
WO2005123034A3
WO2005123034A3 PCT/IT2005/000353 IT2005000353W WO2005123034A3 WO 2005123034 A3 WO2005123034 A3 WO 2005123034A3 IT 2005000353 W IT2005000353 W IT 2005000353W WO 2005123034 A3 WO2005123034 A3 WO 2005123034A3
Authority
WO
WIPO (PCT)
Prior art keywords
biologically active
active substances
microparticulate systems
gastroresistant
oral administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IT2005/000353
Other languages
French (fr)
Other versions
WO2005123034A2 (en
WO2005123034A8 (en
Inventor
Daniele Vigo
Vincenzo Russo
Massimo Faustini
Mario Francesco Pace
Eleonora Munari
Maria Luisa Torre
Ubaldo Conte
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universita degli Studi di Pavia
Universita degli Studi di Milano
Original Assignee
Universita degli Studi di Pavia
Universita degli Studi di Milano
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universita degli Studi di Pavia, Universita degli Studi di Milano filed Critical Universita degli Studi di Pavia
Priority to EP05760593A priority Critical patent/EP1778192A2/en
Publication of WO2005123034A2 publication Critical patent/WO2005123034A2/en
Publication of WO2005123034A8 publication Critical patent/WO2005123034A8/en
Publication of WO2005123034A3 publication Critical patent/WO2005123034A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to microparticulate systems consisting of a gastroresistant, biocompatible and biodegradable polymer matrix, comprising a gastroresistant and enterosoluble polymer, a cryoprotector or lyoprotector, a divalent or trivalent metal salt of i biocompatible and biodegradable polymer having acid groups, and biologically active substances. Such gastroresistant microparticulate systems are used for the administration, preferably oral, of biologically active substances to animal species. The special composition of such microparticulate systems allows the protection of said biologically active substances from degradation by proteases and gastric acid, allowing their release into the intestine, where they may perform their activities.
PCT/IT2005/000353 2004-06-22 2005-06-20 Microparticulate systems for the oral administration of biologically active substances Ceased WO2005123034A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05760593A EP1778192A2 (en) 2004-06-22 2005-06-20 Microparticulate systems for the oral administration of biologically active substances

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2004A001255 2004-06-22
ITMI20041255 ITMI20041255A1 (en) 2004-06-22 2004-06-22 MICROPARTICLE SYSTEMS FOR ORAL ADMINISTRATION OF BIOLOGICALLY ACTIVE SUBSTANCES

Publications (3)

Publication Number Publication Date
WO2005123034A2 WO2005123034A2 (en) 2005-12-29
WO2005123034A8 WO2005123034A8 (en) 2006-03-30
WO2005123034A3 true WO2005123034A3 (en) 2006-09-14

Family

ID=35510243

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2005/000353 Ceased WO2005123034A2 (en) 2004-06-22 2005-06-20 Microparticulate systems for the oral administration of biologically active substances

Country Status (3)

Country Link
EP (1) EP1778192A2 (en)
IT (1) ITMI20041255A1 (en)
WO (1) WO2005123034A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2222315B1 (en) * 2007-12-21 2013-04-24 Inspiration Biopharmaceuticals, Inc. Stabilized factor ix formulations containing trehalose
JP5724108B2 (en) 2009-04-22 2015-05-27 メドスキン ソリューションズ ドクター ズベラック アーゲーＭｅｄＳｋｉｎ Ｓｏｌｕｔｉｏｎｓ Ｄｒ．Ｓｕｗｅｌａｃｋ ＡＧ Lyophilized composition
GB201102865D0 (en) 2011-02-18 2011-04-06 Danisco Feed additive composition
WO2012110776A2 (en) 2011-02-18 2012-08-23 Dupont Nutrition Biosciences Aps Feed additive composition
GB201102857D0 (en) 2011-02-18 2011-04-06 Danisco Feed additive composition
GB201213801D0 (en) 2012-08-03 2012-09-12 Dupont Nutrition Biosci Aps Feed additive composition
BR112015002449B1 (en) 2012-08-03 2021-07-06 Dupont Nutrition Biosciences Aps feed additive composition comprising at least two live direct-fed micro-organisms (dfm) and method of improving gastrointestinal performance
US20160243154A1 (en) * 2013-10-23 2016-08-25 Donald W. Jessup Hyaluronic acid formulation
CN108366582A (en) 2015-11-09 2018-08-03 杜邦营养生物科学有限公司 feed additive composition
EP3397278A1 (en) 2015-12-29 2018-11-07 Intervet International B.V. Coccidiosis vaccine
CN113115952A (en) * 2021-05-27 2021-07-16 江苏恒康生物科技有限公司 Gastric acid resistant blasting bead containing microcrystal ball and preparation method thereof
US11833224B1 (en) 2023-02-08 2023-12-05 Leuvian Llc Lyoprotectant compositions and uses thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0290229A1 (en) * 1987-05-08 1988-11-09 Smith Kline & French Laboratories Limited Pharmaceutical compositions
US5230901A (en) * 1988-03-23 1993-07-27 Knoll Ag Sustained release tablet of a mixture of alginates and polyacrylates
US5695781A (en) * 1995-03-01 1997-12-09 Hallmark Pharmaceuticals, Inc. Sustained release formulation containing three different types of polymers
WO1999039698A1 (en) * 1998-02-04 1999-08-12 Duramed Pharmaceuticals, Inc. Sustained release formulation
US6103269A (en) * 1992-01-17 2000-08-15 Alfatec-Pharma Gmbh Solid bodies containing active substances and a structure consisting of hydrophilic macromolecules, plus a method of producing such bodies

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0290229A1 (en) * 1987-05-08 1988-11-09 Smith Kline & French Laboratories Limited Pharmaceutical compositions
US5230901A (en) * 1988-03-23 1993-07-27 Knoll Ag Sustained release tablet of a mixture of alginates and polyacrylates
US6103269A (en) * 1992-01-17 2000-08-15 Alfatec-Pharma Gmbh Solid bodies containing active substances and a structure consisting of hydrophilic macromolecules, plus a method of producing such bodies
US5695781A (en) * 1995-03-01 1997-12-09 Hallmark Pharmaceuticals, Inc. Sustained release formulation containing three different types of polymers
WO1999039698A1 (en) * 1998-02-04 1999-08-12 Duramed Pharmaceuticals, Inc. Sustained release formulation

Also Published As

Publication number Publication date
EP1778192A2 (en) 2007-05-02
ITMI20041255A1 (en) 2004-09-22
WO2005123034A2 (en) 2005-12-29
WO2005123034A8 (en) 2006-03-30

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