WO2005105060A1 - Plaster - Google Patents

Abstract

A plaster comprising a support and, superimposed on at least one major surface thereof, a sheet-shaped hydrous ointment of ointment base agent, characterized in that the ointment base agent contains: (a) substantially none of gelatin, (b) ≥ 70 mass% of water, (c) 3.0 to 10 mass% of water-soluble polymer, and (d) 0.01 to 1.4 mass% of the total of xanthan gum and/or polyvinylpyrrolidone.

Description

 Specification

 Patch

 Technical field

 The present invention relates to a patch.

 Background art

 [0002] Patches such as knocking agents used as pharmaceuticals, knocking agents used as cosmetics or quasi-drugs, etc. are provided with sheet-like hydrogel bodies. In the sheet-like hydrous plaster, the plaster base is formed into a sheet (for example, formed by applying the plaster base on a support), whereby the patch is directly adhered to the skin. It is easy to use and easy to use. Such a sheet-like hydrous plaster is conventionally prepared from a plaster base containing gelatin and Z or a water-soluble polymer such as polyacrylic acid or polyacrylate in order to increase the water content in the plaster. Had been formed.

 [0003] In particular, a plaster base containing gelatin can form a plaster having a high water content and excellent shape retention and cohesiveness, is excellent in use feeling such as moist feeling, and has a plaster. It is possible to form a sheet-like hydrogel with reduced remaining problems. Also disclosed is a poultice having a sheet-like hydrous plaster formed from a plaster base obtained by further mixing agar with a gelatin-based base with the intention of further improving the water content and shape retention. (See Patent Document 1).

 Patent Document 1: JP-A-57-42617

 Disclosure of the invention

 Problems to be solved by the invention

[0004] In the past, in conventional patches containing gelatin, such as the napping agent described in Patent Document 1, the selection range of compounding substances other than gelatin (for example, a medicinal ingredient) is based on plaster base. Sometimes limited by the pH of the agent. This, _P H of the plaster base is, shape-retaining force of gelatin, when deviated from a predetermined range of pH of cohesion or the like can be sufficiently exhibited, shape retention plaster that will be formed, cohesive, This is because a problem that the adhesiveness or the like is reduced occurs. In particular, when the plaster is formed into a sheet from the plaster base, the seepage of moisture from the plaster is remarkable. It becomes. Therefore, the conventional patches described above were not sufficient in the degree of freedom in designing the patches.

 [0005] It is considered that gelatin may not be blended so that the components that can be added are not limited by the pH of the plaster base. In a conventional plaster base not containing gelatin, the plaster has a sufficient water content. It cannot be used, and the feeling of use such as a feeling of moisture is reduced. In addition, when the water content of a conventional paste base containing no gelatin is increased, there is a problem in that the formed paste strength is oozing out of water and the stickiness of the paste is insufficient. On the other hand, if it is attempted to suppress the exudation of water, the plaster becomes too sticky or sticky.

 [0006] The present invention has been made in view of the above-mentioned problems of the related art, and it has been found that even a composition containing a desired component and having a desired pH can sufficiently provide a feeling of use such as a moist feeling. Another object of the present invention is to provide a patch in which oozing of water from the plaster is sufficiently reduced and which has a sufficient adhesive strength.

 Means for solving the problem

 [0007] The inventors of the present invention have conducted intensive studies to achieve the above object, and as a result, a sheet-like plaster formed from a plaster base containing 70% by mass or more of moisture has a sufficiently excellent moist feeling. By having a specific composition of the plaster base, a plaster having a sufficient water content can be formed into a sheet without containing gelatin, and The present inventors have found that the sheet-like plaster has excellent shape-retaining properties and adhesive strength, and has sufficiently reduced the bleeding of water, thereby completing the present invention.

 [0008] The patch of the present invention is a patch comprising a support, and a sheet-like water-containing plaster composed of a plaster base disposed on at least one surface of the support, the plaster base comprising However, (a) contains substantially no gelatin, (b) contains 70% by mass or more of water, (c) contains 3.0% to 10% by mass of a water-soluble polymer, and (d) ) Xanthan gum and / or polyvinylpyrrolidone are contained in a total amount of 0.01% by mass to 1.4% by mass. That is, the patch of the present invention includes a water-containing plaster formed by forming a plaster base having the above characteristics in a sheet shape.

[0009] In the present invention, "substantially free of gelatin" means that no gelatin is contained, It means that the amount thereof does not affect the jelly strength of the pressure-sensitive adhesive layer formed from the pressure-sensitive adhesive base. Here, whether or not a force affecting the jelly strength of the pressure-sensitive adhesive layer can be determined by the following method. That is, the jelly strength of the pressure-sensitive adhesive layer formed from a certain amount of gelatin contained in the pressure-sensitive adhesive base is larger or changed with respect to the jelly strength of the pressure-sensitive adhesive layer formed from the certain pressure-sensitive adhesive base. In that case, it is determined that the jelly strength of the pressure-sensitive adhesive layer is not affected, and a certain amount of gelatin can be regarded as “substantially free of gelatin”. When comparing the jelly strength, the difference shall be confirmed taking into account the measurement error.

[0010] In the present invention, "jelly strength" refers to a gel prepared by preparing a 1.5% by mass solution of agar, leaving it at 20 ° C for 15 hours, and coagulating the gel for 20 seconds per square centimeter of its surface. Jelly strength (g / cm ² ) is defined as the maximum weight (g number) that can be withstood.

 [0011] The patch of the present invention is provided with a sheet-like water-containing plaster formed from a plaster base satisfying the above-mentioned conditions (a) to (d), and is sufficiently excellent in usability such as moist feeling. In addition, the exudation of water from the plaster is sufficiently reduced, and the adhesive has sufficient adhesive strength.

 [0012] The patch of the present invention solves the above-mentioned problems caused by gelatin by substantially not containing the above-mentioned condition (a) gelatin. That is, in the case of a paste containing gelatin, it is possible to select a formulation (component composition, pH) that does not sufficiently satisfy the shape retention, cohesiveness and adhesiveness of the paste. Further, the problem of sagging of the plaster observed when using a conventional cataplasm containing gelatin is sufficiently reduced. This is because, when the temperature of the outside air becomes high, for example, 30 ° C. or more, the state of gelatin changes and the cohesive force of the plaster decreases, and it can be prevented by substantially not including gelatin.

 [0013] Under the above condition (b), if the water content is less than 70% by mass, the water-containing gypsum sheet cannot provide sufficient moisture and feeling.

[0014] Further, under the above condition (c), if the content of the water-soluble polymer is less than 3.0% by mass, the strength and shape retention of the sheet-like hydrogel body become insufficient, Leaching of water from the body cannot be reduced sufficiently. On the other hand, when the content ratio of the water-soluble polymer exceeds 10% by mass, the sheet-like water-containing plaster becomes too hard to obtain a sufficient adhesive strength. [0015] Also, under the above condition (d), if the total content of xanthan gum and Z or polybutylpyrrolidone is less than 0.01% by mass, sufficient adhesive strength cannot be obtained, and 1. If the content exceeds 4% by mass, the sheet-like hydrogel body becomes sticky and the feeling of use is impaired.

 [0016] In general, when a plaster base having a water content of 70% by mass or more is solidified into a sheet, there is a problem that the shape retention cannot be sufficiently obtained or the shape retention deteriorates with the passage of time. It is considered that the oozing of water from the plaster is sufficiently suppressed, and it is difficult to satisfy a high level of usability and adhesiveness. While applying pressure, the patch of the present invention provides a sheet-like hydrous plaster formed from a plaster base that satisfies all of the above-mentioned conditions (a) to (d), and The dispensing is sufficiently suppressed, and the feeling of use and adhesiveness can be satisfied at a high level. Simultaneously satisfying these characteristics can solve the problem of moisturizing and safety, especially in applications such as sticking to the face.

 [0017] Furthermore, the patch of the present invention has an effect that, when the plaster base satisfies the above conditions (a) to (d), the production time of the patch is shorter than before.

 [0018] In order for the patch to be usable as a product, the water-soluble polymer in the plaster must be sufficiently bridged. That is, a predetermined time was required after the plaster base was applied on the support until the water-soluble polymer was sufficiently crosslinked. Usually, this time was 13 to 18 days at room temperature for a patch provided with a conventional sheet-like hydrogel using gelatin or polyacrylic acid or the like. On the other hand, a plaster base satisfying the above conditions (a) to (d) can form a sheet-like hydrous plaster in a shorter time than before. As a result, the patch of the present invention can reduce the time (lead time) until it is shipped as a product as compared with a patch having a conventional sheet-like hydrogel, and is excellent in productivity. .

 In the patch of the present invention, it is preferable that the plaster base further contains easily soluble agar as a water-soluble polymer.

 [0020] Here, the "soluble agar" means agar that is almost 100% soluble at a temperature of 70 ° C. The composition, molecular weight, morphology, jelly strength, sol viscosity, freezing point, pH, water absorption, syneresis and the like of the agar are not particularly limited as long as they have a powerful property.

[0021] By using the above-mentioned readily soluble agar, conventionally, gelatin or both gelatin and agar are used. By using this method, it becomes possible to more reliably form a sheet-like hydrogel body that satisfies all of the high water content, shape retention, cohesiveness and adhesiveness achieved at a high level. This makes it possible to more effectively realize a patch having sufficient water content, excellent adhesive strength, and a sufficiently reduced plaster residue.

 [0022] In addition, the use of readily soluble agar not only provides the above effects, but also can further improve the degree of freedom in the formulation of a patch. Further, the production of the patch can be made easier (low cost, simplified process, etc.). The reasons for these effects are as follows.

 [0023] The use of readily soluble agar eliminates the need for the high temperature (about 90 ° C or higher) that was required for dissolving general agar, so that volatile or thermally decomposable materials that had a large loss during production were used. Can be efficiently blended into the plaster. Further, it is possible to achieve low cost manufacturing and simple manufacturing process which require an apparatus for cooling the solution of agar, energy, time and the like for mixing volatile or thermally decomposable components. Furthermore, at the time of production, evaporation of not only volatile or thermally decomposable components but also water can be sufficiently suppressed, so that the content ratio of each component in the sheet-shaped hydrogel can be surely included in a desired range. This makes it possible to obtain a patch of excellent quality more stably.

 [0024] When the temperature of the paste base becomes high (about 90 ° C or higher), the reaction of a crosslinking agent (a polyvalent metal salt such as an aluminum compound) contained in the paste base is promoted more than necessary. There is a possibility that inconvenience may occur during the production of such as. However, since easily soluble agar does not require a high temperature (90 ° C or higher) for melting, the above-mentioned problems can be sufficiently reduced, and it is sufficiently excellent in sensation such as moisture and Since the oozing of moisture of physical strength is sufficiently reduced, a patch having a sufficient adhesive strength can be manufactured more easily and reliably.

 [0025] In the patch of the present invention, the plaster base preferably contains, as a water-soluble polymer, easily soluble agar, polyacrylic acid, Z or a salt thereof.

[0026] By combining the easily soluble agar with polyacrylic acid and Z or a salt thereof as the water-soluble polymer and adding it to the plaster base, it is considered that the plaster base is sufficiently excellent in usability such as moistness. In addition, it is possible to more reliably and easily obtain a patch in which oozing of moisture from the plaster is sufficiently reduced and which has a sufficient adhesive strength. [0027] Further, the thickness of the sheet-like water-containing gypsum body included in the patch of the present invention can be appropriately set according to the application. For example, when used on the face, the thickness of the plaster is preferably 1.0 to 1.6 mm.

 The invention's effect

 [0028] According to the present invention, even if the composition contains a desired component and has a desired pH, it is sufficiently excellent in usability such as hydration and the like, and oozing of water from the plaster is sufficiently reduced. Thus, a patch having sufficient adhesive strength can be provided.

 Brief Description of Drawings

FIG. 1 is a perspective view showing a preferred embodiment of the patch of the present invention.

 BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, a preferred embodiment of the present invention will be described in detail with reference to the drawings.

FIG. 1 is a perspective view showing a preferred embodiment of the patch of the present invention. In FIG. 1, a patch 1 comprises a support 2, a sheet-like hydrous body 3 laminated on the support 2, and a release sheet 4 adhered to the sheet-like hydrous body 3. It is.

[0032] The sheet-shaped hydrogel 3 included in the patch 1 of the present embodiment is formed from a plaster base that requires the following conditions.

That is, the plaster base contains (a) substantially no gelatin, and (b) contains 70 mass% of water.

% Or more, (c) 3.0% to 10% by weight of a water-soluble polymer, and (d) 0.01% to 1.4% by weight of xanthan gum and Z or polyvinylpyrrolidone. It is necessary to.

 [0034] The water-containing gypsum sheet 3 formed from a plaster base satisfying the above conditions may contain a desired component and have a desired pH (particularly, pH 4 to 7). In addition to having a sufficient feeling of use such as a feeling of moisturizing, the exudation of water in the plaster strength is sufficiently reduced, and the adhesive has sufficient adhesive strength.

 Further, the patch 1 of the present embodiment is provided with the sheet-shaped hydroplasty body 3, thereby being excellent in convenience, handling, and handling when used.

[0036] Purified water, sterilized water, natural water, or the like can be used as the water mixed with the plaster base. Such water acts as a dispersant for the water-soluble polymer and other components. It is. Water itself also has effects such as significantly improving the feeling of use during and after use.

 [0037] The plaster base used in the present embodiment needs to have a water content of 70% by mass or more. If the water content is less than 70% by mass, a sufficient moist feeling cannot be obtained. In the present embodiment, it is preferable that the water content of the plaster base is 75 to 85% by mass. If the water content is less than 75% by mass, the feeling of cooling and coolness tends to decrease, while if it exceeds 85% by mass, it tends to be difficult to maintain shape retention.

 [0038] Examples of the water-soluble polymer include a natural polymer, a cellulose-based polymer, an acrylic polymer, and a vinyl-based polymer.

 [0039] Examples of natural polymers include agar such as readily soluble agar, agarose, sodium alginate, ammonium alginate, gum arabic, carrageenan, guar gum, locust bean gum, pectin, tragacanth, starch, soluble starch, 13-glucan, pullulan, xanthan gum, dextrin, casein and the like. Examples of cellulosic polymers include etyl cenorellose, canoleboxy methinoresenolerose, canolevoxy methinoresenolerose sodium, hydroxymethinoresenolerose, hydroxyethinoresenorelose, hydroxypropinoresenorelose, and hydroxy. Propinoleetinoresenolerose, methinoresenolerose, nitrosenorelose, kathioni dani cellulose and the like. Examples of the acrylic polymer include polyacrylic acid, polyacrylate, sodium polyacrylate, carboxybutyl polymer, polyacrylamide, polyacrylamide-acrylate copolymer, and methacrylic acid polymer. Examples of the vinyl polymer include polyvinylpyrrolidone, polyvinyl alcohol, polyvinylpyrrolidone, polyvinylpyrrolidone vinyl alcohol copolymer, polyvinyl ether, methoxyethylene maleic anhydride copolymer, and isobutylene maleic anhydride copolymer. Examples thereof include polymers, N-vinylacetamide, and copolymers of N-butylacetamide with acrylic acid and Z or acrylate. Other examples include carboxymethyl amylose and polyethylene oxide. These can be used alone or in combination of two or more.

[0040] In the plaster base used in the present embodiment, xanthan gum and Z or polyvinylpyrrolidone are mixed with the plaster base in a total amount of 0.01% by mass to 1.4% by mass. You If the total amount of the water-soluble polymer to be blended is 3.0% by mass to 10% by mass in the paste base, the type and amount of the water-soluble polymer used in addition to xanthan gum and polybutylpyrrolidone It is not particularly limited.

 In the present embodiment, the water-soluble polymer preferably contains easily soluble agar and polyacrylic acid and Z or a salt thereof!

[0042] In addition, readily soluble agar used in the present embodiment, the jelly strength is more preferably agar preferred instrument 500～800GZcm ² force 390~1200gZcm ^2, 650~750g / cm ² is not particularly preferred. If the jelly strength of the easily soluble agar is less than 390 gZcm ² , the shape retention tends to decrease. On the other hand, when the jelly strength exceeds 1200 gZcm ² , the plaster becomes hard and brittle.

 [0043] The easily soluble agar preferably contains almost no agaropectin, and is preferably agar. Agaropectin contains a large amount of ionic functional groups and has almost gelling ability. For this reason, the easily soluble agar containing almost no agaropectin is preferable because it can efficiently perform gelling with a smaller amount of compounding and can be more easily dissolved.

As the readily soluble agar used in the present embodiment, known ones can be used, and commercially available ones include, for example, “UP-37K”, manufactured by Ina Food Industry Co., Ltd. jelly strength: 700g / cm ^2), "UP- 26K", Ina Food Industry Co., Ltd., jelly strength: 650g / cm ^2), "UP- 16K", Ina Food Industry Co., Ltd., jelly strength: 600g / cm 2), “UZ-5K”, manufactured by Ina Food Industry Co., Ltd., jelly strength: 420 g / cm ² ), “UM-11 K”, manufactured by Ina Food Industry Co., Ltd., jelly strength: 1000 g / cm ² ) Can be

 [0045] With respect to the compounding amount of the above-mentioned easily soluble agar and polyacrylic acid and Z or a salt thereof, the total of the easily soluble agar and polyacrylic acid and Z or a salt thereof is 3 to 8% by mass in the paste base. Is preferred. If the above total is less than 3% by mass, the plaster tends to be soft, and if it exceeds 8% by mass, the plaster tends to be hard.

 [0046] Further, it is preferable that the mass of the easily soluble agar and the sum of polyacrylic acid and Z or a salt thereof is 1: 8 to 1:16. If the proportion of readily soluble agar is less than 1Z16, the shape retention tends to decrease, and if it exceeds 1Z8, the plaster tends to be hard and brittle.

[0047] The plaster base used in the present embodiment includes, in addition to water and the water-soluble polymer, Accordingly, a medicinal component, a cosmetic component, and various components that can be generally blended into a plaster may be contained. Examples of the components that can be generally blended into the plaster include polyhydric alcohols, polyvalent metal salts, and surfactants.

Pharmaceutical ingredients include anti-inflammatory analgesics such as indomethacin, ketoprofen, flurbiprofen, fernavik, ketorolata, diclofenac sodium; anti-emetic agents such as dara-setron hydrochloride, azasetron hydrochloride, ondansetron hydrochloride, ramosetron hydrochloride; estradiol, Estrone, estriol, equilin, echirenine, and their derivatives, progesterone, hydroxyprogesterone dyprosate, hydroxyprogesterone acetate, dydrogesterone acetate, chlormadinone acetate, ethisterone, dimethylesterone, norethisterone, norethisterone acetate, norletosterone enanthate, ethendiol acetate Hormonal agents such as megestrol acetate and allylestrenol; therapeutic agents for pollakiuria such as oxiptinin hydrochloride; Ca antagonists such as pin, dicardipine and -tredipine; corticosteroids such as hydrocortisone, prednisolone and clobetasol propionate; hypnotics and sedatives such as phenovalpital, triazolam, nitrazepam, lorazepam; flufenadine, diazepam, chlorpromazine and the like Tranquilizer; antihypertensives such as clodin, clodin hydrochloride, pindolol, propranolol, ditolendipine, metoprolol; antihypertensive diuretics such as noid mouth thiazide; penicillin, tetracycline, erythromycin, chloramphenol Antibiotics; Lidocaine, dibuforce hydrochloride, anesthetics such as aminoethyl benzoate; antibacterial substances such as benzalco-dum hydrochloride and clotrimazole; vitamins such as vitamin A; antiepileptic drugs such as nitrazepam; Coronary vasodilators such as lyserin and isosorbide dinitrate; antihistamines such as diphenhydramine and chlorphen-lamin; antitussives such as rlobbuterol hydrochloride, salbutamol, ketotifen fumarate, tra-last and isoproterenol hydrochloride; clomiplan hydrochloride and amitriptyline hydrochloride Cerebral circulation improving agents such as dihydroerggotoxine mesylate and ifenprodil; antitumor agents such as 5-fluorouracil; muscle relaxants such as eperisone and dantrolene; analgesics such as fentanyl and morphine; Polypeptide hormones such as releasing hormone (LH-RH) and thyrotropin releasing hormone (TRH); peripheral vasodilators; immunomodulators such as polysaccharides, auranofin, and oral benzarit; urzo Desoxycholic acid, etc. Bold Drugs such as diuretics such as hydroflumethiazide; diabetic agents such as tributamide; ventilation agents such as colchicine; antiparkinson agents such as amantadine and levodopa; and anti-vertigo agents such as diphen-dol and betahistine. . These drugs can be used in combination of two or more as necessary if no inconvenience due to the interaction occurs.

 [0049] The amount of the above-mentioned medicinal component is preferably 0.01 to 10% by mass in the plaster base, although it depends on the drug used and the use. In addition, for example, when a placenta extract is used as a medicinal ingredient, the amount is preferably 0.05 to 0.5% by mass in the plaster base, and 0.1 to 0.4% by mass is preferred. Is more preferred. If the amount of placenta extract is less than 0.05% by mass, the effect tends to be difficult to obtain, while if it exceeds 0.5% by mass, the amount tends to be excessive for the required effect. .

 [0050] Cosmetic components include allantoin, ascorbic acid, ascorbic acid derivatives, malonie extract, water-soluble placenta extract, sage extract, kojic acid, lecithin, amino acids, hormones, placenta extract, vitamin A, vitamin D, Examples include vitamin E and their derivatives, dipotassium glycyrrhizinate, caffeic acid, and fruit juice extracts.

 When the paste base used in the present embodiment incorporates the above-mentioned readily soluble agar, a high temperature (about 90 ° C. or higher) for dissolving the agar is not required, so that the loss during production is A volatile or thermally decomposable component having a large particle size can be suitably blended.

[0052] As the volatile component, any component that can be volatilized by applying heat (for example, heat of about 90 ° C or more) may be used. For example, eucalyptus oil, dirt oil, thiamine oil, heart oil, Terpenes such as menthol, camphor, pinene, borneol, limonene, lavender, peppermint, hatatsu, herbal essential oils such as zeradium, lime, chamomile, lower alcohols such as ethyl alcohol and isopropyl alcohol, fragrances and flavors Flavoring agents, drugs such as amyl nitrite and trimetadione and cosmetics, C8-C22 fatty acids such as isostearic acid, octanoic acid, and oleic acid; C8-C22 fatty alcohols such as oleyl alcohol and lauryl alcohol; Ethyl oleate, isopropyl myristate, butyl stearate, and methyl laurate Lower alkyl S. ethers of fatty acids C8-C22, dialkyl esters of C6~C8 diacid diisopropyl adipate, fatty acid monoglycerides C8-C22, such as glyceryl monolaurate, tetrahydrofurfuryl alcohol Liquid polyethylene excipients such as polyethylene glycol glycol ether, polyethylene glycol, propylene glycol, 21- (2-ethoxyethoxy) ethanol, diethylene glycol monomethyl ether, and mixtures thereof.

[0053] For example, when menthol is used, the amount of these components is 0.005-5.

 It is more preferably 0% by mass, more preferably 0.01% to 2.0% by mass. If the blending ratio of menthol is less than 0.005% by mass, the medicinal effect of menthol tends to be obtained, while if it exceeds 5.0% by mass, menthol is likely to exude from the plaster. It's in the way.

[0054] The thermally decomposable component may be any substance that is unstable to heat (eg, heat of about 90 ° C or higher). For example, non-functional compounds having a carboxylic acid group such as diclofenac, fuerbinac, indomethacin, and ketoprofen may be used. Steroidal anti-inflammatory drugs, prostaglandins, proteins such as albumin, toxins such as diphtheria toxin, enzymes such as catalase, cyclosporine 8, hirudin, somatostatin, peptides such as thymopentin, hormones such as estrogen, human growth hormone, Peptide hormones such as porcine growth hormone, pest growth hormone, human calcitonin, salmon calcitonin, carboxylucitonin and insulin, hormone antagonists, neurotransmitters such as acetylcholine, neurotransmitters antagonists, hyaluronic acid, etc. Glycoprotein, (X-lipoprotein Lipoproteins, immunoglobulins such as IgG, immunomodulators such as interferon and interleukin, cellular receptors such as estrogen receptor protein, unfractionated heparin, low-molecular-weight heparin, chondroitin 4-sulfate, chondroitin Tin 6-sulfuric acid, glycosaminodalicans such as derivatives thereof, plant extracts such as prostaglandins, ginseng, al-force, kinsen-force, yeasts such as selenium yeast, brewer's yeast, ovalbumin, gelatin, etc. Animal proteins, vegetable proteins such as dalten, hydrolyzed collagen, hydrolysates of animal or vegetable proteins such as hydrolyzed wheat dartene, natural polysaccharides such as hyaluronic acid, lecithin, collagen, placenta kiss, Ascorbic acid and its esters, retinol and its esters, vitamin A Oils, vitamins such as hydroxocobalamin acetate, ergocalcifenol, isosorbide dinitrate, nitroglycerin, testosterone enanthate, ergotamine tartrate, pergolide, -cotin, aluminum nitrite, ethichlorbinol, paramethadione, scopolamine, etc. Can be [0055] For example, when ketoprofen is used, the compounding amount is preferably 0.01 to 5.0% by mass in the plaster base, and is 0.1 to 1.0% by mass. Is more preferable. If the mixing ratio of ketoprofen is less than 0.01% by mass, the medicinal effect of ketoprofen tends to be difficult to obtain, while if it exceeds 5.0% by mass, the compounding amount is excessive with respect to the desired medicinal effect. It tends to be.

 [0056] Examples of the polyhydric alcohol include glycerin, polyethylene glycol, 1,3-butylene glycol, propylene glycol, dipropylene glycol, sorbitol, and xylitol. Among them, glycerin is particularly preferred in that it has good workability and usability.

 [0057] The blending amount of the polyhydric alcohol in the paste base is preferably 5 to 15% by mass, more preferably 8 to 12% by mass. If the blending ratio is less than 5% by mass, the plaster tends to be hard, while if it exceeds 12% by mass, the oozing of water from the plaster tends to occur.

 Examples of the polyvalent metal salt include aluminum hydroxide, aluminum hydroxide gel, hydrated aluminum silicate, synthetic aluminum silicate, kaolin, aluminum acetate, aluminum lactate, aluminum stearate, and calcium chloride. , Magnesium chloride, aluminum chloride, dihydroxyaluminum amino acetate, magnesium metasilicate aluminate, magnesium silicate aluminate and the like. These can be used alone or in combination of two or more. Of these, dihydroxyaluminum aminoacetate, synthetic aluminum silicate and magnesium metasilicate aluminate are particularly preferred.

 [0059] The compounding amount of the polyvalent metal salt is preferably 0.01 to 1% by mass, more preferably 0.02 to 0.5% by mass, in the paste base. If the compounding ratio is less than 0.01% by mass, the reaction does not proceed sufficiently and the gel strength tends to be insufficient. On the other hand, if it exceeds 1% by mass, the reaction rate during production is too fast. There is a tendency for the gelling to be uneven and the workability to be reduced, or the adhesiveness of the plaster to be insufficient.

[0060] Examples of the surfactant include sodium octyl sulfosuccinate, alkyl sulfate salt, 2-ethylhexyl alkyl sulfate sodium salt, and normal dodecyl ester. Anionic surfactants such as sodium benzenesulfonate; cationic surfactants such as hexadecyltrimethylammonium-dimethyl chloride, octadecyldimethylbenzylammonium-dimethyl chloride, polyoxyethylene dodecyl monomethylammonium-dimethyl chloride; polyoxyethylene Polyoxyethylene monostearate, sorbitan monostearate, sorbitan monostearate, such as stearyl ether, polyoxyethylene hydrogenated castor oil, polyoxyethylene tridecyl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, and polyethylene glycol monostearate Palmitate, sorbitan sesquioleate, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan Examples include nonionic surfactants such as nooleate, glycerol monostearate, polyglycerin fatty acid ester, and polyoxyethylene octadecylamine. These can be used alone or in combination of two or more. Among these, polyethylene glycol monostearate, polyoxyethylene hydrogenated castor oil, and polyoxyethylene sorbitan monooleate are particularly preferred.

[0061] The blending amount of the surfactant is preferably from 0.01 to 5% by mass, more preferably from 0.1 to 2% by mass in the plaster base. If the blending ratio is less than 0.01% by mass, pread tends to occur, while if it exceeds 5% by mass, it tends to be difficult to maintain the shape retention.

 [0062] Further, the plaster base used in the present embodiment may include, if necessary, a skin-skinning component, a moisturizing component, an antioxidant, a cross-linking agent, a preservative, a tackifier, a dissolving agent, a pigment, a fragrance, an ultraviolet ray. It is also possible to incorporate an absorbent, an inorganic filler, a pH adjuster, and the like.

[0063] Examples of the beautiful skin component include aloe extract, age extract, orange extract, raspberry extract, kiwi extract, cucumber extract, gardenia extract, potato beetle extract, hawthorn extract, sycamore extract, taiso extract, duke extract, and tomato extract. Chima extract, saciner kefuirane, maleile kefuirane, malt root extract, rose extract, collagen, ceramide, squalane, hyaluronic acid, allantoin, malonier extract, water-soluble placenta extract, vitamin A, vitamin B, vitamin C , Vitamin D such as vitamin D and vitamin E, and kojic acid. These can be used alone or in combination of two or more. [0064] In addition to the above, crude drug components such as red bean, katsukon, shatayaku, touki, senkiyu, chiyouji, assembly, soujiyuu, chimpi, biyakuju, spruce, keihi, orelen, obatta, ichiyou, etc., bentonite, montmorillonite, sabonite, Examples include mud components such as hectorite.

 [0065] Examples of the moisturizing component include an aqueous solution of acylated kefuirane, malt extract, urea, and glycols. These can be used alone or in combination of two or more.

 [0066] Antioxidants include, for example, ascorbic acid, propyl gallate, butylhydroxylanol, dibutylhydroxytoluene, nordihydroguaiaretinic acid, tocopherol, tocopherol acetate, natural vitamin E, sodium nitrite, And sodium hydrogen nitrite.

 Examples of the crosslinking agent include thermosetting resins such as hardly water-soluble aluminum compounds, polyfunctional epoxy compounds, amino resins, phenol resins, epoxy resins, alkyd resins, and unsaturated polyesters, and isocyanate resins. Compounds, block isocyanate conjugates, organic crosslinking agents, and inorganic crosslinking agents such as metals or metal compounds. These can be used alone or in combination of two or more.

 [0068] Examples of the preservatives include ethyl ethyl noraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate, sorbic acid, dehydroacetic acid, and the like.

 [0069] Examples of the tackifier include casein, pullulan, dextran, sodium alginate, soluble starch, carboxystarch, dextrin, carboxymethylcellulose, canoleboxy methinoresenorelose sodium, methinoresenorelose, etinoresenorelose. , Hydroxyethyl cellulose, polyvinyl alcohol, polyethylene oxide, polyatarylamide, polyacrylic acid, polyvinylpyrrolidone, carboxyvinyl polymer, polyvinyl ether, polymaleic acid copolymer, methoxyethylene maleic anhydride copolymer, isobutylene anhydride Maleic acid copolymer, polyethyleneimine, polyvinyl alcohol part Kenyidani, hydroxypropyl methylcellulose, xanthan gum, N-butyl acetate Etc. The.

[0070] Examples of the solubilizer include getyl sebacate, N-methyl-2-pyrrolidone, and salici. Examples include methyl luate, glycol salicylate, triacetin, oleyl alcohol, benzyl alcohol, isopropyl myristate, diisopropyl adipate, crotamiton, potato oil, camellia oil, castor oil, and olive oil.

 [0071] Examples of the dye include Red No. 2 (Amaranth), Red No. 3 (Eris Mouth Shin), Red No. 102

 (New Coccin), Red No. 104 (1) (Phloxin B), Red No. 105 (1) (Rose Bengal), Red No. 106 (Acid Red), Yellow No. 4 (Tartrazine), Yellow No. 5 (Sunset) Low FCF), Green No. 3 (Fast Green FCF), Blue No. 1 (Brilliant Blue FCF), Blue No. 2 (Indigo Power Noremin) and the like.

 [0072] Examples of the fragrance include heart oil, keich oil, cinnamon oil, fennel oil, castor oil, turpentine oil, eucalyptus oil, orange oil, lavender oil, lemon oil, rose oil, lemongrass oil and the like. And plant extracts such as marie and sage.

 [0073] Examples of the ultraviolet absorber include, for example, paraaminobenzoic acid, paraaminobenzoic acid ester, paradimethylaminobenzoic acid amyl, salicylate, menthyl anthralate, pumbelliferone, esculin, benzyl cinnamate, sinoxate, guaiazulene, Perocanic acid, 2- (2-hydroxy-15-methylphenyl) benzotriazole, 4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone, dioxybenzone, octabenzone, dihydroxydimethoxybenzophenone, slisobenzone Benzoresorcinol, octyldimethylparaaminobenzoate, ethylhexylparamethoxycinnamate, and butylmethoxydibenzoylmethane.

 [0074] Examples of the inorganic filler include calcium carbonate, magnesium carbonate, silicates (eg, aluminum silicate, magnesium silicate, and the like), citric acid, barium sulfate, calcium sulfate, calcium zincate, and zinc oxide. And titanium oxide.

[0075] Examples of the pH adjuster include acetic acid, formic acid, lactic acid, tartaric acid, oxalic acid, benzoic acid, dalicholic acid, malic acid, citric acid, hydrochloric acid, nitric acid, sulfuric acid, sodium hydroxide, calcium hydroxide, Methylamine, ethylamine, propylamine, dimethylamine, getylamine, dipyramine, trimethylamine, triethylamine, tripropylamine, monomethanolamine, monoethanolamine, monopropanolamine, dimethanolamine, diethanolamine , Dipropanolamine, trimethanolamine, triethanolamine, tripropanol Lumin, citrate buffer, phosphate buffer, glycine buffer, acetate buffer and other buffers.

 [0076] The sheet-shaped hydrogel 3 formed from the plaster base containing the above-described components is disposed on the support 2. The support 2 used for the patch 1 of the present embodiment is not particularly limited as long as it can support the sheet-like hydrogel 3, and a stretchable or non-stretchable support can be used. .

 [0077] Examples of the support 2 include polyurethane, polyester, polypropylene, poly (vinyl acetate), polyvinylidene chloride, polyethylene, polyethylene terephthalate, aluminum sheet, nylon, acrylic, cotton, rayon, and acetate. And the like. Synthetic fibers or natural fibers such as those described above, or a fiber sheet formed by combining these fibers into a woven or nonwoven fabric, and a fiber sheet which is a composite material of these and a film having water vapor permeability.

 [0078] Among these, a woven or nonwoven fiber sheet made of polyethylene terephthalate, which is preferably a woven or nonwoven fiber sheet made of polyester, polyethylene, or polyethylene terephthalate in terms of safety, versatility, and stretchability Is more preferred,. Such a fiber sheet has flexibility, even if it is thick, and follows the skin and has low skin irritation immediately. Furthermore, by using such a fiber sheet, it is possible to obtain a patch having an appropriate self-supporting property.

 Further, in the patch of the present embodiment, when the support is a polyethylene non-woven fabric, the moisture of the plaster can be suppressed from evaporating, so that the feeling of moisture is further improved.

 [0080] Further, the adhesive preparation 1 includes a release sheet 4 adhered on the sheet-like hydrogel body 3. Examples of such a release sheet 4 include polyester such as polyethylene terephthalate, films such as polychloride butyl, polychloride violetidene, and laminating film of high quality paper and polyolefin. These release sheets are preferably subjected to silicone treatment on the surface in contact with the sheet-shaped hydrogel body 3 because the workability when the release sheet 4 is released from the patch 1 is improved.

 Next, a method for producing the patch 1 of the present embodiment will be described.

First, a plaster base is prepared by adding each component such as a water-soluble polymer and a medicinal ingredient to purified water and stirring and mixing these components. For stirring conditions, etc., It may be set appropriately according to the type of the soluble polymer.For example, when easily soluble agar is used, the agar is added to purified water at 65 to 85 ° C and stirred for 5 to 15 minutes to reduce the agar. In minutes to prepare a plaster base.

[0083] Next, the obtained plaster base is applied on a support to form a coating film, and a release sheet is laminated on the coating film. This is stored at room temperature for several days, and the water-soluble polymer is sufficiently crosslinked to form a sheet-like hydrogel. In the present embodiment, it is preferable that the thickness of the formed hydrogel sheet is in the range of 0.8 to 1.6 mm. If the film thickness is less than 0.8 mm, the film thickness is too thin, so that sufficient adhesive strength tends not to be obtained. If the film thickness is more than 1.6 mm, the film thickness is too thin, and the film tends to peel off during use. There is a tendency.

 [0084] After the sheet-like water-containing plaster is formed, the patch is obtained by cutting it into a predetermined shape.

 [0085] In the method for producing patch 1 of the present embodiment, in the preparation of the plaster base, as the water-soluble polymer, easily soluble agar, and polyacrylic acid and Z or a salt thereof are contained. preferable. In this case, since the easily soluble agar does not require a high temperature (90 ° C. or higher) for dissolution, the volatile or thermally decomposable component described above can be efficiently incorporated into the patch. In addition, it is possible to simplify the manufacturing process, which requires an apparatus for cooling the solution of agar, energy, time and the like in order to mix volatile or thermally decomposable components. Furthermore, since the evaporation of water as well as volatile or thermally decomposable components can be sufficiently suppressed at the time of production, the content ratio of each component in the formed sheet-like hydrogel is determined according to the above range. It is easy to put in, and it has a sufficiently excellent usability such as moistness, and has sufficiently reduced oozing of water from the plaster, and has a sufficient adhesive strength to produce a patch. It is possible to get it.

 [0086] Although the preferred embodiment of the patch of the present invention and the method for producing the patch of the present invention have been described above, the present invention is not limited to the above embodiment.

[0087] For example, the patch may have a circular or elliptical shape. Also, holes or cuts may be provided. Further, the shape can be appropriately designed according to the body part where the patch is used. For example, cut it into a facial shape so that it can be attached to the face, , Nose, mouth and chin cut into appropriate shapes.

 [0088] Further, in the method for producing a patch, a paste base is applied onto a release sheet to form a sheet-like hydrous body, and then the support is laminated to the sheet-like hydrous body.て も

 [0089] The patch of the present invention can be used as a pharmaceutical or a poultice similar thereto, a cooling sheet, a cosmetic or a similar pack, and the like.

 Example

 (Example 1)

1.0 part by mass of synthetic aluminum silicate was dispersed in 79.95 parts by mass of purified water, and 1.0 part by mass of polyvinylpyrrolidone was added thereto, and then the mixture was readily soluble in 3.0 parts by mass of polyethylene glycol. A mixture with 0.4 parts by mass of agar (trade name “UP-37K”, manufactured by Ina Food Industry Co., Ltd., jelly strength: 700 g / cm ² ) and 0.25 parts by mass of sodium edetate were added. Further, a mixture of 7.0 parts by mass of sodium polyatalylate, 0.3 parts by mass of magnesium aluminate metasilicate, and 7.0 parts by mass of polyethylene glycol was added and stirred until a uniform solution was obtained. Thereafter, 0.1 part by mass of tartaric acid was added to this solution, and the mixture was further stirred to prepare a plaster base. Table 1 shows the components and mixing ratios of the prepared plaster bases. The values in Table 1 are expressed in mass%. The pH of the plaster base was 6.4.

[0091] [Table 1]

[0092] Next, the obtained plaster base was spread on a cloth (25 cm x 25 cm) manufactured by Nippon Vileen Co., Ltd. as a support so as to have a thickness of 1.4 mm. Formed. Further, a product obtained by attaching a release film to the coating film was stored at room temperature to form a sheet-like hydrogel, thereby obtaining a patch which can be shipped as a product. The criteria for the patch to be ready for shipment are as follows.

[0093] It was determined that shipment was possible when the plaster strength (jelly strength) of the sheet-like hydrous plaster became constant over time. Table 1 shows the number of days (lead time) from the start of preparation of the plaster base to the point where it can be shipped. [0094] Further, with respect to the obtained patch, the adhesive strength of the sheet-shaped hydrogel was measured based on the JIS Z 0237 rolling ball tack test. Table 1 shows the results.

 [0095] Further, the exudation of water from the sheet-like hydrogel body of the obtained patch was evaluated according to the following criteria. The results are shown in Table 1.

 "None": No discoloration of the support cloth or seepage of water on the support cloth side

"Yes": Discoloration of the support cloth or seepage of water to the support cloth side is observed.

[0096] In addition, if there was a problem with the feeling of use (moistness, feeling, presence or absence of stickiness) when the obtained patch was applied to the face, it was described in Table 1. If there is no problem, the symbol "〇

Was described.

(Examples 2 to 4)

 In preparing the plaster base, a plaster base was prepared in the same manner as in Example 1 except that the component compositions shown in Table 1 were used. The pH of the plaster base was 6.3 to 6.5.

Using the obtained plaster base, a patch was obtained in the same manner as in Example 1. Table 1 shows the number of days (lead time) from the start of preparation of the plaster base to the point where it can be shipped. Further, the obtained patch was evaluated in the same manner as in Example 1. The results are shown in Table 1.

[0099] (Comparative Examples 1-3)

 A patch was obtained in the same manner as in Example 1 except that gelatin was used in the preparation of the plaster base and the component composition was as shown in Table 2.

[0100] [Table 2]

Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 Gelatin 1.0 1.2 1 0----Polyacrylic acid------1.5-Polyacrylic acid Na 6.0 3.0 9.0 7.0 1. 0 4.0 10.0 Xanthan gum--0.5-0.5--Polyvinyl 1.1 1.5 1.1 Pyrrolidone

 Highly soluble agar ― ― 0.5 0.4 0.7 0.7 1.0 Synthetic keic acid 4.0 5.0 4.0 1.0 1.0 3.0 4.0 Aluminum

 Polyethylene 8.0 ― 10.0 10.0 8.0 0 8.0 6.0 Glycol

 Glycerin ― 8.0 5.0 ― ― ― 4.0 Aluminic acid metasilicate ― ― ― 0.30 0.30 ― ― Magnesium

 Aluminic acid silicate 0.1 0.6 O C 1.1 0.6 Magnesium

 Dry aluminate 0.25 0.70 ― ― ― 0.30 ― Magnesium

 Sodium edetate 0.40 0.45 0.35 0.25 0.20

 ― D

 Lactic acid 0.10 ― ― ― 0.10 0.10

 O

 Tartaric acid ― 0.10 0.10 0.10 0.10 ― ― Sorbyl! ― ― ― ― ― 10.0 5.0 o Purified water 80.25 81.55 88.20 71.80 69.10 o

 Exudation from plaster Yes Yes Yes No Yes No No No Adhesiveness (mm) ― ― ― 20.5-61. 1 58.2 Usability 〇 o 〇 Sticky o が あ る Moist but low lead time ( Days) ― ― ― 14 ― 14 16

[0101] The obtained patches were evaluated in the same manner as in Example 1. Table 2 shows the results. In the patches of Comparative Examples 1 to 3, the osmosis of water from the hydrogel sheet-like sheet occurred, so that the adhesiveness and the lead time could not be measured.

 [0102] (Comparative Examples 4 to 7)

In preparing the plaster base, the same as in Example 1 except that the component compositions shown in Table 2 were used. To give a patch.

 [0103] The same evaluation as in Example 1 was performed on the obtained patch. Table 2 shows the results. In the patch of Comparative Example 5, the adhesiveness and the lead time were too strong to measure because of the oozing of water from the hydrogel sheet.

 [0104] As shown in Table 1, the patches of Examples 1 to 4 had excellent usability, had sufficiently reduced water seepage from the plaster, and had sufficient adhesive strength. Was confirmed. On the other hand, in the patches of Comparative Examples 1 to 3 using gelatin, the oozing of water was observed as a plaster strength. Further, the patches of Comparative Examples 4 to 7 having a sheet-like hydrous plaster formed from a plaster base did not satisfy the conditions of the present invention! It was confirmed that the reduction, the V of the adhesive strength, and the deviation were insufficient.

 Further, the patches of Examples 1 to 4 had a lead time of 8 to 11 days, whereas the patches of Comparative Examples 4, 6 and 7 had a lead time of 14 to 16 days. From these facts, it was a component that the patches of Examples 1 to 4 were excellent in productivity.

 Industrial applicability

[0106] According to the present invention, even a composition containing a desired component and having a desired pH is sufficiently excellent in usability such as moist feeling and sufficiently reduces oozing of moisture from the plaster. Thus, a patch having sufficient adhesive strength can be provided.

Claims

The scope of the claims  [1] An adhesive patch comprising a support, and a sheet-like water-containing plaster formed of a plaster base disposed on at least one surface of the support,  The plaster base,  (a) substantially free of gelatin,  (b) containing 70% by mass or more of water,  (c) a water-soluble polymer, containing 3.0% by mass to 10% by mass,  (d) containing a total of 0.01% by mass to 1.4% by mass of xanthan gum and Z or polybutylpyrrolidone;  A patch characterized in that: 2. The patch according to claim 1, wherein the plaster base further contains a readily soluble agar as the water-soluble polymer. 3. The patch according to claim 1, wherein the plaster base further contains, as the water-soluble polymer, easily soluble agar, and polyacrylic acid and Z or a salt thereof. .