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WO2004084849A1 - Procede et composition pour la repousse des cheveux - Google Patents

Procede et composition pour la repousse des cheveux Download PDF

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Publication number
WO2004084849A1
WO2004084849A1 PCT/KR2004/000280 KR2004000280W WO2004084849A1 WO 2004084849 A1 WO2004084849 A1 WO 2004084849A1 KR 2004000280 W KR2004000280 W KR 2004000280W WO 2004084849 A1 WO2004084849 A1 WO 2004084849A1
Authority
WO
WIPO (PCT)
Prior art keywords
hair
composition
glucan
action
antioxidant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2004/000280
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English (en)
Inventor
Suk-Bong Shin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2004084849A1 publication Critical patent/WO2004084849A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]

Definitions

  • the present invention relates to a hair regro th method and a hair growth composition.
  • Alopecia areata that causes sudden loss of hair at one or several regions of the scalp is known to occur when hair follicles are attacked by lymphocytes due to a variation in the immune system so that their growth is suddenly stopped.
  • DHT dihydrotestosteron
  • leucocytes recognize the hair follicle as a foreign protein to be removed while they produce self-antibodies to attack the hair follicle.
  • a new method for regrowing hair which is based on such research results and overcomes problems occurring the prior art, is proposed, and . a series of tests to prove the effects of the inventive method are performed.
  • a hair-loss phenomenon was considered in view of immune diseases.
  • hair follicles in general hair loss patients and also in persons with a slippery baldhead as a result of a significant reduction in hair follicle size are activated by a method exhibiting an autoimmune neutralization effect caused by immune-boosting action.
  • the activated hair follicles are supplied with sugars as nutrients to revive the hair follicles.
  • Sebum which is secreted by the active cell division action of the revived hair follicles, is prevented from being accumulated on the scalp in the form of lipid peroxide, by use of an antioxidant.
  • the present invention has reliable effects on hair loss prevention and hair growth.
  • the present invention is directed to a method and composition for regrowing hair in the telogen phase. More particularly, the present invention provides a method for regrowing hair by the telogen phase-breaking action of converting the telogen phase to anagen phase of the hair cycle, the method being characterized by activating a hair follicle shrunk by a hair-loss phenomenon, using the immunity-boosting action of ⁇ -glucan, supplying sugars as nutrients to the activated hair follicle to revive the hair follicle, and preventing sebum, which is secreted by the active cell division action of the revived hair follicle, from being accumulated on the scalp in the form of lipid peroxide, by use of an antioxidant. Also, the present invention provides a hair growth composition, which has reliable effects on hair loss prevention and hair growth and does not cause side effects on the human body.
  • Alopecia that causes falling out of hair from the scalp occurs by a variety of factors, including internal factors, such as genetic constitution and the action of male hormones', and external factors, such as mental stress in daily life, and the accumulation of lipid peroxide on the scalp. Such factors are known to be involved in alopecia in a complicated manner. Recently, in addition to male pattern alopecia and female pattern alopecia, falling out of hair in the youth shows a tendency to increase gradually. To improve such a hair-loss phenomenon, many kinds of hair growth agents or hair growth promoters are being marketed.
  • vasodilators such as capronium chloride, minoxidil and extracts from various plants, which serve to circulate sufficient, blood through the scalp
  • female hormones such as estrogen, estradiol and progesterone, which are attached to hair pailla to inhibit the action of male hormones that ' cause falling out of hair
  • agents for inhibiting the activity of male hormones such as pentadecanic acid and finasteride.
  • drugs approved by US FDA for use as agents for treating alopecia include minoxidil for external application and propecia for oral use, in which the minoxidil is used as an agent for preventing hair loss by its vasodilation action, and the propecia is based on finasteride and used as an agent for treating alopecia by the action of inhibiting the activity of male hormones.
  • the hair growth agents and hair growth promoters as described above were somewhat effective in preventing hair loss, but had an insufficient effect on hair growth. In other words, since such preparations are effective only in a region where the hair root is activated, they have an- excellent effect on hair loss prevention.
  • their effect on the regrowth (i.e., growth) of hair in the telogen phase is insufficient, they are known to have no effect on a bald head where hair loss was already progressed to shrink a hair follicle.
  • telo.gen phase is long and the anagen phase is short. It has been believed that, when the telogen phase became long, the hair follicle was shrunk to make hair regrowth almost impossible. Solving this problem is an object of the present invention. Most of preparations that are currently commercially available will have only the effect of preventing falling out of hair in the telogen phase.
  • a main object of the present invention is to prevent hair loss and make hair regrowth possible, by a method of reviving a hair follicle shrunk by the long telogen phase to -convert the telogen phase to anagen phase of the hair cycle.
  • Another main object of the present invention is to develop a hair growth composition which dose not cause side effects on the human body.
  • FIG. 1 shows hair regrowth factors, which are used in the method of the present invention.
  • a hair follicle in the telogen phase of- the hair cycle is activated by the autoimmune neutralization effect of a biological response modifier (BRM) .
  • BRM biological response modifier
  • the activated hair follicle is supplied with sugars as nutrients to revive the hair follicle.
  • serum which is secreted by the active cell division action of the revived hair follicle, is prevented from being accumulated on the scalp in the form of lipid "peroxide.
  • the telogen phase is converted to the anagen phase while regrowing the hair.
  • a method of treating intractable diseases, such as cancer, by activating immune functions is generally called “immune therapy” in which the following substances are used.
  • a biological response modifier (BRM) , which is a natural substance other than a synthesized chemical substance and serves to increase immunity, stimulates the immune system to change the biological reaction of a host, to show a variety of physiological effects.
  • BRM is used to treat various cancer patients in combination with chemical anticancer agents.
  • Known examples of BRM include krestin, lentinan, ⁇ - glucan and active hexose correlated compounds (AHCC) , which are extracts from mushrooms.
  • AHCC active hexose correlated compounds
  • AHCC is. administered orally to various cancer patients to treat cancers by increasing immunity, and also does not cause side effects. Furthermore, it is characterized by alleviating side effects, such as emesis, alopecia and pains, so that it is used in immunity-boosting complementary therapy for various cancer patients.
  • the hair regrowth method according to the present invention relates to a method for regrowing hair on bald heads where hair loss was significantly progressed.
  • hair follicle cells in the long telogen phase are considered as having similar properties to the normal cells of cancer patients, which have weakened immune functions due to cancer cells.
  • BRM having immunity-boosting action is applied directly on the scalp so that the hair follicle is activated by an autoimmune neutralization effect.
  • ⁇ -glucan among BRMs was selected as a substance promoting the activity of the immune system, and clinically tested on patients with general alopecia and on slippery bald heads where hair follicles were shrunk.
  • the test results showed the BRM substance had a hair loss prevention effect and also a hair regrowth effect even on the bald heads, which had not been expected previously.
  • a hair growth composition according to the present invention contains: (a) 0.01-20% by weight of ⁇ -glucan acting to activate hair follicles by immune-boosting action; (b) 0.1-20% by weight of at least one selected from monosaccharides, such as glucose, xylose, mannose, and arabinose, and disaccharides, such as maltose, sucrose, cellobiose, .
  • ⁇ -glucan serving to activate the hair follicle cells in the telogen phase is not poisonous to the human body, its use amount can be selected from a wide range without special limitations.
  • ⁇ -glucan is preferably used at the amount of 0.01-20% by weight, and more particularly 0.01-10% by weight, relative to the total weight of the composition.
  • One kind or two kinds or more of the sugar component and the antioxidant is used in the hair growth composition.
  • Each of the sugar component and the antioxidant is preferably used at the amount of 0.1-20% by weight, and more preferably 0.1-10% by weight, relative to the total weight of the composition.
  • the contents of the sugar component and the antioxidant are not limited to such amounts.
  • the hair growth composition according to the present invention additionally contains a solvent which is used to dilute and dissolve the ⁇ -glucan, the sugar component and the antioxidant.
  • a solvent which is used to dilute and dissolve the ⁇ -glucan, the sugar component and the antioxidant.
  • the solvent at least one selected from purified water and lower alcohols is used.
  • lower alcohols ethanol or isopropanol is preferred.
  • the amount of the solvent is the remaining amount other than the amounts of the ⁇ -glucan, the sugar component and the antioxidant, as main components, and is concretely 40-99.79% by weight relative to the weight of the composition.
  • the hair growth composition of the present invention may additionally contain a variety of known substances, which are conventionally used in cosmetics having hair growth and hair growth promotion effects.
  • additional substances include antibacterial agents, refreshers, humectants and a mixture thereof.
  • -antibacterial agents include hinokitiol, chitosan, benzoic acid soda and parabens.
  • the fresheners include menthol.
  • the humectants include polyhydric alcohols, such as polyethylene glycol, glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, and annitol, and the humectants are used alone or in a mixture.
  • Example of additives which can also be used in the composition of the present invention, include oil and fats, surfactants, alcohols, fatty acids, antioxidants, pigments, perfumes, UV- absorbing agents, chelating agents, pH-adjusting agents, and buffers, which can be used at suitable amounts.
  • the hair growth composition of the present invention which contains the main components as described above, can be used in the form of various cosmetics, such as hair tonic, hair lotion, hair cream, shampoo, and rinse, which are used on hair or scalp.
  • the hair growth composition of the present invention is administered by a transdermal route, such as direct application or spreading on the scalp.
  • the dose of the inventive composition should be suitably selected depending on age or individual variations, or the formulation or form of the composition, but for adults, it is preferably administered twice daily, 1-2 ml each time.
  • FIG. 1 shows a method for regrowing hair in the telogen phase of the hair cycle.
  • Examples 1-3 Preparation of hair growth composition Components given in Table 1 below were heated and dissolved to prepare hair tonic-type compositions of the present invention.
  • Test Example 1 Hair growth test on man Forty male and ' female patients with various hair loss diseases were divided into four groups each consisting of ten persons, such that the divided groups have similar kind and degree of hair loss diseases.
  • each of the compositions and 50% ethanol was administered twice daily fox six months, and the condition of grown hair was evaluated after six months.
  • the patients were rated on the following four categories:
  • Example 1 was tested on the selected patients in the same manner as Test Example 1. The test results showed that new hair, including vellus hair and terminal hair, was started to appear from one or two months after the test start, and the hair regrowth effect of the composition was confirmed in eight patients at six months after the test start.
  • the hair growth composition of the present invention caused hair regrowth by a method of converting the telogen phase to anagen phase of the hair cycle, in which shrunk hair follicles were activated by the immunity-boosting action of ⁇ - glucan, and the activated hair follicles were supplied with the sugar component as nutrients to revive the hair follicles.
  • the hair growth composition of the present invention has reliable effects on hair loss prevention and hair growth in patients having alopecia.
  • the hair growth composition of the present invention did not cause side effects, such as the abnormal skin conditions of the scalp caused by drugs, in any of the test groups during a test period of six months.
  • the present invention provides the method for regrowing hair by the telogen phase- breaking action of converting the telogen phase to anagen phase of the hair cycle, the method being characterized by activating shrunk hair follicles by the immunity-boosting action of ⁇ -glucan, supplying the sugars as nutrients to the activated hair follicles to revive the hair follicles, and preventing sebum secreted by the active cell division action of the revived hair follicles from being accumulated on the scalp in the form of lipid peroxide, by use of the antioxidant.
  • the present invention provides the hair growth composition, which has reliable effects on hair loss prevention and hair growth, and does not cause side effects on the scalp.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un procédé permettant la repousse des cheveux grâce à l'action de rupture de la phase télogène due à la conversion de la phase télogène en phase anagène du cycle du cheveu. Selon ce procédé, des follicules du cheveu rétrécis sont activés par l'action stimulant l'immunité du β-glucane. Les follicules du cheveu activés reçoivent des sucres en tant que substances nutritives pour être revivifiés. On empêche le sébum sécrété par l'action de division cellulaire active des follicules du cheveu revivifiés de s'accumuler sur le cuir chevelu sous la forme de peroxyde lipidique au moyen d'un antioxydant. En outre, l'invention concerne une composition pour la repousse des cheveux, laquelle présente des effets de prévention de perte des cheveux et de croissance des cheveux et laquelle n'a pas d'effets secondaires sur le cuir chevelu.
PCT/KR2004/000280 2003-03-28 2004-02-12 Procede et composition pour la repousse des cheveux Ceased WO2004084849A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2003-0019436A KR100499564B1 (ko) 2003-03-28 2003-03-28 모발의 재생방법 및 발모제 조성물
KR10-2003-0019436 2003-03-28

Publications (1)

Publication Number Publication Date
WO2004084849A1 true WO2004084849A1 (fr) 2004-10-07

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PCT/KR2004/000280 Ceased WO2004084849A1 (fr) 2003-03-28 2004-02-12 Procede et composition pour la repousse des cheveux

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WO (1) WO2004084849A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006061678A1 (fr) * 2004-12-06 2006-06-15 Sederma Sas Compositions cosmetiques ou dermatologiques de substituts de saccharose
WO2008114141A3 (fr) * 2007-03-21 2008-12-04 Giuliani Spa Composition ayant une activité inhibitrice sur la 5α-réductase

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100796904B1 (ko) * 2006-05-04 2008-01-22 신석봉 안정화된 비타민 ｃ 또는 비타민 ｃ 유도체의 복합체를함유하는 발모제 조성물

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0595209A2 (fr) * 1992-10-23 1994-05-04 R.I.T.A. CORPORATION (an Illinois corp.) Composition cosmétique
WO2000006188A1 (fr) * 1998-07-28 2000-02-10 Mediko Pty. Ltd. Compositions de pousse/conservation des cheveux et methodes faisant appel auxdites compositions
WO2002007699A1 (fr) * 2000-07-21 2002-01-31 L'oreal Utilisation et compositions cosmetiques de betainates d'amison
US6406897B1 (en) * 1999-03-19 2002-06-18 Pacific Corporation Modified protein, method for preparation thereof and compositions for external application containing the modified protein
US6497865B1 (en) * 1999-03-12 2002-12-24 Biotec Pharmacon Asa Cosmetic hair care preparations

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0595209A2 (fr) * 1992-10-23 1994-05-04 R.I.T.A. CORPORATION (an Illinois corp.) Composition cosmétique
WO2000006188A1 (fr) * 1998-07-28 2000-02-10 Mediko Pty. Ltd. Compositions de pousse/conservation des cheveux et methodes faisant appel auxdites compositions
US6497865B1 (en) * 1999-03-12 2002-12-24 Biotec Pharmacon Asa Cosmetic hair care preparations
US6406897B1 (en) * 1999-03-19 2002-06-18 Pacific Corporation Modified protein, method for preparation thereof and compositions for external application containing the modified protein
WO2002007699A1 (fr) * 2000-07-21 2002-01-31 L'oreal Utilisation et compositions cosmetiques de betainates d'amison

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006061678A1 (fr) * 2004-12-06 2006-06-15 Sederma Sas Compositions cosmetiques ou dermatologiques de substituts de saccharose
WO2008114141A3 (fr) * 2007-03-21 2008-12-04 Giuliani Spa Composition ayant une activité inhibitrice sur la 5α-réductase
EA015819B1 (ru) * 2007-03-21 2011-12-30 ДЖУЛИАНИ С.п.А. КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ РУТИН И ПОЛИНЕНАСЫЩЕННУЮ ЖИРНУЮ КИСЛОТУ, ИМЕЮЩАЯ ИНГИБИРУЮЩУЮ АКТИВНОСТЬ В ОТНОШЕНИИ 5α-РЕДУКТАЗЫ
US9144560B2 (en) 2007-03-21 2015-09-29 Giuliani S.P.A. Composition comprising rutin and polyunsaturated fatty acid having an inhibitory activity on 5 α-reductase

Also Published As

Publication number Publication date
KR100499564B1 (ko) 2005-07-07
KR20040084393A (ko) 2004-10-06

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