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WO2004072277A3 - Elk1 phosphorylation related genes - Google Patents

Elk1 phosphorylation related genes Download PDF

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Publication number
WO2004072277A3
WO2004072277A3 PCT/JP2004/001587 JP2004001587W WO2004072277A3 WO 2004072277 A3 WO2004072277 A3 WO 2004072277A3 JP 2004001587 W JP2004001587 W JP 2004001587W WO 2004072277 A3 WO2004072277 A3 WO 2004072277A3
Authority
WO
WIPO (PCT)
Prior art keywords
elk1
kinase
protein
phosphorylates
phosphorylating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2004/001587
Other languages
French (fr)
Other versions
WO2004072277A2 (en
Inventor
Osamu Matsuzaki
Akio Matsuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Pharma Corp
Original Assignee
Asahi Kasei Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2003034875A external-priority patent/JP2006340601A/en
Application filed by Asahi Kasei Pharma Corp filed Critical Asahi Kasei Pharma Corp
Publication of WO2004072277A2 publication Critical patent/WO2004072277A2/en
Publication of WO2004072277A3 publication Critical patent/WO2004072277A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Proteins capable of phosphorylating Elk1 and/or activating a kinase which phosphorylates Elk1, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of MAP kinase cascade are provided. Using the plasmids pFR-Luc and pFA2-Elk1, the cDNA encoding a protein capable of phosphorylating Elk1 and/or activating a kinase wich phosphorylates Elk1 was cloned from the cDNA library constructed from human peripheral blood monocytes, and the cDNA sequence and the deduced amino acid sequence were determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful for screening a substance inhibiting or promoting an action of Elk1 phosphorylation and/or an action of activation of kinase which phosphorylates Elk1.
PCT/JP2004/001587 2003-02-13 2004-02-13 Elk1 phosphorylation related genes Ceased WO2004072277A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2003-034875 2003-02-13
JP2003034875A JP2006340601A (en) 2003-02-13 2003-02-13 Elk1 PHOSPHORYLATION RELATED GENE
US44732003P 2003-02-14 2003-02-14
US60/447,320 2003-02-14

Publications (2)

Publication Number Publication Date
WO2004072277A2 WO2004072277A2 (en) 2004-08-26
WO2004072277A3 true WO2004072277A3 (en) 2004-11-25

Family

ID=32871172

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2004/001587 Ceased WO2004072277A2 (en) 2003-02-13 2004-02-13 Elk1 phosphorylation related genes

Country Status (1)

Country Link
WO (1) WO2004072277A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007096854A1 (en) * 2006-02-21 2007-08-30 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin Compositions and methods for modulating an immune response
KR100822181B1 (en) * 2006-05-09 2008-04-17 크레아젠 주식회사 New Uses of MNL5 Gene or Protein
WO2010022444A1 (en) * 2008-08-25 2010-03-04 The Walter And Eliza Hall Institute Of Medical Research Methods and agents for modulating kinase signalling pathways through modulation of mixed-lineage kinase domain-like protein (mlkl)
EP2886126B1 (en) * 2013-12-23 2017-06-07 Exchange Imaging Technologies GmbH Nanoparticle conjugated to CD44 binding peptides

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001012670A1 (en) * 1999-08-13 2001-02-22 Human Genome Sciences, Inc. Tgf-beta receptor polynucleotides, polypeptides, and antibodies
WO2001060991A2 (en) * 2000-02-17 2001-08-23 Incyte Genomics, Inc. Human kinases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001012670A1 (en) * 1999-08-13 2001-02-22 Human Genome Sciences, Inc. Tgf-beta receptor polynucleotides, polypeptides, and antibodies
WO2001060991A2 (en) * 2000-02-17 2001-08-23 Incyte Genomics, Inc. Human kinases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHUNG K-C ET AL: "Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the immediate early gene pip92 by mitogen-activated protein kinase-independent as well as -dependent signalling pathways", MOLECULAR AND CELLULAR BIOLOGY, vol. 18, no. 4, April 1998 (1998-04-01), pages 2272 - 2281, XP002269785, ISSN: 0270-7306 *

Also Published As

Publication number Publication date
WO2004072277A2 (en) 2004-08-26

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