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WO2003008589A1 - Elk1 PHOSPHORYLATION-ASSOCIATED GENE - Google Patents

Elk1 PHOSPHORYLATION-ASSOCIATED GENE Download PDF

Info

Publication number
WO2003008589A1
WO2003008589A1 PCT/JP2002/007174 JP0207174W WO03008589A1 WO 2003008589 A1 WO2003008589 A1 WO 2003008589A1 JP 0207174 W JP0207174 W JP 0207174W WO 03008589 A1 WO03008589 A1 WO 03008589A1
Authority
WO
WIPO (PCT)
Prior art keywords
map kinase
kinase cascade
protein
dna
usable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/007174
Other languages
French (fr)
Japanese (ja)
Inventor
Osamu Matsuzaki
Akio Matsuda
Yukiko Nagano
Naomi Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Kasei Corp, Asahi Chemical Industry Co Ltd filed Critical Asahi Kasei Corp
Publication of WO2003008589A1 publication Critical patent/WO2003008589A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

It is intended to provide a protein having an MAP kinase cascade activating effect which is usable in, for example, diagnosing, treating or preventing diseases in association with excessive activation or inhibition of MAP kinase cascade. Using plasmids pFR-Luc and pFA2-Elk1, a cDNA encoding a protein having an effect of activating MAP kinase cascade is cloned from a human lung fibroblast-derived cDNA library. Then the DNA sequence and an amino acid sequence deduced therefrom are determined. This protein, DNA encoding it, a recombinant vector containing the DNA and a transformant containing the recombinant vector are usable in screening a substance which inhibits or accelerates the activation of MAP kinase cascade.
PCT/JP2002/007174 2001-07-18 2002-07-15 Elk1 PHOSPHORYLATION-ASSOCIATED GENE Ceased WO2003008589A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2001-218204 2001-07-18
JP2001218204 2001-07-18
JP2001263450 2001-08-31
JP2001-263450 2001-08-31
JP2002-12176 2002-01-21
JP2002012176 2002-01-21

Publications (1)

Publication Number Publication Date
WO2003008589A1 true WO2003008589A1 (en) 2003-01-30

Family

ID=27347180

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/007174 Ceased WO2003008589A1 (en) 2001-07-18 2002-07-15 Elk1 PHOSPHORYLATION-ASSOCIATED GENE

Country Status (1)

Country Link
WO (1) WO2003008589A1 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999046281A2 (en) * 1998-03-10 1999-09-16 Genentech, Inc. Novel polypeptides and nucleic acids encoding the same
WO2000053756A2 (en) * 1999-03-08 2000-09-14 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001012662A2 (en) * 1999-08-17 2001-02-22 Incyte Genomics, Inc. Membrane associated proteins
WO2001016318A2 (en) * 1999-09-01 2001-03-08 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001075167A1 (en) * 2000-03-31 2001-10-11 Fred Hutchinson Cancer Research Center Reverse genetic strategy for identifying functional mutations in genes of known sequence
WO2001090304A2 (en) * 2000-05-19 2001-11-29 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999046281A2 (en) * 1998-03-10 1999-09-16 Genentech, Inc. Novel polypeptides and nucleic acids encoding the same
WO2000053756A2 (en) * 1999-03-08 2000-09-14 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001012662A2 (en) * 1999-08-17 2001-02-22 Incyte Genomics, Inc. Membrane associated proteins
WO2001016318A2 (en) * 1999-09-01 2001-03-08 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001075167A1 (en) * 2000-03-31 2001-10-11 Fred Hutchinson Cancer Research Center Reverse genetic strategy for identifying functional mutations in genes of known sequence
WO2001090304A2 (en) * 2000-05-19 2001-11-29 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies

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