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WO2004064728A3 - Composes de tetracycline possedant des activites therapeutiques ciblees - Google Patents

Composes de tetracycline possedant des activites therapeutiques ciblees Download PDF

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Publication number
WO2004064728A3
WO2004064728A3 PCT/US2004/001036 US2004001036W WO2004064728A3 WO 2004064728 A3 WO2004064728 A3 WO 2004064728A3 US 2004001036 W US2004001036 W US 2004001036W WO 2004064728 A3 WO2004064728 A3 WO 2004064728A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapy
tetracycline compounds
specific tetracycline
specific
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/001036
Other languages
English (en)
Other versions
WO2004064728A2 (fr
Inventor
Stuart B Levy
Michael Draper
Mark L Nelson
Graham Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paratek Pharmaceuticals Inc
Original Assignee
Paratek Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paratek Pharmaceuticals Inc filed Critical Paratek Pharmaceuticals Inc
Publication of WO2004064728A2 publication Critical patent/WO2004064728A2/fr
Publication of WO2004064728A3 publication Critical patent/WO2004064728A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des méthodes et des composés de traitement de maladies avec des composés de tétracycline possédant une activité thérapeutique ciblée.
PCT/US2004/001036 2003-01-16 2004-01-16 Composes de tetracycline possedant des activites therapeutiques ciblees Ceased WO2004064728A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44114103P 2003-01-16 2003-01-16
US60/441,141 2003-01-16

Publications (2)

Publication Number Publication Date
WO2004064728A2 WO2004064728A2 (fr) 2004-08-05
WO2004064728A3 true WO2004064728A3 (fr) 2004-12-16

Family

ID=32771908

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/001036 Ceased WO2004064728A2 (fr) 2003-01-16 2004-01-16 Composes de tetracycline possedant des activites therapeutiques ciblees

Country Status (1)

Country Link
WO (1) WO2004064728A2 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002250331A1 (en) * 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EA200900540A1 (ru) 2002-07-12 2009-12-30 Пэрэтек Фамэсьютикэлс, Инк. Замещённые соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
WO2005070878A1 (fr) * 2004-01-15 2005-08-04 Paratek Pharmaceuticals, Inc. Derives a cycle aromatique a provenant de composes de tetracycline
CA2892332C (fr) * 2004-05-21 2017-03-21 President And Fellows Of Harvard College Synthese de tetracyclines et d'analogues de tetracyclines
SG169238A1 (en) * 2004-08-11 2011-03-30 Williamsburg Holdings Llc Noncardiotoxic pharmaceutical compounds
AU2005299294B2 (en) * 2004-10-25 2012-06-07 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
EP2284151A3 (fr) * 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Composés de tétracycline substituée
WO2006088720A2 (fr) * 2005-02-15 2006-08-24 Wyeth Tetracyclines 9-substituees
JP2009502809A (ja) * 2005-07-21 2009-01-29 パラテック ファーマシューティカルズ インコーポレイテッド １０−置換テトラサイクリンおよびその使用方法
JP2009507793A (ja) * 2005-08-31 2009-02-26 ワイス グリシルサイクリンの９−アミノカルボニル置換誘導体
CN100516067C (zh) * 2006-01-10 2009-07-22 上海恒瑞医药有限公司 具有抗肿瘤活性的紫杉酚衍生物
EP2016044B1 (fr) 2006-04-07 2020-06-10 President and Fellows of Harvard College Dérivés de pentacycline pour le traitement d'infections
US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
EP2479169B1 (fr) 2006-10-11 2014-12-03 President and Fellows of Harvard College Synthèse d'un intermédiaire de l'énone
AU2007338681B2 (en) * 2006-12-21 2013-09-26 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
EP3812372A3 (fr) * 2006-12-21 2021-06-30 Paratek Pharmaceuticals, Inc. Dérivés de sanclycine substitués par 7-hétérocyclyl pour le traitement d'infections bactériennes, virales, et parasitaires (p.e. malaria) ou maladies inflammatoires
GB2446652A (en) * 2007-02-16 2008-08-20 Inion Ltd Osteogenic compounds
GB0708507D0 (en) 2007-05-02 2007-06-13 Queen Mary & Westfield College Substituted phosphonates and their use
PT2271348T (pt) * 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
EP2307027A4 (fr) * 2008-07-11 2012-08-15 Neumedics Dérivés de tétracycline présentant une activité antibiotique réduite et des bénéfices neuroprotecteurs
CA2737470A1 (fr) * 2008-09-19 2010-03-25 Paratek Pharmaceuticals, Inc. Composes de tetracycline utilises dans le traitement de la polyarthrite rhumatoide et methodes therapeutiques associees
US9073829B2 (en) 2009-04-30 2015-07-07 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
CN102821769A (zh) * 2010-03-10 2012-12-12 大学健康网络 替加环素用于治疗癌症的用途
CN102204921B (zh) * 2011-04-14 2012-12-26 苏州大学 一种四环素类衍生物在制备放疗增敏药物中的应用
HUE036696T2 (hu) * 2011-07-26 2018-07-30 Kbp Biosciences Usa Inc 9-aminometil-szubsztituált tetraciklin-vegyületek
ES2728260T3 (es) 2012-11-21 2019-10-23 Nippon Soda Co Material de impresión producido utilizando un compuesto no fenólico
CN103142624A (zh) * 2013-03-01 2013-06-12 西南大学 抗生素替加环素在制备抗癌药物中的应用
MX388561B (es) 2013-03-15 2025-03-11 Melinta Subsidiary Corp Metodos para tratar infecciones en pacientes obesos y con sobrepeso usando antibioticos.
CA2974925C (fr) * 2015-02-09 2022-03-22 Yeda Research And Development Co. Ltd. Procedes pour prevenir des infections secondaires
TWI656116B (zh) * 2016-06-22 2019-04-11 山東亨利醫藥科技有限責任公司 Crystal form of 9-aminomethyl substituted tetracycline compound and preparation method thereof
CA3103614C (fr) 2018-06-13 2024-05-28 Texas Tech University System Tetracycline modifiee pour le traitement des troubles de l'usage de l'alcool, de la douleur et d'autres troubles impliquant des processus inflammatoires potentiels
WO2021021951A1 (fr) 2019-07-29 2021-02-04 Vanderbilt University Inhibiteurs de wdr5-myc
EP4228655B1 (fr) 2020-10-14 2025-08-27 Institut du Cerveau et de la Moelle Epiniere Dérivés de tétracycline pour le traitement de maladies neurodégénératives ou neuro-inflammatoires
CN117597149A (zh) 2021-02-03 2024-02-23 天空生物有限责任公司 用于低疏水性生物活性药物进入中枢神经系统的化学偶联转运体
EP4551552A1 (fr) 2022-07-08 2025-05-14 ICM (Institut du Cerveau et de la Moelle Épinière) Dérivés de tétracycline

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998052575A1 (fr) * 1997-05-20 1998-11-26 The Trustees Of Columbia University In The City Of New York Utilisation d'inhibiteurs de la proteinase pour le traitement de l'emphyseme pulmonaire
WO2000016783A1 (fr) * 1998-09-21 2000-03-30 The Research Foundation Of State University Of New York Methode de prevention des lesions pulmonaires aiguës
WO2001062261A1 (fr) * 2000-02-25 2001-08-30 Arakis Ltd. Inhibiteurs de metalloproteinase utilises dans le traitement des maladies respiratoires
WO2002072022A2 (fr) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues, en tant qu'agents antifongiques
WO2002072031A2 (fr) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitue utilises en tant qu'antifongiques synergiques
WO2003061767A1 (fr) * 2002-01-25 2003-07-31 Atopic Pty Ltd Techniques et compositions destines au traitement de l'asthme et de troubles associes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998052575A1 (fr) * 1997-05-20 1998-11-26 The Trustees Of Columbia University In The City Of New York Utilisation d'inhibiteurs de la proteinase pour le traitement de l'emphyseme pulmonaire
WO2000016783A1 (fr) * 1998-09-21 2000-03-30 The Research Foundation Of State University Of New York Methode de prevention des lesions pulmonaires aiguës
WO2001062261A1 (fr) * 2000-02-25 2001-08-30 Arakis Ltd. Inhibiteurs de metalloproteinase utilises dans le traitement des maladies respiratoires
WO2002072022A2 (fr) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues, en tant qu'agents antifongiques
WO2002072031A2 (fr) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitue utilises en tant qu'antifongiques synergiques
WO2003061767A1 (fr) * 2002-01-25 2003-07-31 Atopic Pty Ltd Techniques et compositions destines au traitement de l'asthme et de troubles associes

Also Published As

Publication number Publication date
WO2004064728A2 (fr) 2004-08-05

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