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WO2004064728A3 - Use of specific tetracycline compounds in therapy - Google Patents

Use of specific tetracycline compounds in therapy Download PDF

Info

Publication number
WO2004064728A3
WO2004064728A3 PCT/US2004/001036 US2004001036W WO2004064728A3 WO 2004064728 A3 WO2004064728 A3 WO 2004064728A3 US 2004001036 W US2004001036 W US 2004001036W WO 2004064728 A3 WO2004064728 A3 WO 2004064728A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapy
tetracycline compounds
specific tetracycline
specific
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/001036
Other languages
French (fr)
Other versions
WO2004064728A2 (en
Inventor
Stuart B Levy
Michael Draper
Mark L Nelson
Graham Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paratek Pharmaceuticals Inc
Original Assignee
Paratek Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paratek Pharmaceuticals Inc filed Critical Paratek Pharmaceuticals Inc
Publication of WO2004064728A2 publication Critical patent/WO2004064728A2/en
Publication of WO2004064728A3 publication Critical patent/WO2004064728A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Methods and compounds for treating diseases with tetracycline compounds having a target therapeutic activity are described.
PCT/US2004/001036 2003-01-16 2004-01-16 Use of specific tetracycline compounds in therapy Ceased WO2004064728A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44114103P 2003-01-16 2003-01-16
US60/441,141 2003-01-16

Publications (2)

Publication Number Publication Date
WO2004064728A2 WO2004064728A2 (en) 2004-08-05
WO2004064728A3 true WO2004064728A3 (en) 2004-12-16

Family

ID=32771908

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/001036 Ceased WO2004064728A2 (en) 2003-01-16 2004-01-16 Use of specific tetracycline compounds in therapy

Country Status (1)

Country Link
WO (1) WO2004064728A2 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002250331A1 (en) * 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EA200900540A1 (en) 2002-07-12 2009-12-30 Пэрэтек Фамэсьютикэлс, Инк. SUBSTITUTED COMPOUNDS OF TETRACYCLINE, PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATMENT OF TETRACYCLINE-SENSITIVE CONDITION IN SUBJECT
WO2005070878A1 (en) * 2004-01-15 2005-08-04 Paratek Pharmaceuticals, Inc. Aromatic a-ring derivatives of tetracycline compounds
CA2892332C (en) * 2004-05-21 2017-03-21 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
SG169238A1 (en) * 2004-08-11 2011-03-30 Williamsburg Holdings Llc Noncardiotoxic pharmaceutical compounds
AU2005299294B2 (en) * 2004-10-25 2012-06-07 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
EP2284151A3 (en) * 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
WO2006088720A2 (en) * 2005-02-15 2006-08-24 Wyeth 9-substituted tetracyclines
JP2009502809A (en) * 2005-07-21 2009-01-29 パラテック ファーマシューティカルズ インコーポレイテッド 10-Substituted Tetracycline and Method of Use
JP2009507793A (en) * 2005-08-31 2009-02-26 ワイス 9-aminocarbonyl substituted derivatives of glycylcycline
CN100516067C (en) * 2006-01-10 2009-07-22 上海恒瑞医药有限公司 Taxol derivatives with antitumor activity
EP2016044B1 (en) 2006-04-07 2020-06-10 President and Fellows of Harvard College Pentacycline derivatives for the treatment of infections
US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
EP2479169B1 (en) 2006-10-11 2014-12-03 President and Fellows of Harvard College Synthesis of Enone Intermediate
AU2007338681B2 (en) * 2006-12-21 2013-09-26 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
EP3812372A3 (en) * 2006-12-21 2021-06-30 Paratek Pharmaceuticals, Inc. 7-heterocyclyl substituted sancycline derivatives for treating bacterial, viral and parasitic infections (e.g. malaria) or inflammatory diseases
GB2446652A (en) * 2007-02-16 2008-08-20 Inion Ltd Osteogenic compounds
GB0708507D0 (en) 2007-05-02 2007-06-13 Queen Mary & Westfield College Substituted phosphonates and their use
PT2271348T (en) * 2008-03-28 2018-04-16 Paratek Pharm Innc FORMULATION OF ORAL TETRACYCIN COMPOUND TABLET
EP2307027A4 (en) * 2008-07-11 2012-08-15 Neumedics Tetracycline derivatives with reduced antibiotic activity and neuroprotective benefits
CA2737470A1 (en) * 2008-09-19 2010-03-25 Paratek Pharmaceuticals, Inc. Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment
US9073829B2 (en) 2009-04-30 2015-07-07 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
CN102821769A (en) * 2010-03-10 2012-12-12 大学健康网络 Use of tigecycline for treatment of cancer
CN102204921B (en) * 2011-04-14 2012-12-26 苏州大学 Application of tetracycline derivative in preparing sensitizing drug for radiotherapy
HUE036696T2 (en) * 2011-07-26 2018-07-30 Kbp Biosciences Usa Inc 9-aminomethyl substituted tetracycline compounds
ES2728260T3 (en) 2012-11-21 2019-10-23 Nippon Soda Co Printing material produced using a non-phenolic compound
CN103142624A (en) * 2013-03-01 2013-06-12 西南大学 Application of antibiotic tigecycline in preparing anti-cancer medicine
MX388561B (en) 2013-03-15 2025-03-11 Melinta Subsidiary Corp METHODS FOR TREATING INFECTIONS IN OBESE AND OVERWEIGHT PATIENTS USING ANTIBIOTICS.
CA2974925C (en) * 2015-02-09 2022-03-22 Yeda Research And Development Co. Ltd. Methods of preventing secondary infections
TWI656116B (en) * 2016-06-22 2019-04-11 山東亨利醫藥科技有限責任公司 Crystal form of 9-aminomethyl substituted tetracycline compound and preparation method thereof
CA3103614C (en) 2018-06-13 2024-05-28 Texas Tech University System Modified tetracycline for treatment of alcohol use disorder, pain and other disorders involving potential inflammatory processes
WO2021021951A1 (en) 2019-07-29 2021-02-04 Vanderbilt University Wdr5-myc inhibitors
EP4228655B1 (en) 2020-10-14 2025-08-27 Institut du Cerveau et de la Moelle Epiniere Tetracycline derivatives for treating neurodegenerative or neuroinflammatory diseases
CN117597149A (en) 2021-02-03 2024-02-23 天空生物有限责任公司 Chemically coupled transporters for entry of low hydrophobic bioactive drugs into the central nervous system
EP4551552A1 (en) 2022-07-08 2025-05-14 ICM (Institut du Cerveau et de la Moelle Épinière) Tetracycline derivatives

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998052575A1 (en) * 1997-05-20 1998-11-26 The Trustees Of Columbia University In The City Of New York Use of metalloproteinase inhibitors in the treatment and prevention of pulmonary emphysema
WO2000016783A1 (en) * 1998-09-21 2000-03-30 The Research Foundation Of State University Of New York Method of preventing acute lung injury
WO2001062261A1 (en) * 2000-02-25 2001-08-30 Arakis Ltd. Metalloproteinase inhibitors for the treatment of respiratory diseases
WO2002072022A2 (en) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as antifungal agents
WO2002072031A2 (en) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as synergistic antifungal agents
WO2003061767A1 (en) * 2002-01-25 2003-07-31 Atopic Pty Ltd Methods and compositions for the treatment of asthma and related disorders

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998052575A1 (en) * 1997-05-20 1998-11-26 The Trustees Of Columbia University In The City Of New York Use of metalloproteinase inhibitors in the treatment and prevention of pulmonary emphysema
WO2000016783A1 (en) * 1998-09-21 2000-03-30 The Research Foundation Of State University Of New York Method of preventing acute lung injury
WO2001062261A1 (en) * 2000-02-25 2001-08-30 Arakis Ltd. Metalloproteinase inhibitors for the treatment of respiratory diseases
WO2002072022A2 (en) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as antifungal agents
WO2002072031A2 (en) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as synergistic antifungal agents
WO2003061767A1 (en) * 2002-01-25 2003-07-31 Atopic Pty Ltd Methods and compositions for the treatment of asthma and related disorders

Also Published As

Publication number Publication date
WO2004064728A2 (en) 2004-08-05

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