[go: up one dir, main page]

WO2004044204A3 - Fragments variables d'anticorps de camelides a chaine unique et leurs applications pour le diagnostic et le traitement de pathologies diverses. - Google Patents

Fragments variables d'anticorps de camelides a chaine unique et leurs applications pour le diagnostic et le traitement de pathologies diverses. Download PDF

Info

Publication number
WO2004044204A3
WO2004044204A3 PCT/FR2003/003319 FR0303319W WO2004044204A3 WO 2004044204 A3 WO2004044204 A3 WO 2004044204A3 FR 0303319 W FR0303319 W FR 0303319W WO 2004044204 A3 WO2004044204 A3 WO 2004044204A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibodies
camelide
chain
diagnosing
variable fragments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2003/003319
Other languages
English (en)
Other versions
WO2004044204A2 (fr
Inventor
Francois Rougeon
Pierre Lafaye
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Institut Pasteur
Original Assignee
Centre National de la Recherche Scientifique CNRS
Institut Pasteur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Institut Pasteur filed Critical Centre National de la Recherche Scientifique CNRS
Priority to AU2003290158A priority Critical patent/AU2003290158A1/en
Publication of WO2004044204A2 publication Critical patent/WO2004044204A2/fr
Publication of WO2004044204A3 publication Critical patent/WO2004044204A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Fragments variables d'anticorps de camélidés à chaîne unique dirigée contre le peptiole B-amyloiole 1-42 ainsi que contre la phosphorylcholine. Est également décrit, l’application pour le traitement ou le diagnostic des pathologies associées aux molécules reconnues par ces anticorps, et notamment les maladies neurodégénératives, comme la maladie d’Alzheimer ou des maladies infectieuses induites par des agents pathogènes (virus ou bactéries).
PCT/FR2003/003319 2002-11-06 2003-11-06 Fragments variables d'anticorps de camelides a chaine unique et leurs applications pour le diagnostic et le traitement de pathologies diverses. Ceased WO2004044204A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003290158A AU2003290158A1 (en) 2002-11-06 2003-11-06 Variable fragments of single-chain camelide antibodies and uses thereof for diagnosing and treating various pathologies

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR02/13866 2002-11-06
FR0213866A FR2846667B1 (fr) 2002-11-06 2002-11-06 Fragments variables d'anticorps de camelides a chaine unique diriges contre le peptide beta-amyloide 1-42 et leurs applications pour le diagnostic et le traitement des maladies neuroagregatives

Publications (2)

Publication Number Publication Date
WO2004044204A2 WO2004044204A2 (fr) 2004-05-27
WO2004044204A3 true WO2004044204A3 (fr) 2004-09-10

Family

ID=32104491

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2003/003319 Ceased WO2004044204A2 (fr) 2002-11-06 2003-11-06 Fragments variables d'anticorps de camelides a chaine unique et leurs applications pour le diagnostic et le traitement de pathologies diverses.

Country Status (3)

Country Link
AU (1) AU2003290158A1 (fr)
FR (1) FR2846667B1 (fr)
WO (1) WO2004044204A2 (fr)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7575880B1 (en) 2000-05-26 2009-08-18 Elan Pharma International Limited Method of screening an antibody for activity in clearing an amyloid deposit
US7582733B2 (en) 1998-11-30 2009-09-01 Elan Pharma International Limited Humanized antibodies that recognize beta amyloid peptide
US7588766B1 (en) 2000-05-26 2009-09-15 Elan Pharma International Limited Treatment of amyloidogenic disease
US7625560B2 (en) 2004-12-15 2009-12-01 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
US7790856B2 (en) 1998-04-07 2010-09-07 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US7871615B2 (en) 2003-05-30 2011-01-18 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US7893214B2 (en) 1997-12-02 2011-02-22 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
US8003097B2 (en) 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
US8034348B2 (en) 1997-12-02 2011-10-11 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidogenic disease
US8128928B2 (en) 2002-03-12 2012-03-06 Wyeth Llc Humanized antibodies that recognize beta amyloid peptide
US8497072B2 (en) 2005-11-30 2013-07-30 Abbott Laboratories Amyloid-beta globulomer antibodies
US8613920B2 (en) 2007-07-27 2013-12-24 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
US8877190B2 (en) 2006-11-30 2014-11-04 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
US8916165B2 (en) 2004-12-15 2014-12-23 Janssen Alzheimer Immunotherapy Humanized Aβ antibodies for use in improving cognition
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
US9176150B2 (en) 2003-01-31 2015-11-03 AbbVie Deutschland GmbH & Co. KG Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof
US9644025B2 (en) 2007-10-17 2017-05-09 Wyeth Llc Immunotherapy regimes dependent on ApoE status

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2564432A1 (fr) 2004-04-27 2005-11-10 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Anticorps de .beta. peptide antiamyloide humain et fragment anticorps de celui-ci
BRPI0518151A2 (pt) * 2004-10-13 2009-06-16 Ablynx Nv polipetìdeos contra amiloide-beta, ácido nucléico que codifica tal polipetìdeo, composição compreendendo tal polipetìdeo, método para produzir um polipetìdeo e uso do mesmo
WO2006066118A2 (fr) * 2004-12-15 2006-06-22 Neuralab Limited Conditionnement contextuel des peurs pour predire l'efficacite immunotherapeutique
EP1934611A2 (fr) * 2005-09-23 2008-06-25 Academisch Ziekenhuis Leiden Vhh pour le diagnostique, prevention et traitement des maladies dues a la formation d'agregats
EP1785434A1 (fr) * 2005-11-11 2007-05-16 Ludwig-Maximilians-Universität München Ciblage et suivi d'antigènes dans des cellules vivantes
AU2008220785B2 (en) 2007-03-01 2013-02-21 Vivoryon Therapeutics N.V. New use of glutaminyl cyclase inhibitors
EP1978035A1 (fr) * 2007-04-05 2008-10-08 Hans-Knöll-Institut Leibniz-Institut für Naturstoff-Forschung Anticorps anti-amyloïdes et leur utilisation dans le diagnostic et la thérapie des maladies amyloïdes
WO2008128985A1 (fr) 2007-04-18 2008-10-30 Probiodrug Ag Dérivés de thio-urée utilisés comme inhibiteurs de la glutaminyl cyclase
EP2009445A1 (fr) * 2007-06-29 2008-12-31 Institut Pasteur Utilisation d'anticorps à domaine simple de chaînes pour détecter une formule oligomérique d'un peptide amyloide bêta et ses applications
EP2008666A1 (fr) 2007-06-29 2008-12-31 Institut Pasteur Utilisation d'anticorps VHH pour la préparation de vecteurs de peptide pour fournir une substance d'intérêt et leurs applications
AU2009267417A1 (en) * 2008-07-07 2010-01-14 Athera Biotechnologies Ab New therapeutic and diagnostic methods for Alzheimer's disease
EP2143735A1 (fr) 2008-07-10 2010-01-13 Institut Pasteur Domaines variables d'anticorps de camélidé à chaîne lourde dirigés contre les protéines acides fibrillaires gliales
US20100136584A1 (en) * 2008-09-22 2010-06-03 Icb International, Inc. Methods for using antibodies and analogs thereof
WO2011029920A1 (fr) 2009-09-11 2011-03-17 Probiodrug Ag Dérivés hétérocycliques en tant qu'inhibiteurs de glutaminyle cyclase
MX2012009460A (es) 2010-03-03 2012-09-12 Boehringer Ingelheim Int Polipeptidos biparatopicos de union abeta.
EP2542549B1 (fr) 2010-03-03 2016-05-11 Probiodrug AG Inhibiteurs de glutaminyl cyclase
AU2011226074B2 (en) 2010-03-10 2015-01-22 Vivoryon Therapeutics N.V. Heterocyclic inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5)
US8541596B2 (en) 2010-04-21 2013-09-24 Probiodrug Ag Inhibitors
MX358739B (es) 2010-08-14 2018-09-03 Abbvie Inc Star Proteinas de union a amiloide beta.
US11644471B2 (en) 2010-09-30 2023-05-09 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
EP2621953B1 (fr) 2010-09-30 2017-04-05 Ablynx N.V. Matières biologiques associées à c-met
US8530670B2 (en) 2011-03-16 2013-09-10 Probiodrug Ag Inhibitors
IN2014CN00414A (fr) 2011-06-23 2015-04-03 Ablynx Nv
CN108659121A (zh) 2011-06-23 2018-10-16 埃博灵克斯股份有限公司 用于预测、检测和减少涉及免疫球蛋白单可变结构域的测定法中的非特异性蛋白干扰的技术
US10112988B2 (en) 2012-01-09 2018-10-30 Icb International, Inc. Methods of assessing amyloid-beta peptides in the central nervous system by blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an anti-amyloid-beta peptide
US10112987B2 (en) 2012-01-09 2018-10-30 Icb International, Inc. Blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an amyloid-beta peptide
EP2873679A1 (fr) 2013-11-13 2015-05-20 F.Hoffmann-La Roche Ag Anticorps à domaine unique de camélidés dirigés contre une substance amyloïde bêta et procédés pour produire des conjugués de ceux-ci
EP2873680A1 (fr) 2013-11-13 2015-05-20 F.Hoffmann-La Roche Ag Oligopeptide et procédés pour produire des conjugués de ceux-ci
EP2899208A1 (fr) 2014-01-28 2015-07-29 F.Hoffmann-La Roche Ag Anticorps à domaine unique de camélidés dirigés contre des protéines tau phosphorylées et procédés de production de conjugués de ceux-ci
PT3143042T (pt) 2014-05-16 2020-09-01 Ablynx Nv Domínios variáveis de imunoglobulina
HUE056738T2 (hu) 2014-05-16 2022-03-28 Ablynx Nv Eljárás gyógyszer elleni antitestek, különösen kezelés kapcsán kialakuló gyógyszer elleni antitestek detektálására és/vagy mérésére
WO2018111099A1 (fr) 2016-12-12 2018-06-21 Stichting Vumc Biomarqueurs et traitements de l'angiopathie amyloïde cérébrale (aac)
DK3461819T3 (da) 2017-09-29 2020-08-10 Probiodrug Ag Inhibitorer af glutaminylcyklase

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0954978A1 (fr) * 1998-03-12 1999-11-10 Unilever N.V. Produits contenant des levures ou des moisissures inactivées, ayant sur leur surface externe des anticorps actifs
WO2000065057A1 (fr) * 1999-04-22 2000-11-02 Unilever Plc Inhibition d'une infection virale au moyen de proteines de liaison a l'antigene monovalentes
WO2000072880A2 (fr) * 1999-05-28 2000-12-07 Neuralab Limited Prevention et traitement de maladie amyloidogene
WO2001062801A2 (fr) * 2000-02-24 2001-08-30 Washington University Anticorps humanises sequestrant un peptide a$g(b)
WO2003062415A2 (fr) * 2002-01-24 2003-07-31 Erasmus University Animal transgenique et procedes associes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0954978A1 (fr) * 1998-03-12 1999-11-10 Unilever N.V. Produits contenant des levures ou des moisissures inactivées, ayant sur leur surface externe des anticorps actifs
WO2000065057A1 (fr) * 1999-04-22 2000-11-02 Unilever Plc Inhibition d'une infection virale au moyen de proteines de liaison a l'antigene monovalentes
WO2000072880A2 (fr) * 1999-05-28 2000-12-07 Neuralab Limited Prevention et traitement de maladie amyloidogene
WO2001062801A2 (fr) * 2000-02-24 2001-08-30 Washington University Anticorps humanises sequestrant un peptide a$g(b)
WO2003062415A2 (fr) * 2002-01-24 2003-07-31 Erasmus University Animal transgenique et procedes associes

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
ARBABI GHAHROUDI M ET AL: "Selection and identification of single domain antibody fragments from camel heavy-chain antibodies", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 414, no. 3, 15 September 1997 (1997-09-15), pages 521 - 526, XP004261105, ISSN: 0014-5793 *
BARD F ET AL: "Peripherally administered antibodies against amyloid beta- peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease", NATURE MEDICINE, NATURE PUBLISHING, CO, US, vol. 6, no. 8, August 2000 (2000-08-01), pages 916 - 919, XP002154518, ISSN: 1078-8956 *
DAVIES J ET AL: "Affinity improvement of single antibody VH domains: residues in all three hypervariable regions affect antigen binding", IMMUNOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, NL, vol. 2, no. 3, 1 September 1996 (1996-09-01), pages 169 - 179, XP004070292, ISSN: 1380-2933 *
DUMOULIN M ET AL: "A single-domain antibody fragment that stabilises the native state of two amyloidogenic lysozyme variants and hence prevents aggregation.", BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 30, no. 3, 2002, 676th Meeting of the Biochemical Society;Edinburgh, UK; April 08-10, 2002, pages A93, XP002236935, ISSN: 0300-5127 *
FRENKEL D ET AL: "MODULATION OF ALZHEIMER'S BETA-AMYLOID NEUROTOXICITY BY SITE-DIRECTED SINGLE-CHAIN ANTIBODY", NEUROIMMUNOMODULATION, KARGER, BASEL,, CH, vol. 6, no. 6, November 1999 (1999-11-01), pages 444, XP008000881, ISSN: 1021-7401 *
HAMERS-CASTERMAN C ET AL: "NATURALLY OCCURRING ANTIBODIES DEVOID OF LIGHT CHAINS", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 363, 3 June 1993 (1993-06-03), pages 446 - 448, XP002048619, ISSN: 0028-0836 *
MARTIN F ET AL: "Affinity selection of a camelized VH domain antibody inhibitor of hepatitis C virus NS3 protease", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 10, no. 5, May 1997 (1997-05-01), pages 607 - 614, XP002117441, ISSN: 0269-2139 *
MUYLDERMANS S: "Single domain camel antibodies: current status.", JOURNAL OF BIOTECHNOLOGY. NETHERLANDS JUN 2001, vol. 74, no. 4, June 2001 (2001-06-01), pages 277 - 302, XP002236934, ISSN: 0168-1656 *
SOLOMON B: "Immunotherapeutic strategies for prevention and treatment of Alzheimer's disease.", DNA AND CELL BIOLOGY. UNITED STATES NOV 2001, vol. 20, no. 11, November 2001 (2001-11-01), pages 697 - 703, XP002236936, ISSN: 1044-5498 *
VAN DER LINDEN R ET AL: "Induction of immune responses and molecular cloning of the heavy chain antibody repertoire of Lama glama", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 240, no. 1-2, June 2000 (2000-06-01), pages 185 - 195, XP004201577, ISSN: 0022-1759 *

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8535673B2 (en) 1997-12-02 2013-09-17 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidogenic disease
US8642044B2 (en) 1997-12-02 2014-02-04 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidogenic disease
US9051363B2 (en) 1997-12-02 2015-06-09 Janssen Sciences Ireland Uc Humanized antibodies that recognize beta amyloid peptide
US8034339B2 (en) 1997-12-02 2011-10-11 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidogenic disease
US8034348B2 (en) 1997-12-02 2011-10-11 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidogenic disease
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
US7893214B2 (en) 1997-12-02 2011-02-22 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US7790856B2 (en) 1998-04-07 2010-09-07 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US7582733B2 (en) 1998-11-30 2009-09-01 Elan Pharma International Limited Humanized antibodies that recognize beta amyloid peptide
US7588766B1 (en) 2000-05-26 2009-09-15 Elan Pharma International Limited Treatment of amyloidogenic disease
US7575880B1 (en) 2000-05-26 2009-08-18 Elan Pharma International Limited Method of screening an antibody for activity in clearing an amyloid deposit
US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
US8128928B2 (en) 2002-03-12 2012-03-06 Wyeth Llc Humanized antibodies that recognize beta amyloid peptide
US9176150B2 (en) 2003-01-31 2015-11-03 AbbVie Deutschland GmbH & Co. KG Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof
US7871615B2 (en) 2003-05-30 2011-01-18 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US7625560B2 (en) 2004-12-15 2009-12-01 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US8916165B2 (en) 2004-12-15 2014-12-23 Janssen Alzheimer Immunotherapy Humanized Aβ antibodies for use in improving cognition
US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
US8497072B2 (en) 2005-11-30 2013-07-30 Abbott Laboratories Amyloid-beta globulomer antibodies
US9540432B2 (en) 2005-11-30 2017-01-10 AbbVie Deutschland GmbH & Co. KG Anti-Aβ globulomer 7C6 antibodies
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
US8877190B2 (en) 2006-11-30 2014-11-04 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US9359430B2 (en) 2006-11-30 2016-06-07 Abbvie Inc. Abeta conformer selective anti-Abeta globulomer monoclonal antibodies
US9394360B2 (en) 2006-11-30 2016-07-19 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
US8003097B2 (en) 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
US8613920B2 (en) 2007-07-27 2013-12-24 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
US9644025B2 (en) 2007-10-17 2017-05-09 Wyeth Llc Immunotherapy regimes dependent on ApoE status
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins

Also Published As

Publication number Publication date
WO2004044204A2 (fr) 2004-05-27
FR2846667A1 (fr) 2004-05-07
AU2003290158A8 (en) 2004-06-03
AU2003290158A1 (en) 2004-06-03
FR2846667B1 (fr) 2004-12-31

Similar Documents

Publication Publication Date Title
WO2004044204A3 (fr) Fragments variables d'anticorps de camelides a chaine unique et leurs applications pour le diagnostic et le traitement de pathologies diverses.
WO2007064972A3 (fr) Anticorps monoclonaux et utilisation de ceux-ci
EP1596809A4 (fr) Molecules de liaison au peptide abeta
WO2008150946A8 (fr) Anticorps humanisés qui se lient au globulomère aβ(1-42) et leurs utilisations
WO2004029093A3 (fr) Anticorps anti-granulocytes chimeres, humains et humainises
CY1115014T1 (el) ΜΟΝΟΚΛΩΝΙΚΑ ΑΝΤΙΣΩΜΑΤΑ ΕΙΔΙΚΑ ΓΙΑ Αβ1-42 ΜΕ ΘΕΡΑΠΕΥΤΙΚΕΣ ΙΔΙΟΤΗΤΕΣ
WO2005003171A3 (fr) Fragments d'anticorps modifies
WO2005018424A3 (fr) Anticorps specifiques de la proteine amyloide fibrillaire et procedure permettant de detecter des depots de proteines amyloides fibrillaires
WO2003039467A3 (fr) Methodes et compositions d'anticorps monoclonaux specifiques des proteines beta-amyloides
WO2006014638A3 (fr) Anticorps anti-oligomeres reticules de la proteine $g(b)-amyloide
EA200700083A1 (ru) Антитела, направленные против бета-амилоидного пептида, и способы их применения
WO2006040153A3 (fr) Nanocorps™ contre la proteine beta-amyloide et polypeptides les renfermant pour le traitement de maladies degeneratives neurales, telles que la maladie d'alzheimer
GB0117326D0 (en) Napthoquinone-type inhibitors of protein aggregation
WO2004108895A3 (fr) Anticorps humanises qui reconnaissent le peptide beta-amyloide
ATE507839T1 (de) Kombinationstherapie
WO2004106380A3 (fr) Molecules humaines de liaison a cd3 anti-humain
NO20076014L (no) Fremgangsmate for behandling av demens eller Alzheimers sykdom
DE60230029D1 (de) Immunisierungstherapie zur behandlung von atherosklerose
TW200510459A (en) RG1 antibodies and uses thereof
IL185754A0 (en) Novel anti-plgf antibody
WO2005061545A3 (fr) Methode
WO2002085285A3 (fr) Methodes et compositions permettant de reguler la formation osseuse et cartilagineuse
WO2004029072A3 (fr) Molecules interagissant avec prpsc et utilisations associees
WO2005016127A3 (fr) Reactifs peptidiques specifiques du prion
WO2004092210A3 (fr) Molecule

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP