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WO2003039523A3 - Oligonucleotides modifies a l'aide de nouveaux analogues d'arn-l-alpha - Google Patents

Oligonucleotides modifies a l'aide de nouveaux analogues d'arn-l-alpha Download PDF

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Publication number
WO2003039523A3
WO2003039523A3 PCT/IB2002/005080 IB0205080W WO03039523A3 WO 2003039523 A3 WO2003039523 A3 WO 2003039523A3 IB 0205080 W IB0205080 W IB 0205080W WO 03039523 A3 WO03039523 A3 WO 03039523A3
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novel
rna
oligonucleotides modified
rna analogues
relates
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PCT/IB2002/005080
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WO2003039523A2 (fr
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Jesper Wengel
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Exiqon AS
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Exiqon AS
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Publication of WO2003039523A3 publication Critical patent/WO2003039523A3/fr
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Abstract

La présente invention concerne de nouveaux monomères d'ARN-L-α, qui, lorsqu'ils sont incorporés dans un oligonucléotide altèrent une tendance plus élevée à l'hybridation avec un complément d'ARN, comparé à un complément d'ADN. L'invention concerne également un procédé de préparation d'un oligonucléotide modifié d'ARN-L-α et un intermédiaire permettant sa fabrication. Lesdits nouveaux oligonucléotides sont utiles dans une variété d'applications thérapeutiques, diagnostiques et de biologie moléculaire générales.
PCT/IB2002/005080 2001-11-05 2002-11-05 Oligonucleotides modifies a l'aide de nouveaux analogues d'arn-l-alpha Ceased WO2003039523A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002351077A AU2002351077A1 (en) 2001-11-05 2002-11-05 Oligonucleotides modified with novel alpha-l-rna analogues

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33744701P 2001-11-05 2001-11-05
DKPA200101640 2001-11-05
US60/337,447 2001-11-05
DKPA200101640 2001-11-05

Publications (2)

Publication Number Publication Date
WO2003039523A2 WO2003039523A2 (fr) 2003-05-15
WO2003039523A3 true WO2003039523A3 (fr) 2003-12-04

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PCT/IB2002/005080 Ceased WO2003039523A2 (fr) 2001-11-05 2002-11-05 Oligonucleotides modifies a l'aide de nouveaux analogues d'arn-l-alpha

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AU (1) AU2002351077A1 (fr)
WO (1) WO2003039523A2 (fr)

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US7582618B2 (en) 2002-06-28 2009-09-01 Idenix Pharmaceuticals, Inc. 2′-C-methyl-3′-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7598373B2 (en) 2002-12-12 2009-10-06 Idenix Pharmaceuticals, Inc. Process for the production of 2-C-methyl-D-ribonolactone
US7608597B2 (en) 2000-05-23 2009-10-27 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus
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US9938590B2 (en) 2010-09-16 2018-04-10 Gen-Probe Incorporated Capture probes immobilizable via L-nucleotide tail
US10653711B2 (en) 2015-08-26 2020-05-19 Janssen Pharmaceutica Nv 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors
US10898504B2 (en) 2016-03-10 2021-01-26 Janssen Pharmaceutica Nv Substituted nucleoside analogues for use as PRMT5 inhibitors
US11279970B2 (en) 2017-02-27 2022-03-22 Janssen Pharmaceutica Nv Use of biomarkers in identifying cancer patients that will be responsive to treatment with a PRMT5 inhibitor
US11571437B2 (en) 2019-06-06 2023-02-07 Janssen Pharmaceutica Nv Methods of treating cancer using PRMT5 inhibitors

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