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WO2003013488A3 - Procedes et compositions visant a inhiber rad51 - Google Patents

Procedes et compositions visant a inhiber rad51 Download PDF

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Publication number
WO2003013488A3
WO2003013488A3 PCT/US2001/024986 US0124986W WO03013488A3 WO 2003013488 A3 WO2003013488 A3 WO 2003013488A3 US 0124986 W US0124986 W US 0124986W WO 03013488 A3 WO03013488 A3 WO 03013488A3
Authority
WO
WIPO (PCT)
Prior art keywords
pnp
aif4
group
tdp
gdp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/024986
Other languages
English (en)
Other versions
WO2003013488A2 (fr
Inventor
Gurucharan Reddy
David A Zarling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pangene Corp
Original Assignee
Pangene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pangene Corp filed Critical Pangene Corp
Priority to AU2001283226A priority Critical patent/AU2001283226A1/en
Priority to PCT/US2001/024986 priority patent/WO2003013488A2/fr
Publication of WO2003013488A2 publication Critical patent/WO2003013488A2/fr
Publication of WO2003013488A3 publication Critical patent/WO2003013488A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des procédés visant à inhiber l'activité de Rad51 par l'administration d'un inhibiteur de Rad51. Les inhibiteurs de Rad51 décrits constituent de petites molécules, de préférence de moins de 4 kDa.
PCT/US2001/024986 2001-08-09 2001-08-09 Procedes et compositions visant a inhiber rad51 Ceased WO2003013488A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001283226A AU2001283226A1 (en) 2001-08-09 2001-08-09 Methods and compositions for inhibiting rad51
PCT/US2001/024986 WO2003013488A2 (fr) 2001-08-09 2001-08-09 Procedes et compositions visant a inhiber rad51

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2001/024986 WO2003013488A2 (fr) 2001-08-09 2001-08-09 Procedes et compositions visant a inhiber rad51

Publications (2)

Publication Number Publication Date
WO2003013488A2 WO2003013488A2 (fr) 2003-02-20
WO2003013488A3 true WO2003013488A3 (fr) 2003-08-21

Family

ID=21742766

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024986 Ceased WO2003013488A2 (fr) 2001-08-09 2001-08-09 Procedes et compositions visant a inhiber rad51

Country Status (2)

Country Link
AU (1) AU2001283226A1 (fr)
WO (1) WO2003013488A2 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7531542B2 (en) 2005-05-18 2009-05-12 Wyeth Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
US7534796B2 (en) 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
US7538113B2 (en) 2005-02-18 2009-05-26 Wyeth 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7582634B2 (en) 2005-02-18 2009-09-01 Wyeth 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7582636B2 (en) 2005-05-26 2009-09-01 Wyeth Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009018219A2 (fr) 2007-07-28 2009-02-05 University Of Chicago Procédés et compositions pour moduler rad51, et recombinaison homologue
CA2909383C (fr) 2012-04-12 2020-11-10 University Of Saskatchewan Composes phtalocyanine utiles en tant qu'inhibiteurs reca et procedes d'utilisation associes
US10912761B2 (en) 2012-11-30 2021-02-09 The University Of Chicago Methods and compositions involving RAD51 inhibitors
JP2015051946A (ja) * 2013-09-06 2015-03-19 学校法人早稲田大学 細胞増殖抑制活性を有する化合物、医薬組成物及びスクリーニング方法
MX2018014366A (es) 2016-05-27 2019-04-11 Synthex Inc Interfaces de proteina.
WO2019104244A1 (fr) 2017-11-22 2019-05-31 Synthex, Inc. Peptides destinés à inhiber rad51

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998020030A2 (fr) * 1996-11-05 1998-05-14 Lexicon Genetics Incorporated DISLOCATION DE LA PROTEINE Rad51 DU MAMMIFERE ET DISLOCATION DE PROTEINES S'ASSOCIANT A Rad51 DU MAMMIFERE, POUR INHIBER LA PROLIFERATION CELLULAIRE
WO1998034118A1 (fr) * 1997-01-30 1998-08-06 Yale University Methodes diagnostiques et compositions basees sur la repartition de rad51
EP1006185A1 (fr) * 1998-10-06 2000-06-07 Vlaams Interuniversitair Instituut voor Biotechnologie vzw. Variant tissu-spécifiques d'épissure du gène de recombinaison-réparation rad51b associé aux leiomyomas t(12;14) utérins
WO2000047231A2 (fr) * 1999-02-10 2000-08-17 Pangene Corporation Nouvelle inhibition antisens de rad51
WO2001011369A1 (fr) * 1999-08-10 2001-02-15 Pangene Corporation Traitements et diagnostics du cancer utilisant des molecules et procedes en rapport avec le rad51

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998020030A2 (fr) * 1996-11-05 1998-05-14 Lexicon Genetics Incorporated DISLOCATION DE LA PROTEINE Rad51 DU MAMMIFERE ET DISLOCATION DE PROTEINES S'ASSOCIANT A Rad51 DU MAMMIFERE, POUR INHIBER LA PROLIFERATION CELLULAIRE
WO1998034118A1 (fr) * 1997-01-30 1998-08-06 Yale University Methodes diagnostiques et compositions basees sur la repartition de rad51
EP1006185A1 (fr) * 1998-10-06 2000-06-07 Vlaams Interuniversitair Instituut voor Biotechnologie vzw. Variant tissu-spécifiques d'épissure du gène de recombinaison-réparation rad51b associé aux leiomyomas t(12;14) utérins
WO2000047231A2 (fr) * 1999-02-10 2000-08-17 Pangene Corporation Nouvelle inhibition antisens de rad51
WO2001011369A1 (fr) * 1999-08-10 2001-02-15 Pangene Corporation Traitements et diagnostics du cancer utilisant des molecules et procedes en rapport avec le rad51

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BUCHHOP SABINE ET AL: "Interaction of p53 with the human Rad51 protein", NUCLEIC ACIDS RESEARCH, IRL PRESS LTD., OXFORD, GB, vol. 25, no. 19, 1997, pages 3868 - 3874, XP002146663, ISSN: 0305-1048 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7534796B2 (en) 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
US7538113B2 (en) 2005-02-18 2009-05-26 Wyeth 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7582634B2 (en) 2005-02-18 2009-09-01 Wyeth 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7531542B2 (en) 2005-05-18 2009-05-12 Wyeth Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
US7582636B2 (en) 2005-05-26 2009-09-01 Wyeth Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor

Also Published As

Publication number Publication date
AU2001283226A1 (en) 2003-02-24
WO2003013488A2 (fr) 2003-02-20

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