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WO2003066652A3 - Jlp cytoplasmic scaffolding protein and nucleic acids encoding it - Google Patents

Jlp cytoplasmic scaffolding protein and nucleic acids encoding it Download PDF

Info

Publication number
WO2003066652A3
WO2003066652A3 PCT/US2003/003355 US0303355W WO03066652A3 WO 2003066652 A3 WO2003066652 A3 WO 2003066652A3 US 0303355 W US0303355 W US 0303355W WO 03066652 A3 WO03066652 A3 WO 03066652A3
Authority
WO
WIPO (PCT)
Prior art keywords
jlp
nucleic acids
scaffolding protein
acids encoding
cytoplasmic scaffolding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/003355
Other languages
French (fr)
Other versions
WO2003066652A2 (en
WO2003066652A8 (en
Inventor
Clement M Lee
N Dhanasekaran
Premkumar E Reddy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Temple Univ School of Medicine
Original Assignee
Temple Univ School of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Temple Univ School of Medicine filed Critical Temple Univ School of Medicine
Priority to AU2003216170A priority Critical patent/AU2003216170A1/en
Publication of WO2003066652A2 publication Critical patent/WO2003066652A2/en
Publication of WO2003066652A3 publication Critical patent/WO2003066652A3/en
Publication of WO2003066652A8 publication Critical patent/WO2003066652A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A cytoplasmic scaffolding protein named JLP has been isolated, which tethers MEKK3, MKK4, JNK,p38 MAPK, C-Myc and MAX into a sign aling module that controls the apoptotic response. Nucleic acid sequences which encode JLP, and methods of using the JLP nucleic acids and proteins, and mutants thereof, to modulate the apoptotic response in cells are provided.
PCT/US2003/003355 2002-02-05 2003-02-04 Jlp cytoplasmic scaffolding protein and nucleic acids encoding it Ceased WO2003066652A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003216170A AU2003216170A1 (en) 2002-02-05 2003-02-04 Jlp cytoplasmic scaffolding protein and nucleic acids encoding it

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35437702P 2002-02-05 2002-02-05
US60/354,377 2002-02-05

Publications (3)

Publication Number Publication Date
WO2003066652A2 WO2003066652A2 (en) 2003-08-14
WO2003066652A3 true WO2003066652A3 (en) 2003-10-30
WO2003066652A8 WO2003066652A8 (en) 2004-02-19

Family

ID=27734363

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/003355 Ceased WO2003066652A2 (en) 2002-02-05 2003-02-04 Jlp cytoplasmic scaffolding protein and nucleic acids encoding it

Country Status (2)

Country Link
AU (1) AU2003216170A1 (en)
WO (1) WO2003066652A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090042805A1 (en) * 2004-11-24 2009-02-12 David Chauvier Peptides Useful As Dual Caspase-2/-6 Inhibitors And Their Biological Applications

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030589A2 (en) * 1997-01-10 1998-07-16 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
WO2001057188A2 (en) * 2000-02-03 2001-08-09 Hyseq, Inc. Novel nucleic acids and polypeptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030589A2 (en) * 1997-01-10 1998-07-16 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
WO2001057188A2 (en) * 2000-02-03 2001-08-09 Hyseq, Inc. Novel nucleic acids and polypeptides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] NAGASE ET AL.: "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro", XP002967298, Database accession no. (AB011088) *
DNA RES., vol. 5, no. 1, 28 February 1998 (1998-02-28), pages 31 - 39 *

Also Published As

Publication number Publication date
AU2003216170A1 (en) 2003-09-02
AU2003216170A8 (en) 2003-09-02
WO2003066652A2 (en) 2003-08-14
WO2003066652A8 (en) 2004-02-19

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