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WO2003014303A3 - Molecular interactions in cells - Google Patents

Molecular interactions in cells Download PDF

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Publication number
WO2003014303A3
WO2003014303A3 PCT/US2002/024655 US0224655W WO03014303A3 WO 2003014303 A3 WO2003014303 A3 WO 2003014303A3 US 0224655 W US0224655 W US 0224655W WO 03014303 A3 WO03014303 A3 WO 03014303A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
molecular interactions
interactions
variety
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/024655
Other languages
French (fr)
Other versions
WO2003014303A2 (en
Inventor
Peter S Lu
Joshua D Rabinowitz
Johannes Schweizer
Deanna Marie Carrick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arbor Vita Corp
Original Assignee
Arbor Vita Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arbor Vita Corp filed Critical Arbor Vita Corp
Priority to US10/485,788 priority Critical patent/US20050282743A1/en
Priority to CA002457424A priority patent/CA2457424A1/en
Priority to EP02756934A priority patent/EP1443951A4/en
Priority to AU2002321903A priority patent/AU2002321903A1/en
Publication of WO2003014303A2 publication Critical patent/WO2003014303A2/en
Priority to US10/630,590 priority patent/US7312041B2/en
Publication of WO2003014303A3 publication Critical patent/WO2003014303A3/en
Priority to US10/684,796 priority patent/US20050019841A1/en
Priority to US10/714,537 priority patent/US20060148711A1/en
Priority to AU2003291558A priority patent/AU2003291558B2/en
Anticipated expiration legal-status Critical
Priority to US10/789,102 priority patent/US20040229298A1/en
Priority to US11/053,076 priority patent/US20050255460A1/en
Priority to US11/403,141 priority patent/US20070099199A1/en
Priority to US11/650,455 priority patent/US8048676B2/en
Priority to US11/881,724 priority patent/US7972774B2/en
Priority to US11/833,848 priority patent/US20090075377A1/en
Priority to US12/606,905 priority patent/US20100120700A1/en
Priority to US12/779,501 priority patent/US20110039758A1/en
Priority to US13/212,991 priority patent/US20120052484A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention provides reagents and methods for inhibiting or enhancing interactions between proteins in cells, particularly interactions between a PDZ protein and a PL protein. Reagents and methods that are provided are useful for treatment of a variety of diseases and conditions in a variety of cell types.
PCT/US2002/024655 1999-05-14 2002-08-02 Molecular interactions in cells Ceased WO2003014303A2 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
US10/485,788 US20050282743A1 (en) 2001-08-03 2002-08-02 Molecular interactions in cells
CA002457424A CA2457424A1 (en) 2001-08-03 2002-08-02 Molecular interactions in cells
EP02756934A EP1443951A4 (en) 2001-08-03 2002-08-02 Molecular interactions in cells
AU2002321903A AU2002321903A1 (en) 2001-08-03 2002-08-02 Molecular interactions in cells
US10/630,590 US7312041B2 (en) 2001-02-16 2003-07-29 Methods of diagnosing cervical cancer
US10/684,796 US20050019841A1 (en) 1999-05-14 2003-10-14 Modulation of signaling pathways
AU2003291558A AU2003291558B2 (en) 2001-08-03 2003-11-14 Molecular interactions in neurons
US10/714,537 US20060148711A1 (en) 1999-05-14 2003-11-14 Molecular interactions in neurons
US10/789,102 US20040229298A1 (en) 2000-11-11 2004-02-27 Methods and compositions for treating cervical cancer
US11/053,076 US20050255460A1 (en) 2000-11-11 2005-02-07 Methods of diagnosing cervical cancer
US11/403,141 US20070099199A1 (en) 2000-11-11 2006-04-11 Methods and compositions for treating cervical cancer
US11/650,455 US8048676B2 (en) 2000-11-11 2007-01-05 Systems of diagnosing cervical cancer
US11/881,724 US7972774B2 (en) 2001-02-16 2007-07-27 Methods of diagnosing cervical cancer
US11/833,848 US20090075377A1 (en) 2001-08-03 2007-08-03 Molecular interactions in cells
US12/606,905 US20100120700A1 (en) 2000-11-11 2009-10-27 Methods and compositions for treating cervical cancer
US12/779,501 US20110039758A1 (en) 1999-05-14 2010-05-13 Molecular Interactions in Neurons
US13/212,991 US20120052484A1 (en) 2001-02-16 2011-08-18 Methods of diagnosing cervical cancer

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30984101P 2001-08-03 2001-08-03
US60/309,841 2001-08-03
US36006102P 2002-02-25 2002-02-25
US60/360,061 2002-02-25

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/080,273 Continuation-In-Part US20030049695A1 (en) 1999-05-14 2002-02-19 PDZ domain interactions and lipid rafts

Related Child Applications (7)

Application Number Title Priority Date Filing Date
US10/630,590 Continuation-In-Part US7312041B2 (en) 2000-11-11 2003-07-29 Methods of diagnosing cervical cancer
US10/684,796 Continuation-In-Part US20050019841A1 (en) 1999-05-14 2003-10-14 Modulation of signaling pathways
US10/714,537 Continuation-In-Part US20060148711A1 (en) 1999-05-14 2003-11-14 Molecular interactions in neurons
US10/789,102 Continuation-In-Part US20040229298A1 (en) 2000-11-11 2004-02-27 Methods and compositions for treating cervical cancer
US11/053,076 Continuation-In-Part US20050255460A1 (en) 2000-11-11 2005-02-07 Methods of diagnosing cervical cancer
US11/650,455 Continuation-In-Part US8048676B2 (en) 2000-11-11 2007-01-05 Systems of diagnosing cervical cancer
US11/833,848 Continuation US20090075377A1 (en) 2001-08-03 2007-08-03 Molecular interactions in cells

Publications (2)

Publication Number Publication Date
WO2003014303A2 WO2003014303A2 (en) 2003-02-20
WO2003014303A3 true WO2003014303A3 (en) 2003-08-14

Family

ID=26977039

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/024655 Ceased WO2003014303A2 (en) 1999-05-14 2002-08-02 Molecular interactions in cells

Country Status (4)

Country Link
EP (1) EP1443951A4 (en)
AU (1) AU2002321903A1 (en)
CA (1) CA2457424A1 (en)
WO (1) WO2003014303A2 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6942981B1 (en) 1999-05-14 2005-09-13 Arbor Vita Corporation Method of determining interactions with PDZ-domain polypeptides
US20020110841A1 (en) 2000-12-22 2002-08-15 KUFE Donald W. Regulation of cell growth by MUC1
AU2003291558B2 (en) * 2001-08-03 2009-08-13 Arbor Vita Corporation Molecular interactions in neurons
WO2004045535A2 (en) * 2002-11-14 2004-06-03 Arbor Vita Corporation Molecular interactions in neurons
DE10254601A1 (en) 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Gene products differentially expressed in tumors and their use
EP1599214A4 (en) * 2003-02-27 2006-06-21 Arbor Vita Corp METHODS AND COMPOSITIONS FOR TREATING UTERINE COLON CANCER
JP2006525300A (en) * 2003-05-02 2006-11-09 スコティッシュ バイオメディカル リミテッド Regulation of guanine nucleotide exchange factors of proteins belonging to the Rap family of low molecular weight GTPases
WO2004108142A2 (en) * 2003-06-06 2004-12-16 The University Of Manchester Inhibitors of tip-1 for treatment tissue damage
EP1651671A2 (en) 2003-07-30 2006-05-03 University Of Pittsburgh Of The Commonwealth System Of Higher Education Epha2 t-cell epitope agonists and uses therefor
US8129506B2 (en) 2003-10-24 2012-03-06 Genzyme Corporation Modulation of the interaction of MUC1 with MUC1 ligands
CA2551190A1 (en) 2003-12-23 2005-07-07 Nono Inc. Polypeptides for modulating binding of trp channel proteins and trp-associated proteins.
US7399467B2 (en) 2003-12-23 2008-07-15 Arbor Vita Corporation Antibodies for oncogenic strains of HPV and methods of their use
DE102004024617A1 (en) 2004-05-18 2005-12-29 Ganymed Pharmaceuticals Ag Differentially expressed in tumors gene products and their use
WO2006068768A2 (en) * 2004-11-24 2006-06-29 Hanna Skubatch Methods and compositions for treating conditions
US9408381B2 (en) 2004-12-21 2016-08-09 Musc Foundation For Research Development Alpha Connexin c-Terminal (ACT) peptides for use in transplant
DK2377546T3 (en) 2004-12-21 2017-02-13 Musc Found For Res Dev Compositions and Methods to Promote Wound Healing and Tissue Regeneration
DE102005022182A1 (en) * 2005-05-09 2006-11-16 Combinature Biopharm Ag Modulators of the PDZ domain
CN101287988B (en) * 2005-07-01 2012-10-10 阿波维塔公司 Methods and compositions for diagnosis and treatment of influenza
EP1790664A1 (en) 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Monoclonal antibodies against claudin-18 for treatment of cancer
US8633160B2 (en) 2005-12-30 2014-01-21 Nono Inc. Small molecule inhibitors of PDZ interactions
WO2008097840A2 (en) 2007-02-02 2008-08-14 Dana-Farber Cancer Institute, Inc. Methods and compositions relating to the regulation of muc1 by hsf1 and stat3
US7871784B2 (en) 2007-02-02 2011-01-18 Dana-Farber Cancer Institute, Inc. Methods and compositions relating to the regulation of apoptosis by MUC1 and BH3-containing proapoptotic proteins
ES2542522T3 (en) 2008-07-09 2015-08-06 University Of Copenhagen Modified peptides as potent inhibitors of the interaction between NMDA / PSD-95 receptor
AU2013225716B2 (en) 2012-03-01 2017-10-12 Xequel Bio, Inc. Topical gels containing alpha connexin C-terminal (ACT) peptides
WO2013167153A1 (en) 2012-05-09 2013-11-14 Ganymed Pharmaceuticals Ag Antibodies useful in cancer diagnosis
US20160166637A1 (en) * 2013-08-02 2016-06-16 Virginia Tech Intellectual Properties, Inc. Methods of treating a cancer through targeted disruption of alpha connexin 43-zonula occludens-1 (zo-1) interaction
EP3074030A4 (en) * 2013-11-26 2017-08-16 Trustees of Dartmouth College Method for mitigating or alleviating synaptic and cognitive deficits
CN114010788A (en) 2014-08-22 2022-02-08 奥克兰联合服务有限公司 channel modulator
JP7002788B2 (en) * 2017-07-05 2022-03-03 拜西欧斯（北京）生物技術有限公司 Pharmaceutically acceptable salts of polypeptides and their use
US12138293B2 (en) 2020-10-22 2024-11-12 Xequel Bio, Inc. Peptide formulations and ophthalmic uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976819A (en) * 1995-11-21 1999-11-02 National Jewish Medical And Research Center Product and process to regulate actin polymerization in T lymphocytes
WO2000069896A2 (en) * 1999-05-14 2000-11-23 Arbor Vita Corporation Molecular interactions in haematopoietic cells
US20020058607A1 (en) * 1996-07-22 2002-05-16 Takaaki Sato Compounds that inhibit the interaction between signal-transducing proteins and the glgf (pdz/dhr) domain and uses thereof
US20020147306A1 (en) * 1998-11-20 2002-10-10 Danny Lin Peptides that modulate the interaction of B class ephrins and PDZ domains

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976819A (en) * 1995-11-21 1999-11-02 National Jewish Medical And Research Center Product and process to regulate actin polymerization in T lymphocytes
US20020058607A1 (en) * 1996-07-22 2002-05-16 Takaaki Sato Compounds that inhibit the interaction between signal-transducing proteins and the glgf (pdz/dhr) domain and uses thereof
US20020147306A1 (en) * 1998-11-20 2002-10-10 Danny Lin Peptides that modulate the interaction of B class ephrins and PDZ domains
WO2000069896A2 (en) * 1999-05-14 2000-11-23 Arbor Vita Corporation Molecular interactions in haematopoietic cells

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DOYLE ET AL., CELL, vol. 85, June 1996 (1996-06-01), pages 1067 - 1076, XP002196674 *
See also references of EP1443951A4 *
SONGYANG ET AL., SCIENCE, vol. 275, January 1997 (1997-01-01), pages 73 - 77, XP000887129 *

Also Published As

Publication number Publication date
EP1443951A4 (en) 2006-05-03
AU2002321903A1 (en) 2003-02-24
CA2457424A1 (en) 2003-02-20
WO2003014303A2 (en) 2003-02-20
EP1443951A2 (en) 2004-08-11

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