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WO2002032876A3 - Novel m-amino-phenylimino-imidazolidine derivatives for treating urinary incontinence - Google Patents

Novel m-amino-phenylimino-imidazolidine derivatives for treating urinary incontinence Download PDF

Info

Publication number
WO2002032876A3
WO2002032876A3 PCT/EP2001/011764 EP0111764W WO0232876A3 WO 2002032876 A3 WO2002032876 A3 WO 2002032876A3 EP 0111764 W EP0111764 W EP 0111764W WO 0232876 A3 WO0232876 A3 WO 0232876A3
Authority
WO
WIPO (PCT)
Prior art keywords
phenylimino
amino
urinary incontinence
novel
treating urinary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/011764
Other languages
German (de)
French (fr)
Other versions
WO2002032876A2 (en
Inventor
Franz Esser
Pascale Arielle Jane-Jo Pouzet
Hisato Kitagawa
Kenji Sakai
Ikunobu Muramatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2002536060A priority Critical patent/JP2004511547A/en
Priority to BR0114603-3A priority patent/BR0114603A/en
Priority to IL15533801A priority patent/IL155338A0/en
Priority to HU0302245A priority patent/HUP0302245A3/en
Priority to SK434-2003A priority patent/SK4342003A3/en
Priority to AU2002215943A priority patent/AU2002215943A1/en
Priority to EA200300460A priority patent/EA200300460A1/en
Priority to PL01361359A priority patent/PL361359A1/en
Priority to KR10-2003-7005143A priority patent/KR20030046503A/en
Priority to EEP200300177A priority patent/EE200300177A/en
Priority to CA002425563A priority patent/CA2425563A1/en
Priority to EP01987747A priority patent/EP1328517A2/en
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority to MXPA03003162A priority patent/MXPA03003162A/en
Publication of WO2002032876A2 publication Critical patent/WO2002032876A2/en
Publication of WO2002032876A3 publication Critical patent/WO2002032876A3/en
Priority to BG107711A priority patent/BG107711A/en
Priority to NO20031697A priority patent/NO20031697L/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention relates to m-amino-phenylimino-imidazolidine derivatives with a novel substituent pattern on the phenyl ring, of general formula (I) or of general formula (II), wherein R1 is F, Cl, Br, CH2F, CF2H or CF3, R2 is NR6R7, R6 being Me, Et, Pr or iPr and R7 being Me, Et or Pr; and R3, R4 and R5 are each, independently of each other, H, Me, F, Cl, Br, CH2F, CF2H and/or CF3 and if R4 is Me, F, Cl, Br, CH2F, CF2H or CF3, then R1 is additionally also H or Me; and or their pharmacologically compatible salts, to the use thereof for producing medicaments, especially for treating urinary incontinence, and to a method for producing the same.
PCT/EP2001/011764 2000-10-14 2001-10-11 Novel m-amino-phenylimino-imidazolidine derivatives for treating urinary incontinence Ceased WO2002032876A2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
BR0114603-3A BR0114603A (en) 2000-10-14 2001-10-11 M-Amino-phenylimino-imidazolidine derivatives for the treatment of urinary incontinence
IL15533801A IL155338A0 (en) 2000-10-14 2001-10-11 Novel m-amino-phenylimino-imidazolidine derivatives for treating urinary incontinence
HU0302245A HUP0302245A3 (en) 2000-10-14 2001-10-11 Novel m-amino-phenylimino-imidazolidine derivatives, their use and pharmaceutical compositions for treating urinary incontinence
SK434-2003A SK4342003A3 (en) 2000-10-14 2001-10-11 Novel m-amino-phenylimino-imidazolidine derivatives for treating urinary incontinence
AU2002215943A AU2002215943A1 (en) 2000-10-14 2001-10-11 Novel M-amino-phenylimino-imidazolidine derivatives for treating urinary incontinence
EA200300460A EA200300460A1 (en) 2000-10-14 2001-10-11 NEW DERIVATIVES m-AMINOPHENILIMINOIMIDAZOLIDINE FOR THE TREATMENT OF URINARY HOLDING
PL01361359A PL361359A1 (en) 2000-10-14 2001-10-11 Novel m-amino-phenylimino-imidazolidine derivatives for treating urinary incontinence
EEP200300177A EE200300177A (en) 2000-10-14 2001-10-11 m-aminophenyliminoimidazolidine derivatives for the treatment of urinary incontinence
KR10-2003-7005143A KR20030046503A (en) 2000-10-14 2001-10-11 Novel m-amino-phenylimino-imidazolidine derivatives for treating urinary incontinence
JP2002536060A JP2004511547A (en) 2000-10-14 2001-10-11 Novel m-amino-phenylimino-imidazolidine derivatives for the treatment of urinary incontinence
EP01987747A EP1328517A2 (en) 2000-10-14 2001-10-11 Novel m-amino-phenylimino-imidazolidine derivatives for treating urinary incontinence
CA002425563A CA2425563A1 (en) 2000-10-14 2001-10-11 Novel m-amino-phenylimino-imidazolidine derivatives for treating urinary incontinence
MXPA03003162A MXPA03003162A (en) 2000-10-14 2001-10-11 Novel m-amino-phenylimino-imidazolidine derivatives for treating urinary incontinence.
BG107711A BG107711A (en) 2000-10-14 2003-04-08 NEW M-AMINO-PHENYLIMINO-IMIDAZOLIDINE DERIVATIVES FOR TREATMENT OF URIN INCONTINENCE
NO20031697A NO20031697L (en) 2000-10-14 2003-04-11 New m-amino-phenylimino-imidazoline derivatives for the treatment of urinary incontinence

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10051005 2000-10-14
DE10051005.1 2000-10-14

Publications (2)

Publication Number Publication Date
WO2002032876A2 WO2002032876A2 (en) 2002-04-25
WO2002032876A3 true WO2002032876A3 (en) 2002-07-18

Family

ID=7659815

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/011764 Ceased WO2002032876A2 (en) 2000-10-14 2001-10-11 Novel m-amino-phenylimino-imidazolidine derivatives for treating urinary incontinence

Country Status (23)

Country Link
EP (1) EP1328517A2 (en)
JP (1) JP2004511547A (en)
KR (1) KR20030046503A (en)
CN (1) CN1471514A (en)
AR (1) AR035923A1 (en)
AU (1) AU2002215943A1 (en)
BG (1) BG107711A (en)
BR (1) BR0114603A (en)
CA (1) CA2425563A1 (en)
CZ (1) CZ20031333A3 (en)
DE (1) DE10150312A1 (en)
EA (1) EA200300460A1 (en)
EC (1) ECSP034517A (en)
EE (1) EE200300177A (en)
HU (1) HUP0302245A3 (en)
IL (1) IL155338A0 (en)
MX (1) MXPA03003162A (en)
NO (1) NO20031697L (en)
PL (1) PL361359A1 (en)
SK (1) SK4342003A3 (en)
WO (1) WO2002032876A2 (en)
YU (1) YU28203A (en)
ZA (1) ZA200302345B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4168086B1 (en) * 2008-04-16 2008-10-22 国立大学法人福井大学 Imidazoline derivatives

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2806811A1 (en) * 1978-02-17 1979-08-23 Boehringer Sohn Ingelheim NEW SUBSTITUTED 2-PHENYLIMINO-IMIDAZOLIDINE, THEIR ACID-ADDITIONAL SALTS, THESE MEDICINAL PRODUCTS AND METHOD FOR MANUFACTURING THE SAME
EP0081924A1 (en) * 1981-11-20 1983-06-22 Alcon Laboratories, Inc. Topical compostions for lowering intraocular pressure
WO1996032939A1 (en) * 1995-04-20 1996-10-24 Boehringer Ingelheim Kg USE OF α1L AGONISTS IN THE TREATMENT OF INCONTINENCE

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2806811A1 (en) * 1978-02-17 1979-08-23 Boehringer Sohn Ingelheim NEW SUBSTITUTED 2-PHENYLIMINO-IMIDAZOLIDINE, THEIR ACID-ADDITIONAL SALTS, THESE MEDICINAL PRODUCTS AND METHOD FOR MANUFACTURING THE SAME
EP0081924A1 (en) * 1981-11-20 1983-06-22 Alcon Laboratories, Inc. Topical compostions for lowering intraocular pressure
WO1996032939A1 (en) * 1995-04-20 1996-10-24 Boehringer Ingelheim Kg USE OF α1L AGONISTS IN THE TREATMENT OF INCONTINENCE

Also Published As

Publication number Publication date
KR20030046503A (en) 2003-06-12
NO20031697D0 (en) 2003-04-11
DE10150312A1 (en) 2002-07-04
MXPA03003162A (en) 2004-12-06
SK4342003A3 (en) 2003-10-07
ECSP034517A (en) 2003-04-25
HUP0302245A2 (en) 2003-10-28
ZA200302345B (en) 2004-04-23
WO2002032876A2 (en) 2002-04-25
CA2425563A1 (en) 2002-04-25
AU2002215943A1 (en) 2002-04-29
CZ20031333A3 (en) 2003-08-13
HUP0302245A3 (en) 2004-01-28
EA200300460A1 (en) 2004-02-26
EP1328517A2 (en) 2003-07-23
AR035923A1 (en) 2004-07-28
CN1471514A (en) 2004-01-28
EE200300177A (en) 2003-08-15
JP2004511547A (en) 2004-04-15
IL155338A0 (en) 2003-11-23
YU28203A (en) 2006-05-25
BG107711A (en) 2004-02-27
NO20031697L (en) 2003-05-26
BR0114603A (en) 2003-10-14
PL361359A1 (en) 2004-10-04

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