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WO2002018541A3 - A neural specific cystosolic sulfotransferase for drug screening - Google Patents

A neural specific cystosolic sulfotransferase for drug screening Download PDF

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Publication number
WO2002018541A3
WO2002018541A3 PCT/US2001/041986 US0141986W WO0218541A3 WO 2002018541 A3 WO2002018541 A3 WO 2002018541A3 US 0141986 W US0141986 W US 0141986W WO 0218541 A3 WO0218541 A3 WO 0218541A3
Authority
WO
WIPO (PCT)
Prior art keywords
sultn
expressed
sulfotransferase
cystosolic
nervous system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/041986
Other languages
French (fr)
Other versions
WO2002018541A2 (en
Inventor
David H Farb
Stella Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston University
Original Assignee
Boston University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston University filed Critical Boston University
Priority to AU2001295018A priority Critical patent/AU2001295018A1/en
Publication of WO2002018541A2 publication Critical patent/WO2002018541A2/en
Anticipated expiration legal-status Critical
Publication of WO2002018541A3 publication Critical patent/WO2002018541A3/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A gene encoding a novel nervous system-specific sulfotransferase, SULTn, has been identified by searching an expressed sequence tag database for sulfotransferase specifically expressed in the brain. SULTn is a polypeptide of 33,085 MW that structurally resembles cytosolic sulfotransferases. SULTn specifically binds to adenosine 3',5'-diphosphate-agarose. The human SULTn gene is located on chromosome 22 (22q13), has 7 coding exons, and spans over 47 kb.Unlike all known cytosolic sulfotransferases, which are highly expressed in liver, SULTn transcripts (2.4 kb) were detected only in the adult brain. SULTn is expressed early in rat development in the central, peripheral and enteric nervous systems. SULTn is widely expressed in the adult nervous system, including the Purkinje cell layer of the cerebellum, apparently in neurons.
PCT/US2001/041986 2000-09-01 2001-09-04 A neural specific cystosolic sulfotransferase for drug screening Ceased WO2002018541A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001295018A AU2001295018A1 (en) 2000-09-01 2001-09-04 A neural specific cystosolic sulfotransferase for drug screening

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22992900P 2000-09-01 2000-09-01
US60/229,929 2000-09-01

Publications (2)

Publication Number Publication Date
WO2002018541A2 WO2002018541A2 (en) 2002-03-07
WO2002018541A3 true WO2002018541A3 (en) 2003-04-10

Family

ID=22863257

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/041986 Ceased WO2002018541A2 (en) 2000-09-01 2001-09-04 A neural specific cystosolic sulfotransferase for drug screening

Country Status (2)

Country Link
AU (1) AU2001295018A1 (en)
WO (1) WO2002018541A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7628989B2 (en) 2001-04-10 2009-12-08 Agensys, Inc. Methods of inducing an immune response

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1589985A4 (en) * 2003-02-04 2007-06-06 Millennium Pharm Inc Methods and compositions in treating pain and painful disorders using 16386, 15402, 21165, 1423, 636, 12303, 21425, 27410, 38554, 38555, 55063, 57145, 59914, 94921, 16852, 33260, 58573, 30911, 85913, 14303, 16816, 17827 or 32620
US20060223065A1 (en) * 2003-09-30 2006-10-05 Evotec Neuroscience Gmbh Diagnostic and therapeutic use of a sulfotransferase for neurodegenerative diseases
US7951542B2 (en) 2009-11-04 2011-05-31 Surgene, LLC Methods and compositions for the treatment of psychotic disorders through the identification of the SULT4A1-1 haplotype
US7985551B2 (en) 2009-11-04 2011-07-26 Suregene, Llc Methods and compositions for the treatment of psychotic disorders through the identification of the SULT4A1-1 haplotype
US7951543B2 (en) 2009-11-04 2011-05-31 Suregene, Llc Methods and compositions for the treatment of psychotic disorders through the identification of the SULT4A1-1 haplotype
US7972793B2 (en) 2009-11-04 2011-07-05 Suregene, Llc Methods and compositions for the treatment of psychotic disorders through the identification of the SULT4A1-1 haplotype
CN119752835B (en) * 2025-01-10 2025-10-14 华中农业大学 A molecular marker related to the content of sulfone metabolites in tea plants and its application

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BIOCHEM. J., vol. 346, no. PT. 2, 3 April 2000 (2000-04-03), pages 857 - 864 *
BIOCHEM. J., vol. 346, no. PT. 3, 3 April 2000 (2000-04-03), pages 857 - 864 *
DATABASE GENBANK [online] 22 June 2001 (2001-06-22), MARTIN ET AL.: "Molecular identificatioon of a rat nervouw system cytoplasmic sulfotransferase, NST", XP002957205, Database accession no. (AF176343) *
DATABASE GENBANK [online] US NATIONAL LIBRARY OF MEDICINE (BERHESDA, MD, USA); 1 January 2000 (2000-01-01), SAKAKIBARA ET AL.: "Molecular cloning, expression and functional characterization of novel sulfotransferase from brain", XP002957201, Database accession no. (AF115311) *
DATABASE GENBANK [online] US NATIONAL LIBRARY OF MEDICINE (BETHESDA, MD, USA); 12 December 1999 (1999-12-12), BURGESS J., XP002956900, Database accession no. (Z97055) *
DATABASE GENBANK [online] US NATIONAL LIBRARY OF MEDICINE (BETHESDA, MD, USA); 22 June 2001 (2001-06-22), MARTIN ET AL.: "Molecular identification of a human nervous system cytoplasmic sulfotransferase, NST", XP002957204, Database accession no. (AF176342) *
DATABASE GENBANK [online] US NATIONAL LIBRARY OF MEDICINE (BETHESDA, MD, USA); 9 August 2000 (2000-08-09), WALTHER ET AL.: "Molecular and physical characterization of human SULT4A1, representing a novel cytosolic sulfotransferase family", XP002957202, Database accession no. (AF251263) *
DATABASE GENBANK [online] US NATIONAL LIBRARY OF MEDICINE (BETHESDA, MD, USA); FALANY ET AL.: "Molecular cloning and expression of novel sulfotransferase-like cDNAs from human and rat brain", XP002957203, Database accession no. (AF188698) *
DATABASE GENBANK [online] US NATIONAL LIBRARY OF MEDICINE (BETHESDA, MD, USA); FALANY ET AL.: "Molecular cloning and expression of novel sulfotransferase-like cDNAs from human and rat brain", XP002957206, Database accession no. (AF188699) *
FALANY ET AL.: "Molecular cloning and expression of novel sulfotransferase-like cDNAs from human and rat brain", BIOCHEMICAL JOURNAL, vol. 346, no. PART 3, 15 March 2000 (2000-03-15), pages 857 - 864, XP002957207 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7628989B2 (en) 2001-04-10 2009-12-08 Agensys, Inc. Methods of inducing an immune response
US7641905B2 (en) 2001-04-10 2010-01-05 Agensys, Inc. Methods of inducing an immune response

Also Published As

Publication number Publication date
AU2001295018A1 (en) 2002-03-13
WO2002018541A2 (en) 2002-03-07

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