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WO2002060417A8 - Lagerstabiles haft- und bindemittel für pharmazeutische anwendungen - Google Patents

Lagerstabiles haft- und bindemittel für pharmazeutische anwendungen

Info

Publication number
WO2002060417A8
WO2002060417A8 PCT/EP2001/000923 EP0100923W WO02060417A8 WO 2002060417 A8 WO2002060417 A8 WO 2002060417A8 EP 0100923 W EP0100923 W EP 0100923W WO 02060417 A8 WO02060417 A8 WO 02060417A8
Authority
WO
WIPO (PCT)
Prior art keywords
binding agent
acrylate
meth
stable
storage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/000923
Other languages
English (en)
French (fr)
Other versions
WO2002060417A1 (de
Inventor
Hans-Ulrich Petereit
Manfred Assmus
Thomas Beckert
Guenther Bergmann
Stephanie Zacharias
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roehm GmbH Darmstadt
Original Assignee
Roehm GmbH Darmstadt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roehm GmbH Darmstadt filed Critical Roehm GmbH Darmstadt
Priority to DE20180358U priority Critical patent/DE20180358U1/de
Priority to JP2002560610A priority patent/JP2004517157A/ja
Priority to PCT/EP2001/000923 priority patent/WO2002060417A1/de
Priority to US10/239,187 priority patent/US20050019381A1/en
Publication of WO2002060417A1 publication Critical patent/WO2002060417A1/de
Publication of WO2002060417A8 publication Critical patent/WO2002060417A8/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
    • C09J133/04—Homopolymers or copolymers of esters
    • C09J133/14—Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur or oxygen atoms in addition to the carboxy oxygen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2666/00—Composition of polymers characterized by a further compound in the blend, being organic macromolecular compounds, natural resins, waxes or and bituminous materials, non-macromolecular organic substances, inorganic substances or characterized by their function in the composition
    • C08L2666/28—Non-macromolecular organic substances
    • C08L2666/34—Oxygen-containing compounds, including ammonium and metal salts

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Die Erfindung betrifft ein Haft- und Bindemittel für dermale oder transdermale Therapiesysteme bestehend aus (a) einem (Meth)acrylat-Copolymer aus radikalisch polymerisierten C1-bis C4-Alkylestern der Acryl- oder der Methacrylsäure und (Meth)acrylat-Monomeren mit einer kationischen Ammoniumgruppe im Alkylrest, enthaltend (b) 0,1 45 Gew.-% bezogen auf (a) einer organischen Di- oder Tricarbonsäure oder eines säuregruppenhaltigen Acrylat- oder (Meth)acrylat Polymeren oder Copolymeren sowie (c) 20 80 Gew.-%, bezogen auf (a), eines Weichmachers und (d) gegebenenfalls einem pharmazeutischer Wirkstoff und/oder pharmazeutisch üblichen Zuschlagstoffen dadurch gekennzeichnet, dass als Weichmacher Dibutylsebacat enthalten ist.
PCT/EP2001/000923 2001-01-29 2001-01-29 Lagerstabiles haft- und bindemittel für pharmazeutische anwendungen Ceased WO2002060417A1 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE20180358U DE20180358U1 (de) 2001-01-29 2001-01-29 Lagerstabiles Haft- und Bindemittel für pharmazeutische Anwendungen
JP2002560610A JP2004517157A (ja) 2001-01-29 2001-01-29 薬学的適用のための貯蔵安定性接着および結合剤
PCT/EP2001/000923 WO2002060417A1 (de) 2001-01-29 2001-01-29 Lagerstabiles haft- und bindemittel für pharmazeutische anwendungen
US10/239,187 US20050019381A1 (en) 2001-01-29 2001-01-29 Binding agent which is stable in storage and used for pharmaceutical applications

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2001/000923 WO2002060417A1 (de) 2001-01-29 2001-01-29 Lagerstabiles haft- und bindemittel für pharmazeutische anwendungen

Publications (2)

Publication Number Publication Date
WO2002060417A1 WO2002060417A1 (de) 2002-08-08
WO2002060417A8 true WO2002060417A8 (de) 2002-12-05

Family

ID=8164264

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/000923 Ceased WO2002060417A1 (de) 2001-01-29 2001-01-29 Lagerstabiles haft- und bindemittel für pharmazeutische anwendungen

Country Status (4)

Country Link
US (1) US20050019381A1 (de)
JP (1) JP2004517157A (de)
DE (1) DE20180358U1 (de)
WO (1) WO2002060417A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10220470A1 (de) * 2002-04-30 2003-11-20 Roehm Gmbh ph-sensitives Polymer
DE19961334A1 (de) * 1999-12-17 2001-06-21 Roehm Gmbh Spritzgußverfahren für neutrale und säuregruppenhaltige (Meth)acrylat-Copolymere
DE10127134A1 (de) * 2001-06-05 2002-12-12 Roehm Gmbh verfahren zur Herstellung von Formkörpern aus (Meth)acrylat-Copolymeren mittels Spritzguß
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
US7005031B2 (en) 2002-01-16 2006-02-28 3M Innovative Properties Company Pressure sensitive adhesives having quaternary ammonium functionality, articles, and methods
DE10208335A1 (de) * 2002-02-27 2003-09-04 Roehm Gmbh Arzneiform und Verfahren zu ihrer Herstellung
DE10250543A1 (de) * 2002-10-29 2004-05-19 Röhm GmbH & Co. KG Mehrschichtige Arzneiform
MXPA04010956A (es) 2003-01-30 2005-01-25 Roehm Gmbh Forma de dosis farmaceutica y metodo para la produccion de la misma.
DE102007060175A1 (de) * 2007-12-13 2009-06-18 Johannes Gutenberg-Universität Mainz Quartärnisierung des Zusatzstoffs Aminoalkyl Methacrylat Copolymer E zur Verbesserung der Permeabilität und Löslichkeit von Arzneistoffen
PL2459634T3 (pl) 2009-07-30 2017-09-29 Evonik Röhm Gmbh Sproszkowana lub granulowana kompozycja zawierająca kopolimer, kwas dikarboksylowy i monokarboksylowy kwas tłuszczowy
CN105419206B (zh) * 2009-07-30 2017-12-15 赢创罗姆有限公司 包含共聚物、二羧酸和脂肪单羧酸的粉末状或粒状组合物
EP2550863A1 (de) 2011-07-27 2013-01-30 Bayer Intellectual Property GmbH Aktivstoffhaltige Partikel auf Polyacrylat-Basis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4026992A1 (de) * 1990-08-25 1992-02-27 Roehm Gmbh Verfahren zur herstellung von traegersystemen fuer biologisch aktive materialien
DE4310012A1 (de) * 1993-03-27 1994-09-29 Roehm Gmbh Dermales therapeutisches System aus einer schmelzfähigen Poly(meth)acrylat-Mischung
US6211425B1 (en) * 1996-10-04 2001-04-03 Saitama Daiichi Seiyaku Kabushiki Kaisha Patch
DE19653605C2 (de) * 1996-12-20 2002-11-28 Roehm Gmbh Haft- und Bindemittel für dermale oder transdermale Therapiesysteme und dessen Verwendung zur Herstellung eines transdermalen Therapiesystems
DE19653606A1 (de) * 1996-12-20 1998-06-25 Roehm Gmbh Haft- und Bindemittel aus (Meth)acrylatpolymer, organischer Säure und Weichmacher
DE19715794C1 (de) * 1997-04-16 1998-12-03 Roehm Gmbh Laminare Arzneiform und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
JP2004517157A (ja) 2004-06-10
US20050019381A1 (en) 2005-01-27
DE20180358U1 (de) 2003-01-30
WO2002060417A1 (de) 2002-08-08

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