TR200100196T2 - Oral veya dermal ilaç biçimleri için kaplama ve birleştirme maddeleri - Google Patents
Oral veya dermal ilaç biçimleri için kaplama ve birleştirme maddeleriInfo
- Publication number
- TR200100196T2 TR200100196T2 TR2001/00196T TR200100196T TR200100196T2 TR 200100196 T2 TR200100196 T2 TR 200100196T2 TR 2001/00196 T TR2001/00196 T TR 2001/00196T TR 200100196 T TR200100196 T TR 200100196T TR 200100196 T2 TR200100196 T2 TR 200100196T2
- Authority
- TR
- Turkey
- Prior art keywords
- coating
- oral
- weight
- binding agents
- drug forms
- Prior art date
Links
- 239000011248 coating agent Substances 0.000 title abstract 3
- 238000000576 coating method Methods 0.000 title abstract 3
- 230000002500 effect on skin Effects 0.000 title abstract 2
- 239000011230 binding agent Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 229920001577 copolymer Polymers 0.000 abstract 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 abstract 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000003995 emulsifying agent Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
- 125000001302 tertiary amino group Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S524/00—Synthetic resins or natural rubbers -- part of the class 520 series
- Y10S524/904—Powder coating compositions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Paints Or Removers (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Bulus, (a) akril veya metakril asitlerinin ve fonksiyonel üçlü amonyum gruplarina sahip olan baska (met) akrilat monomerlerinin köklü olarak polimerize edilmis olan C1 ila C4 esterlerinden olusan bir kopolimerinin 35-98 agirlik yüzdesinden ve (b) bir yumusaticinin 1-50 agirlik yüzdesi ve en az 14 HLB degerindeki emülgatörün 1-15 agirlik yüzdesinden meydana gelen , bunun yaninda (a), (b) ve (c) bilesenlerinin su ilavesi yapilarak veya yapilmayarak ve gerektiginde farmasötik bir etkin maddenin ilave edilmesiyle ve diger mutat ilave maddelerin birbirleriyle karistirildigi, kaplama ve birlestirme maddesinin eritme, döküm, sürme veya püskürtme yoluyla imal edildigi, oral veya dermal ilaç biçimleri için bir kaplama ve birlestirme maddesinin imalat yöntemidir.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833016 | 1998-07-23 | ||
| DE19918435A DE19918435A1 (de) | 1998-07-23 | 1999-04-23 | Überzugs- und Bindemittel für orale oder dermale Arzneiformen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200100196T2 true TR200100196T2 (tr) | 2001-06-21 |
Family
ID=26047615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2001/00196T TR200100196T2 (tr) | 1998-07-23 | 1999-07-02 | Oral veya dermal ilaç biçimleri için kaplama ve birleştirme maddeleri |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6624210B1 (tr) |
| EP (1) | EP1098935B1 (tr) |
| JP (1) | JP4636687B2 (tr) |
| KR (2) | KR100663663B1 (tr) |
| CN (1) | CN1142212C (tr) |
| AT (1) | ATE230426T1 (tr) |
| AU (1) | AU4781599A (tr) |
| BR (1) | BR9912353B1 (tr) |
| CA (1) | CA2338750C (tr) |
| DE (2) | DE19918435A1 (tr) |
| ES (1) | ES2190226T3 (tr) |
| HK (1) | HK1041014B (tr) |
| IL (1) | IL140771A (tr) |
| MX (1) | MX217361B (tr) |
| PL (1) | PL199235B1 (tr) |
| SK (1) | SK287838B6 (tr) |
| TR (1) | TR200100196T2 (tr) |
| WO (1) | WO2000005307A1 (tr) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10220470A1 (de) * | 2002-04-30 | 2003-11-20 | Roehm Gmbh | ph-sensitives Polymer |
| BRPI0108145B8 (pt) * | 2000-02-10 | 2021-05-25 | Bpsi Holdings Inc | composições de revestimento entérico acrílicas |
| DE10011447A1 (de) | 2000-03-10 | 2001-09-20 | Roehm Gmbh | Dispersion mit nichtionischem Emulgator |
| AU2002219151B2 (en) * | 2000-12-04 | 2008-04-10 | Grussner, Uwe Emil | Method for producing a partial or complete active ingredient coating on and in implants and onplants |
| DE10061704A1 (de) * | 2000-12-12 | 2002-06-20 | Hans Joerg Bauer | Verfahren und Vorrichtung zur Herstellung von biologischem Gewebe in einer Wachstumskammer |
| GB0102342D0 (en) * | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
| HU229344B1 (en) * | 2001-02-27 | 2013-11-28 | Evonik Roehm Gmbh | Coating and binding agent for pharmaceutical formulations with improved storage stability |
| JP2002255807A (ja) * | 2001-02-28 | 2002-09-11 | Kobayashi Pharmaceut Co Ltd | 抗菌剤 |
| DE10239999A1 (de) * | 2002-08-27 | 2004-03-04 | Röhm GmbH & Co. KG | Granulat oder Pulver zur Herstellung von Überzugs- und Bindemitteln für Arzneiformen |
| DE10260920A1 (de) | 2002-12-20 | 2004-07-01 | Röhm GmbH & Co. KG | Verfahren zur Herstellung von Arnzeiformen oder Nahrungsergänzungsmitteln mit pigmentierten Polymerüberzügen |
| DE10260919A1 (de) * | 2002-12-20 | 2004-07-01 | Röhm GmbH & Co. KG | Verfahren zur Herstellung von überzogenen Arzneiformen und Nahrungsergänzungsmitteln mit Konzentrationsgradienten im Überzug |
| DE10260921A1 (de) * | 2002-12-20 | 2004-07-01 | Röhm GmbH & Co. KG | Verfahren zum Überziehen von Substraten für pharmazeutische Anwendungen mit einem Gemisch aus zwei filmbildenden Überzugsmitteln |
| DE10304403A1 (de) * | 2003-01-28 | 2004-08-05 | Röhm GmbH & Co. KG | Verfahren zur Herstellung einer oralen Arzneiform mit unmittelbarem Zerfall und Wirkstofffreisetzung |
| DE10306604A1 (de) * | 2003-02-18 | 2004-08-26 | Goldschmidt Ag | Kosmetische Zubereitungen mit Wirkstoffen in Mikrokapseln |
| WO2004112756A1 (en) | 2003-06-26 | 2004-12-29 | Isa Odidi | Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient |
| WO2005055987A1 (en) * | 2003-12-15 | 2005-06-23 | Council Of Scientific & Industrial Research | TASTE MASKED PHARMACEUTICAL COMPOSITIONS COMPRISING BITTER DRUG AND pH SENSITIVE POLYMER |
| JP2007518669A (ja) * | 2003-12-15 | 2007-07-12 | カウンシル オブ サイエンティフィク アンド インダストリアル リサーチ | pH感受性ポリマーを含む風味マスクされる医薬組成物 |
| US20050136114A1 (en) * | 2003-12-19 | 2005-06-23 | Council Of Scientific And Industrial Research | Taste masked pharmaceutical compositions comprising bitter drug and pH sensitive polymer |
| US8394409B2 (en) | 2004-07-01 | 2013-03-12 | Intellipharmaceutics Corp. | Controlled extended drug release technology |
| US10624858B2 (en) * | 2004-08-23 | 2020-04-21 | Intellipharmaceutics Corp | Controlled release composition using transition coating, and method of preparing same |
| US20060127479A1 (en) * | 2004-10-08 | 2006-06-15 | Natrajan Kumaraperumal | Solvent free taste masked pharmaceutical compositions |
| BRPI0419125A (pt) * | 2004-12-10 | 2007-12-11 | Council Scient Ind Res | composição farmacêutica e processo para a preparação de uma composição farmacêutica |
| US8874082B2 (en) * | 2005-05-25 | 2014-10-28 | Qualcomm Incorporated | Apparatus and methods for protecting data on a wireless device |
| DE102005042039A1 (de) * | 2005-09-02 | 2007-03-08 | Basf Ag | Wässrige Polyvinylacetatdispersionen mit hoher Scherstabilität |
| US7811604B1 (en) | 2005-11-14 | 2010-10-12 | Barr Laboratories, Inc. | Non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising clozapine and methods of making and using the same |
| US10064828B1 (en) | 2005-12-23 | 2018-09-04 | Intellipharmaceutics Corp. | Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems |
| CN101453993A (zh) | 2006-04-03 | 2009-06-10 | 伊萨·奥迪迪 | 含有机溶胶涂层的受控释放递送物件 |
| US10960077B2 (en) | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
| WO2009016258A1 (de) * | 2007-08-02 | 2009-02-05 | Basf Se | Wässrige polymerdispersion auf basis von n, n-diethylaminoethylmethacrylat, deren herstellung und verwendung |
| WO2009079555A2 (en) * | 2007-12-17 | 2009-06-25 | Anna Love | Soft tissue filler |
| CN102365083A (zh) * | 2009-03-18 | 2012-02-29 | 赢创罗姆有限公司 | 采用包含聚合物混合物和赋形剂的包衣的具有耐乙醇影响的控释药物组合物 |
| EP2493452B1 (en) * | 2009-10-28 | 2013-07-17 | Basf Se | Stable protective coatings for pharmaceutical dosage forms |
| EP2613770A1 (de) | 2010-09-07 | 2013-07-17 | Basf Se | Verwendung von copolymeren auf basis von aminogruppenhaltigen polymeren als matrixbindemittel für die herstellung von wirkstoffhaltigen granulaten und darreichungsformen |
| US9795576B2 (en) | 2010-09-27 | 2017-10-24 | Basf Se | Protective coatings for acidic active ingredients |
| WO2012041788A1 (de) | 2010-09-27 | 2012-04-05 | Basf Se | Protektive überzüge für saure wirkstoffe |
| EP2627677B1 (en) * | 2010-10-13 | 2014-07-16 | Evonik Röhm GmbH | Process for preparing a (meth)acrylate copolymer containing tertiary amino groups by free-radical polymerization in solution |
| EP2681263B1 (de) | 2011-02-28 | 2018-09-12 | Basf Se | Herstellung von pulverförmigen überzugsmitteln für stabile protektive überzüge für pharmazeutische dosierungsformen |
| WO2012116941A1 (de) | 2011-02-28 | 2012-09-07 | Basf Se | Herstellung von pulverförmigen überzugsmitteln für stabile protektive überzüge für pharmazeutische dosierungsformen |
| US8865250B2 (en) | 2011-02-28 | 2014-10-21 | Basf Se | Production of pulverulent coating compositions for stable protective coatings for pharmaceutical dosage forms |
| US8962064B2 (en) | 2011-02-28 | 2015-02-24 | Basf Se | Production of pulverulent coating compositions for stable protective coatings for pharmaceutical dosage forms |
| US9044734B2 (en) | 2011-09-23 | 2015-06-02 | Basf Se | Diesel oxidation catalyst with layered structure containing ceria composition as palladium support material for enhanced HC and CO gas conversion |
| US20130236505A1 (en) | 2012-03-09 | 2013-09-12 | Basf Se | Production Of Pharmaceutical Protective Coatings With Good Resistance In A Neutral Environment |
| EP2636403A1 (de) | 2012-03-09 | 2013-09-11 | Basf Se | Herstellung von pharmazeutischen protektiven Überzügen mit guter Resistenz im neutralen Milieu |
| US10668156B2 (en) | 2012-06-22 | 2020-06-02 | Basf Se | Active-ingredient-containing solid dispersions based on diethylaminoethyl methacrylate copolymers |
| EP2863953A1 (de) | 2012-06-22 | 2015-04-29 | Basf Se | Wirkstoffhaltige festen dispersionen auf basis von diethylaminoethylmethacrylat-copolymeren |
| CA2886626A1 (en) | 2012-09-28 | 2014-04-03 | Evonik Industries Ag | Process for preparing aqueous dispersions |
| FR3007290B1 (fr) * | 2013-06-25 | 2015-06-26 | Expressions Aromatiques | Procede de fabrication de granules contenant un principe actif, a dluo et charge en principe actif optimisees |
| WO2016205701A1 (en) | 2015-06-19 | 2016-12-22 | University Of Southern California | Enteral fast access tract platform system |
| WO2016205754A1 (en) | 2015-06-19 | 2016-12-22 | University Of Southern California | Compositions and methods for modified nutrient delivery |
| WO2021101944A1 (en) * | 2019-11-21 | 2021-05-27 | Dow Global Technologies Llc | Multistage polymer |
| CN111410714A (zh) * | 2020-05-16 | 2020-07-14 | 连云港万泰医药辅料技术有限公司 | 一种胃溶型包衣材料聚丙烯酸树脂ⅳ的制备方法 |
| CA3203975A1 (en) | 2020-12-03 | 2022-06-09 | Battelle Memorial Institute | Polymer nanoparticle and dna nanostructure compositions and methods for non-viral delivery |
| AU2022253899A1 (en) | 2021-04-07 | 2023-10-26 | Battelle Memorial Institute | Rapid design, build, test, and learn technologies for identifying and using non-viral carriers |
| WO2025072751A1 (en) | 2023-09-29 | 2025-04-03 | Battelle Memorial Institute | Polymer nanoparticle compositions for in vivo expression of polypeptides |
| WO2025122954A1 (en) | 2023-12-08 | 2025-06-12 | Battelle Memorial Institute | Use of dna origami nanostructures for molecular information based data storage systems |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3049179A1 (de) * | 1975-03-20 | 1982-07-29 | Röhm GmbH, 6100 Darmstadt | Bindemittel fuer arzneimittelueberzuege. |
| DE2543542C2 (de) * | 1975-09-30 | 1986-10-02 | Röhm GmbH, 6100 Darmstadt | Verfahren zur Herstellung eines Plastisols |
| DE3421860C2 (de) * | 1984-06-13 | 1994-09-15 | Roehm Gmbh | Verfahren zum Überziehen von Arzneiformen |
| EP0164669B1 (de) * | 1984-06-13 | 1991-01-23 | Röhm Gmbh | Verfahren zum Überziehen von Arzneiformen |
| DE3438291A1 (de) * | 1984-10-19 | 1986-04-24 | Röhm GmbH, 6100 Darmstadt | Verfahren zur herstellung einer waessrigen ueberzugsmitteldispersion und ihre verwendung zum ueberziehen von arzneimitteln |
| US5025004A (en) * | 1988-06-13 | 1991-06-18 | Eastman Kodak Company | Water-dispersible polymeric compositions |
| US5292522A (en) * | 1989-06-20 | 1994-03-08 | Rohm Gmbh | Aqueous film coating agent for solid medicaments |
| DE4310012A1 (de) * | 1993-03-27 | 1994-09-29 | Roehm Gmbh | Dermales therapeutisches System aus einer schmelzfähigen Poly(meth)acrylat-Mischung |
| DE29502547U1 (de) * | 1995-02-16 | 1995-03-30 | Röhm GmbH, 64293 Darmstadt | Thermoplastisches Überzugs- und Bindemittel für Arzneiformen |
| US6391338B1 (en) * | 1995-09-07 | 2002-05-21 | Biovail Technologies Ltd. | System for rendering substantially non-dissoluble bio-affecting agents bio-available |
| AU2576797A (en) * | 1996-04-22 | 1997-11-12 | Toyama Chemical Co. Ltd. | Patch containing 1,2-ethanediol derivatives or salts thereof |
| JP4227677B2 (ja) * | 1996-12-10 | 2009-02-18 | 杏林製薬株式会社 | 被膜形成性抗真菌剤組成物 |
| DE19653606A1 (de) * | 1996-12-20 | 1998-06-25 | Roehm Gmbh | Haft- und Bindemittel aus (Meth)acrylatpolymer, organischer Säure und Weichmacher |
| JP3962963B2 (ja) * | 1997-06-09 | 2007-08-22 | 荒川化学工業株式会社 | 四級アンモニウム塩基を有するポリマーおよびその製造方法 |
| EP1027036A2 (en) * | 1997-10-03 | 2000-08-16 | ELAN CORPORATION, Plc | Taste masked formulations |
-
1999
- 1999-04-23 DE DE19918435A patent/DE19918435A1/de not_active Withdrawn
- 1999-07-02 MX MXPA01000793 patent/MX217361B/es not_active IP Right Cessation
- 1999-07-02 KR KR1020067014125A patent/KR100663663B1/ko not_active Expired - Fee Related
- 1999-07-02 US US09/764,993 patent/US6624210B1/en not_active Expired - Lifetime
- 1999-07-02 HK HK02100486.9A patent/HK1041014B/zh not_active IP Right Cessation
- 1999-07-02 ES ES99931245T patent/ES2190226T3/es not_active Expired - Lifetime
- 1999-07-02 IL IL14077199A patent/IL140771A/xx not_active IP Right Cessation
- 1999-07-02 AU AU47815/99A patent/AU4781599A/en not_active Abandoned
- 1999-07-02 CN CNB998079669A patent/CN1142212C/zh not_active Expired - Fee Related
- 1999-07-02 WO PCT/EP1999/004620 patent/WO2000005307A1/de not_active Ceased
- 1999-07-02 EP EP99931245A patent/EP1098935B1/de not_active Expired - Lifetime
- 1999-07-02 SK SK79-2001A patent/SK287838B6/sk not_active IP Right Cessation
- 1999-07-02 CA CA002338750A patent/CA2338750C/en not_active Expired - Fee Related
- 1999-07-02 JP JP2000561259A patent/JP4636687B2/ja not_active Expired - Fee Related
- 1999-07-02 TR TR2001/00196T patent/TR200100196T2/tr unknown
- 1999-07-02 PL PL345581A patent/PL199235B1/pl unknown
- 1999-07-02 DE DE59903917T patent/DE59903917D1/de not_active Expired - Lifetime
- 1999-07-02 AT AT99931245T patent/ATE230426T1/de active
- 1999-07-02 BR BRPI9912353-3A patent/BR9912353B1/pt not_active IP Right Cessation
- 1999-07-02 KR KR1020017001032A patent/KR100646114B1/ko not_active Expired - Fee Related
-
2003
- 2003-06-18 US US10/463,539 patent/US6846891B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR20060092288A (ko) | 2006-08-22 |
| HK1041014B (zh) | 2004-10-08 |
| US6846891B2 (en) | 2005-01-25 |
| US20030220413A1 (en) | 2003-11-27 |
| MXPA01000793A (es) | 2002-04-08 |
| KR100663663B1 (ko) | 2007-01-03 |
| ATE230426T1 (de) | 2003-01-15 |
| BR9912353A (pt) | 2001-04-17 |
| SK792001A3 (en) | 2002-01-07 |
| SK287838B6 (sk) | 2011-12-05 |
| WO2000005307A1 (de) | 2000-02-03 |
| CA2338750C (en) | 2009-12-08 |
| IL140771A0 (en) | 2002-02-10 |
| PL199235B1 (pl) | 2008-08-29 |
| EP1098935A1 (de) | 2001-05-16 |
| CN1142212C (zh) | 2004-03-17 |
| KR20010079560A (ko) | 2001-08-22 |
| ES2190226T3 (es) | 2003-07-16 |
| DE59903917D1 (de) | 2003-02-06 |
| MX217361B (es) | 2003-11-04 |
| DE19918435A1 (de) | 2000-01-27 |
| PL345581A1 (en) | 2001-12-17 |
| US6624210B1 (en) | 2003-09-23 |
| KR100646114B1 (ko) | 2006-11-17 |
| CA2338750A1 (en) | 2000-02-03 |
| EP1098935B1 (de) | 2003-01-02 |
| BR9912353B1 (pt) | 2012-01-24 |
| JP2002521393A (ja) | 2002-07-16 |
| AU4781599A (en) | 2000-02-14 |
| JP4636687B2 (ja) | 2011-02-23 |
| CN1307613A (zh) | 2001-08-08 |
| HK1041014A1 (en) | 2002-06-28 |
| IL140771A (en) | 2005-06-19 |
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