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WO2001075149A3 - Biosensor, biosensor-array und verfahren zum ermitteln makromolekularer biopolymere mit einem biosensor - Google Patents

Biosensor, biosensor-array und verfahren zum ermitteln makromolekularer biopolymere mit einem biosensor Download PDF

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Publication number
WO2001075149A3
WO2001075149A3 PCT/DE2001/001240 DE0101240W WO0175149A3 WO 2001075149 A3 WO2001075149 A3 WO 2001075149A3 DE 0101240 W DE0101240 W DE 0101240W WO 0175149 A3 WO0175149 A3 WO 0175149A3
Authority
WO
WIPO (PCT)
Prior art keywords
biosensor
array
macromolecular biopolymers
electrode
detecting macromolecular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2001/001240
Other languages
English (en)
French (fr)
Other versions
WO2001075149A2 (de
Inventor
Roland Thewes
Werner Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Infineon Technologies AG
Original Assignee
Infineon Technologies AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Infineon Technologies AG filed Critical Infineon Technologies AG
Priority to JP2001573023A priority Critical patent/JP3810688B2/ja
Priority to US10/239,481 priority patent/US7223330B2/en
Priority to EP01927636A priority patent/EP1272849A2/de
Publication of WO2001075149A2 publication Critical patent/WO2001075149A2/de
Publication of WO2001075149A3 publication Critical patent/WO2001075149A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3277—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a redox reaction, e.g. detection by cyclic voltammetry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Cell Biology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Der Biosensor weist drei Elektroden auf, wobei die erste Elektrode eines Haltebereichs zum Halten von Sondenmolekülen aufweist, die makromolekulare Biopolymere binden können. Die zweite Elektrode und die dritte Elektrode sind derart ausgestaltet, dass dere Redox-Prozess im Rahmen eines Redox-Recycling-Vorgangs an der zweiten Elektrode und an der dritten Elektrode erfolgt.
PCT/DE2001/001240 2000-03-30 2001-03-29 Biosensor, biosensor-array und verfahren zum ermitteln makromolekularer biopolymere mit einem biosensor Ceased WO2001075149A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2001573023A JP3810688B2 (ja) 2000-03-30 2001-03-29 バイオセンサー、バイオセンサーアレイ、および、バイオセンサーを用いた巨大分子生体高分子の検出方法
US10/239,481 US7223330B2 (en) 2000-03-30 2001-03-29 Biosensor, biosensor array and method for detecting macromolecular biopolymers with a biosensor
EP01927636A EP1272849A2 (de) 2000-03-30 2001-03-29 Biosensor, biosensor-array und verfahren zum ermitteln makromolekularer biopolymere mit einem biosensor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10015959 2000-03-30
DE10015959.1 2000-03-30

Publications (2)

Publication Number Publication Date
WO2001075149A2 WO2001075149A2 (de) 2001-10-11
WO2001075149A3 true WO2001075149A3 (de) 2002-05-23

Family

ID=7637060

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2001/001240 Ceased WO2001075149A2 (de) 2000-03-30 2001-03-29 Biosensor, biosensor-array und verfahren zum ermitteln makromolekularer biopolymere mit einem biosensor

Country Status (4)

Country Link
US (1) US7223330B2 (de)
EP (1) EP1272849A2 (de)
JP (1) JP3810688B2 (de)
WO (1) WO2001075149A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6922081B2 (en) 2000-10-16 2005-07-26 Infineon Technologies Ag Electronic circuit, sensor arrangement and method for processing a sensor signal
DE10220935B3 (de) * 2002-05-10 2004-02-05 Siemens Ag Verfahren für die biochemische Analytik von DNA und zugehörige Anordnung
DE102004031370B4 (de) * 2004-06-29 2022-03-24 Siemens Aktiengesellschaft Vorrichtung und Verfahren zur Emulation einer Gegenelektrode in einem monolithisch integrierten elektrochemischen Analysesystem
DE102004031672A1 (de) * 2004-06-30 2006-01-19 Infineon Technologies Ag Planar-Sensor-Anordnung, Sensor-Array und Verfahren zum Herstellen einer Planar-Sensor-Anordnung
US20140042038A1 (en) * 2008-04-14 2014-02-13 University Of South Florida Microfluidic electrochemical genotyping system
KR20100025328A (ko) * 2008-08-27 2010-03-09 삼성전자주식회사 이중가닥 영역과 말단 단일가닥 영역을 포함하는 이중가닥 핵산 프로브가 고정된 마이크로어레이를 제조하는 방법
EP2462238B1 (de) * 2009-08-07 2013-07-17 Ohmx Corporation Enzyme-gesteuerter redox-ändernder chemischer eliminierungs- (e-trace-) immunassay
WO2015151395A1 (ja) * 2014-03-31 2015-10-08 パナソニックＩｐマネジメント株式会社 電気化学測定デバイス
JP6116080B1 (ja) * 2016-04-26 2017-04-19 日本航空電子工業株式会社 電気化学測定方法、電気化学測定装置及びトランスデューサ
TWI745392B (zh) * 2017-06-29 2021-11-11 瑞禾生物科技股份有限公司 生物感測元件及其製造方法以及生物分子檢測方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999007879A1 (en) * 1997-08-12 1999-02-18 University Of Southern California Electrochemical reporter system for detecting analytical immunoassay and molecular biology procedures
WO1999060399A1 (en) * 1998-05-21 1999-11-25 Cornell Research Foundation, Inc. Liposome-enhanced test device and method
WO1999063346A1 (en) * 1998-06-01 1999-12-09 Roche Diagnostics Corporation Method and device for electrochemical immunoassay of multiple analytes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08128987A (ja) 1994-10-31 1996-05-21 Matsushita Electric Ind Co Ltd バイオセンサー及びその製造方法
DE69632921T2 (de) * 1995-12-01 2005-07-14 Innogenetics N.V. System und verfahren zur bestimmung der impedanz und herstellungsverfahren
IL116921A (en) 1996-01-26 2000-11-21 Yissum Res Dev Co Electrochemical system for determination of an analyte in a liquid medium
US6682648B1 (en) * 1997-08-12 2004-01-27 University Of Southern California Electrochemical reporter system for detecting analytical immunoassay and molecular biology procedures

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999007879A1 (en) * 1997-08-12 1999-02-18 University Of Southern California Electrochemical reporter system for detecting analytical immunoassay and molecular biology procedures
WO1999060399A1 (en) * 1998-05-21 1999-11-25 Cornell Research Foundation, Inc. Liposome-enhanced test device and method
WO1999063346A1 (en) * 1998-06-01 1999-12-09 Roche Diagnostics Corporation Method and device for electrochemical immunoassay of multiple analytes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HINTSCHE R ET AL: "Microbiosensors using electrodes made in Si-technology.", EXPERIENTIA SUPPLEMENTUM (BASEL), vol. 80, 1997, Birkhaeuser Verlag; P. O. Box 133, CH-4010 Basel, Switzerland., pages 267 - 283, XP000863543 *
NIWA O ET AL: "Small-volume voltammetric detection of 4-aminophenol with interdigitated array electrodes and its application to electrochemical enzyme immunoassay", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 65, no. 11, 1993, pages 1559 - 1563, XP002082750, ISSN: 0003-2700 *
VAN GERWEN ET AL: "Nanoscaled interdigitated electrode arrays for biochemical sensors", 1997 INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS AND ACTUATORS. DIGEST OF TECHNICAL PAPERS. TRANSDUCERS 97. CHICAGO, IL, JUNE 16 - 19, 1997. SESSIONS 3A1 - 4D3. PAPERS NO. 3A1.01 - 4D3.14P, INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS AND ACTU, vol. 2, 16 June 1997 (1997-06-16), pages 907 - 910, XP010240622, ISBN: 0-7803-3829-4 *

Also Published As

Publication number Publication date
EP1272849A2 (de) 2003-01-08
WO2001075149A2 (de) 2001-10-11
JP2003529771A (ja) 2003-10-07
US20040045839A1 (en) 2004-03-11
JP3810688B2 (ja) 2006-08-16
US7223330B2 (en) 2007-05-29

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