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WO2001074341A3 - Composition for treating allergic and inflammatory conditions with cough containing a non-sedating histamine and an expectorant - Google Patents

Composition for treating allergic and inflammatory conditions with cough containing a non-sedating histamine and an expectorant Download PDF

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Publication number
WO2001074341A3
WO2001074341A3 PCT/US2001/010019 US0110019W WO0174341A3 WO 2001074341 A3 WO2001074341 A3 WO 2001074341A3 US 0110019 W US0110019 W US 0110019W WO 0174341 A3 WO0174341 A3 WO 0174341A3
Authority
WO
WIPO (PCT)
Prior art keywords
expectorant
inflammatory conditions
cough
composition
treating allergic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/010019
Other languages
French (fr)
Other versions
WO2001074341A2 (en
Inventor
Lugo Sergio Rolando Ulloa
Ramos Jose De Jesus Villacampa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to NZ520826A priority Critical patent/NZ520826A/en
Priority to AU4786701A priority patent/AU4786701A/en
Priority to AU2001247867A priority patent/AU2001247867B2/en
Publication of WO2001074341A2 publication Critical patent/WO2001074341A2/en
Publication of WO2001074341A3 publication Critical patent/WO2001074341A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

The use of a non-sedating antihistamine in combination with an expectorant for the preparation of a medicament for treatment and/or prevention allergic and inflammatory conditions with cough in humans in need of such treating and/or preventing which comprise an effective amount of a non-sedating antihistamine, preferably loratadine, in combination with an expectorant, preferably ambroxol are disclosed. Pharmaceutical compositions for treating and/or preventing allergic and inflammatory conditions with cough in humans comprising an effective amount of a non-sedating antihistamine in combination with an expectorant and a pharmaceutically acceptable carrier are also disclosed.
PCT/US2001/010019 2000-03-30 2001-03-28 Composition for treating allergic and inflammatory conditions with cough containing a non-sedating histamine and an expectorant Ceased WO2001074341A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
NZ520826A NZ520826A (en) 2000-03-30 2001-03-28 Compositions and methods for treating allergic and inflammatory conditions with cough containing a non-sedating histamine and an expectorant
AU4786701A AU4786701A (en) 2000-03-30 2001-03-28 Compositions and methods for treating allergic and inflammatory conditions with cough
AU2001247867A AU2001247867B2 (en) 2000-03-30 2001-03-28 Composition for treating allergic and inflammatory conditions with cough containing a non-sedating histamine and an expectorant

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19331000P 2000-03-30 2000-03-30
US60/193,310 2000-03-30

Publications (2)

Publication Number Publication Date
WO2001074341A2 WO2001074341A2 (en) 2001-10-11
WO2001074341A3 true WO2001074341A3 (en) 2002-05-16

Family

ID=22713096

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/010019 Ceased WO2001074341A2 (en) 2000-03-30 2001-03-28 Composition for treating allergic and inflammatory conditions with cough containing a non-sedating histamine and an expectorant

Country Status (13)

Country Link
CN (1) CN1422162A (en)
AR (1) AR025308A1 (en)
AU (2) AU4786701A (en)
BR (1) BR0003648A (en)
CO (1) CO5200779A1 (en)
CR (1) CR6232A (en)
NZ (1) NZ520826A (en)
PA (1) PA8500101A1 (en)
PE (1) PE20010576A1 (en)
SG (1) SG96611A1 (en)
TW (1) TWI243671B (en)
WO (1) WO2001074341A2 (en)
ZA (1) ZA200102605B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1323662C (en) * 2004-06-18 2007-07-04 江苏恒瑞医药股份有限公司 Pharmaceutical composition containing ambroxol and erdosteine or acetylcysteine and application thereof
WO2005123052A1 (en) * 2004-06-18 2005-12-29 Jiangsu Hengrui Medicine Co., Ltd. Drug composition containing ambroxol and erdosteine or acetylcysteine

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985004589A1 (en) * 1984-04-09 1985-10-24 Abraham Sunshine Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs
WO1988008302A1 (en) * 1987-04-24 1988-11-03 Abraham Sunshine Cough/cold mixtures comprising non-sedating antihistamine drugs
WO1988009656A1 (en) * 1987-06-08 1988-12-15 Abraham Sunshine Cough/cold mixtures comprising non-sedating antihistamine drugs
WO1995007103A1 (en) * 1993-09-07 1995-03-16 The Procter & Gamble Company Compositions containing an amino acid salt of propionic acid non-steroidal anti-inflammatory agent and at least one of a decongestant, an expectorant, an antihistamine and an antitussive
WO1999066919A1 (en) * 1998-06-19 1999-12-29 Mcneil-Ppc, Inc. Pharmaceutical composition containing a salt of acetaminophen and at least one other active ingredient

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985004589A1 (en) * 1984-04-09 1985-10-24 Abraham Sunshine Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs
WO1988008302A1 (en) * 1987-04-24 1988-11-03 Abraham Sunshine Cough/cold mixtures comprising non-sedating antihistamine drugs
WO1988009656A1 (en) * 1987-06-08 1988-12-15 Abraham Sunshine Cough/cold mixtures comprising non-sedating antihistamine drugs
WO1995007103A1 (en) * 1993-09-07 1995-03-16 The Procter & Gamble Company Compositions containing an amino acid salt of propionic acid non-steroidal anti-inflammatory agent and at least one of a decongestant, an expectorant, an antihistamine and an antitussive
WO1999066919A1 (en) * 1998-06-19 1999-12-29 Mcneil-Ppc, Inc. Pharmaceutical composition containing a salt of acetaminophen and at least one other active ingredient

Also Published As

Publication number Publication date
ZA200102605B (en) 2001-10-03
CO5200779A1 (en) 2002-09-27
PA8500101A1 (en) 2002-09-17
TWI243671B (en) 2005-11-21
AU4786701A (en) 2001-10-15
CN1422162A (en) 2003-06-04
AR025308A1 (en) 2002-11-20
PE20010576A1 (en) 2001-05-08
AU2001247867B2 (en) 2005-09-01
CR6232A (en) 2008-12-01
NZ520826A (en) 2004-07-30
WO2001074341A2 (en) 2001-10-11
BR0003648A (en) 2002-01-02
SG96611A1 (en) 2003-06-16

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