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WO2001068137A3 - Compositions for regulating memory consolidation - Google Patents

Compositions for regulating memory consolidation Download PDF

Info

Publication number
WO2001068137A3
WO2001068137A3 PCT/US2001/008091 US0108091W WO0168137A3 WO 2001068137 A3 WO2001068137 A3 WO 2001068137A3 US 0108091 W US0108091 W US 0108091W WO 0168137 A3 WO0168137 A3 WO 0168137A3
Authority
WO
WIPO (PCT)
Prior art keywords
animal
compositions
agonist
memory consolidation
regulating memory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/008091
Other languages
French (fr)
Other versions
WO2001068137A2 (en
Inventor
Cristina M Alberini
Mark F Bear
Kjesten A Wiig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brown University Research Foundation Inc
Howard Hughes Medical Institute
Original Assignee
Brown University Research Foundation Inc
Howard Hughes Medical Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brown University Research Foundation Inc, Howard Hughes Medical Institute filed Critical Brown University Research Foundation Inc
Priority to AU2001243635A priority Critical patent/AU2001243635A1/en
Publication of WO2001068137A2 publication Critical patent/WO2001068137A2/en
Publication of WO2001068137A3 publication Critical patent/WO2001068137A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Enhancing memory consolidation in an animal, by administering to the animal an adrenergic neurotransmitter or agonist thereof, and a cholinergic or glutaminergic neurotransmitter or agonist thereof, in an amount sufficient to enhance long-term memory in the animal. Enhancing memory consolidation in an animal, by administering to the animal a cAMP agonist and a PKC agonist in an amount sufficient to enhance long-term memory in the animal.
PCT/US2001/008091 2000-03-14 2001-03-14 Compositions for regulating memory consolidation Ceased WO2001068137A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001243635A AU2001243635A1 (en) 2000-03-14 2001-03-14 Methods and compositions for regulating memory consolidation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18915900P 2000-03-14 2000-03-14
US60/189,159 2000-03-14

Publications (2)

Publication Number Publication Date
WO2001068137A2 WO2001068137A2 (en) 2001-09-20
WO2001068137A3 true WO2001068137A3 (en) 2002-04-11

Family

ID=22696176

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/008091 Ceased WO2001068137A2 (en) 2000-03-14 2001-03-14 Compositions for regulating memory consolidation

Country Status (2)

Country Link
AU (1) AU2001243635A1 (en)
WO (1) WO2001068137A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001251242A1 (en) * 2000-03-31 2001-10-15 Brown University Reseach Foundation Methods and compositions for regulating memory consolidation
DE10142175A1 (en) * 2001-10-09 2003-03-27 Eucro Europe Contract Res Gmbh Use of beta-adrenoceptor agonists, e.g. reproterol, salmeterol or terbutaline, for restoring and/or maintaining function of damaged nerve cells, e.g. for treatment of neurodegenerative diseases
US6825229B2 (en) 2002-03-07 2004-11-30 Blanchette Rockefeller Neurosciences Institute Methods for Alzheimer's Disease treatment and cognitive enhancement
US20050065205A1 (en) 2002-03-07 2005-03-24 Daniel Alkon Methods for Alzheimer's disease treatment and cognitive enhance
TW200538181A (en) 2004-05-18 2005-12-01 Brni Neurosciences Inst Treatment of depressive disorders
WO2007016202A1 (en) 2005-07-29 2007-02-08 Blanchette Rockefeller Neurosciences Institute Use of a pkc activator, alone or combined with a pkc inhibitor to enhance long term memory
US20080058396A1 (en) * 2006-07-28 2008-03-06 Alkon Daniel L Methods of stimulating cellular growth, synaptic remodelling and consolidation of long-term memory
KR20090119894A (en) * 2007-02-09 2009-11-20 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 Therapeutic Effects of Briostatin, Briolog and Other Related Substances on Head Trauma-Induced Memory Disorder and Brain Injury
PL220308B1 (en) 2011-06-03 2015-10-30 Kobel Buys Krystyna Use of clenbuterol for autism treatment
WO2013139700A1 (en) * 2012-03-21 2013-09-26 Ac Immune S.A. Memory genes

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2821778A1 (en) * 1978-05-18 1979-12-20 Dso Pharmachim Prophylactic antidotes to organo-phosphorus poisoning - contain hyoscine butyl bromate, a propanol chlor:hydrate, di:methyl-carbamoxy-phenyl-tri:methyl ammonium bromate and ephedrine
RO82672A2 (en) * 1981-06-26 1983-10-15 Intreprinderea De Medicamente"Biofarm",Ro ANTIASMATIC SOLUTION FOR AEROSOLS
FR2710267A1 (en) * 1993-07-12 1995-03-31 Urso Michel Composition for the treatment of male impotence.
US5603918A (en) * 1995-06-09 1997-02-18 Boehringer Ingelheim Pharmaceuticals, Inc. Aerosol composition of a salt of ipratropium and a salt of albuterol
US5871771A (en) * 1989-05-31 1999-02-16 Boehringer Ingelheim Kg Micronized biodegradable particles, process for preparing them and use thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2821778A1 (en) * 1978-05-18 1979-12-20 Dso Pharmachim Prophylactic antidotes to organo-phosphorus poisoning - contain hyoscine butyl bromate, a propanol chlor:hydrate, di:methyl-carbamoxy-phenyl-tri:methyl ammonium bromate and ephedrine
RO82672A2 (en) * 1981-06-26 1983-10-15 Intreprinderea De Medicamente"Biofarm",Ro ANTIASMATIC SOLUTION FOR AEROSOLS
US5871771A (en) * 1989-05-31 1999-02-16 Boehringer Ingelheim Kg Micronized biodegradable particles, process for preparing them and use thereof
FR2710267A1 (en) * 1993-07-12 1995-03-31 Urso Michel Composition for the treatment of male impotence.
US5603918A (en) * 1995-06-09 1997-02-18 Boehringer Ingelheim Pharmaceuticals, Inc. Aerosol composition of a salt of ipratropium and a salt of albuterol

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BUCCAFUSCO, JERRY J. ET AL: "Effects of concomitant cholinergic and adrenergic stimulation on learning and memory performance by primates", LIFE SCI. (1992), 51(2), PL7-PL12, XP001033725 *
CAMACHO FERNANDO ET AL: "Alpha-2-Adrenoceptor antagonists potentiate acetylcholinesterase inhibitor effects on passive avoidance learning in the rat.", PSYCHOPHARMACOLOGY, vol. 124, no. 4, 1996, pages 347 - 354, XP001029453, ISSN: 0033-3158 *
DALMAZ CARLA ET AL: "Noradrenergic and cholinergic interactions in the amygdala and the modulation of memory storage.", BEHAVIOURAL BRAIN RESEARCH, vol. 58, no. 1-2, 1993, pages 167 - 174, XP001029450, ISSN: 0166-4328 *
DATABASE WPI Section Ch Week 198412, Derwent World Patents Index; Class B05, AN 1984-072819, XP002181558 *
INTROINI-COLLISON I B ET AL: "MODULATION OF MEMORY BY POST-TRAINING EPINEPHRINE INVOLVEMENT OF CHOLINERGIC MECHANISMS", PSYCHOPHARMACOLOGY, vol. 94, no. 3, 1988, pages 379 - 385, XP001029456, ISSN: 0033-3158 *
INTROINI-COLLISON, INES B. ET AL: "Memory-modulatory effects of centrally acting noradrenergic drugs: possible involvement of brain cholinergic mechanisms", BEHAV. NEURAL BIOL. (1992), 57(3), 248-55, XP001033701 *

Also Published As

Publication number Publication date
AU2001243635A1 (en) 2001-09-24
WO2001068137A2 (en) 2001-09-20

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