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WO2001040461A3 - cDNA-SEQUENZEN VON ZWEI INTERAKTOREN FANCIP4 UND FANCIP5 DER FANCONI-ANÄMIE-PROTEINE DER KOMPLEMENTATIONSGRUPPEN A UND C - Google Patents

cDNA-SEQUENZEN VON ZWEI INTERAKTOREN FANCIP4 UND FANCIP5 DER FANCONI-ANÄMIE-PROTEINE DER KOMPLEMENTATIONSGRUPPEN A UND C Download PDF

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Publication number
WO2001040461A3
WO2001040461A3 PCT/EP2000/012197 EP0012197W WO0140461A3 WO 2001040461 A3 WO2001040461 A3 WO 2001040461A3 EP 0012197 W EP0012197 W EP 0012197W WO 0140461 A3 WO0140461 A3 WO 0140461A3
Authority
WO
WIPO (PCT)
Prior art keywords
fancip5
fancip4
proteins
interactors
cdna sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/012197
Other languages
English (en)
French (fr)
Other versions
WO2001040461A2 (de
Inventor
Hans Joachim Gross
Tanja Reuter
Helmut Hanenberg
Sabine Herterich
Matthias Wagner
Holger Hoehn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MultiGene Biotech GmbH
Original Assignee
MultiGene Biotech GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MultiGene Biotech GmbH filed Critical MultiGene Biotech GmbH
Priority to AU33628/01A priority Critical patent/AU3362801A/en
Publication of WO2001040461A2 publication Critical patent/WO2001040461A2/de
Anticipated expiration legal-status Critical
Publication of WO2001040461A3 publication Critical patent/WO2001040461A3/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Die vorliegende Erfindung betrifft die cDNAs von zwei Interaktoren (FANCIP4 UND FANCIP5) des Fanconi-Anämie-Proteins der Komplementationsgruppen A und C (FANCA und FANCC) sowie die davon codierten Polypeptide und Proteine. Weitere Gegenstände sind die entsprechenden Gene, gegen die Proteine gerichtete Antikörper, FANCIP4- bzw. FANCIP5-transgene Organismen und Zellen sowie die Verwendung von FANCIP4 bzw. FANCIP5 zum Effektor-Screening und die pharmazeutische Anwendung der Nukleinsäuren, der Polypeptide, der Proteine und der Antikörper.
PCT/EP2000/012197 1999-12-06 2000-12-05 cDNA-SEQUENZEN VON ZWEI INTERAKTOREN FANCIP4 UND FANCIP5 DER FANCONI-ANÄMIE-PROTEINE DER KOMPLEMENTATIONSGRUPPEN A UND C Ceased WO2001040461A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU33628/01A AU3362801A (en) 1999-12-06 2000-12-05 Cdna sequence of two interactors fancip4 and fancip5 of the fanconi anaemia proteins of the complementation groups a and

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19958680.2 1999-12-06
DE1999158680 DE19958680A1 (de) 1999-12-06 1999-12-06 cDNA-Sequenzen von zwei Interaktoren FANCIP4 und FANCIP5 der Fanconi-Anämie-Pr oteine der Komplementationsgruppen A und C

Publications (2)

Publication Number Publication Date
WO2001040461A2 WO2001040461A2 (de) 2001-06-07
WO2001040461A3 true WO2001040461A3 (de) 2002-06-20

Family

ID=7931548

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/012197 Ceased WO2001040461A2 (de) 1999-12-06 2000-12-05 cDNA-SEQUENZEN VON ZWEI INTERAKTOREN FANCIP4 UND FANCIP5 DER FANCONI-ANÄMIE-PROTEINE DER KOMPLEMENTATIONSGRUPPEN A UND C

Country Status (3)

Country Link
AU (1) AU3362801A (de)
DE (1) DE19958680A1 (de)
WO (1) WO2001040461A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2381526A (en) * 2001-11-03 2003-05-07 Sequenom Inc Detection of predisposition to osteoporosis
CA2500731A1 (en) * 2002-10-02 2004-04-15 Robert Y. L. Tsai Methods for controlling proliferation of cells

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998045428A1 (de) * 1997-04-07 1998-10-15 Roche Diagnostics Gmbh Fanconi-gen ii
WO1999004265A2 (en) * 1997-07-17 1999-01-28 Ludwig Institute For Cancer Research Cancer associated nucleic acids and polypeptides
EP1033401A2 (de) * 1999-02-26 2000-09-06 Genset Exprimierte Sequenzmarker und kodierte menschliche Proteine
WO2001012790A2 (en) * 1999-08-17 2001-02-22 Incyte Genomics, Inc. Isomerase proteins

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2134678A1 (en) * 1992-04-29 1993-11-11 Manuel Buchwald Fanconi anemia gene for complementation group c

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998045428A1 (de) * 1997-04-07 1998-10-15 Roche Diagnostics Gmbh Fanconi-gen ii
WO1999004265A2 (en) * 1997-07-17 1999-01-28 Ludwig Institute For Cancer Research Cancer associated nucleic acids and polypeptides
EP1033401A2 (de) * 1999-02-26 2000-09-06 Genset Exprimierte Sequenzmarker und kodierte menschliche Proteine
WO2001012790A2 (en) * 1999-08-17 2001-02-22 Incyte Genomics, Inc. Isomerase proteins

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
DATABASE EM_EST EMBL; 14 May 1996 (1996-05-14), MACKE J ET AL.: "24b2 Human retina cDNA randomly primed sublibrary Homo sapiens cDNA, mRNA sequence.", XP002183687 *
DATABASE EM_EST EMBL; 22 July 1999 (1999-07-22), HILLIER L ET AL.: "ap24h02.x1 Schiller oligodendroglioma Homo sapiens cDNA clone IMAGE:1956339 3' similar to WP:F39H2.2 CE16017 PEPTIDYLPROLYL ISOMERASE ;, mRNA sequence.", XP002183686 *
DATABASE EM_HUM EMBL; 26 April 2000 (2000-04-26), ZHAO Z ET AL.: "Homo sapiens HDCME13P mRNA, partial cds.", XP002183689 *
DATABASE GENBANK NCBI; 17 April 2000 (2000-04-17), WILLIAMS S: "Human DNA sequence from clone RP1-12G14 on chromosome 6q24.1-25.2. Contains the 5' end of the gene for a novel cyclophilin type Ribosomal protein S18) pseudogene, the 3' end of the KATNA1 gene for ATPase containing P60 katanin A1, ESTs, STSs, GSSs and two putative CpG islands, complete sequence.", XP002183688 *
DATABASE GSN / GSP EMBL; 6 October 2000 (2000-10-06), DUMAS MILNE EDWARDS J B ET AL.: "Human secreted protein 5' EST, SEQ ID NO: 2250 / human secreted protein, SEQ ID NO: 6327", XP002183695 *
GARCIA-HIGUERA I ET AL.: "Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex.", MOLECULAR AND CELLULAR BIOLOGY, vol. 19, no. 7, July 1999 (1999-07-01), pages 4866 - 4873, XP002183683, ISSN: 0270-7306 *
GARCIA-HIGUERA I ET AL.: "The molecular and cellular biology of Fanconi anemia", CURRENT OPINION IN HEMATOLOGY, vol. 6, no. 2, March 1999 (1999-03-01), pages 83 - 88, XP001041493 *
GÖTHEL S F ET AL: "Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts.", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 55, no. 3, March 1999 (1999-03-01), pages 423 - 436, XP001034726, ISSN: 1420-682X *
HOSHINO T ET AL: "Molecular chaperone GRP94 binds to the Fanconi anemia group C protein and regulates its intracellular expression", BLOOD, vol. 91, no. 11, 1 June 1998 (1998-06-01), pages 4379 - 4386, XP002159187, ISSN: 0006-4971 *
MCMAHON L W ET AL.: "Human alpha spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 46, 12 November 1999 (1999-11-12), pages 32904 - 32908, XP002183682, ISSN: 0021-9258 *
OTSUKI T ET AL.: "SNX5, a new member of the sorting nexin family, binds to the Fanconi anemia complementation group A protein.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 265, no. 3, 30 November 1999 (1999-11-30), pages 630 - 635, XP002183684, ISSN: 0006-291X *

Also Published As

Publication number Publication date
WO2001040461A2 (de) 2001-06-07
AU3362801A (en) 2001-06-12
DE19958680A1 (de) 2001-06-13

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