[go: up one dir, main page]

WO2000010522A1 - Agents de soins dermatologiques et cosmetiques pour la peau - Google Patents

Agents de soins dermatologiques et cosmetiques pour la peau Download PDF

Info

Publication number
WO2000010522A1
WO2000010522A1 PCT/EP1999/005723 EP9905723W WO0010522A1 WO 2000010522 A1 WO2000010522 A1 WO 2000010522A1 EP 9905723 W EP9905723 W EP 9905723W WO 0010522 A1 WO0010522 A1 WO 0010522A1
Authority
WO
WIPO (PCT)
Prior art keywords
cosmetic
skin
wax
dermatological
lipid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1999/005723
Other languages
German (de)
English (en)
Inventor
Thomas Förster
Martina Hollenbrock
Armin Wadle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henkel AG and Co KGaA
Original Assignee
Henkel AG and Co KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henkel AG and Co KGaA filed Critical Henkel AG and Co KGaA
Publication of WO2000010522A1 publication Critical patent/WO2000010522A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/044—Suspensions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/60—Particulates further characterized by their structure or composition
    • A61K2800/65—Characterized by the composition of the particulate/core
    • A61K2800/652—The particulate/core comprising organic material

Definitions

  • the invention relates to aqueous preparations for the cosmetic and dermatological treatment of the skin containing lipid-soluble cosmetic or dermatological active ingredients, which are contained therein as a component of finely dispersed wax particles with a particle size of less than 500 nm and are absorbed particularly well by the skin in this way .
  • the invention therefore relates to aqueous preparations for the cosmetic and dermatological treatment of the skin containing lipid-soluble cosmetic or dermatological active ingredients, which are contained as components of finely dispersed wax particles with a particle size of less than 500 nm (nanometers).
  • the preparations according to the invention are those preparations which, after being applied to the skin, remain on the skin at least until the next washing operation, or preparations which are preferably applied to the skin after cleaning and optionally massaged in.
  • Such preparations are e.g. cosmetic or dermatological skin creams, lotions, emulsions or gels that are suitable for the application of lipid-soluble active ingredients.
  • Lipid-soluble cosmetic or pharmaceutical active substances in the sense of the invention are to be understood in particular as dermatologically active compounds which e.g. have an anti-inflammatory, local anesthetic, skin-softening, antimicrobial, radiation-absorbing, skin-protecting, circulation-promoting or skin-aging protection and hardly in water, but in e.g. Paraffin oil is soluble in an amount of more than 1 wt .-%.
  • suitable lipid-soluble active ingredients are e.g. D-biotin, vitamins such as vitamin A (retinols), vitamin E (tocopherols), vitamin F (polyene fatty acids), ß-carotene (pro vitamin A) and the lipid-soluble derivatives (e.g. esters) of these substances.
  • vitamins such as vitamin A (retinols), vitamin E (tocopherols), vitamin F (polyene fatty acids), ß-carotene (pro vitamin A) and the lipid-soluble derivatives (e.g. esters) of these substances.
  • the lipid-soluble esters of ascorbic acid e.g. Stearyl ascorbate.
  • natural or synthetic tocopherols and their lipid-soluble derivatives are preferably used in the personal cleansing agents according to the invention.
  • Suitable tocopherols are, for example, the natural tocopherols and their mixtures and synthetic tocopherols.
  • Suitable esters are, for example, tocopherol acetate, tocopherol nicotinate, tocopherol ascorbate, tocopheryl retinoate, tocopheryl succinate, tocopheryl linoleate or tocopheryl benzoate.
  • the active substances mentioned are incorporated into the wax particles suitable according to the invention by converting them into a finely divided dispersion using suitable wax components and emulsifiers by known processes. Such a method for producing finely dispersed wax dispersions is known, for example, from DE 43 37 030 AI.
  • the dispersions obtained by the phase inversion process (PIT process) described there have a low viscosity and a very small particle size of less than 500 nm, preferably 100-200 nm, and are particularly suitable as carriers for the lipid-soluble active ingredients in cosmetics and dermatological preparations for the treatment and care of the skin.
  • Suitable waxes are natural or artificially obtained substances that are solid and kneadable at 20 ° C, coarse to fine crystalline and only change to a flowable, low-viscosity state above about 40 ° C without decomposition.
  • the type and origin of the waxes (A) are not subject to any restrictions in the context of the present invention.
  • the waxes (A) can accordingly be selected from each of the three groups into which the waxes are usually classified. These three groups are:
  • Waxes such as candelilla, carnauba, japan, esparto grass, ouricoury wax and in fossil waxes such as montan wax, etc .:
  • animal waxes such as bees wax, shellac wax, walrus, lanolin (wool wax), pretzel fat, etc .;
  • mineral waxes such as ceresin, ozokerite (earth wax), petrolium, paraffin and micro waxes,
  • synthetic waxes also called synthetic waxes, for example from the paraffins obtained by the Fischer-Tropsch process, which are converted into a series of hard waxes by air oxidation, selective solvent treatment, esterification, saponification, etc.
  • polyethylene waxes some of them High-pressure polymerization of ethylene, some of which are produced by cracking, from the high-molecular low-pressure polyethylene, as well as corresponding oxidized products, are among the synthetic waxes.
  • fatty acid esters of monohydric or polyhydric alcohols which, because of their consistency and melting range, exhibit waxy behavior.
  • Such products are, for example, the esters of saturated, linear C 12 -C 22 fatty acids and saturated, linear C 12 -C 22 fatty alcohols, for example cetyl palmitate, stearyl stearate or cetyl behenate, triglycerides of saturated, linear C 12 -C 22 fatty acids and hydrogenated vegetable and animal fats such as hardened palm fat, hardened valley or hardened castor oil.
  • the preparations according to the invention preferably contain the lipid-soluble active substances in an amount of 0.01-2.0% by weight, based on the entire preparation.
  • Such an active ingredient concentration can e.g. achieve when the active ingredient-containing wax particles are contained in the preparation in an amount of 1-10% by weight.
  • the preparations according to the invention are preferably prepared in such a way that the active ingredient is mixed into the rest of the preparation in the form of an aqueous dispersion of active ingredient-containing wax particles at a temperature below the melting point of the wax particles.
  • the wax particles contained according to the invention preferably contain
  • Range from 40 - 120 ° C 0.1 - 30 wt .-% of a lipid-soluble, cosmetic or dermatological active ingredient and up to 30 wt .-% of one or more emulsifiers.
  • the type and amount of the emulsifiers required are selected in a manner known per se based on the HLB value of the wax components and the amount of the waxes and active ingredients to be emulsified.
  • emulsifiers are e.g. nonionic compounds with a lipophilic alkyl or acyl group and a hydrophilic polyol or polyether group.
  • suitable emulsifiers are e.g. Ethylene oxide addition products on fatty alcohols with 16-22 C atoms, on fatty acid monoglycerides or on sorbitan monoesters of fatty acids with 16-22 C atoms.
  • Suitable emulsifiers preferably have an HLB value of 8-18.
  • L is the weight fraction of the lipophilic groups, i.e. of the fatty alkyl or fatty acyl groups in percent in the nonionic emulsifiers.
  • a lipophilic co-emulsifier can be advantageous for producing the wax dispersion containing the active ingredient.
  • polar lipids with one or two C 12 - C 22 alkyl or acyl groups and a hydrophilic group, the size of which is not sufficient to make the molecule water-soluble, for example the hydroxyl group, a dihydroxyethyl group or a polyhydroxyalkoxy group with 3 - 6 carbon atoms and 2 - 5 hydroxyl groups.
  • Such polar lipids are often also referred to as “lipophilic co-emulsifiers”.
  • lipids are, for example, cetyl and stearyl alcohol, 1,2-dodecanediol, glycerol monocetyl ether, glycerol monostearate, stearyl monoglucoside, sorbitan monopalmitate or methyl glucoside dioleate.
  • Aqueous preparations are understood to be creams, emulsions and dispersions, gels and lotions, the outer phase of which is aqueous. Liquid oil-in-water emulsions or oil-in-water creams are particularly preferred. Mixed emulsion systems, for example of the water-in-oil-in-water type, are also suitable for introducing the wax dispersions loaded with lipophilic active ingredients.
  • Such aqueous preparations can contain all the usual components of such preparations in the usual amounts.
  • customary cosmetic oil components in emulsified or microemulsified form emulsifiers, thickeners, water-soluble active ingredients, proteins or protein derivatives, complexing agents, buffer salts, preservatives, pigments, dyes and fragrances can be present in customary amounts.
  • composition V a conventional OAV emulsion
  • composition 3 an analog emulsion which contains an equal amount of the vitamin E contains acetate as a component of finely divided wax particles
  • Wax components, emulsifiers, vitamins and water were introduced and heated with stirring until the phase inversion temperature (PIT) was reached at approx. 70 - 85 ° C. After exceeding the PIT, the dispersion was cooled to room temperature (25 ° C.) with stirring. Finely divided dispersions with a bluish shimmer in incident light with a wax particle diameter below 500 nm were obtained.
  • PIT phase inversion temperature
  • the vitamin-containing wax dispersions (DI, D3 and D5) were added to the cream (40 ° C) in the cooling phase and homogeneously distributed while stirring.
  • the vitamin E acetate was determined analytically in the skin samples. For this purpose, the tesa tears were extracted and the vitamin E acetate in the extract was isolated by liquid chromatography and determined on a substance-specific basis. The quantification was achieved by standard calibration and comparison with blank samples (untreated skin areas).

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nanotechnology (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne des préparations aqueuses pour des soins dermatologiques et cosmétiques de la peau, contenant des principes actifs cosmétiques ou dermatologiques, liposolubles. Ces préparations sont appliquées de préférence après nettoyage de la peau et doivent rester sur la peau au moins jusqu'à la toilette suivante. Leur pouvoir de pénétration dans la peau est nettement amélioré, lorsque les principes actifs qu'elles contiennent se présentent sous la forme de constituants de fines particules de cire possédant une dimension de particules inférieure à 500 nanomètres. De préférence, les particules de cire contiennent 0,1 à 30 % en poids d'un principe actif liposoluble, et les préparations renferment 1 à 10 % en poids de telles particules de cire.
PCT/EP1999/005723 1998-08-17 1999-08-07 Agents de soins dermatologiques et cosmetiques pour la peau Ceased WO2000010522A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1998137191 DE19837191A1 (de) 1998-08-17 1998-08-17 Kosmetische und dermatologische Hautbehandlungsmittel
DE19837191.8 1998-08-17

Publications (1)

Publication Number Publication Date
WO2000010522A1 true WO2000010522A1 (fr) 2000-03-02

Family

ID=7877744

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/005723 Ceased WO2000010522A1 (fr) 1998-08-17 1999-08-07 Agents de soins dermatologiques et cosmetiques pour la peau

Country Status (2)

Country Link
DE (1) DE19837191A1 (fr)
WO (1) WO2000010522A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001039729A1 (fr) * 1999-12-04 2001-06-07 Cognis Deutschland Gmbh & Co. Kg Utilisation de cires nanometriques
WO2002043673A3 (fr) * 2000-12-01 2003-04-17 Henkel Kgaa Utilisation de cires nanoparticulaires en cosmetique pour la peau
WO2005020949A1 (fr) * 2003-08-27 2005-03-10 Beiersdorf Ag Preparations cosmetiques sous forme spherique pour application topique
EP2002864A1 (fr) 2003-08-27 2008-12-17 Beiersdorf AG Capsule à usage cosmétique et/ou dermatologique
US8236333B2 (en) * 2005-10-19 2012-08-07 Unirem, Inc. Active agent delivery and/or odor retentive composition and methods of use thereof
WO2014060566A1 (fr) * 2012-10-18 2014-04-24 Dsm Ip Assets B.V. Granules comprenant des caroténoïdes
US8741321B2 (en) 2003-08-27 2014-06-03 Beiersdorf Ag Capsule whose envelope is separately imperceptible during the topical use thereof
EP3086863B1 (fr) 2013-12-24 2020-06-17 The Procter and Gamble Company Compositions cosmétiques et procédés permettant de procurer une pénétration améliorée de principes actifs pour soin de la peau

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19911041A1 (de) * 1999-03-12 2000-09-14 Henkel Kgaa Mit Nanopartikel-Dispersionen ausgerüstete, flexible und saugfähige Träger zur Behandlung der Haut
DE19919770A1 (de) * 1999-04-30 2000-11-02 Henkel Kgaa Verwendung nanoskaliger antimikrobieller Wirkstoffe in der Mund- und/oder Zahnpflege
DE10027948A1 (de) * 2000-06-08 2001-12-20 Henkel Kgaa Verfahren zur Herstellung von Nanopartikel-Suspensionen
DE10059670A1 (de) * 2000-12-01 2002-06-20 Henkel Kgaa Verwendung von nanopartikulären Wachsen in der Haarkosmetik
DE10238450A1 (de) * 2002-08-22 2004-03-04 Beiersdorf Ag Zubereitung zur Behandlung von Fehlpigmentierungen der Haut
DE10300506A1 (de) * 2003-01-08 2004-07-22 Cognis Deutschland Gmbh & Co. Kg Wachsdispersionen
FR2856314B1 (fr) * 2003-06-20 2005-08-26 Oreal Procede de preparation d'une microdispersion de cire
WO2005007280A2 (fr) * 2003-06-20 2005-01-27 L'oreal Procede de preparation d’une microdispersion de cire
DE10339760A1 (de) * 2003-08-27 2005-03-17 Cognis Deutschland Gmbh & Co. Kg Compound für Zubereitungen zur Behandlung keretinischer Fasern
FR2859116B1 (fr) * 2003-09-01 2006-01-21 Oreal Procede de preparation d'une microdispersion de cire
WO2005023412A2 (fr) * 2003-09-01 2005-03-17 L'oreal Procede de preparation d'une microdispersion de cire
DE102004061610A1 (de) * 2004-12-17 2006-06-22 Henkel Kgaa Kosmetisches Kit zur Haar-und Kopfhautbehandlung
DE102006015517B4 (de) * 2006-03-31 2012-04-19 Sasol Wax Gmbh Verwendung von nano-partikulären Wachsdispersionen, Verfahren zu deren Herstellung und Verfahren zur Hydrophobierung von Werkstoffen mit diesen
JP4341983B2 (ja) * 2007-12-07 2009-10-14 株式会社資生堂 皮膚外用剤

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2666015A1 (fr) * 1990-08-23 1992-02-28 Oreal Composition cosmetique et/ou dermopharmaceutique contenant de l'acide retinouique ou ses derives, destinee au traitement des cheveux ou du cuir chevelu.
EP0506197A1 (fr) * 1991-03-25 1992-09-30 Yamanouchi Europe B.V. Préparation topique contenant une suspension de particules lipidiques solides
DE4336407A1 (de) * 1993-10-21 1995-04-27 Rotring Int Gmbh Wasserfeste Kosmetik
DE4337030A1 (de) * 1993-10-29 1995-05-04 Henkel Kgaa Verfahren zur Herstellung von Wachsdispersionen
DE4441029A1 (de) * 1994-11-17 1996-05-23 Henkel Kgaa Kationische Wachsdispersionen
US5620693A (en) * 1993-11-24 1997-04-15 L'oreal Mascara containing wax(es) and carboxyl-functional film-forming polymer aqueous dispersion
DE19710149A1 (de) * 1997-03-12 1998-09-17 Henkel Kgaa Körperreinigungsmittel

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2666015A1 (fr) * 1990-08-23 1992-02-28 Oreal Composition cosmetique et/ou dermopharmaceutique contenant de l'acide retinouique ou ses derives, destinee au traitement des cheveux ou du cuir chevelu.
EP0506197A1 (fr) * 1991-03-25 1992-09-30 Yamanouchi Europe B.V. Préparation topique contenant une suspension de particules lipidiques solides
DE4336407A1 (de) * 1993-10-21 1995-04-27 Rotring Int Gmbh Wasserfeste Kosmetik
DE4337030A1 (de) * 1993-10-29 1995-05-04 Henkel Kgaa Verfahren zur Herstellung von Wachsdispersionen
US5620693A (en) * 1993-11-24 1997-04-15 L'oreal Mascara containing wax(es) and carboxyl-functional film-forming polymer aqueous dispersion
DE4441029A1 (de) * 1994-11-17 1996-05-23 Henkel Kgaa Kationische Wachsdispersionen
DE19710149A1 (de) * 1997-03-12 1998-09-17 Henkel Kgaa Körperreinigungsmittel

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001039729A1 (fr) * 1999-12-04 2001-06-07 Cognis Deutschland Gmbh & Co. Kg Utilisation de cires nanometriques
WO2002043673A3 (fr) * 2000-12-01 2003-04-17 Henkel Kgaa Utilisation de cires nanoparticulaires en cosmetique pour la peau
WO2005020949A1 (fr) * 2003-08-27 2005-03-10 Beiersdorf Ag Preparations cosmetiques sous forme spherique pour application topique
EP2002864A1 (fr) 2003-08-27 2008-12-17 Beiersdorf AG Capsule à usage cosmétique et/ou dermatologique
US8741321B2 (en) 2003-08-27 2014-06-03 Beiersdorf Ag Capsule whose envelope is separately imperceptible during the topical use thereof
US8741320B2 (en) 2003-08-27 2014-06-03 Beiersdorf Ag Spherical cosmetic preparations for topical application
US8236333B2 (en) * 2005-10-19 2012-08-07 Unirem, Inc. Active agent delivery and/or odor retentive composition and methods of use thereof
WO2014060566A1 (fr) * 2012-10-18 2014-04-24 Dsm Ip Assets B.V. Granules comprenant des caroténoïdes
EP3086863B1 (fr) 2013-12-24 2020-06-17 The Procter and Gamble Company Compositions cosmétiques et procédés permettant de procurer une pénétration améliorée de principes actifs pour soin de la peau
EP3086863B2 (fr) † 2013-12-24 2023-01-11 The Procter & Gamble Company Compositions cosmétiques et procédés permettant de procurer une pénétration améliorée de principes actifs pour soin de la peau

Also Published As

Publication number Publication date
DE19837191A1 (de) 2000-02-24

Similar Documents

Publication Publication Date Title
WO2000010522A1 (fr) Agents de soins dermatologiques et cosmetiques pour la peau
DE69534536T2 (de) Verwendung zur topischen anwendung von tocotrienol auf die haut und haare
DE69823016T2 (de) Wässrige Lösungen von Salicylsäurederivaten
DE69915798T2 (de) Erweichende zusammensetzung basierend auf jojoba ester
EP0967958B1 (fr) Nettoyant corporel
AT390372B (de) Verwendung von solarfiltern zur stabilisierung und verbesserung der hautvertraeglichkeit von benzoylperoxyd enthaltenden zubereitungen zur lokalen aknebehandlung
DE60000235T2 (de) Zusammensetzung und insbesondere kosmetische Zusammensetzung, die ein Sapogenin enthält
DE69500315T2 (de) Kosmetische oder dermatologische Wasser-in-Öl Emulsion mit hohem Gehalt an Hydroxysäuren
DE69600017T2 (de) Verwendung von amphiphilen Verbindungen als Verdickungsmittel in nichtwässrigen Medien und die so hergestellte Zusammensetzungen
DE19643238A1 (de) Antitranspirant- und Deodorantstifte mit hohem Wassergehalt
KR20180101378A (ko) 유중수 에멀젼
DE69410119T2 (de) Wasser-in-oel-lotion, die ein corticosteroid enthaelt
DE69912760T2 (de) Verwendung von topischen formulierungen des öl-in-wasser typs, enthaltend galaktolipid material als emulsionsmittel, um eine länger anhaltende wirkung eines darin enthaltenen aktiven wirkstoffs zu vermitteln
EP0973484A1 (fr) Emulsions huile dans l'eau pour la restitution de la lamellarite de la structure lipidique de la peau endommagee
DE4431251C2 (de) Hautcreme
EP0467218A2 (fr) Combinaison d'agents actifs pour le soin de la peau
EP2658610B1 (fr) Système support colloïdal présentant des propriétés de pénétration pour l'encapsulage d'agents actifs lipophiles et d'huiles pour l'application topique
WO1992022282A1 (fr) Composants oleagineux cosmetiques et pharmaceutiques
EP3981379B1 (fr) Composition en nanoémulsion pour application de soins de la peau
EP0804150B1 (fr) Lotions contenant des derives d'acide gras
DE69524581T2 (de) Retinal enthaltendes arzneimittel
DE69705107T2 (de) Dermokosmetisches mittel enthaltend retinal
DE69114796T2 (de) Antioxydantsystem auf Basis einer basischen Aminosäure und eines Tocopherols.
DE69705968T2 (de) Zubereitung auf der basis von kokosöl und ihre verwendung
EP0120224A2 (fr) Bain de crème huileux fonctionnel

Legal Events

Date Code Title Description
AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
CR1 Correction of entry in section i

Free format text: PAT. BUL. 06/2002 UNDER (81) ADD "JP" AND ADD "(84) DESIGNATED STATES (REGIONAL): EP (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE"; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE