[go: up one dir, main page]

WO2000003997A1 - Thiobenzimidazole derivatives - Google Patents

Thiobenzimidazole derivatives Download PDF

Info

Publication number
WO2000003997A1
WO2000003997A1 PCT/JP1999/003799 JP9903799W WO0003997A1 WO 2000003997 A1 WO2000003997 A1 WO 2000003997A1 JP 9903799 W JP9903799 W JP 9903799W WO 0003997 A1 WO0003997 A1 WO 0003997A1
Authority
WO
WIPO (PCT)
Prior art keywords
thiobenzimidazole derivatives
human chymase
thiobenzimidazole
derivatives
preventives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP1999/003799
Other languages
English (en)
French (fr)
Inventor
Yoshiyuki Matsumoto
Susumu Takeuchi
Naoki Hase
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to PL345540A priority Critical patent/PL203730B1/pl
Priority to BR9912098-4A priority patent/BR9912098A/pt
Priority to JP2000560104A priority patent/JP3923255B2/ja
Priority to HR20010030A priority patent/HRP20010030A2/hr
Priority to NZ509207A priority patent/NZ509207A/xx
Priority to EP99929832A priority patent/EP1097926A4/en
Priority to EEP200100022A priority patent/EE04904B1/xx
Priority to SK21-2001A priority patent/SK212001A3/sk
Priority to HU0103256A priority patent/HUP0103256A3/hu
Priority to AU46519/99A priority patent/AU758789B2/en
Priority to CA002336909A priority patent/CA2336909C/en
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to IL14086299A priority patent/IL140862A/xx
Publication of WO2000003997A1 publication Critical patent/WO2000003997A1/ja
Priority to NO20010193A priority patent/NO318957B1/no
Priority to IS5807A priority patent/IS5807A/is
Anticipated expiration legal-status Critical
Priority to UA2001021023A priority patent/UA70953C2/uk
Priority to US10/963,710 priority patent/US7268145B2/en
Priority to US11/129,508 priority patent/US20050267148A1/en
Priority to US11/797,975 priority patent/US20070275995A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PCT/JP1999/003799 1998-07-15 1999-07-14 Thiobenzimidazole derivatives Ceased WO2000003997A1 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
CA002336909A CA2336909C (en) 1998-07-15 1999-07-14 Thiobenzimidazole derivatives which are useful as inhibitors of human chymase activity
JP2000560104A JP3923255B2 (ja) 1998-07-15 1999-07-14 チオベンズイミダゾール誘導体
HR20010030A HRP20010030A2 (en) 1998-07-15 1999-07-14 Thiobenzimidazole derivatives
NZ509207A NZ509207A (en) 1998-07-15 1999-07-14 Thiobenzimidazole derivative compounds, and usage as chymase activity inhibitors
EP99929832A EP1097926A4 (en) 1998-07-15 1999-07-14 THIOBENZIMIDAZOLE DERIVATIVES
EEP200100022A EE04904B1 (et) 1998-07-15 1999-07-14 Tiobensimidasooli derivaadid ja farmatseutiline kompositsioon
SK21-2001A SK212001A3 (en) 1998-07-15 1999-07-14 Thiobenzimidazole derivatives
HU0103256A HUP0103256A3 (en) 1998-07-15 1999-07-14 Thiobenzimidazole derivatives and pharmaceutical compositions containing the compounds
IL14086299A IL140862A (en) 1998-07-15 1999-07-14 Thiobenzimidazole derivatives and pharmaceutical compositions containing the same
PL345540A PL203730B1 (pl) 1998-07-15 1999-07-14 Pochodna tiobenzimidazolu, kompozycja farmaceutyczna i jej zastosowanie
BR9912098-4A BR9912098A (pt) 1998-07-15 1999-07-14 Derivado de tiobenzimidazol, composição farmacêutica, e, agente preventivo e/ou terapêutico
AU46519/99A AU758789B2 (en) 1998-07-15 1999-07-14 Thiobenzimidazole derivatives
NO20010193A NO318957B1 (no) 1998-07-15 2001-01-12 Tiobenzimidazol-derivater og farmasoytiske preparater inneholdene disse
IS5807A IS5807A (is) 1998-07-15 2001-01-12 Þíóbensimídasólafleiður
UA2001021023A UA70953C2 (uk) 1998-07-15 2001-09-17 Похідні тіобензімідазолу та фармацевтична композиція, що їх містить
US10/963,710 US7268145B2 (en) 1998-07-15 2004-10-14 Thiobenzimidazole derivatives
US11/129,508 US20050267148A1 (en) 1998-07-15 2005-05-16 Benzimidazole derivative
US11/797,975 US20070275995A1 (en) 1998-07-15 2007-05-09 Thiobenzimidazole derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10/200250 1998-07-15
JP20025098 1998-07-15

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09743483 A-371-Of-International 1999-07-14
US10/963,710 Continuation US7268145B2 (en) 1998-07-15 2004-10-14 Thiobenzimidazole derivatives

Publications (1)

Publication Number Publication Date
WO2000003997A1 true WO2000003997A1 (en) 2000-01-27

Family

ID=16421274

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1999/003799 Ceased WO2000003997A1 (en) 1998-07-15 1999-07-14 Thiobenzimidazole derivatives

Country Status (22)

Country Link
US (2) US7268145B2 (ja)
EP (1) EP1097926A4 (ja)
JP (1) JP3923255B2 (ja)
KR (1) KR100903531B1 (ja)
CN (1) CN1187337C (ja)
AU (1) AU758789B2 (ja)
BG (1) BG65514B1 (ja)
BR (1) BR9912098A (ja)
CA (1) CA2336909C (ja)
EE (1) EE04904B1 (ja)
HR (1) HRP20010030A2 (ja)
HU (1) HUP0103256A3 (ja)
ID (1) ID26899A (ja)
IL (1) IL140862A (ja)
IS (1) IS5807A (ja)
NO (1) NO318957B1 (ja)
NZ (1) NZ509207A (ja)
PL (1) PL203730B1 (ja)
RU (1) RU2237663C2 (ja)
SK (1) SK212001A3 (ja)
TR (1) TR200100047T2 (ja)
WO (1) WO2000003997A1 (ja)

Cited By (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001053272A1 (en) * 2000-01-17 2001-07-26 Teijin Limited Human chymase inhibitors
WO2001053291A1 (en) * 2000-01-17 2001-07-26 Teijin Limited Benzimidazole derivatives
WO2002066457A1 (en) * 2001-02-22 2002-08-29 Teijin Limited BENZO[b]THIOPHENE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME
WO2004007464A1 (ja) * 2002-07-10 2004-01-22 Sumitomo Pharmaceuticals Co., Ltd. イミダゾール誘導体
WO2004101551A1 (ja) * 2003-05-14 2004-11-25 Teijin Pharma Limited ベンズイミダゾール誘導体の結晶及びその製造方法
WO2005018672A1 (ja) * 2003-08-22 2005-03-03 Teijin Pharma Limited キマーゼ阻害剤を有効成分として含有する薬剤
WO2006052026A1 (ja) * 2004-11-12 2006-05-18 Teijin Pharma Limited ベンズイミダゾール誘導体の酸性塩及びその結晶
US7176320B2 (en) 2000-01-17 2007-02-13 Teijin Limited Benzimidazole derivative
JP2007119483A (ja) * 2001-02-22 2007-05-17 Teijin Ltd ベンゾ［ｂ］チオフェン誘導体、およびその製造方法
US7268145B2 (en) 1998-07-15 2007-09-11 Teijin Pharma Limited Thiobenzimidazole derivatives
JP2008510760A (ja) * 2004-08-26 2008-04-10 アクテリオン ファーマシューティカルズ リミテッド ２−スルファニル−ベンゾイミダゾール−１−イル−酢酸誘導体
WO2008153129A1 (ja) * 2007-06-14 2008-12-18 Teijin Pharma Limited 尿酸値低下剤
JP2009519291A (ja) * 2005-12-15 2009-05-14 エフ．ホフマン−ラ ロシュ アーゲー 新規な縮合ピロール誘導体
WO2009133964A1 (ja) * 2008-04-28 2009-11-05 国立大学法人九州大学 酸化ストレス抑制剤
US7618977B2 (en) 2000-02-22 2009-11-17 Asubio Pharma Co., Ltd. Method of treating dermatitis comprising administering a chymase inhibitor
WO2010047982A1 (en) 2008-10-22 2010-04-29 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2010051206A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2011106273A1 (en) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2012116145A1 (en) 2011-02-25 2012-08-30 Merck Sharp & Dohme Corp. Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
US8394969B2 (en) 2008-09-26 2013-03-12 Merck Sharp & Dohme Corp. Cyclic benzimidazole derivatives useful as anti-diabetic agents
US8563746B2 (en) 2008-10-29 2013-10-22 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
WO2014022528A1 (en) 2012-08-02 2014-02-06 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
WO2014031465A1 (en) 2012-08-22 2014-02-27 Merck Sharp & Dohme Corp. Novel azabenzimidazole tetrahydropyran derivatives
WO2014139388A1 (en) 2013-03-14 2014-09-18 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
WO2015051725A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
WO2015095256A1 (en) 2013-12-19 2015-06-25 Merck Sharp & Dohme Corp. Antidiabetic substituted heteroaryl compounds
US9290517B2 (en) 2012-08-22 2016-03-22 Merck Sharp & Dohme Corp. Azabenzimidazole hexahydrofuro[3,2-b]furan derivatives
US9394285B2 (en) 2013-03-15 2016-07-19 Pfizer Inc. Indole and indazole compounds that activate AMPK
US9527839B2 (en) 2012-08-22 2016-12-27 Merck Sharp & Dohme Corp. Benzimidazole tetrahydropyran derivatives
US9540364B2 (en) 2012-08-22 2017-01-10 Merck Sharp & Dohme Corp. Benzimidazole tetrahydrofuran derivatives
US9556193B2 (en) 2012-08-22 2017-01-31 Merck Shapr & Dohme Corp. Benzimidazole hexahydrofuro[3,2-b]furan derivatives
US9868733B2 (en) 2012-08-22 2018-01-16 Merck Sharp & Dohme Corp. Azabenzimidazole tetrahydrofuran derivatives
US10519115B2 (en) 2013-11-15 2019-12-31 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007119478A (ja) * 1998-07-15 2007-05-17 Teijin Ltd チオベンズイミダゾール誘導体
RU2267487C1 (ru) * 2004-10-19 2006-01-10 Закрытое акционерное общество "Деско" (ЗАО "Деско") Средство для стимуляции процесса обучения, восстановления памяти и эмоционального статуса
JP4339371B2 (ja) * 2007-03-22 2009-10-07 株式会社ソニー・コンピュータエンタテインメント 情報処理装置および情報処理方法
KR101435496B1 (ko) * 2012-10-22 2014-08-28 한국과학기술연구원 미토콘드리아 기능 조절제로서의 벤즈이미다졸 유도체

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62212386A (ja) 1986-03-14 1987-09-18 Suntory Ltd ２−ピリジルメチルベンズイミダゾ−ル誘導体
US5124336A (en) * 1990-02-16 1992-06-23 Laboratoires Upsa Azabenzimidazole derivatives which are thromboxane receptor antagonists

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5617073B2 (ja) * 1971-10-28 1981-04-20
DE2648411C2 (de) * 1976-10-26 1984-05-17 Mtu Motoren- Und Turbinen-Union Friedrichshafen Gmbh, 7990 Friedrichshafen Mehrzylindrige Dieselbrennkraftmaschine
FR2430950A1 (fr) 1978-07-10 1980-02-08 Delalande Sa Nouveaux derives heterocycliques de la benzimidazole, leur procede de preparation et leur application en therapeutique
US4312308A (en) * 1980-02-21 1982-01-26 Slattery Gordon C Compression relief system for internal combustion engine
EP0251536A1 (en) 1986-06-24 1988-01-07 FISONS plc Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors
US4839365A (en) 1987-05-19 1989-06-13 Shinogi & Co., Ltd. Thienopyridine derivatives useful in treating gastric ulcers
AT389107B (de) 1987-12-03 1989-10-25 Fisons Plc Neue benzimidazole, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
JPH01265089A (ja) 1988-04-15 1989-10-23 Zeria Pharmaceut Co Ltd 新規１−（イミダゾール−４−イル）メチルベンズイミダゾール誘導体およびその製造法ならびにこれを含有する抗潰瘍剤
DE3928177A1 (de) * 1989-04-08 1991-02-28 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5128339A (en) 1990-11-01 1992-07-07 Sterling Winthrop Inc. Proteolytic enzyme inhibition method
GB8911453D0 (en) 1989-05-18 1989-07-05 Minnesota Mining & Mfg Speed and contrast promoted silver halide rhodium doped emulsions
IL94390A (en) 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
JPH0314566A (ja) 1989-06-09 1991-01-23 Sankyo Co Ltd ベンズイミダゾール誘導体
US5449682A (en) 1990-02-13 1995-09-12 Merck & Co., Inc. Angiotensin II antagonists incorporating a substituted benzyl element
US5128359A (en) 1990-02-16 1992-07-07 Laboratoires Upsa Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation
US5196444A (en) 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US5374615A (en) 1990-10-31 1994-12-20 E. R. Squibb & Sons, Inc. Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives
CA2061159A1 (en) 1991-02-26 1992-08-27 Michael A. Poss Imidazole and benzimidazole derivatives
US5191086A (en) 1991-03-19 1993-03-02 E.R. Squibb & Sons, Inc. Imidazole and benzimidazole derivatives
US5128327A (en) 1991-03-25 1992-07-07 Merck & Co., Inc. Angiotensin II antagonists incorporating a nitrogen containing six membered ring heterocycle
TW300219B (ja) 1991-09-14 1997-03-11 Hoechst Ag
JPH05112559A (ja) 1991-10-18 1993-05-07 Morishita Roussel Kk ４−アミノ−５−ピリミジンカルボン酸誘導体
EP0577023A3 (en) 1992-07-01 1996-12-18 Hoechst Ag Angiotensin-ii receptor-antagonists for the treatment of arrhythmices
JPH0820584A (ja) 1994-07-04 1996-01-23 Takeda Chem Ind Ltd イミダゾール誘導体及びその用途
AU3086095A (en) 1994-07-29 1996-03-04 Suntory Limited Imidazolidine derivative and use thereof
JPH08208654A (ja) 1994-11-24 1996-08-13 Wakamoto Pharmaceut Co Ltd キマーゼ活性を阻害し、かつ一酸化窒素生成を抑制する新規トリアジン誘導体
DE69634122D1 (de) 1995-04-27 2005-02-03 Mitsubishi Pharma Corp Heterocyclische amidverbindungen und deren medizinische verwendung
US5998456A (en) 1995-07-17 1999-12-07 Fuji Photo Film Co., Ltd. Benzimidazole compounds containing 1,2,4-triazole ring, and compositions and methods of use containing the same
JP3537231B2 (ja) 1995-07-24 2004-06-14 第一サントリーファーマ株式会社 ヒダントイン誘導体およびその用途
WO1997011941A1 (fr) 1995-09-28 1997-04-03 Suntory Limited Derives de la quinazoline et leurs emplois
WO1998008818A1 (en) 1996-08-26 1998-03-05 Genetics Institute, Inc. Inhibitors of phospholipase enzymes
EP0940400A4 (en) * 1996-10-25 2002-10-02 Mitsubishi Pharma Corp HETEROCYCLIC AMID COMPOUNDS AND THEIR MEDICAL APPLICATION
WO1999026932A1 (en) 1997-11-26 1999-06-03 Axys Pharmaceuticals, Inc. By amidino group substituted heterocyclic derivatives and their use as anticoagulants
WO1999057103A1 (en) 1998-04-30 1999-11-11 Nippon Chemiphar Co., Ltd. Condensed imidazole derivative and therapeutic agent for liver disease
IL140862A (en) 1998-07-15 2005-05-17 Teijin Ltd Thiobenzimidazole derivatives and pharmaceutical compositions containing the same
CZ20014573A3 (cs) 1999-06-28 2002-05-15 Janssen Pharmaceutica N. V. Inhibitory replikace respiračně syncyciálního viru

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62212386A (ja) 1986-03-14 1987-09-18 Suntory Ltd ２−ピリジルメチルベンズイミダゾ−ル誘導体
US5124336A (en) * 1990-02-16 1992-06-23 Laboratoires Upsa Azabenzimidazole derivatives which are thromboxane receptor antagonists
JPH05155858A (ja) * 1990-02-16 1993-06-22 Lab Up Sa トロンボキサン受容体アンタゴニストである新規ベンズイミダゾールおよびアザベンズイミダゾール誘導体、それらの製造方法、およびそれらを含む合成中間体および薬剤組成物

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ANAN'EVA ET AL.: "Cyclic thioamides in nucleophilic addition reactions II", UZB. KHIM. ZH., vol. 17, no. 5, 1973, pages 56 - 59
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 47905R
CHEMICAL ABSTRACTS, vol. 85, 1976, Columbus, Ohio, US; abstract no. 172661N, page 126; XP002926393 *
ERIC NICOLAI ET AL.,, J. MED. CHEM., vol. 36, no. 9, 1993, pages 1175 - 1187, XP002926392 *
See also references of EP1097926A4
UZB. BIOL. ZH.(RUSS), vol. 4, 1976, pages 19 - 21 *

Cited By (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7268145B2 (en) 1998-07-15 2007-09-11 Teijin Pharma Limited Thiobenzimidazole derivatives
US7176320B2 (en) 2000-01-17 2007-02-13 Teijin Limited Benzimidazole derivative
WO2001053291A1 (en) * 2000-01-17 2001-07-26 Teijin Limited Benzimidazole derivatives
WO2001053272A1 (en) * 2000-01-17 2001-07-26 Teijin Limited Human chymase inhibitors
CN100415723C (zh) * 2000-01-17 2008-09-03 帝人株式会社 苯并咪唑衍生物
US7618977B2 (en) 2000-02-22 2009-11-17 Asubio Pharma Co., Ltd. Method of treating dermatitis comprising administering a chymase inhibitor
CN100457750C (zh) * 2001-02-22 2009-02-04 帝人株式会社 苯并[b]噻吩衍生物及其制备方法
US6884896B2 (en) 2001-02-22 2005-04-26 Teijin Limited Benzo[b]thiophene derivatives and process for preparing the same
WO2002066457A1 (en) * 2001-02-22 2002-08-29 Teijin Limited BENZO[b]THIOPHENE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME
EP1362854A4 (en) * 2001-02-22 2004-06-09 Teijin Ltd BENZO [B] THIOPHENE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
JP2007119483A (ja) * 2001-02-22 2007-05-17 Teijin Ltd ベンゾ［ｂ］チオフェン誘導体、およびその製造方法
EP1792614A1 (en) * 2001-02-22 2007-06-06 Teijin Pharma Limited Benzo[b]thiophene derivatives
WO2004007464A1 (ja) * 2002-07-10 2004-01-22 Sumitomo Pharmaceuticals Co., Ltd. イミダゾール誘導体
RU2332417C2 (ru) * 2003-05-14 2008-08-27 Тейдзин Фарма Лимитед Кристалл производного бензимидазола и способ его получения
WO2004101551A1 (ja) * 2003-05-14 2004-11-25 Teijin Pharma Limited ベンズイミダゾール誘導体の結晶及びその製造方法
JPWO2004101551A1 (ja) * 2003-05-14 2006-07-13 帝人ファーマ株式会社 ベンズイミダゾール誘導体の結晶及びその製造方法
US7649008B2 (en) 2003-05-14 2010-01-19 Teijin Pharma Limited Crystal of benzimidazole derivative and process for producing the same
WO2005018672A1 (ja) * 2003-08-22 2005-03-03 Teijin Pharma Limited キマーゼ阻害剤を有効成分として含有する薬剤
JP2008510760A (ja) * 2004-08-26 2008-04-10 アクテリオン ファーマシューティカルズ リミテッド ２−スルファニル−ベンゾイミダゾール−１−イル−酢酸誘導体
WO2006052026A1 (ja) * 2004-11-12 2006-05-18 Teijin Pharma Limited ベンズイミダゾール誘導体の酸性塩及びその結晶
JP2009519291A (ja) * 2005-12-15 2009-05-14 エフ．ホフマン−ラ ロシュ アーゲー 新規な縮合ピロール誘導体
WO2008153129A1 (ja) * 2007-06-14 2008-12-18 Teijin Pharma Limited 尿酸値低下剤
WO2009133964A1 (ja) * 2008-04-28 2009-11-05 国立大学法人九州大学 酸化ストレス抑制剤
US8394969B2 (en) 2008-09-26 2013-03-12 Merck Sharp & Dohme Corp. Cyclic benzimidazole derivatives useful as anti-diabetic agents
US8410284B2 (en) 2008-10-22 2013-04-02 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
WO2010047982A1 (en) 2008-10-22 2010-04-29 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US8563746B2 (en) 2008-10-29 2013-10-22 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
US8329914B2 (en) 2008-10-31 2012-12-11 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
WO2010051206A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2011106273A1 (en) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US8895596B2 (en) 2010-02-25 2014-11-25 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
WO2012116145A1 (en) 2011-02-25 2012-08-30 Merck Sharp & Dohme Corp. Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
EP3243385A1 (en) 2011-02-25 2017-11-15 Merck Sharp & Dohme Corp. Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
US8796258B2 (en) 2011-02-25 2014-08-05 Merck Sharp & Dohme Corp. Cyclic azabenzimidazole derivatives useful as anti-diabetic agents
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
WO2014022528A1 (en) 2012-08-02 2014-02-06 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
US9527875B2 (en) 2012-08-02 2016-12-27 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
US9290517B2 (en) 2012-08-22 2016-03-22 Merck Sharp & Dohme Corp. Azabenzimidazole hexahydrofuro[3,2-b]furan derivatives
US9540364B2 (en) 2012-08-22 2017-01-10 Merck Sharp & Dohme Corp. Benzimidazole tetrahydrofuran derivatives
US9868733B2 (en) 2012-08-22 2018-01-16 Merck Sharp & Dohme Corp. Azabenzimidazole tetrahydrofuran derivatives
US9382243B2 (en) 2012-08-22 2016-07-05 Merck Sharp & Dohme Corp. Azabenzimidazole tetrahydropyran derivatives
WO2014031465A1 (en) 2012-08-22 2014-02-27 Merck Sharp & Dohme Corp. Novel azabenzimidazole tetrahydropyran derivatives
US9556193B2 (en) 2012-08-22 2017-01-31 Merck Shapr & Dohme Corp. Benzimidazole hexahydrofuro[3,2-b]furan derivatives
US9527839B2 (en) 2012-08-22 2016-12-27 Merck Sharp & Dohme Corp. Benzimidazole tetrahydropyran derivatives
US9650375B2 (en) 2013-03-14 2017-05-16 Merck Sharp & Dohme Corp. Indole derivatives useful as anti-diabetic agents
WO2014139388A1 (en) 2013-03-14 2014-09-18 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
US9394285B2 (en) 2013-03-15 2016-07-19 Pfizer Inc. Indole and indazole compounds that activate AMPK
WO2015051725A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
US9932311B2 (en) 2013-10-08 2018-04-03 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
US10519115B2 (en) 2013-11-15 2019-12-31 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
WO2015095256A1 (en) 2013-12-19 2015-06-25 Merck Sharp & Dohme Corp. Antidiabetic substituted heteroaryl compounds
US9834563B2 (en) 2013-12-19 2017-12-05 Merck Sharp & Dohme Corp. Antidiabetic substituted heteroaryl compounds
EP3974413A1 (en) 2013-12-19 2022-03-30 Merck Sharp & Dohme Corp. Antidiabetic substituted heteroaryl compounds
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds
US11452711B2 (en) 2020-09-03 2022-09-27 Pfizer Inc. Nitrile-containing antiviral compounds
US11541034B2 (en) 2020-09-03 2023-01-03 Pfizer Inc. Nitrile-containing antiviral compounds

Also Published As

Publication number Publication date
IL140862A0 (en) 2002-02-10
EE200100022A (et) 2002-06-17
NO20010193L (no) 2001-01-12
JP3923255B2 (ja) 2007-05-30
BG105149A (en) 2001-08-31
SK212001A3 (en) 2001-11-06
HUP0103256A3 (en) 2002-05-28
BR9912098A (pt) 2001-09-25
IS5807A (is) 2001-01-12
EE04904B1 (et) 2007-10-15
US20070275995A1 (en) 2007-11-29
EP1097926A1 (en) 2001-05-09
PL203730B1 (pl) 2009-11-30
CA2336909C (en) 2009-10-20
NZ509207A (en) 2003-01-31
HRP20010030A2 (en) 2001-12-31
RU2237663C2 (ru) 2004-10-10
ID26899A (id) 2001-02-15
HUP0103256A2 (hu) 2002-04-29
CN1316998A (zh) 2001-10-10
CA2336909A1 (en) 2000-01-27
KR20010079527A (ko) 2001-08-22
AU758789B2 (en) 2003-03-27
US20060040976A1 (en) 2006-02-23
KR100903531B1 (ko) 2009-06-23
PL345540A1 (en) 2001-12-17
US7268145B2 (en) 2007-09-11
NO20010193D0 (no) 2001-01-12
TR200100047T2 (tr) 2001-10-22
NO318957B1 (no) 2005-05-30
AU4651999A (en) 2000-02-07
CN1187337C (zh) 2005-02-02
EP1097926A4 (en) 2004-06-30
BG65514B1 (bg) 2008-10-31
IL140862A (en) 2005-05-17

Similar Documents

Publication Publication Date Title
WO2000003997A1 (en) Thiobenzimidazole derivatives
WO2003037864A1 (en) Indole compound and medicinal use thereof
EP0795548A4 (en) CHINAZOZINE DERIVATIVES AND THEIR USE
BG103945A (en) Derivatives of 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a
WO2003024955A3 (en) Small molecule inhibitors of caspases
RU95101048A (ru) Производные пролинамида, фармкомпозиция на их основе
MY134880A (en) Thiazolyl amide derivatives
HK1046405A1 (zh) 作为nmda受体拮抗剂用於治疗疼痛的取代的1，5-二氢吡咯-2-酮衍生物
AU4249700A (en) Hydroxamic acid derivative
EP1666041A3 (en) Xanthine derivatives for treating neurodegenerative disorders
BG104447A (en) Biphenylamidine derivatives
WO2000059449A3 (en) Purine derivatives having phosphodiesterase iv inhibition activity
WO2002032901A3 (en) Bridged piperazine derivatives
EP1602645A4 (en) NITROGENIC HETEROCYCLIC DERIVATIVE WITH 2,6-DISUBSTITUTED STYRYL REST
WO2000006606A3 (en) Erythromycin derivatives with antibiotic activity
CA2263353A1 (en) Arylsulfonylimidazolone derivatives as an antitumor agent
EP1191022A4 (en) NEW DIHYDROPYRIDINE DERIVATIVES
WO2002026732A1 (en) Benzodiazepine derivative
EP0842663A4 (en) OPHTHALMIC PREPARATIONS
EP1043311A4 (en) BIPHENYLAMIDINE DERIVATIVES
CA2380455A1 (en) 9a-azalides with antibacterial activity
WO2005053702A3 (en) Anti-inflammatory agents
MXPA01004457A (es) Derivados pirimidina novedosos y procesos para la preparacion de los mismos.
EP1191021A4 (en) Dihydropyridine derivative
CA2260863A1 (en) Treatment of psychotic disorders

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 99810816.2

Country of ref document: CN

AK Designated states

Kind code of ref document: A1

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 509207

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 212001

Country of ref document: SK

ENP Entry into the national phase

Ref document number: 2336909

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: PA/a/2001/000011

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 09743483

Country of ref document: US

ENP Entry into the national phase

Ref document number: 2000 560104

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: IN/PCT/2001/00039/MU

Country of ref document: IN

Ref document number: 2001/00047

Country of ref document: TR

Ref document number: 1200100041

Country of ref document: VN

Ref document number: 140862

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: PV2001-153

Country of ref document: CZ

Ref document number: P20010030A

Country of ref document: HR

Ref document number: 1020017000503

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 46519/99

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 1999929832

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1999929832

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: PV2001-153

Country of ref document: CZ

WWP Wipo information: published in national office

Ref document number: 1020017000503

Country of ref document: KR

WWG Wipo information: grant in national office

Ref document number: 46519/99

Country of ref document: AU