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NO20010193L - Tiobenzimidazol-derivater - Google Patents

Tiobenzimidazol-derivater

Info

Publication number
NO20010193L
NO20010193L NO20010193A NO20010193A NO20010193L NO 20010193 L NO20010193 L NO 20010193L NO 20010193 A NO20010193 A NO 20010193A NO 20010193 A NO20010193 A NO 20010193A NO 20010193 L NO20010193 L NO 20010193L
Authority
NO
Norway
Prior art keywords
tiobenzimidazol
derivatives
tiobenzimidazol derivatives
Prior art date
Application number
NO20010193A
Other languages
English (en)
Other versions
NO20010193D0 (no
NO318957B1 (no
Inventor
Yoshiyuki Matsumoto
Susumu Takeuchi
Naoki Hase
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Publication of NO20010193L publication Critical patent/NO20010193L/no
Publication of NO20010193D0 publication Critical patent/NO20010193D0/no
Publication of NO318957B1 publication Critical patent/NO318957B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20010193A 1998-07-15 2001-01-12 Tiobenzimidazol-derivater og farmasoytiske preparater inneholdene disse NO318957B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20025098 1998-07-15
PCT/JP1999/003799 WO2000003997A1 (en) 1998-07-15 1999-07-14 Thiobenzimidazole derivatives

Publications (3)

Publication Number Publication Date
NO20010193L true NO20010193L (no) 2001-01-12
NO20010193D0 NO20010193D0 (no) 2001-01-12
NO318957B1 NO318957B1 (no) 2005-05-30

Family

ID=16421274

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20010193A NO318957B1 (no) 1998-07-15 2001-01-12 Tiobenzimidazol-derivater og farmasoytiske preparater inneholdene disse

Country Status (22)

Country Link
US (2) US7268145B2 (no)
EP (1) EP1097926A4 (no)
JP (1) JP3923255B2 (no)
KR (1) KR100903531B1 (no)
CN (1) CN1187337C (no)
AU (1) AU758789B2 (no)
BG (1) BG65514B1 (no)
BR (1) BR9912098A (no)
CA (1) CA2336909C (no)
EE (1) EE04904B1 (no)
HR (1) HRP20010030A2 (no)
HU (1) HUP0103256A3 (no)
ID (1) ID26899A (no)
IL (1) IL140862A (no)
IS (1) IS5807A (no)
NO (1) NO318957B1 (no)
NZ (1) NZ509207A (no)
PL (1) PL203730B1 (no)
RU (1) RU2237663C2 (no)
SK (1) SK212001A3 (no)
TR (1) TR200100047T2 (no)
WO (1) WO2000003997A1 (no)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040010004A1 (en) 2000-01-17 2004-01-15 Naoki Tsuchiya Benzimidazole derivatives
IL140862A (en) 1998-07-15 2005-05-17 Teijin Ltd Thiobenzimidazole derivatives and pharmaceutical compositions containing the same
JP2007119478A (ja) * 1998-07-15 2007-05-17 Teijin Ltd チオベンズイミダゾール誘導体
US20030083315A1 (en) * 2000-01-17 2003-05-01 Naoki Tsuchiya Human chymase inhibitors
SI1249450T1 (sl) * 2000-01-17 2008-04-30 Teijin Pharma Ltd Derivati benzimidola kot inhibitorji humane kimaze
WO2001062294A1 (en) 2000-02-22 2001-08-30 Suntory Limited Preventive or therapeutic drugs for dermatitises containing chymase inhibitors as the active ingredient
JP3999128B2 (ja) * 2001-02-22 2007-10-31 帝人株式会社 ベンゾ［ｂ］チオフェン誘導体、およびその製造方法
JP4759500B2 (ja) * 2001-02-22 2011-08-31 帝人株式会社 ベンゾ［ｂ］チオフェン誘導体、およびその製造方法
WO2004007464A1 (ja) * 2002-07-10 2004-01-22 Sumitomo Pharmaceuticals Co., Ltd. イミダゾール誘導体
CL2004001034A1 (es) 2003-05-14 2005-03-28 Teijin Pharma Ltd Formas cristalinas de acido 4-(1-((,etilbenzotiofen-3-il)me til)benzimidazol-2-iltio)butanoico; procedimiento de preparacion de las formas cristalinas; composicion farmaceutica; y su uso para el tratamiento de enfermedades inflamatorias, alergicas, r
KR20060120601A (ko) * 2003-08-22 2006-11-27 데이진 화-마 가부시키가이샤 키마제 저해제를 유효 성분으로서 함유하는 약제
RU2409569C2 (ru) * 2004-08-26 2011-01-20 Актелион Фармасьютиклз Лтд Производные 2-сульфанилбензимидазол-1-илуксусной кислоты в качестве антагонистов crth2
RU2267487C1 (ru) * 2004-10-19 2006-01-10 Закрытое акционерное общество "Деско" (ЗАО "Деско") Средство для стимуляции процесса обучения, восстановления памяти и эмоционального статуса
EP1826207A4 (en) * 2004-11-12 2009-05-20 Teijin Pharma Ltd ACID SALT OF A BENZIMIDAZOLE DERIVATIVE AND CRYSTAL THEREOF
UA95788C2 (en) * 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
JP4339371B2 (ja) * 2007-03-22 2009-10-07 株式会社ソニー・コンピュータエンタテインメント 情報処理装置および情報処理方法
TW200916098A (en) * 2007-06-14 2009-04-16 Teijin Pharma Ltd Agent for lowering uric acid level
WO2009133964A1 (ja) * 2008-04-28 2009-11-05 国立大学法人九州大学 酸化ストレス抑制剤
AU2009296820B2 (en) 2008-09-26 2014-03-20 Merck Sharp & Dohme Llc Novel cyclic benzimidazole derivatives useful anti-diabetic agents
EP2348857B1 (en) 2008-10-22 2016-02-24 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
CA2741300A1 (en) 2008-10-29 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
AU2009309037A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
JP2013520502A (ja) 2010-02-25 2013-06-06 メルク・シャープ・エンド・ドーム・コーポレイション 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体
JP5728099B2 (ja) 2011-02-25 2015-06-03 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 抗糖尿病剤として有用な新規環状アザベンゾイミダゾール誘導体
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
RU2015106909A (ru) 2012-08-02 2016-09-27 Мерк Шарп И Доум Корп. Антидиабетические трициклические соединения
WO2014031445A1 (en) 2012-08-22 2014-02-27 Merck Sharp & Dohme Corp. Novel benzimidazole tetrahydropyran derivatives
EP2887807B1 (en) 2012-08-22 2019-09-18 Merck Sharp & Dohme Corp. Benzimidazole hexahydrofuro[3,2-b]furan derivatives useful as amp-activated protein kinase activators
US9540364B2 (en) 2012-08-22 2017-01-10 Merck Sharp & Dohme Corp. Benzimidazole tetrahydrofuran derivatives
EP2888008B1 (en) 2012-08-22 2018-12-26 Merck Sharp & Dohme Corp. Novel azabenzimidazole tetrahydrofuran derivatives
EP2888005B1 (en) 2012-08-22 2019-04-03 Merck Sharp & Dohme Corp. Novel azabenzimidazole hexahydrofuro[3,2-b]furan derivatives
EP2888006B1 (en) 2012-08-22 2019-04-24 Merck Sharp & Dohme Corp. Novel azabenzimidazole tetrahydropyran derivatives useful as ampk activators
KR101435496B1 (ko) * 2012-10-22 2014-08-28 한국과학기술연구원 미토콘드리아 기능 조절제로서의 벤즈이미다졸 유도체
EP2970119B1 (en) 2013-03-14 2021-11-03 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
JP6064062B2 (ja) 2013-03-15 2017-01-18 ファイザー・インク Ａｍｐｋを活性化させるインダゾール化合物
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
US10519115B2 (en) 2013-11-15 2019-12-31 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
WO2015089809A1 (en) 2013-12-19 2015-06-25 Merck Sharp & Dohme Corp. Antidiabetic substituted heteroaryl compounds
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5617073B2 (no) * 1971-10-28 1981-04-20
DE2648411C2 (de) * 1976-10-26 1984-05-17 Mtu Motoren- Und Turbinen-Union Friedrichshafen Gmbh, 7990 Friedrichshafen Mehrzylindrige Dieselbrennkraftmaschine
FR2430950A1 (fr) 1978-07-10 1980-02-08 Delalande Sa Nouveaux derives heterocycliques de la benzimidazole, leur procede de preparation et leur application en therapeutique
US4312308A (en) * 1980-02-21 1982-01-26 Slattery Gordon C Compression relief system for internal combustion engine
JPS62212386A (ja) * 1986-03-14 1987-09-18 Suntory Ltd ２−ピリジルメチルベンズイミダゾ−ル誘導体
EP0251536A1 (en) 1986-06-24 1988-01-07 FISONS plc Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors
US4839365A (en) 1987-05-19 1989-06-13 Shinogi & Co., Ltd. Thienopyridine derivatives useful in treating gastric ulcers
AT389107B (de) 1987-12-03 1989-10-25 Fisons Plc Neue benzimidazole, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
JPH01265089A (ja) 1988-04-15 1989-10-23 Zeria Pharmaceut Co Ltd 新規１−（イミダゾール−４−イル）メチルベンズイミダゾール誘導体およびその製造法ならびにこれを含有する抗潰瘍剤
DE3928177A1 (de) * 1989-04-08 1991-02-28 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5128339A (en) 1990-11-01 1992-07-07 Sterling Winthrop Inc. Proteolytic enzyme inhibition method
GB8911453D0 (en) 1989-05-18 1989-07-05 Minnesota Mining & Mfg Speed and contrast promoted silver halide rhodium doped emulsions
IL94390A (en) 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
JPH0314566A (ja) 1989-06-09 1991-01-23 Sankyo Co Ltd ベンズイミダゾール誘導体
US5449682A (en) 1990-02-13 1995-09-12 Merck & Co., Inc. Angiotensin II antagonists incorporating a substituted benzyl element
FR2658511B1 (fr) * 1990-02-16 1992-06-19 Union Pharma Scient Appl Nouveaux derives de benzimidazole et d'azabenzimidazole, antagonistes des recepteurs au thromboxane; leurs procedes de preparation, compositions pharmaceutiques les contenant.
US5128359A (en) 1990-02-16 1992-07-07 Laboratoires Upsa Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation
US5196444A (en) 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US5374615A (en) 1990-10-31 1994-12-20 E. R. Squibb & Sons, Inc. Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives
CA2061159A1 (en) 1991-02-26 1992-08-27 Michael A. Poss Imidazole and benzimidazole derivatives
US5191086A (en) 1991-03-19 1993-03-02 E.R. Squibb & Sons, Inc. Imidazole and benzimidazole derivatives
US5128327A (en) 1991-03-25 1992-07-07 Merck & Co., Inc. Angiotensin II antagonists incorporating a nitrogen containing six membered ring heterocycle
TW300219B (no) 1991-09-14 1997-03-11 Hoechst Ag
JPH05112559A (ja) 1991-10-18 1993-05-07 Morishita Roussel Kk ４−アミノ−５−ピリミジンカルボン酸誘導体
EP0577023A3 (en) 1992-07-01 1996-12-18 Hoechst Ag Angiotensin-ii receptor-antagonists for the treatment of arrhythmices
JPH0820584A (ja) 1994-07-04 1996-01-23 Takeda Chem Ind Ltd イミダゾール誘導体及びその用途
AU3086095A (en) 1994-07-29 1996-03-04 Suntory Limited Imidazolidine derivative and use thereof
JPH08208654A (ja) 1994-11-24 1996-08-13 Wakamoto Pharmaceut Co Ltd キマーゼ活性を阻害し、かつ一酸化窒素生成を抑制する新規トリアジン誘導体
DE69634122D1 (de) 1995-04-27 2005-02-03 Mitsubishi Pharma Corp Heterocyclische amidverbindungen und deren medizinische verwendung
US5998456A (en) 1995-07-17 1999-12-07 Fuji Photo Film Co., Ltd. Benzimidazole compounds containing 1,2,4-triazole ring, and compositions and methods of use containing the same
JP3537231B2 (ja) 1995-07-24 2004-06-14 第一サントリーファーマ株式会社 ヒダントイン誘導体およびその用途
WO1997011941A1 (fr) 1995-09-28 1997-04-03 Suntory Limited Derives de la quinazoline et leurs emplois
WO1998008818A1 (en) 1996-08-26 1998-03-05 Genetics Institute, Inc. Inhibitors of phospholipase enzymes
EP0940400A4 (en) * 1996-10-25 2002-10-02 Mitsubishi Pharma Corp HETEROCYCLIC AMID COMPOUNDS AND THEIR MEDICAL APPLICATION
WO1999026932A1 (en) 1997-11-26 1999-06-03 Axys Pharmaceuticals, Inc. By amidino group substituted heterocyclic derivatives and their use as anticoagulants
WO1999057103A1 (en) 1998-04-30 1999-11-11 Nippon Chemiphar Co., Ltd. Condensed imidazole derivative and therapeutic agent for liver disease
IL140862A (en) 1998-07-15 2005-05-17 Teijin Ltd Thiobenzimidazole derivatives and pharmaceutical compositions containing the same
CZ20014573A3 (cs) 1999-06-28 2002-05-15 Janssen Pharmaceutica N. V. Inhibitory replikace respiračně syncyciálního viru

Also Published As

Publication number Publication date
IL140862A0 (en) 2002-02-10
EE200100022A (et) 2002-06-17
JP3923255B2 (ja) 2007-05-30
WO2000003997A1 (en) 2000-01-27
BG105149A (en) 2001-08-31
SK212001A3 (en) 2001-11-06
HUP0103256A3 (en) 2002-05-28
BR9912098A (pt) 2001-09-25
IS5807A (is) 2001-01-12
EE04904B1 (et) 2007-10-15
US20070275995A1 (en) 2007-11-29
EP1097926A1 (en) 2001-05-09
PL203730B1 (pl) 2009-11-30
CA2336909C (en) 2009-10-20
NZ509207A (en) 2003-01-31
HRP20010030A2 (en) 2001-12-31
RU2237663C2 (ru) 2004-10-10
ID26899A (id) 2001-02-15
HUP0103256A2 (hu) 2002-04-29
CN1316998A (zh) 2001-10-10
CA2336909A1 (en) 2000-01-27
KR20010079527A (ko) 2001-08-22
AU758789B2 (en) 2003-03-27
US20060040976A1 (en) 2006-02-23
KR100903531B1 (ko) 2009-06-23
PL345540A1 (en) 2001-12-17
US7268145B2 (en) 2007-09-11
NO20010193D0 (no) 2001-01-12
TR200100047T2 (tr) 2001-10-22
NO318957B1 (no) 2005-05-30
AU4651999A (en) 2000-02-07
CN1187337C (zh) 2005-02-02
EP1097926A4 (en) 2004-06-30
BG65514B1 (bg) 2008-10-31
IL140862A (en) 2005-05-17

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