[go: up one dir, main page]

WO2000074662A3 - Traitement de l'arthrite - Google Patents

Traitement de l'arthrite Download PDF

Info

Publication number
WO2000074662A3
WO2000074662A3 PCT/GB2000/002048 GB0002048W WO0074662A3 WO 2000074662 A3 WO2000074662 A3 WO 2000074662A3 GB 0002048 W GB0002048 W GB 0002048W WO 0074662 A3 WO0074662 A3 WO 0074662A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
arthritis treatment
catechins
arthritic
arthritis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2000/002048
Other languages
English (en)
Other versions
WO2000074662A2 (fr
Inventor
David Buttle
Clair Adcocks
Peter Collin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Sheffield
Original Assignee
University of Sheffield
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0007321A external-priority patent/GB0007321D0/en
Application filed by University of Sheffield filed Critical University of Sheffield
Priority to JP2001501199A priority Critical patent/JP2003501381A/ja
Priority to AU50894/00A priority patent/AU5089400A/en
Priority to EP00935346A priority patent/EP1207862A2/fr
Publication of WO2000074662A2 publication Critical patent/WO2000074662A2/fr
Anticipated expiration legal-status Critical
Publication of WO2000074662A3 publication Critical patent/WO2000074662A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention porte sur l'utilisation de cathéchines dans le traitement de diverses formes de l'arthrite, et sur l'utilisation de combinaisons de catéchines et autres agents antiarthritiques ; sur des médicaments et des compositions destinés à être utilisés dans ce traitement et sur des procédés d'identification d'agents aux propriétés antiarthritiques.
PCT/GB2000/002048 1999-06-07 2000-06-06 Traitement de l'arthrite Ceased WO2000074662A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2001501199A JP2003501381A (ja) 1999-06-07 2000-06-06 関節炎の処置
AU50894/00A AU5089400A (en) 1999-06-07 2000-06-06 Arthritis treatment
EP00935346A EP1207862A2 (fr) 1999-06-07 2000-06-06 Traitement de l'arthrite

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13769999P 1999-06-07 1999-06-07
US60/137,699 1999-06-07
GB0007321.3 2000-03-27
GB0007321A GB0007321D0 (en) 2000-03-27 2000-03-27 Arthritis treatment

Publications (2)

Publication Number Publication Date
WO2000074662A2 WO2000074662A2 (fr) 2000-12-14
WO2000074662A3 true WO2000074662A3 (fr) 2002-03-14

Family

ID=26243965

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/002048 Ceased WO2000074662A2 (fr) 1999-06-07 2000-06-06 Traitement de l'arthrite

Country Status (4)

Country Link
EP (1) EP1207862A2 (fr)
JP (1) JP2003501381A (fr)
AU (1) AU5089400A (fr)
WO (1) WO2000074662A2 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020146472A1 (en) 2000-11-15 2002-10-10 Chen Kuang Yu Black tea extract for prevention of disease
WO2002069883A2 (fr) * 2001-02-06 2002-09-12 Universita Degli Studi Di Padova Procede pour inhiber l'elastase leucocytaire
JP2005521629A (ja) * 2001-06-25 2005-07-21 デピユイ・インターナシヨナル・リミテツド 関節炎の関節を治療するためのグリコサミノグリカンとヒアルロニダーゼ阻害剤を含んで成る組成物
CA2451245A1 (fr) * 2001-06-25 2003-01-03 Depuy International Limited Encapsulation liposomale de glycosaminoglycanes pour le traitement d'articulations arthrosees
US7108868B2 (en) 2002-03-22 2006-09-19 Unigen Pharmaceuticals, Inc. Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia
US7972632B2 (en) 2003-02-28 2011-07-05 Unigen Pharmaceuticals, Inc. Identification of Free-B-Ring flavonoids as potent COX-2 inhibitors
AU2003228777C1 (en) 2002-04-30 2009-08-13 Unigen, Inc. Formulation of a mixture of free-B-ring flavonoids and flavans as a therapeutic agent
US8034387B2 (en) 2002-04-30 2011-10-11 Unigen, Inc. Formulation of a mixture of free-B-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments
CN1798568B (zh) 2003-04-04 2011-05-11 尤尼根制药公司 用于哺乳动物皮肤护理的双重环氧合酶(cox)以及脂氧合酶(lox)抑制剂的组合物
US20060193962A1 (en) * 2003-04-11 2006-08-31 Kyowa Hakko Kogyo Co., Ltd. Preventive or remedy for arthritis
WO2006124000A1 (fr) * 2005-05-20 2006-11-23 Agency For Science, Technology And Research Preparations de flavonoides conjugues a des aldehydes
US7858080B2 (en) 2005-05-20 2010-12-28 Agency For Science, Technology And Research Aldehyde conjugated flavonoid preparations
AU2006249771A1 (en) * 2005-05-24 2006-11-30 Wellgen, Inc. Compositions and methods for the prevention and treatment of conditions associated with inflammation
DE102005029845B4 (de) * 2005-06-27 2017-03-23 Orgentec Diagnostika Gmbh Verfahren zur Diagnose von rheumatischen Erkrankungen
CA2627953A1 (fr) * 2005-11-01 2007-05-10 Mars, Incorporated Flavanols, procyanidines de type b et inflammation
US8455436B2 (en) 2010-12-28 2013-06-04 Depuy Mitek, Llc Compositions and methods for treating joints
US8398611B2 (en) 2010-12-28 2013-03-19 Depuy Mitek, Inc. Compositions and methods for treating joints
CN105431159B (zh) 2013-05-14 2020-12-01 马斯公司 关节护理组合物
JP6484633B2 (ja) * 2013-09-03 2019-03-13 エイジェンシー フォー サイエンス，テクノロジー アンド リサーチ ポリマー−フラボノイド接合体およびバイオメディカル応用のためのヒドロゲル
JP6242669B2 (ja) * 2013-11-27 2017-12-06 日本メナード化粧品株式会社 サルナシ抽出物を含有するヒアルロン酸生成促進剤
UA118479C2 (uk) * 2014-05-09 2019-01-25 Едженсі Фор Саєнс, Текнолоджі Енд Рісерч Міцелярний нанокомплекс
EP3142705B1 (fr) * 2014-05-15 2020-08-19 Agency For Science, Technology And Research Conjugué polymere-flavonoïde et utilisations associées
US9682099B2 (en) 2015-01-20 2017-06-20 DePuy Synthes Products, Inc. Compositions and methods for treating joints
JP6742575B2 (ja) * 2015-07-02 2020-08-19 株式会社東洋新薬 関節機能改善組成物
JP2018100238A (ja) * 2016-12-21 2018-06-28 花王株式会社 歩行機能改善剤
IT202200013867A1 (it) * 2022-06-30 2023-12-30 Lo Li Pharma Srl Composizione per il trattamento dell’ infezione da papilloma virus (hpv)
WO2025219934A1 (fr) * 2024-04-18 2025-10-23 The Wave Innovation Group S.R.L. Composition à base d'acide hyaluronique, d'épigallocatéchine-3-o-gallate et/ou de xanthohumol

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268517A (en) * 1979-08-30 1981-05-19 Continental Pharma Pharmaceutical composition and therapeutical method for treating degenerative affections of the articular cartilage
BE886568A (fr) * 1980-12-09 1981-06-09 Continental Pharma Composition pharmaceutique pour le traitement des affections degeneratives du cartilage articulaire, et methode d'utilisation de celle-ci.
JPH07223941A (ja) * 1994-02-14 1995-08-22 Nippon Ham Kk 抗補体作用物質
WO1996028178A1 (fr) * 1995-03-14 1996-09-19 Indena S.P.A. Fractions polyphenol du the, utilisation desdites fractions et compositions les contenant
EP0742012A2 (fr) * 1995-05-10 1996-11-13 Kureha Chemical Industry Co., Ltd. Composition pharmaceutique contenant une substance inhibant la production de HSP47
JPH099987A (ja) * 1995-06-28 1997-01-14 Amano Pharmaceut Co Ltd 配糖体及び糖転移生成物の製造法
GB2306321A (en) * 1995-10-24 1997-05-07 Anne Child The use of (+)-catechin in the treatment or prophylaxis of connective tissue disorders
JPH09227374A (ja) * 1996-02-28 1997-09-02 Taiyo Kagaku Co Ltd ストレスタンパク質産生抑制組成物
JP2000226329A (ja) * 1998-12-04 2000-08-15 Meiji Milk Prod Co Ltd Ｍｍｐ阻害剤
WO2000047193A2 (fr) * 1999-02-12 2000-08-17 Karolinska Innovations Ab Inhibition de l'angiogenese par epigallo-catechin-3-gallate (egcg)

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268517A (en) * 1979-08-30 1981-05-19 Continental Pharma Pharmaceutical composition and therapeutical method for treating degenerative affections of the articular cartilage
BE886568A (fr) * 1980-12-09 1981-06-09 Continental Pharma Composition pharmaceutique pour le traitement des affections degeneratives du cartilage articulaire, et methode d'utilisation de celle-ci.
JPH07223941A (ja) * 1994-02-14 1995-08-22 Nippon Ham Kk 抗補体作用物質
WO1996028178A1 (fr) * 1995-03-14 1996-09-19 Indena S.P.A. Fractions polyphenol du the, utilisation desdites fractions et compositions les contenant
EP0742012A2 (fr) * 1995-05-10 1996-11-13 Kureha Chemical Industry Co., Ltd. Composition pharmaceutique contenant une substance inhibant la production de HSP47
JPH099987A (ja) * 1995-06-28 1997-01-14 Amano Pharmaceut Co Ltd 配糖体及び糖転移生成物の製造法
GB2306321A (en) * 1995-10-24 1997-05-07 Anne Child The use of (+)-catechin in the treatment or prophylaxis of connective tissue disorders
JPH09227374A (ja) * 1996-02-28 1997-09-02 Taiyo Kagaku Co Ltd ストレスタンパク質産生抑制組成物
JP2000226329A (ja) * 1998-12-04 2000-08-15 Meiji Milk Prod Co Ltd Ｍｍｐ阻害剤
WO2000047193A2 (fr) * 1999-02-12 2000-08-17 Karolinska Innovations Ab Inhibition de l'angiogenese par epigallo-catechin-3-gallate (egcg)

Non-Patent Citations (16)

* Cited by examiner, † Cited by third party
Title
AKIZAWA ET AL: "Catechin derivatives as matrix metalloprotease (MMP) inhibitors for treatment of MMP-related diseases", CHEMICAL ABSTRACTS + INDEXES,AMERICAN CHEMICAL SOCIETY. COLUMBUS,US, vol. 133, no. 13, 2000, XP002154308, ISSN: 0009-2258 *
AUCAMP J ET AL: "INHIBITION OF XANTHINE OXIDASE BY CATECHINS FROM TEA (CAMELLIA SINENSIS)", ANTICANCER RESEARCH,HELENIC ANTICANCER INSTITUTE, ATHENS,,GR, vol. 17, no. 6D, November 1997 (1997-11-01), pages 4381 - 4385, XP000925670, ISSN: 0250-7005 *
BLUMENKRANTZ N ET AL: "EFFECTS OF SOME CONNECTIVE TISSUE ACTIVE DRUGS ON PROTO COLLAGEN PROLINE HYDROXYLASE ACTIVITY", SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, vol. 7, no. 2, 1978, EN, pages 123 - 127, XP000981242, ISSN: 0300-9742 *
CARNEY S.L. ET AL: "Anthraquinones related to rhein inhibit glucose uptake into chondrocytes, a mechanism for anti- osteoarthritis drugs?.", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, (1997) 7/7 (817-822)., XP004136136 *
DATABASE WPI Section Ch Week 199712, Derwent World Patents Index; Class B04, AN 1997-126438, XP002169738 *
DATABASE WPI Section Ch Week 200059, Derwent World Patents Index; Class B04, AN 2000-614836, XP002169737 *
GARIBOLDI EMANUELE ET AL: "LC-UV-electrospray-MS-MS mass spectrometry analysis of plant constituents inhibiting xanthine oxidase.", PHARMACEUTICAL RESEARCH (NEW YORK), vol. 15, no. 6, June 1998 (1998-06-01), pages 936 - 943, XP001003087, ISSN: 0724-8741 *
HAQQI T M ET AL: "PREVENTION OF COLLAGEN-INDUCED ARTHRITIS IN MICE BY A POLYPHENOLIC FRACTION FROM GREEN TEA", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,NATIONAL ACADEMY OF SCIENCE. WASHINGTON,US, vol. 96, no. 8, 13 April 1999 (1999-04-13), pages 4524 - 4529, XP000961089, ISSN: 0027-8424 *
ISLAM S ET AL: "INHIBITION OF TNF-ALPHA-INDUCED CASPASE-3 ACTIVITY BY EPIGALLOCATECHIN-3-GALLATE (EGCG) IN HUMAN ARTICULAR CHONDROCYTES", ARTHRITIS AND RHEUMATISM,LIPPINCOTT, PHILADELPHIA,US, vol. 42, no. 9, September 1999 (1999-09-01), pages S92, XP000972239, ISSN: 0004-3591 *
NIEBES P ET AL: "EFFECT OF DRUGS ON COLLAGEN FIBRILLATION AND COLLAGEN DEGRADATION IN VITRO", EUROPEAN JOURNAL OF RHEUMATOLOGY AND INFLAMMATION,GB,CAMERON PUBLISHERS, CASTLETOWN, vol. 2, no. 2, 1979, pages 226 - 229, XP000614080, ISSN: 0104-1610 *
PATENT ABSTRACTS OF JAPAN vol. 1995, no. 11 26 December 1995 (1995-12-26) *
PATENT ABSTRACTS OF JAPAN vol. 1998, no. 01 30 January 1998 (1998-01-30) *
RAO C N ET AL: "BIO FLAVONOID MEDIATED STABILIZATION OF COLLAGEN IN ADJUVANT INDUCED ARTHRITIS", SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, vol. 12, no. 1, 1983, pages 39 - 42, XP000981292, ISSN: 0300-9742 *
RAO, C. N. ET AL: "Influence of bioflavonoids on the collagen metabolism in rats with adjuvant induced arthritis", ITAL. J. BIOCHEM. (1981), 30(1), 54-62, XP000981289 *
SHEU SHIOW-YUN ET AL: "Superoxide anion scavenge effect of Quercus glauca Thunb. in whole blood of patients with ankylosing spondylitis.", AMERICAN JOURNAL OF CHINESE MEDICINE, vol. 25, no. 3-4, 1997, pages 307 - 315, XP000981297, ISSN: 0192-415X *
SWARNALAKSHMI T ET AL: "ANTI INFLAMMATORY ACTIVITY OF LEVO EPI CATECHIN A BIO FLAVONOID ISOLATED FROM ANACARDIUM-OCCIDENTALE", INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 43, no. 6, 1981, pages 205 - 208, XP000981290, ISSN: 0250-474X *

Also Published As

Publication number Publication date
WO2000074662A2 (fr) 2000-12-14
JP2003501381A (ja) 2003-01-14
EP1207862A2 (fr) 2002-05-29
AU5089400A (en) 2000-12-28

Similar Documents

Publication Publication Date Title
WO2000074662A3 (fr) Traitement de l'arthrite
AU2002213975A1 (en) Novel anticholinergic agents that can be used as medicaments and method for the production thereof
WO1998057937A3 (fr) INHIBITEURS DU FACTEUR Xa COMPRENANT UN GROUPE A SPECIFICITE P1 NEUTRE
WO2001045679A3 (fr) Utilisation d'agents chimiotherapeutiques
AU2002213977A1 (en) Novel anticholinergics, method for the production thereof and use thereof as medicaments
TW200724033A (en) Anthranilamide arthropodicide treatment
AU2001279905A2 (en) Azabicyclic compounds, preparation thereof and use as medicines, in particular as antibacterial agents
WO1999054326A8 (fr) Dihydropyrimidines
DZ3165A1 (fr) Composition alimentaire ou pharmaceutique utiliseepour prevenir ou traiter l'hyperoxalurie.
IT1317359B1 (it) Polisaccaridi percarbossilati, quali l'acido ialuronico, processo perla loro preparazione e loro impiego in campo farmaceutico e
TW200505483A (en) New medicament compositions based on anticholinergically-effective compounds and β-mimetics
EP0639611A3 (fr) Compositions contenant des polyamides aromatiques ayant des propriétés électrostatiques améliorées, les articles formés obtenus, leur utilisation et procédés de leur préparation.
WO2000071493A3 (fr) INHIBITEURS DU FACTEUR Xa
EP2772254A3 (fr) Nouveaux agents antibactériens
WO2003057135A3 (fr) Compositions aqueuses contenant du metronidazole
FI19992203L (fi) Menetelmä kauran beeta-glukaanin rikastamiseksi, menetelmällä saatava tuote sekä tuotteen käyttö
WO2002036106A3 (fr) Nouvelle composition medicamenteuse a base d'anticholinergiques et de corticosteroides
SI1648484T1 (sl) Farmacevtske oblike za zdravljenje artritiäśnih stanj
WO2001039723A3 (fr) Composes triazospiro presentant une affinite pour le recepteur de la nociceptine
WO2002072571A3 (fr) Pyridinyl-pyrazoles utiles pour le traitement de la bronchopneumopathie chronique obstructive
WO2003039453A3 (fr) Compositions de peroxyde de dibenzoyle pour le traitement de troubles dermatologiques, et procedes d'utilisation correspondants
BG105120A (en) Chemotaxis-inhibiting protein of staphylococcus (chips) and its use
AU2001252132A1 (en) Substituted 5-methyldihydropyridazinones and their use in the prophylaxis and/ortreatment of anemias
WO2000069841A3 (fr) Benzofuranylaminoalcools
PT1572217E (pt) Medicamento combinado de r,r-formoterol e ciclesonida

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2000935346

Country of ref document: EP

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2001 501199

Kind code of ref document: A

Format of ref document f/p: F

AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWE Wipo information: entry into national phase

Ref document number: 10009057

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 2000935346

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2000935346

Country of ref document: EP