[go: up one dir, main page]

WO1999032621A3 - Sequences d'acide nucleique codant des proteines de co-activateur de recepteur nucleaire et utilisation de ces sequences - Google Patents

Sequences d'acide nucleique codant des proteines de co-activateur de recepteur nucleaire et utilisation de ces sequences Download PDF

Info

Publication number
WO1999032621A3
WO1999032621A3 PCT/US1998/025478 US9825478W WO9932621A3 WO 1999032621 A3 WO1999032621 A3 WO 1999032621A3 US 9825478 W US9825478 W US 9825478W WO 9932621 A3 WO9932621 A3 WO 9932621A3
Authority
WO
WIPO (PCT)
Prior art keywords
src
nuclear receptor
steroid
receptor
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/025478
Other languages
English (en)
Other versions
WO1999032621A2 (fr
Inventor
Chen-Shian Suen
Donald Edward Frail
Cecil Richard Lyttle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Priority to AU18010/99A priority Critical patent/AU1801099A/en
Publication of WO1999032621A2 publication Critical patent/WO1999032621A2/fr
Publication of WO1999032621A3 publication Critical patent/WO1999032621A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Cette invention concerne un nouveau co-activateur 3 de récepteur stéroïde (SRC-3), ainsi qu'un co-activateur de transcription de récepteur nucléaire stéroïde qui a été cloné et caractérisé. Le SRC-3 représente un nouveau membre qui appartient à une famille de co-activateurs de récepteur stéroïde et qui comprend TAF-1 et TIF-2. Le SRC-3 a fait preuve d'une transcription de gène stimulée par récepteur nucléaire et sélective dans des conditions de dépendance envers les ligands. Cette invention concerne également des dosages d'interaction protéine-protéine qui comprennent des analyses BIACORE et qui ont prouvé que l'interaction entre SRC-3 et ER était bien plus importante que celle observée entre SRC-3 et ER b. Une fonction de transactivation intrinsèque a été observée dans la moitié de la terminaison C du SRC-3. Le SRC-3 a été exprimé de manière différentielle dans divers tissus et, parmi plusieurs cellules tumorales examinées, était plus abondant dans la fraction nucléaire de cellules du cancer du sein MCF-7. Le SRC-3 représente ainsi un troisième membre de la famille des co-activateurs de récepteur stéroïde, et possède une répartition tissulaire distincte ainsi qu'une sélectivité intrinsèque entre ER et ER b.
PCT/US1998/025478 1997-12-22 1998-12-01 Sequences d'acide nucleique codant des proteines de co-activateur de recepteur nucleaire et utilisation de ces sequences Ceased WO1999032621A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU18010/99A AU1801099A (en) 1997-12-22 1998-12-01 Nucleic acid sequences encoding nuclear receptor coactivator proteins and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6851197P 1997-12-22 1997-12-22
US60/068,511 1997-12-22

Publications (2)

Publication Number Publication Date
WO1999032621A2 WO1999032621A2 (fr) 1999-07-01
WO1999032621A3 true WO1999032621A3 (fr) 1999-09-16

Family

ID=22083052

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/025478 Ceased WO1999032621A2 (fr) 1997-12-22 1998-12-01 Sequences d'acide nucleique codant des proteines de co-activateur de recepteur nucleaire et utilisation de ces sequences

Country Status (2)

Country Link
AU (1) AU1801099A (fr)
WO (1) WO1999032621A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116600818A (zh) 2020-10-28 2023-08-15 贝勒医学院 靶向免疫细胞中的src-3作为治疗癌症的免疫调节治疗剂

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997010337A1 (fr) * 1995-09-15 1997-03-20 Baylor College Of Medicine Compositions coactivatrices de recepteurs de steroides et leurs procedes d'utilisation
WO1998002455A2 (fr) * 1996-07-12 1998-01-22 Institut National De La Sante Et De La Recherche Medicale Facteur-2 intermediaire de la transcription
WO1998057982A2 (fr) * 1997-06-17 1998-12-23 The United States Of America, Represented By The Nouveau co-activateur du recepteur steroidien (aib1)

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997010337A1 (fr) * 1995-09-15 1997-03-20 Baylor College Of Medicine Compositions coactivatrices de recepteurs de steroides et leurs procedes d'utilisation
WO1998002455A2 (fr) * 1996-07-12 1998-01-22 Institut National De La Sante Et De La Recherche Medicale Facteur-2 intermediaire de la transcription
WO1998057982A2 (fr) * 1997-06-17 1998-12-23 The United States Of America, Represented By The Nouveau co-activateur du recepteur steroidien (aib1)

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
A TAKESHITA ET AL: "TRAM-1, a novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 44, 31 October 1997 (1997-10-31), pages 27629 - 27634, XP002088095, ISSN: 0021-9258 *
CHEN H ET AL: "NUCLEAR RECEPTOR COACTIVATOR ACTR IS A NOVEL HISTONE ACETYLTRANSFERASE AND FORMS A MULTIMERIC ACTIVATION COMPLEX WITH P/CAF AND CBP/P300", CELL, vol. 90, 8 August 1997 (1997-08-08), pages 569 - 580, XP002910264, ISSN: 0092-8674 *
HONG H ET AL: "GRIP1, A TRANSCRIPTIONAL COACTIVATOR FOR THE AF-2 TRANSACTIVATION DOMAIN OF STEROID, THYROID, RETINOID, AND VITAMIN D RECEPTORS", MOLECULAR AND CELLULAR BIOLOGY, vol. 17, no. 5, 1 May 1997 (1997-05-01), pages 2735 - 2744, XP002045758, ISSN: 0270-7306 *
J TORCHIA ET AL: "The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function", NATURE, vol. 387, no. 6634, 12 June 1997 (1997-06-12), pages 677 - 684, XP002088153, ISSN: 0028-0836 *
KIM HAN-JONG ET AL.,: "Molecular cloning of xSRC-3, a novel transcription coactivator factor from xenopus, that is related to AIB1, p/CIP, and TIF2", MOLECULAR ENDOCRINOLOGY, vol. 12, no. 7, 1 July 1998 (1998-07-01), pages 1038 - 1047, XP002109674 *
LI H ET AL: "RAC3, A STEROID/NUCLEAR RECEPTOR-ASSOCIATED COACTIVATOR THAT IS RELATED TO SRC-1 AND TIF2", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 94, August 1997 (1997-08-01), pages 8479 - 8484, XP002910265, ISSN: 0027-8424 *
ONATE S A ET AL: "SEQUENCE AND CHARACTERIZATION OF A COACTIVATOR FOR THE STEROID HORMONE RECEPTOR SUPERFAMILY", SCIENCE, vol. 270, 24 November 1995 (1995-11-24), pages 1354 - 1357, XP002911375, ISSN: 0036-8075 *
S L ANZICK ET AL: "AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer", SCIENCE, vol. 277, no. 5328, 15 August 1997 (1997-08-15), pages 965 - 968, XP002088093, ISSN: 0036-8075 *
SHUGHRUE P J ET AL: "Comparative distribution of estrogen receptor-alpha (ER-alpha) and beta (ER-beta) mRNA in the rat pituitary, gonad, and reproductive tract", STEROIDS: STRUCTURE, FUNCTION, AND REGULATION, vol. 63, no. 10, 1 October 1998 (1998-10-01), pages 498-504, XP004140830, ISSN: 0039-128X *
SUEN CHEN-SHIAN ET AL.,: "A transcriptional coactivator, steroid receptor coactivator-3, selectively augments steroid receptor transcriptional activity", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 42, 16 October 1998 (1998-10-16), pages 27645-27653, XP002109675 *
VOEGEL J J ET AL: "TIF2, A 160 KDA TRANSCRIPTIONAL MEDIATOR FOR THE LIGAND-DEPENDENT ACTIVATION FUNCTION AF-2 OF NUCLEAR RECEPTORS", EMBO JOURNAL, vol. 15, no. 14, 1 January 1996 (1996-01-01), pages 3667 - 3675, XP002045757, ISSN: 0261-4189 *
WITKOWSKA H E ET AL: "Characterization of bacterially expressed rat estrogen receptor beta ligand binding domain by mass spectrometry: Structural comparison with estrogen receptor alpha", STEROIDS: STRUCTURE, FUNCTION, AND REGULATION, vol. 62, no. 8-9, 9 August 1997 (1997-08-09), pages 621-631, XP004091560, ISSN: 0039-128X *
X-Y GUAN ET AL: "Hybrid selection of transcribed sequences from microdissected DNA: Isolation of genes within an amplified region at 20q11-q13.2 in breast cancer", CANCER RESEARCH, vol. 56, no. 15, 1 August 1996 (1996-08-01), pages 3446 - 3450, XP002088091, ISSN: 0008-5472 *

Also Published As

Publication number Publication date
AU1801099A (en) 1999-07-12
WO1999032621A2 (fr) 1999-07-01

Similar Documents

Publication Publication Date Title
Croxton et al. Direct repression of the Mcl-1 promoter by E2F1
Pabst et al. AML1–ETO downregulates the granulocytic differentiation factor C/EBPα in t (8; 21) myeloid leukemia
Rizos et al. Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization
Dauphinot et al. Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2 and c-Myc expression
Hittelman et al. Differential regulation of glucocorticoid receptor transcriptional activation via AF‐1‐associated proteins
Waseem et al. Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA) Structural conservation and the detection of a nucleolar form
Schuh et al. ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis
Zwerner et al. PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors
Datta et al. p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition
Belandia et al. Targeting of SWI/SNF chromatin remodelling complexes to estrogen‐responsive genes
Bai et al. ZBP-89 promotes growth arrest through stabilization of p53
HUP9700636A2 (hu) Új ösztrogénreceptorok
WO1998050547A3 (fr) Recepteur proteique humain du type toll, reactifs connexes et techniques afferentes
DK0914345T3 (da) Antistoffer, som binder til monocyt-kemoattraktant-protein-1-receptor (MCP-1-receptor) (CCR2)
Barlev et al. A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription
Sel et al. Human renal cell carcinogenesis is accompanied by a coordinate loss of the tissue specific transcription factors HNF4α and HNF1α
Cohen‐Kaminsky et al. Chromatin immunoselection defines a TAL‐1 target gene
Jarrett et al. Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling
Ito et al. SYT, a partner of SYT-SSX oncoprotein in synovial sarcomas, interacts with mSin3A, a component of histone deacetylase complex
Natesampillai et al. Regulation of Kruppel-like factor 4, 9, and 13 genes and the steroidogenic genes LDLR, StAR, and CYP11A in ovarian granulosa cells
WO1999032621A3 (fr) Sequences d'acide nucleique codant des proteines de co-activateur de recepteur nucleaire et utilisation de ces sequences
Kim et al. MDM2 regulates estrogen receptor α and estrogen-responsiveness in breast cancer cells
Chin et al. Human T-cell leukemia virus oncoprotein tax represses nuclear receptor–dependent transcription by targeting coactivator TAX1BP1
ATE393163T1 (de) Aib1, ein steroidrezeptor co-aktivator
Redeuilh et al. Transcriptional activation by the oestrogen receptor α is modulated through inhibition of cyclin-dependent kinases

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
NENP Non-entry into the national phase

Ref country code: KR

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase