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WO1999032621A3 - Nucleic acid sequences encoding nuclear receptor coactivator proteins and uses thereof - Google Patents

Nucleic acid sequences encoding nuclear receptor coactivator proteins and uses thereof Download PDF

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Publication number
WO1999032621A3
WO1999032621A3 PCT/US1998/025478 US9825478W WO9932621A3 WO 1999032621 A3 WO1999032621 A3 WO 1999032621A3 US 9825478 W US9825478 W US 9825478W WO 9932621 A3 WO9932621 A3 WO 9932621A3
Authority
WO
WIPO (PCT)
Prior art keywords
src
nuclear receptor
steroid
receptor
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/025478
Other languages
French (fr)
Other versions
WO1999032621A2 (en
Inventor
Chen-Shian Suen
Donald Edward Frail
Cecil Richard Lyttle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Priority to AU18010/99A priority Critical patent/AU1801099A/en
Publication of WO1999032621A2 publication Critical patent/WO1999032621A2/en
Publication of WO1999032621A3 publication Critical patent/WO1999032621A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A novel steroid receptor coactivator-3 (SRC-3), a coactivator of steroid nuclear receptor transcription was cloned and characterized. SRC-3 represents a new member of a family of steroid receptor coactivators that includes TAF-1 and TIF-2. SRC-3 demonstrated selective nuclear receptor-stimulated gene transcription in a ligand-dependent manner. Protein-protein interaction assays, including BIACORE analyses, demonstrated that the interaction between SRC-3 and ER a was much stronger than that observed for SRC-3 and ER b. An intrinsic transactivation function was observed in the C-terminal half of SRC-3. SRC-3 was differentially expressed in various tissues and, among several tumor cells examined, was most abundant in the nuclear fraction of MCF-7 breast cancer cells. Therefore, SRC-3 is a third member of a family of steroid receptor coactivators that has a distinct tissue distribution and intriguing selectivity between ER a and ER b.
PCT/US1998/025478 1997-12-22 1998-12-01 Nucleic acid sequences encoding nuclear receptor coactivator proteins and uses thereof Ceased WO1999032621A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU18010/99A AU1801099A (en) 1997-12-22 1998-12-01 Nucleic acid sequences encoding nuclear receptor coactivator proteins and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6851197P 1997-12-22 1997-12-22
US60/068,511 1997-12-22

Publications (2)

Publication Number Publication Date
WO1999032621A2 WO1999032621A2 (en) 1999-07-01
WO1999032621A3 true WO1999032621A3 (en) 1999-09-16

Family

ID=22083052

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/025478 Ceased WO1999032621A2 (en) 1997-12-22 1998-12-01 Nucleic acid sequences encoding nuclear receptor coactivator proteins and uses thereof

Country Status (2)

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AU (1) AU1801099A (en)
WO (1) WO1999032621A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230093329A (en) 2020-10-28 2023-06-27 베이롤 칼리지 오브 메드신 Targeting of SRC-3 in Immune Cells as an Immunomodulatory Therapeutic for the Treatment of Cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997010337A1 (en) * 1995-09-15 1997-03-20 Baylor College Of Medicine Steroid receptor coactivator compositions and methods of use
WO1998002455A2 (en) * 1996-07-12 1998-01-22 Institut National De La Sante Et De La Recherche Medicale Transcriptional intermediary factor-2 (tfif2)
WO1998057982A2 (en) * 1997-06-17 1998-12-23 The United States Of America, Represented By The Aib1, a steroid receptor co-activator

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997010337A1 (en) * 1995-09-15 1997-03-20 Baylor College Of Medicine Steroid receptor coactivator compositions and methods of use
WO1998002455A2 (en) * 1996-07-12 1998-01-22 Institut National De La Sante Et De La Recherche Medicale Transcriptional intermediary factor-2 (tfif2)
WO1998057982A2 (en) * 1997-06-17 1998-12-23 The United States Of America, Represented By The Aib1, a steroid receptor co-activator

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
A TAKESHITA ET AL: "TRAM-1, a novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 44, 31 October 1997 (1997-10-31), pages 27629 - 27634, XP002088095, ISSN: 0021-9258 *
CHEN H ET AL: "NUCLEAR RECEPTOR COACTIVATOR ACTR IS A NOVEL HISTONE ACETYLTRANSFERASE AND FORMS A MULTIMERIC ACTIVATION COMPLEX WITH P/CAF AND CBP/P300", CELL, vol. 90, 8 August 1997 (1997-08-08), pages 569 - 580, XP002910264, ISSN: 0092-8674 *
HONG H ET AL: "GRIP1, A TRANSCRIPTIONAL COACTIVATOR FOR THE AF-2 TRANSACTIVATION DOMAIN OF STEROID, THYROID, RETINOID, AND VITAMIN D RECEPTORS", MOLECULAR AND CELLULAR BIOLOGY, vol. 17, no. 5, 1 May 1997 (1997-05-01), pages 2735 - 2744, XP002045758, ISSN: 0270-7306 *
J TORCHIA ET AL: "The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function", NATURE, vol. 387, no. 6634, 12 June 1997 (1997-06-12), pages 677 - 684, XP002088153, ISSN: 0028-0836 *
KIM HAN-JONG ET AL.,: "Molecular cloning of xSRC-3, a novel transcription coactivator factor from xenopus, that is related to AIB1, p/CIP, and TIF2", MOLECULAR ENDOCRINOLOGY, vol. 12, no. 7, 1 July 1998 (1998-07-01), pages 1038 - 1047, XP002109674 *
LI H ET AL: "RAC3, A STEROID/NUCLEAR RECEPTOR-ASSOCIATED COACTIVATOR THAT IS RELATED TO SRC-1 AND TIF2", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 94, August 1997 (1997-08-01), pages 8479 - 8484, XP002910265, ISSN: 0027-8424 *
ONATE S A ET AL: "SEQUENCE AND CHARACTERIZATION OF A COACTIVATOR FOR THE STEROID HORMONE RECEPTOR SUPERFAMILY", SCIENCE, vol. 270, 24 November 1995 (1995-11-24), pages 1354 - 1357, XP002911375, ISSN: 0036-8075 *
S L ANZICK ET AL: "AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer", SCIENCE, vol. 277, no. 5328, 15 August 1997 (1997-08-15), pages 965 - 968, XP002088093, ISSN: 0036-8075 *
SHUGHRUE P J ET AL: "Comparative distribution of estrogen receptor-alpha (ER-alpha) and beta (ER-beta) mRNA in the rat pituitary, gonad, and reproductive tract", STEROIDS: STRUCTURE, FUNCTION, AND REGULATION, vol. 63, no. 10, 1 October 1998 (1998-10-01), pages 498-504, XP004140830, ISSN: 0039-128X *
SUEN CHEN-SHIAN ET AL.,: "A transcriptional coactivator, steroid receptor coactivator-3, selectively augments steroid receptor transcriptional activity", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 42, 16 October 1998 (1998-10-16), pages 27645-27653, XP002109675 *
VOEGEL J J ET AL: "TIF2, A 160 KDA TRANSCRIPTIONAL MEDIATOR FOR THE LIGAND-DEPENDENT ACTIVATION FUNCTION AF-2 OF NUCLEAR RECEPTORS", EMBO JOURNAL, vol. 15, no. 14, 1 January 1996 (1996-01-01), pages 3667 - 3675, XP002045757, ISSN: 0261-4189 *
WITKOWSKA H E ET AL: "Characterization of bacterially expressed rat estrogen receptor beta ligand binding domain by mass spectrometry: Structural comparison with estrogen receptor alpha", STEROIDS: STRUCTURE, FUNCTION, AND REGULATION, vol. 62, no. 8-9, 9 August 1997 (1997-08-09), pages 621-631, XP004091560, ISSN: 0039-128X *
X-Y GUAN ET AL: "Hybrid selection of transcribed sequences from microdissected DNA: Isolation of genes within an amplified region at 20q11-q13.2 in breast cancer", CANCER RESEARCH, vol. 56, no. 15, 1 August 1996 (1996-08-01), pages 3446 - 3450, XP002088091, ISSN: 0008-5472 *

Also Published As

Publication number Publication date
AU1801099A (en) 1999-07-12
WO1999032621A2 (en) 1999-07-01

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