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WO1999008665A3 - Verwendung von thiolverbindungen zur inaktivierung von viren - Google Patents

Verwendung von thiolverbindungen zur inaktivierung von viren Download PDF

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Publication number
WO1999008665A3
WO1999008665A3 PCT/DE1998/002370 DE9802370W WO9908665A3 WO 1999008665 A3 WO1999008665 A3 WO 1999008665A3 DE 9802370 W DE9802370 W DE 9802370W WO 9908665 A3 WO9908665 A3 WO 9908665A3
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WIPO (PCT)
Prior art keywords
blood
viral inactivation
thiol compounds
compounds
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE1998/002370
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English (en)
French (fr)
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WO1999008665A2 (de
Inventor
Peter Hofschneider
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Individual
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to US09/485,793 priority Critical patent/US6426370B1/en
Publication of WO1999008665A2 publication Critical patent/WO1999008665A2/de
Publication of WO1999008665A3 publication Critical patent/WO1999008665A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
    • A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
    • A01N41/04—Sulfonic acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/12—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
    • A01N47/14—Di-thio analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C12N7/06—Inactivation or attenuation by chemical treatment

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Die vorliegende Erfindung betrifft die Verwendung von Thiolverbindungen zur Inaktivierung von Viren in zellfreier Umgebung, insbesondere in Blut, Blutplasma, Blutserum, Blutkonserven, Blutprodukten, Zellkulturflüssigkeiten und Nährmedien sowie beim Aufbringen auf die Oberfläche von Pflanzen oder Tieren. Dabei erfolgt die Inaktivierung der Viren, ohne daß es des Zellstoffwechsels bedarf. Bevorzugte Thiolverbindungen sind Cystein und dessen Derivate, Mercaptoalkanole, Dithiocarbamat, Thiolphenol und 2-Mercaptoethansulfonsäure.
PCT/DE1998/002370 1997-08-13 1998-08-12 Verwendung von thiolverbindungen zur inaktivierung von viren Ceased WO1999008665A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US09/485,793 US6426370B1 (en) 1997-08-13 1998-08-12 Use of thiol compounds in viral inactivation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19735120A DE19735120A1 (de) 1997-08-13 1997-08-13 Verwendung von Thiolverbindungen zur Inaktivierung von Viren
DE19735120.4 1997-08-13

Publications (2)

Publication Number Publication Date
WO1999008665A2 WO1999008665A2 (de) 1999-02-25
WO1999008665A3 true WO1999008665A3 (de) 1999-09-10

Family

ID=7838880

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1998/002370 Ceased WO1999008665A2 (de) 1997-08-13 1998-08-12 Verwendung von thiolverbindungen zur inaktivierung von viren

Country Status (3)

Country Link
US (1) US6426370B1 (de)
DE (1) DE19735120A1 (de)
WO (1) WO1999008665A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1549709A (zh) * 2001-07-16 2004-11-24 ����ɯ�ס����ڵ��ɿ� 一类抗病毒化合物在制造用于治疗或预防在呼吸道中病毒感染的制剂中的应用
WO2007033180A1 (en) 2005-09-12 2007-03-22 Abela Pharmaceuticals, Inc. Materials for facilitating administration of dimethyl sulfoxide (dmso) and related compounds
EP1966229B1 (de) 2005-09-12 2015-10-21 Abela Pharmaceuticals, Inc. Systeme zur entfernung von dimethylsulfoxid (dmso) oder verwandten verbindungen, oder damit assoziierten gerüchen
EP2324838A1 (de) 2005-09-12 2011-05-25 Abela Pharmaceuticals, Inc. Zusammensetzungen mit Dimethyl-Sulfoxid
US8480797B2 (en) 2005-09-12 2013-07-09 Abela Pharmaceuticals, Inc. Activated carbon systems for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors
BRPI0921494A2 (pt) 2008-11-03 2018-10-30 Prad Reasearch And Development Ltd método de planejamento de uma operação de amostragem para uma formação subterrãnea, método de contolar uma operação de amostragem de formação subterrânea, método de controlar uma operação de perfuração para uma formação subterrãnea, e método de realizar uma amostragem durante a operação de perfuração.
CA2779111C (en) 2009-10-30 2019-08-13 Abela Pharmaceuticals, Inc. Dimethyl sulfoxide (dmso) and methylsulfonylmethane (msm) formulations to treat osteoarthritis
EP2493464B8 (de) 2009-10-30 2018-06-27 Biogenic Innovations, LLC Methylsulfonylmethan (msm) zur behandlung wirkstoffresistenter mikroorganismen

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708965A (en) * 1985-09-16 1987-11-24 Morgan Lee R Method of treating herpes virus infections with N,N'-diacetylcystine and derivatives
WO1990005135A2 (fr) * 1988-11-02 1990-05-17 Pasteur Merieux Serums Et Vaccins Procede de synthese specifique de nouveaux esters d'acides dithiocarbamiques par substitution de sites hydroxyles sur des molecules mono- ou polyhydroxylees, produits obtenus par ce procede et leurs applications
WO1995003792A1 (de) * 1993-07-29 1995-02-09 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verwendung von thiolverbindungen zur therapie von viralen erkrankungen
WO1996004242A1 (en) * 1994-08-05 1996-02-15 Warner-Lambert Company Arylthio compounds as antibacterial and antiviral agents
WO1996010402A1 (en) * 1994-10-04 1996-04-11 Knox Van Dyke Multi-faceted method to repress reproduction of latent viruses in humans and animals
US5580577A (en) * 1990-01-11 1996-12-03 Herzenberg; Leonard A. Method of treating the symptoms of human rhinovirus infection

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4534972A (en) * 1983-03-29 1985-08-13 Miles Laboratories, Inc. Protein compositions substantially free from infectious agents

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708965A (en) * 1985-09-16 1987-11-24 Morgan Lee R Method of treating herpes virus infections with N,N'-diacetylcystine and derivatives
WO1990005135A2 (fr) * 1988-11-02 1990-05-17 Pasteur Merieux Serums Et Vaccins Procede de synthese specifique de nouveaux esters d'acides dithiocarbamiques par substitution de sites hydroxyles sur des molecules mono- ou polyhydroxylees, produits obtenus par ce procede et leurs applications
US5580577A (en) * 1990-01-11 1996-12-03 Herzenberg; Leonard A. Method of treating the symptoms of human rhinovirus infection
WO1995003792A1 (de) * 1993-07-29 1995-02-09 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verwendung von thiolverbindungen zur therapie von viralen erkrankungen
WO1996004242A1 (en) * 1994-08-05 1996-02-15 Warner-Lambert Company Arylthio compounds as antibacterial and antiviral agents
WO1996010402A1 (en) * 1994-10-04 1996-04-11 Knox Van Dyke Multi-faceted method to repress reproduction of latent viruses in humans and animals

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BARNETT, O. W. ET AL: "Differential response of Prunus necrotic ringspot and tulare apple mosaic viruses to stabilizing agents", VIROLOGY (1971), 46(3), 611-17 CODEN: VIRLAX, 1971, XP002103433 *
KAMEOKA, MASANORI ET AL: "Intracellular glutathione as a possible direct blocker of HIV type 1 reverse transcription", AIDS RES. HUM. RETROVIRUSES (1996), 12(17), 1635-1638 CODEN: ARHRE7;ISSN: 0889-2229, 1996, XP002103432 *
KLIMOCHKIN, YU. N. ET AL: "Sulfur-containing adamantane derivatives: synthesis and antiviral-- activity", KHIM.-FARM. ZH. (1991), 25(7), 49-51 CODEN: KHFZAN;ISSN: 0023-1134, 1991, XP002103436 *
LIOY, JANET ET AL: "Thiol suppression of human immunodeficiency virus type 1 replication in primary cord blood monocyte-derived macrophages in vitro", J. CLIN. INVEST. (1993), 91(2), 495-8 CODEN: JCINAO;ISSN: 0021-9738, 1993, XP002103431 *
MCDONNELL, NAZLI B. ET AL: "Zinc Ejection as a New Rationale for the Use of Cystamine and Related Disulfide-Containing Antiviral Agents in the Treatment of AIDS", J. MED. CHEM. (1997), 40(13), 1969-1976 CODEN: JMCMAR;ISSN: 0022-2623, 1997, XP002103430 *
MURATA, AKIRA ET AL: "Mechanism of inactivation of bacteriophage J1 by dithiotheritol, cysteine, mercaptoethanol, or thioglycollate", AGR. BIOL. CHEM. (1973), 37(9), 2159-65 CODEN: ABCHA6, 1973, XP002103429 *
OLIVIER, R. ET AL: "Prevention of early cell death in peripheral blood lymphocytes of HIV infected individuals by an anti-oxidant: N-acetyl-cysteine", OXID. STRESS, CELL ACT. VIRAL INFECT. (1994) 323-32 CODEN: 60KKAM, 1994, XP002103435 *
SHOJI, SHOZO ET AL: "Thiamine disulfide as a potent inhibitor of human immunodeficiency virus (type-1) production", BIOCHEM. BIOPHYS. RES. COMMUN. (1994), 205(1), 967-75 CODEN: BBRCA9;ISSN: 0006-291X, 1994, XP002103434 *
TOTSUKA A ET AL: "THE EFFECTS OF AMINO ACIDS AND METALS ON THE INFECTIVITY OF POLIOVIRUS RIBONUCLEIC ACID", JAPANESE JOURNAL OF MICROBIOLOGY, vol. 18, no. 2, 1 March 1974 (1974-03-01), pages 107 - 112, XP000644692 *

Also Published As

Publication number Publication date
DE19735120A1 (de) 1999-02-18
US20020040057A1 (en) 2002-04-04
US6426370B1 (en) 2002-07-30
WO1999008665A2 (de) 1999-02-25

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