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WO1998015535B1 - 1,4-benzodiazepinones et leurs utilisations en tant qu'antagonistes de cck - Google Patents

1,4-benzodiazepinones et leurs utilisations en tant qu'antagonistes de cck

Info

Publication number
WO1998015535B1
WO1998015535B1 PCT/JP1997/003483 JP9703483W WO9815535B1 WO 1998015535 B1 WO1998015535 B1 WO 1998015535B1 JP 9703483 W JP9703483 W JP 9703483W WO 9815535 B1 WO9815535 B1 WO 9815535B1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
formula
cycloalkyl
benzodiazepinones
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP1997/003483
Other languages
English (en)
Other versions
WO1998015535A1 (fr
Filing date
Publication date
Priority claimed from AUPO2843A external-priority patent/AUPO284396A0/en
Application filed filed Critical
Priority to JP51737298A priority Critical patent/JP2001504454A/ja
Priority to US09/269,752 priority patent/US6291452B1/en
Priority to EP97941281A priority patent/EP0934282A1/fr
Publication of WO1998015535A1 publication Critical patent/WO1998015535A1/fr
Publication of WO1998015535B1 publication Critical patent/WO1998015535B1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

L'invention concerne des dérivés de benzodiazépine de formule (I), qui sont utiles en tant qu'antogonistes de la cholécystokinine. Dans la formule (I), R2 représente alkyle ou cycloalkyle-alkyle lorsque R4 représente hydrogène, ou R2 représente divers groupes spécifiés lorsque R4 représente alkyle, halogène ou dialkylamino.
PCT/JP1997/003483 1996-10-08 1997-09-29 1,4-benzodiazepinones et leurs utilisations en tant qu'antagonistes de cck Ceased WO1998015535A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP51737298A JP2001504454A (ja) 1996-10-08 1997-09-29 ベンゾジアゼピン誘導体
US09/269,752 US6291452B1 (en) 1996-10-08 1997-09-29 1,4-benzodiazepinones and their uses as CCK antagonists
EP97941281A EP0934282A1 (fr) 1996-10-08 1997-09-29 1,4-benzodiazepinones et leurs utilisations en tant qu'antagonistes de cck

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPO2843A AUPO284396A0 (en) 1996-10-08 1996-10-08 Benzodiazepine derivatives
AUPO2843 1996-10-08

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09/269,752 A-371-Of-International US6291452B1 (en) 1996-10-08 1997-09-29 1,4-benzodiazepinones and their uses as CCK antagonists
US09/897,888 Continuation US20020002163A1 (en) 1996-10-08 2001-07-05 1,4-benzodiazepinones and their uses as CCK antagonists

Publications (2)

Publication Number Publication Date
WO1998015535A1 WO1998015535A1 (fr) 1998-04-16
WO1998015535B1 true WO1998015535B1 (fr) 1998-06-11

Family

ID=3797154

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1997/003483 Ceased WO1998015535A1 (fr) 1996-10-08 1997-09-29 1,4-benzodiazepinones et leurs utilisations en tant qu'antagonistes de cck

Country Status (5)

Country Link
US (3) US6291452B1 (fr)
EP (1) EP0934282A1 (fr)
JP (1) JP2001504454A (fr)
AU (1) AUPO284396A0 (fr)
WO (1) WO1998015535A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6821935B1 (en) 1999-08-27 2004-11-23 Procter & Gamble Company Color safe laundry methods employing zwitterionic formulation components
CA2381890A1 (fr) 1999-08-27 2001-03-08 The Procter & Gamble Company Composants de formulation ameliorant la stabilite, et compositions et procedes de blanchissage les utilisant
US6903060B1 (en) 1999-08-27 2005-06-07 Procter & Gamble Company Stable formulation components, compositions and laundry methods employing same
US6818607B1 (en) 1999-08-27 2004-11-16 Procter & Gamble Company Bleach boosting components, compositions and laundry methods
CA2381892A1 (fr) * 1999-08-27 2001-03-08 The Procter & Gamble Company Composants, compositions et procedes de blanchissage destines a renforcer le blanchiment
US6825160B1 (en) 1999-08-27 2004-11-30 Procter & Gamble Company Color safe laundry methods employing cationic formulation components
US7109156B1 (en) 1999-08-27 2006-09-19 Procter & Gamble Company Controlled availability of formulation components, compositions and laundry methods employing same
US7557076B2 (en) 2002-06-06 2009-07-07 The Procter & Gamble Company Organic catalyst with enhanced enzyme compatibility
US7169744B2 (en) 2002-06-06 2007-01-30 Procter & Gamble Company Organic catalyst with enhanced solubility
JP4705908B2 (ja) * 2003-04-15 2011-06-22 メルク・シャープ・エンド・ドーム・コーポレイション Ｃｇｒｐ受容体拮抗薬
CN1812982B (zh) * 2003-06-26 2010-10-27 默沙东公司 苯并二氮杂*cgrp受体拮抗剂
JP4705912B2 (ja) * 2003-06-26 2011-06-22 メルク・シャープ・エンド・ドーム・コーポレイション ベンゾジアゼピンｃｇｒｐ受容体拮抗物質
MXPA06004308A (es) * 2003-10-23 2006-06-05 Bayer Cropscience Ag Isopentilcarboxanilidas para la lucha contra los microorganismos indeseables.
DE10352067A1 (de) * 2003-10-23 2005-05-25 Bayer Cropscience Ag Isopentylcarboxanilide
WO2005072308A2 (fr) * 2004-01-29 2005-08-11 Merck & Co., Inc. Antagonistes des recepteurs du cgrp
AR051659A1 (es) 2005-06-17 2007-01-31 Procter & Gamble Una composicion que comprende un catalizador organico con compatibilidada enzimatica mejorada
GB201414116D0 (en) 2014-08-08 2014-09-24 Trio Medicines Ltd Benzodiazepine derivatives
GB201513979D0 (en) 2015-08-07 2015-09-23 Trio Medicines Ltd Synthesis of benzodiazepine derivatives
CN113816914B (zh) * 2021-09-28 2024-04-09 华中药业股份有限公司 一种劳拉西泮中间体的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
US5264433A (en) 1988-07-07 1993-11-23 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
US4970207A (en) 1988-07-07 1990-11-13 Fujisawa Pharmaceutical Company, Ltd. Benzodiazepine derivatives
US5248679A (en) 1988-09-09 1993-09-28 Fujisawa Pharmaceutical Co., Ltd. Tricyclic compounds
IL91361A (en) 1988-09-09 1994-10-07 Fujisawa Pharmaceutical Co Disubstituted 1,9-annelated [1,4] benzodiazepinone compounds, processes for the preparation thereof and pharmaceutical compositions containing the same
IL96613A0 (en) * 1989-12-18 1991-09-16 Merck & Co Inc Pharmaceutical compositions containing benzodiazepine analogs
GB9018601D0 (en) 1990-08-24 1990-10-10 Fujisawa Pharmaceutical Co Tricyclic compounds
CA2068355A1 (fr) * 1991-05-14 1992-11-15 Mark S. Chambers Derives de benzodiazepines, compositions les contenant et leur utilisation therapeutique
EP0549039B1 (fr) * 1991-12-20 1995-08-09 MERCK SHARP & DOHME LTD. 3-phényluréido-1,4-benzodiazépinones et leur utilisation comme antagonistes de cholécystokinine ou de gastrine
GB9203790D0 (en) * 1992-02-21 1992-04-08 Merck Sharp & Dohme Therapeutic agents
IL104853A (en) * 1992-02-27 1997-11-20 Yamanouchi Pharma Co Ltd Benzodiazepine derivatives, their preparation and pharmaceutical compositions containing them
JPH07504908A (ja) * 1992-03-16 1995-06-01 メルク　シヤープ　エンド　ドーム　リミテツド ベンゾジアゼピン誘導体，該誘導体を含有する組成物及び治療におけるその使用
JPH07505155A (ja) * 1992-03-24 1995-06-08 メルク　シヤープ　エンド　ドーム　リミテツド コレシストキニン及び／又はガストリン拮抗活性を有する３−ウレイド置換ベンゾジアゼピン−２−オン及び治療におけるその使用
US5360802A (en) * 1992-05-11 1994-11-01 Merck Sharpe & Dohme Ltd. Benzodiazepine derivatives, compositions containing them and their use in therapy
GB9225492D0 (en) * 1992-12-05 1993-01-27 Glaxo Group Ltd Amine derivatives
WO1995028399A1 (fr) * 1994-04-15 1995-10-26 Glaxo Wellcome Inc. Procede d'induction d'une activite agoniste de la cholecystokinine a l'aide de composes 1,4-benzodiazepines
US5763437A (en) 1994-07-29 1998-06-09 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
US5556969A (en) * 1994-12-07 1996-09-17 Merck Sharp & Dohme Ltd. Benzodiazepine derivatives
US5929071A (en) * 1996-07-02 1999-07-27 Merck & Co., Inc. Method for the treatment of preterm labor

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