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WO1998015535B1 - 1,4-benzodiazepinones and their uses as cck antagonists - Google Patents

1,4-benzodiazepinones and their uses as cck antagonists

Info

Publication number
WO1998015535B1
WO1998015535B1 PCT/JP1997/003483 JP9703483W WO9815535B1 WO 1998015535 B1 WO1998015535 B1 WO 1998015535B1 JP 9703483 W JP9703483 W JP 9703483W WO 9815535 B1 WO9815535 B1 WO 9815535B1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
formula
cycloalkyl
benzodiazepinones
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP1997/003483
Other languages
French (fr)
Other versions
WO1998015535A1 (en
Filing date
Publication date
Priority claimed from AUPO2843A external-priority patent/AUPO284396A0/en
Application filed filed Critical
Priority to JP51737298A priority Critical patent/JP2001504454A/en
Priority to US09/269,752 priority patent/US6291452B1/en
Priority to EP97941281A priority patent/EP0934282A1/en
Publication of WO1998015535A1 publication Critical patent/WO1998015535A1/en
Publication of WO1998015535B1 publication Critical patent/WO1998015535B1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

Benzodiazepine derivatives of formula (I) wherein R2 is alkyl or cycloalkyl-alkyl when R4 is hydrogen, or R2 is a variety of specified groups when R4 is alkyl, halogen or dialkylamino, are useful as cholecystokinin antagonists.

Claims

[received by the International Bureau on 23 April 1998 (23.04.98); original claim 5 amended; remaining claims unchanged (1 page)]
(3) chlorine, or
(4) N,N-dimethylamino, with proviso that when R4 is hydrogen, then R- is isopropyl, isobutyl, methyl, isopenty], ethyl, butyl or cyclohexylmethyl,
or a pharmaceutically acceptable salt thereof.
5. A compound of claim 1, which is a compound of the formula:
Figure imgf000003_0001
wherein R: is lower alkyl or C3-C3 cycloalkyl,
R4 is lower alkyl,
R5 is C3-C3 cycloalkyl,
R6 is lower alkylphenyl and
A is lower alkylene,
or a pharmaceutically acceptable salt thereof.
6. A compound of claim 1, which is a compound of the formula:
326
STATEMENT UNDER ARTICLE 19
The formula in claim 5 is corrected by changing the broken line between a carbon of benzene ring and R4 into a solid line, so that the construction of the compound is clarified.
PCT/JP1997/003483 1996-10-08 1997-09-29 1,4-benzodiazepinones and their uses as cck antagonists Ceased WO1998015535A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP51737298A JP2001504454A (en) 1996-10-08 1997-09-29 Benzodiazepine derivatives
US09/269,752 US6291452B1 (en) 1996-10-08 1997-09-29 1,4-benzodiazepinones and their uses as CCK antagonists
EP97941281A EP0934282A1 (en) 1996-10-08 1997-09-29 1,4-benzodiazepinones and their uses as cck antagonists

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPO2843A AUPO284396A0 (en) 1996-10-08 1996-10-08 Benzodiazepine derivatives
AUPO2843 1996-10-08

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09/269,752 A-371-Of-International US6291452B1 (en) 1996-10-08 1997-09-29 1,4-benzodiazepinones and their uses as CCK antagonists
US09/897,888 Continuation US20020002163A1 (en) 1996-10-08 2001-07-05 1,4-benzodiazepinones and their uses as CCK antagonists

Publications (2)

Publication Number Publication Date
WO1998015535A1 WO1998015535A1 (en) 1998-04-16
WO1998015535B1 true WO1998015535B1 (en) 1998-06-11

Family

ID=3797154

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1997/003483 Ceased WO1998015535A1 (en) 1996-10-08 1997-09-29 1,4-benzodiazepinones and their uses as cck antagonists

Country Status (5)

Country Link
US (3) US6291452B1 (en)
EP (1) EP0934282A1 (en)
JP (1) JP2001504454A (en)
AU (1) AUPO284396A0 (en)
WO (1) WO1998015535A1 (en)

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JP2003508587A (en) 1999-08-27 2003-03-04 ザ、プロクター、エンド、ギャンブル、カンパニー Stability enhancing compounding component, composition using the same, and washing method
US6903060B1 (en) 1999-08-27 2005-06-07 Procter & Gamble Company Stable formulation components, compositions and laundry methods employing same
JP2003510251A (en) * 1999-08-27 2003-03-18 ザ、プロクター、エンド、ギャンブル、カンパニー Bleach enhancing component, composition and washing method
US7109156B1 (en) 1999-08-27 2006-09-19 Procter & Gamble Company Controlled availability of formulation components, compositions and laundry methods employing same
US6821935B1 (en) 1999-08-27 2004-11-23 Procter & Gamble Company Color safe laundry methods employing zwitterionic formulation components
US7169744B2 (en) 2002-06-06 2007-01-30 Procter & Gamble Company Organic catalyst with enhanced solubility
US7557076B2 (en) 2002-06-06 2009-07-07 The Procter & Gamble Company Organic catalyst with enhanced enzyme compatibility
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EP1641781B1 (en) * 2003-06-26 2013-03-06 Merck Sharp & Dohme Corp. Benzodiazepine CGRP receptor antagonists
JP4705912B2 (en) * 2003-06-26 2011-06-22 メルク・シャープ・エンド・ドーム・コーポレイション Benzodiazepine CGRP receptor antagonist
DE10352067A1 (en) * 2003-10-23 2005-05-25 Bayer Cropscience Ag Isopentylcarboxanilide
WO2005042494A1 (en) * 2003-10-23 2005-05-12 Bayer Cropscience Aktiengesellschaft Isopentyl carboxanilides for combating undesired micro-organisms
AU2005208834B2 (en) * 2004-01-29 2009-10-08 Merck Sharp & Dohme Corp. CGRP receptor antagonists
AR051659A1 (en) 2005-06-17 2007-01-31 Procter & Gamble A COMPOSITION THAT INCLUDES AN ORGANIC CATALYST WITH IMPROVED ENZYMATIC COMPATIBILITY
GB201414116D0 (en) 2014-08-08 2014-09-24 Trio Medicines Ltd Benzodiazepine derivatives
GB201513979D0 (en) 2015-08-07 2015-09-23 Trio Medicines Ltd Synthesis of benzodiazepine derivatives
CN113816914B (en) * 2021-09-28 2024-04-09 华中药业股份有限公司 Preparation method of lorazepam intermediate

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