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WO1998006690B1 - UTILISATION D'AMIDES DE L'ACIDE η-HYDROXYBUTYRIQUE DANS LE TRAITEMENT DES TOXICOMANIES ET NOTAMMENT DE L'ALCOOLISME - Google Patents

UTILISATION D'AMIDES DE L'ACIDE η-HYDROXYBUTYRIQUE DANS LE TRAITEMENT DES TOXICOMANIES ET NOTAMMENT DE L'ALCOOLISME

Info

Publication number
WO1998006690B1
WO1998006690B1 PCT/EP1997/004309 EP9704309W WO9806690B1 WO 1998006690 B1 WO1998006690 B1 WO 1998006690B1 EP 9704309 W EP9704309 W EP 9704309W WO 9806690 B1 WO9806690 B1 WO 9806690B1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
formula
amide
alcohol
butyrolactone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1997/004309
Other languages
English (en)
Other versions
WO1998006690A1 (fr
Filing date
Publication date
Priority claimed from IT96MI001732A external-priority patent/IT1283782B1/it
Priority to AT97941921T priority Critical patent/ATE215065T1/de
Application filed filed Critical
Priority to DK97941921T priority patent/DK0932597T3/da
Priority to AU43790/97A priority patent/AU4379097A/en
Priority to SI9730343T priority patent/SI0932597T1/xx
Priority to CA002263328A priority patent/CA2263328C/fr
Priority to EP97941921A priority patent/EP0932597B1/fr
Priority to HU9902437A priority patent/HU228595B1/hu
Priority to JP50937298A priority patent/JP4259615B2/ja
Priority to US09/242,048 priority patent/US6436998B1/en
Priority to DE69711411T priority patent/DE69711411T2/de
Publication of WO1998006690A1 publication Critical patent/WO1998006690A1/fr
Publication of WO1998006690B1 publication Critical patent/WO1998006690B1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

L'invention concerne l'utilisation d'amides de l'acide η-hydroxybutyrique, dénommés ici GHB, dans le traitement des toxicomanies, telles que les toxicomanies à l'héroïne, à la morphine et aux psychotropes, dans le traitement de l'alcoolisme, notamment pour diminuer l'envie de boissons alcoolisées qu'ont les alcooliques chroniques et leur habitude d'en consommer, et dans le traitement du syndrome de sevrage.
PCT/EP1997/004309 1996-08-09 1997-08-07 UTILISATION D'AMIDES DE L'ACIDE η-HYDROXYBUTYRIQUE DANS LE TRAITEMENT DES TOXICOMANIES ET NOTAMMENT DE L'ALCOOLISME Ceased WO1998006690A1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
HU9902437A HU228595B1 (en) 1996-08-09 1997-08-07 Gamma-hydroxybutyric acid amides, process to prepare them, use gamma-hydroxybutyric acid amides, and pharmaceuticals contg. them for the treatmant of drug abusing
EP97941921A EP0932597B1 (fr) 1996-08-09 1997-08-07 Utilisation d'amides de l'acide gamma-hydroxybutyrique dans le traitement des toxicomanies et notamment de l'alcoolisme
DK97941921T DK0932597T3 (da) 1996-08-09 1997-08-07 Anvendelse af gamma-hydroxysmørsyreamider til behandling af lægemiddelafhængighed og især alkoholisme
AU43790/97A AU4379097A (en) 1996-08-09 1997-08-07 Use of gamma-hydroxybutyric acid amides in the treatment of drug addiction and in particular of alcoholism
SI9730343T SI0932597T1 (en) 1996-08-09 1997-08-07 Use of gamma-hydroxybutyric acid amides in the treatment of drug addiction and in particular of alcoholism
CA002263328A CA2263328C (fr) 1996-08-09 1997-08-07 Utilisation d'amides de l'acide .gamma.-hydroxybutyrique dans le traitement des toxicomanies et notamment de l'alcoolisme
JP50937298A JP4259615B2 (ja) 1996-08-09 1997-08-07 薬物常用および特にアルコール中毒の治寮へのγ―ヒドロキシ酪酸アミドの使用
AT97941921T ATE215065T1 (de) 1996-08-09 1997-08-07 Verwendung von gamma-hydroxybuttersäureamiden in der behandlung von drogenabhängigkeit und insbesondere von alcoholismus
DE69711411T DE69711411T2 (de) 1996-08-09 1997-08-07 Verwendung von gamma-hydroxybuttersäureamiden in der behandlung von drogenabhängigkeit und insbesondere von alcoholismus
US09/242,048 US6436998B1 (en) 1996-08-09 1997-08-07 Use of gamma-hydroxybutyric acid amides in the treatment of drug addiction and in particular of alcoholism

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI001732A IT1283782B1 (it) 1996-08-09 1996-08-09 Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo
ITMI96A001732 1996-08-09

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/013,971 Division US6770784B2 (en) 1996-08-09 2001-12-11 Use of γ-hydroxybutyric acid amides in the treatment of drug addiction and in particular of alcoholism

Publications (2)

Publication Number Publication Date
WO1998006690A1 WO1998006690A1 (fr) 1998-02-19
WO1998006690B1 true WO1998006690B1 (fr) 1998-04-16

Family

ID=11374795

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/004309 Ceased WO1998006690A1 (fr) 1996-08-09 1997-08-07 UTILISATION D'AMIDES DE L'ACIDE η-HYDROXYBUTYRIQUE DANS LE TRAITEMENT DES TOXICOMANIES ET NOTAMMENT DE L'ALCOOLISME

Country Status (13)

Country Link
US (2) US6436998B1 (fr)
EP (1) EP0932597B1 (fr)
JP (1) JP4259615B2 (fr)
AT (1) ATE215065T1 (fr)
AU (1) AU4379097A (fr)
CA (1) CA2263328C (fr)
DE (1) DE69711411T2 (fr)
DK (1) DK0932597T3 (fr)
ES (1) ES2174287T3 (fr)
HU (1) HU228595B1 (fr)
IT (1) IT1283782B1 (fr)
PT (1) PT932597E (fr)
WO (1) WO1998006690A1 (fr)

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ES2193777T3 (es) 1998-12-23 2003-11-01 Orphan Medical Inc Disoluciones estables e inalterables microbiologicamente de sal de gamma-hidroxibutirato para el tratamiento de la narcolepsia.
FR2827859B1 (fr) 2001-07-30 2005-09-23 Lipha Derives 4-(arylthio) - ou 4-(heteroarylthio) -butyrique dans la preparation de medicaments destines au traitement du diabete
AU2003295393A1 (en) * 2002-11-01 2004-06-07 Baylor Research Institute Ghb treatment methods
US7838556B2 (en) * 2006-02-21 2010-11-23 University Of Maryland, Baltimore Ethers of 3-hydroxyphenylacetic acid as selective gamma-hydroxybutyric acid receptor ligands
EP2062875A1 (fr) * 2007-11-13 2009-05-27 LABORATORIO FARMACEUTICO C.T. S.r.l. Nouvelles formes polymorphes de N-[4-(trifluorométhyl)benzyl)-4-méthoxybutyramide
US8771735B2 (en) * 2008-11-04 2014-07-08 Jazz Pharmaceuticals, Inc. Immediate release dosage forms of sodium oxybate
US8778398B2 (en) * 2008-11-04 2014-07-15 Jazz Pharmaceuticals, Inc. Immediate release formulations and dosage forms of gamma-hydroxybutyrate
US20120076865A1 (en) 2010-03-24 2012-03-29 Jazz Pharmaceuticals, Inc. Controlled release dosage forms for high dose, water soluble and hygroscopic drug substances
US8591922B1 (en) 2012-12-14 2013-11-26 Jazz Pharmacuticals, Inc. Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
ITMI20132041A1 (it) * 2013-12-06 2015-06-07 Ct Lab Farm Srl Derivati dell'acido gamma-idrossibutirrico, loro preparazione e loro uso medico.
US10398662B1 (en) 2015-02-18 2019-09-03 Jazz Pharma Ireland Limited GHB formulation and method for its manufacture
ITUB20152860A1 (it) * 2015-08-04 2017-02-04 Laboratorio Farm C T S R L Selezionata amide dell?acido ?-idrossibutirrico e suoi usi nel trattamento dell?abuso da alcool
ITUA20164040A1 (it) * 2016-06-01 2017-12-01 Laboratorio Farm C T S R L Procedimento per la preparazione di polimorfo a
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US12186296B1 (en) 2016-07-22 2025-01-07 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US12478604B1 (en) 2016-07-22 2025-11-25 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US20180263936A1 (en) 2017-03-17 2018-09-20 Jazz Pharmaceuticals Ireland Limited Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
US11400052B2 (en) 2018-11-19 2022-08-02 Jazz Pharmaceuticals Ireland Limited Alcohol-resistant drug formulations
BR112021013766A2 (pt) 2019-03-01 2021-09-21 Flamel Ireland Limited Composições de gama-hidroxibutirato com farmacocinética melhorada no estado alimentado
TW202139986A (zh) 2020-02-21 2021-11-01 愛爾蘭商爵士製藥愛爾蘭有限責任公司 治療原發性嗜睡症之方法
WO2023126076A1 (fr) 2022-01-03 2023-07-06 Laboratorio Farmaceutico C.T. S.R.L. Utilisation médicale d'un amide d'acide y-hydroxybutyrique dans le traitement du syndrome de l'x fragile
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3940258A (en) * 1971-11-26 1976-02-24 Gaf Corporation Method for controlling aquatic weeds with N-phenylalkyl-γ-hydroxybutyramide
JPS6016432B2 (ja) * 1977-07-26 1985-04-25 グレラン製薬株式会社 複素環式化合物類およびその製造法
DE3855875T2 (de) * 1987-02-23 1997-08-28 Ono Pharmaceutical Co Thiazolidin-Derivate
IT1217783B (it) * 1988-06-03 1990-03-30 Farmaceutico Ct S R L Lab Impiego di salo dell,acido gamma idrossi butirrico per la preparazione di composizioni farmaceutiche adatta ad essereimpiegate nella terapia dell,alcolismo e composizioni relative
IT1248588B (it) 1991-06-28 1995-01-19 Gaetano Crepaldi Composizioni farmaceutiche per la terapia dell'astinenza, del " craving", della dipendenza da sostanze stupefacenti, da sostanze psicoattive, da nicotina e dei disturbi alimentari.
US5656660A (en) * 1994-06-01 1997-08-12 Arris Pharmaceutical Corporation Compositions and methods for treating mast-cell mediated conditions
HUP9602538A3 (en) * 1995-09-18 1997-08-28 Sankyo Co New urea and amide derivatives having acat inhibitory activity, their preparation and their use
JP3329337B2 (ja) * 1997-10-14 2002-09-30 三菱ウェルファーマ株式会社 ピペラジン化合物およびその医薬としての用途

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