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WO1998003172A1 - Derives arylpiperidinol et arylpiperidine et medicaments les contenant - Google Patents

Derives arylpiperidinol et arylpiperidine et medicaments les contenant Download PDF

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Publication number
WO1998003172A1
WO1998003172A1 PCT/JP1997/002531 JP9702531W WO9803172A1 WO 1998003172 A1 WO1998003172 A1 WO 1998003172A1 JP 9702531 W JP9702531 W JP 9702531W WO 9803172 A1 WO9803172 A1 WO 9803172A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
substituted
phenyl
bond
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP1997/002531
Other languages
English (en)
Japanese (ja)
Inventor
Hirokazu Annoura
Kyoko Nakanishi
Shigeki Tamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suntory Ltd
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Priority to AT97930865T priority Critical patent/ATE278402T1/de
Priority to US09/043,563 priority patent/US6455549B1/en
Priority to DE69731070T priority patent/DE69731070T2/de
Priority to EP97930865A priority patent/EP0867183B1/fr
Priority to CA002231879A priority patent/CA2231879C/fr
Priority to AU34640/97A priority patent/AU710594B2/en
Priority to KR1019980702029A priority patent/KR100537843B1/ko
Publication of WO1998003172A1 publication Critical patent/WO1998003172A1/fr
Anticipated expiration legal-status Critical
Priority to US10/799,681 priority patent/US7498344B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/12—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Definitions

  • X represents no hydrogen atom
  • Y and Z represent the same or different and may be a hydrogen atom, a halogen atom, an alkoxy group or an alkyl group optionally substituted by a halogen atom
  • R represents When it represents a phenyl group which may be substituted or a phenyl group which may be substituted, B does not represent an alkylene group, X represents a hydroxyl group, and R may be substituted
  • B represents a phenolic group
  • B does not represent an unsubstituted alkylene group;
  • X represents a hydroxyl group;
  • R represents an optionally substituted phenyl group; and
  • A represents a bond.
  • Example 11 It was produced in the same manner as in Example 11 from the compound (12) synthesized in Example 6 and 1-phenylene 1-bromo-1-propane methyl bromide.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des dérivés arylpipéridinol et arylpipéridine représentés par la formule générale (I) ainsi que des médicaments contenant ces dérivés et notamment, d'une part des médicaments permettant le traitement symptomatique, voire la guérison des affections ischémiques, des états et symptômes convulsifs et épileptiques d'origine hémicrânienne, et d'autre part des inhibiteurs de la surcharge en ions calcium. Dans cette formule générale (I), E est H, phényl éventuellement substitué, phénoxy éventuellement substitué ou benzoyl éventuellement substitué; A est une liaison, cycloalkylène ou alcénylène éventuellement substitué par un alkyl inférieur; B est alkylène éventuellement substitué par OH, alcoxy ou -NHCO(CH2)n- (auquel cas n est un entier valant de 1 à 5); E est une liaison, O ou méthylène; X est OH ou H, sous la réserve que X ne soit pas H si E est O ou méthylène; et Y et Z sont chacun indépendamment halogéno, alcoxy ou alkyl éventuellement halogéné.
PCT/JP1997/002531 1996-07-22 1997-07-22 Derives arylpiperidinol et arylpiperidine et medicaments les contenant Ceased WO1998003172A1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AT97930865T ATE278402T1 (de) 1996-07-22 1997-07-22 Arylpiperidinol und arylpiperidin-derivate und sie enthaltende arzneimittel
US09/043,563 US6455549B1 (en) 1996-07-22 1997-07-22 Arylpiperidinol and arylpiperidine derivatives and drugs containing the same
DE69731070T DE69731070T2 (de) 1996-07-22 1997-07-22 Arylpiperidinol und arylpiperidin-derivate und sie enthaltende arzneimittel
EP97930865A EP0867183B1 (fr) 1996-07-22 1997-07-22 Derives arylpiperidinol et arylpiperidine et medicaments les contenant
CA002231879A CA2231879C (fr) 1996-07-22 1997-07-22 Derives arylpiperidinol et arylpiperidine et medicaments les contenant
AU34640/97A AU710594B2 (en) 1996-07-22 1997-07-22 Arylpiperidinol and arylpiperidine derivatives and pharmaceuticals containing the same
KR1019980702029A KR100537843B1 (ko) 1996-07-22 1997-07-22 아릴피페리디놀및아릴피페리딘유도체및이들을함유하는약제
US10/799,681 US7498344B2 (en) 1996-07-22 2004-03-15 Arylpiperidinol and arylpiperidine derivatives and pharmaceuticals containing the same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP8/192123 1996-07-22
JP19212396 1996-07-22
JP9602613 1996-09-12

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09/043,563 A-371-Of-International US6455549B1 (en) 1996-07-22 1997-07-22 Arylpiperidinol and arylpiperidine derivatives and drugs containing the same
US10/196,362 Division US6706734B2 (en) 1996-07-22 2002-07-17 Arylpiperidinol and arylpiperidine derivatives and pharmaceuticals containing the same

Publications (1)

Publication Number Publication Date
WO1998003172A1 true WO1998003172A1 (fr) 1998-01-29

Family

ID=26437242

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1997/002531 Ceased WO1998003172A1 (fr) 1996-07-22 1997-07-22 Derives arylpiperidinol et arylpiperidine et medicaments les contenant

Country Status (1)

Country Link
WO (1) WO1998003172A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999023072A1 (fr) * 1997-10-31 1999-05-14 Suntory Limited Rylpiperidinopropanol et derives d'arylpiperazinopropanol et produits pharmaceutiques contenant lesdits composes
US6753336B2 (en) * 2000-07-06 2004-06-22 Neurogen Corporation Melanin concentrating hormone receptor ligands
US9562222B2 (en) 2011-11-18 2017-02-07 Novozymes A/S Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and polynucleotides encoding same

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5395963A (en) * 1977-01-27 1978-08-22 Hoechst Ag Novel azacyclic compounds and method for their production
US4241071A (en) * 1977-01-27 1980-12-23 American Hoechst Corporation Antidepressant (α-phenyl-2-tolyl)azacycloalkanes
JPS63126866A (ja) * 1986-11-03 1988-05-30 ノボ・ノルデイスク・アクツイエルスカブ ピペリジン化合物、その製造方法及びその使用方法
JPH01313461A (ja) * 1988-04-28 1989-12-18 Ferrosan:As ピペリジン化合物、その製造方法及びその使用方法
WO1996022977A1 (fr) * 1995-01-23 1996-08-01 Suntory Limited Ameliorant ou remede contre des symptomes provoques par des maladies ischemiques et composes utiles a cet effet
WO1996026924A1 (fr) * 1995-02-28 1996-09-06 Suntory Limited Derives d'arylpiperidine et d'arylpiperazine et medicaments contenant lesdits derives

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5395963A (en) * 1977-01-27 1978-08-22 Hoechst Ag Novel azacyclic compounds and method for their production
US4241071A (en) * 1977-01-27 1980-12-23 American Hoechst Corporation Antidepressant (α-phenyl-2-tolyl)azacycloalkanes
JPS63126866A (ja) * 1986-11-03 1988-05-30 ノボ・ノルデイスク・アクツイエルスカブ ピペリジン化合物、その製造方法及びその使用方法
JPH01313461A (ja) * 1988-04-28 1989-12-18 Ferrosan:As ピペリジン化合物、その製造方法及びその使用方法
WO1996022977A1 (fr) * 1995-01-23 1996-08-01 Suntory Limited Ameliorant ou remede contre des symptomes provoques par des maladies ischemiques et composes utiles a cet effet
WO1996026924A1 (fr) * 1995-02-28 1996-09-06 Suntory Limited Derives d'arylpiperidine et d'arylpiperazine et medicaments contenant lesdits derives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0867183A4 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999023072A1 (fr) * 1997-10-31 1999-05-14 Suntory Limited Rylpiperidinopropanol et derives d'arylpiperazinopropanol et produits pharmaceutiques contenant lesdits composes
US6407099B1 (en) 1997-10-31 2002-06-18 Suntory Limited Arylpiperidinopropanol and arylpiperazinopropanol derivatives and pharmaceuticals containing the same
US6525199B1 (en) 1997-10-31 2003-02-25 Suntory Limited Arylpiperidinopropanol and arylpiperazinopropanol derivatives and pharmaceuticals containing the same
US6838470B2 (en) 1997-10-31 2005-01-04 Daiichi Suntory Pharma Co., Ltd. Arylpiperidinopropanol and arylpiprazinopropanol derivatives and pharmaceuticals containing the same
US7642262B2 (en) 1997-10-31 2010-01-05 Asubio Pharma Co., Ltd. Arylipiperdinopropanol and arylipiperazinopropanol derivatives and pharmaceuticals containing the same
US6753336B2 (en) * 2000-07-06 2004-06-22 Neurogen Corporation Melanin concentrating hormone receptor ligands
US9562222B2 (en) 2011-11-18 2017-02-07 Novozymes A/S Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and polynucleotides encoding same
US10227614B2 (en) 2011-11-18 2019-03-12 Novozymes A/S Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and polynucleotides encoding same

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