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WO1998002137A1 - Composition sous forme de gel regulateur de la seborrhee epidermique - Google Patents

Composition sous forme de gel regulateur de la seborrhee epidermique Download PDF

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Publication number
WO1998002137A1
WO1998002137A1 PCT/BR1997/000026 BR9700026W WO9802137A1 WO 1998002137 A1 WO1998002137 A1 WO 1998002137A1 BR 9700026 W BR9700026 W BR 9700026W WO 9802137 A1 WO9802137 A1 WO 9802137A1
Authority
WO
WIPO (PCT)
Prior art keywords
weight
skin
agent
composition
gel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/BR1997/000026
Other languages
English (en)
Inventor
Simoni Chitarra Souza
Luiz Gustavo Martins Matheus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industria e Comercio de Cosmeticos Natura Ltda
Original Assignee
Industria e Comercio de Cosmeticos Natura Ltda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Industria e Comercio de Cosmeticos Natura Ltda filed Critical Industria e Comercio de Cosmeticos Natura Ltda
Publication of WO1998002137A1 publication Critical patent/WO1998002137A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/008—Preparations for oily skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/75—Anti-irritant

Definitions

  • the present invention provides a new composition, in gel form, to be applied to the skin of individuals subjected to skin affections, as acne, pimples and blackheads, caused due to excessive oiliness of the sebaceous secreting glands, with the aim of reducing skin oiliness, maintaining it balanced in relation to cutis optimizing conditions.
  • This gel promotes antiseptic action and mild refreshing sensation when applied to the skin.
  • the invented gel also exhibits a keratolytic action, acting on cellular renovation and capillary and sebaceous follicle clearance.
  • this gel contains active principles acting on skin oiliness regulation, maintaining the skin in an optimized level for the performance of its own functions when directly exposed to the environment, specially the face.
  • the present invention makes the cooperative association of various active principles in mutually optimizing ratios.
  • a renovating agent for cutis cells being this allantoin, added in a 0,05 to 0,50% ratio, by weight, in relation to the global composition.
  • the allantoin favors the cellular proliferation, restoring the affected tissue, calming down irritations and dissipating skin roughness.
  • a specific moisturizing agent being this a sodium PCA, in other words, the sodium PCA salt, a skin moisturizing natural component, v.g. NMF (Natural Moisturizing Factor) moisturizing compound.
  • This component corresponds to 0,10 to 2,00%, by weight, in relation to the global composition.
  • One reinforcing moisturizing agent being this a natural product, namely Aloe vera extract. This component, contributing to cutaneous hydration, efficiently collaborates to the skin anti-inflammatory and restoring scaring action, exerted by the invented gel.
  • This agent corresponds to 0,10 to 0,50%, by weight, in relation to the global composition.
  • a keratolytic agent added in a 0,30 to 2,00% ratio, by weight, in relation to the composition.
  • This agent is salicylic acid, which collaborates to the formation of an unfavorable medium for bacterial proliferation, helping in skin's irritations and inflammations treatment.
  • the Hawthorn extract is also a vegetable extract, being rich in organic acids and natural antioxidants, flavonoids and procyanides, which have a significant action in skin lesions reduction, caused by inflammations and acne.
  • This extract is capable of reducing the Propionibacte um acnes population. Great quantities of this microorganism can be found in the skin subjected to acne affections. This extract collaborates to the inflammatory process reduction and, in association to salicylic acid, mitigates the hyperkeratinization.
  • This oiliness regulating agents association corresponds to composition's 10,00 to 50,00%, by weight.
  • the relative proportion of Hawthorn extract in relation to Cytobiol iris extract varies between 1 :1 and 2:3, by weight.
  • a specially adequate ratio of Hawthorn extract varies between 5,00% to 20,00%, by weight, and between 5,00% to 30,00%, by weight, of Cytobiol iris extract, in relation to the global composition.
  • Cytobiol iris extract is a product extracted from Iris germanica, a complex containing zinc and vitamin A in hydrosoluble forms, having proved favorable action in the bacteriostatic and anti-inflammatory (in case of acne) actuation area and sebaceous secretion regulation.
  • the above listed active substances are formulated in the form of an aqueous gel through usual processing techniques, and can be processed at room temperature, with adjunction of adequate additives, also known by themselves.
  • adjuvant additives form the liquid basis, which acts as vehicle for the active substances dispersion or dissolution, being adjusted to guarantee the physical, chemical and also microbiological formulation stability and a pleasant sensorial when the product is applied to the skin.
  • the formulation can also contain perfume.
  • the referred additives comprise: a) An aqueous vehicle, in a ratio varying between 60,00 to 80,00%, by weight, corresponding to the basis.
  • An antioxidant agent to avoid the deterioration of the substances sensible to the oxygen contained in the air, contributing for composition's chemical stability. This antioxidant is chosen between butyl hydroxytoluene (BHT), butyl hydroxyanisole (BHA), di-alpha-tocopherol and ascorbic acid, added in a ratio varying between 0,01 to 0,10%, by weight, in relation to the basis.
  • BHT butyl hydroxytoluene
  • BHA butyl hydroxyanisole
  • di-alpha-tocopherol and ascorbic acid added in a ratio varying between 0,01 to 0,10%, by weight, in relation to the basis.
  • a thickener agent which corroborates in the aqueous phase gelling, giving the composition a gel consistency.
  • This thickener is at least one component of the group comprising vinyl polymers, as poly(vinyl acetate) and/or poly(vinyl alcohol), acrylics, specially hydrophilic (met)acrylates, gums, starch and modified starches, modified aluminium and magnesium silicates, alkylaryl ammonium compounds, esmectitas, cellulose derivatives, specially cellulosic esters and ethers, fatty alcohols, polyethylene glycol stearates and hydrated aluminium silicates. These agents are added in a 0,10 to 5,00% ratio, by weight, in relation to the basis.
  • vinyl polymers as poly(vinyl acetate) and/or poly(vinyl alcohol), acrylics, specially hydrophilic (met)acrylates, gums, starch and modified starches, modified aluminium and magnesium silicates, alkylaryl ammonium compounds, esmectitas, cellulose derivatives, specially cellulosic esters and ethers, fatty alcohols, poly
  • a solutizing agent of hydroinsoluble or hydrofuge components that is chosen between at least one ethanolic compounds, ethoxylated and/or hydrogenated and/or modified fatty alcohols derivatives, sulphonic alkyl benzene derivatives and dependent. These are added in a ratio varying between 1 ,00 to 15,00%, by weight, in relation to the basis.
  • An humectant agent as glycerols, glycols, sorbitol, hydrosoluble silicones, to facilitate the dispersion of components which are not soluble in the aqueous phase. Its ratio, in relation to the basis, varies between 2,00 to 20,00%, by weight.
  • the first step is the keratolytic agent, namely the salicylic acid, and the antiseptic agent triclosan cold solubilization, in a chosen solutizing agent ratio, for example ethanol or one of its derivatives and/or ethyl ether.
  • a solutizing agent ratio for example ethanol or one of its derivatives and/or ethyl ether.
  • This solution is than incorporated to the vehicle, preferably, already containing the thickener, humectant and antioxidant agents, specially, through mechanical homogenization.
  • Example 1 represents the milder formulation type, to be used for the care of skins little affected by irritations and inflammations.
  • the invention provides a component variation, specially, of the actives described in example 1 , obtaining two complementary formulations, one exhibiting intermediate activity, example 2, for skins more affected by acne and other inflammations, and the other, example 3, of more vigorous action and higher active principles concentration for skins exhibiting high oiliness or deeper skin lesions.
  • example 2 the mentioned active principles are added in a ratio, on the average, 1 ,50 times higher than in example 1.
  • the addition ratios of the active agents: allantoin, sodium PCA and salicylic acid are two times higher than the ones described in example 1
  • the ratios of Aloe vera, Hawthorn and Cytobiol iris extracts are three times higher than the ones described in example 1.
  • the adjuvant components are accordingly adjusted, so that it is possible to obtain an aqueous gel, exhibiting the desired consistency for skin application, without exhibiting free flowing, according to cosmetics laboratory routines.
  • the gels for skin oiliness balancing were submitted to dermatological tests, including primary and cumulative or accumulative dermal irritability evaluations, sensitization, phototoxicity and photoallergy.
  • the invented products were approved in the tests and, thus, considered dermatologist tested and accepted.
  • the invented product received the status of "not comedogenic".
  • a clinical test was conducted to verify the specific action of the invented products, with 12 to 24 years old volunteers. The main objective was to evaluate their efficiency in acne grades I and II incidence and similar skin affections, caused due to excessive oiliness. The obtained results were positive in approximately 2/3 of the examined cases.
  • the application of the present gel in association to the liquid antiseptic soap which is the object of a co-pending request of the same claimant, resulted in a skin oiliness reduction in 92,5% of the volunteers and in lesions number reduction in 65,0% of the examined cases.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un gel fluide, antiseptique, à action kératolitique pour les soins de la peau et procurant une sensation de fraîcheur agréable lors de son application sur la peau. Ledit gel est constitué d'un ensemble de nouvelles substances actives, chacune d'elle agissant de manière spécifique, à savoir : un agent régénérant, l'allantoïne, un agent humectant, le PCA de sodium, un agent restaurateur dermique, l'extrait d'Aloe vera, un agent kératolitique, l'acide salicylique, un agent antiseptique, le triclosan, deux agents de régulation séborrhéique de la peau, l'extrait d'aubépine et l'extrait de Cytobiol iris. Tous ces éléments coopèrent pour la régulation séborrhéique de la peau, en empêchant les excès de sécrétion et/ou l'obstruction des glandes sébacées ou des follicules, évitant ainsi les irritations de la peau. On prépare ces substances actives au moyen d'additifs classiques qui sont dissous et/ou dispersés dans un excipient aqueux, épaissis selon les techniques habituelles pour former un gel de consistance et de stabilité adéquates. L'usage dudit gel est particulièrement recommandé dans la composition d'un savon liquide antiseptique qui fait l'objet d'une requête séparée du même déposant.
PCT/BR1997/000026 1996-07-12 1997-07-10 Composition sous forme de gel regulateur de la seborrhee epidermique Ceased WO1998002137A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BRPI9603086-0 1996-07-12
BR9603086A BR9603086A (pt) 1996-07-12 1996-07-12 Composição em forma de gel para equilíbrio da oleosidade da pele

Publications (1)

Publication Number Publication Date
WO1998002137A1 true WO1998002137A1 (fr) 1998-01-22

Family

ID=4064626

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR1997/000026 Ceased WO1998002137A1 (fr) 1996-07-12 1997-07-10 Composition sous forme de gel regulateur de la seborrhee epidermique

Country Status (5)

Country Link
AR (1) AR007870A1 (fr)
BR (1) BR9603086A (fr)
CO (1) CO5300391A1 (fr)
PE (1) PE95998A1 (fr)
WO (1) WO1998002137A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999043205A1 (fr) * 1998-02-26 1999-09-02 Pro-Ren A/S Desinfectant de type gel ayant une faible teneur en alcool
FR2777185A1 (fr) * 1998-04-08 1999-10-15 Serobiologiques Lab Sa Composition cosmetique et/ou pharmaceutique pour le traitement des rides et procede de traitement mettant en oeuvre cette composition
WO2003028762A1 (fr) * 2001-09-28 2003-04-10 Ethicon, Inc. Nouvelles compositions bloquant la resistance antimicrobienne
WO2005023207A1 (fr) * 2003-09-10 2005-03-17 Unilever Plc Procede pour reduire la production de sebum
CN106176542A (zh) * 2016-08-26 2016-12-07 樊之雄 一种补水抗衰老蜜露及其制备方法
EP3369459A1 (fr) * 2017-03-01 2018-09-05 The Boots Company PLC Kit de compositions cosmétiques de soins pour la peau
CN114533809A (zh) * 2022-03-02 2022-05-27 北京鲁齐生物科技有限公司 一种维生素e抑菌膏及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993011780A1 (fr) * 1991-12-09 1993-06-24 Royale Renaissance, Inc. Melange therapeutique pour la peau, contenant un extrait d'aloes vera traite a froid dont la seve jaune et l'aloine ont ete enlevees
WO1993021899A1 (fr) * 1992-05-05 1993-11-11 The Procter & Gamble Company Composition de traitement de l'acne
JPH07157415A (ja) * 1993-12-03 1995-06-20 Shiseido Co Ltd 頭髪化粧料

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993011780A1 (fr) * 1991-12-09 1993-06-24 Royale Renaissance, Inc. Melange therapeutique pour la peau, contenant un extrait d'aloes vera traite a froid dont la seve jaune et l'aloine ont ete enlevees
WO1993021899A1 (fr) * 1992-05-05 1993-11-11 The Procter & Gamble Company Composition de traitement de l'acne
JPH07157415A (ja) * 1993-12-03 1995-06-20 Shiseido Co Ltd 頭髪化粧料

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 95, no. 009 (C - ) *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999043205A1 (fr) * 1998-02-26 1999-09-02 Pro-Ren A/S Desinfectant de type gel ayant une faible teneur en alcool
US6627207B1 (en) 1998-02-26 2003-09-30 Pro-Ren A/S Water-based, quick-drying, gel-type disinfectant having low alcohol content
FR2777185A1 (fr) * 1998-04-08 1999-10-15 Serobiologiques Lab Sa Composition cosmetique et/ou pharmaceutique pour le traitement des rides et procede de traitement mettant en oeuvre cette composition
WO2003028762A1 (fr) * 2001-09-28 2003-04-10 Ethicon, Inc. Nouvelles compositions bloquant la resistance antimicrobienne
WO2005023207A1 (fr) * 2003-09-10 2005-03-17 Unilever Plc Procede pour reduire la production de sebum
CN106176542A (zh) * 2016-08-26 2016-12-07 樊之雄 一种补水抗衰老蜜露及其制备方法
EP3369459A1 (fr) * 2017-03-01 2018-09-05 The Boots Company PLC Kit de compositions cosmétiques de soins pour la peau
WO2018157976A1 (fr) * 2017-03-01 2018-09-07 The Boots Company Plc Kit de compositions cosmétiques de soins de la peau
CN110430862A (zh) * 2017-03-01 2019-11-08 布茨公司 化妆品护肤组合物套盒
CN114533809A (zh) * 2022-03-02 2022-05-27 北京鲁齐生物科技有限公司 一种维生素e抑菌膏及其制备方法

Also Published As

Publication number Publication date
BR9603086A (pt) 1998-05-05
PE95998A1 (es) 1998-12-15
AR007870A1 (es) 1999-11-24
CO5300391A1 (es) 2003-07-31

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