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WO1998000539A3 - (mitogen-activated protein kinase) kinase-3 (mkk3) interacting protein (mip) - Google Patents

(mitogen-activated protein kinase) kinase-3 (mkk3) interacting protein (mip) Download PDF

Info

Publication number
WO1998000539A3
WO1998000539A3 PCT/US1997/010866 US9710866W WO9800539A3 WO 1998000539 A3 WO1998000539 A3 WO 1998000539A3 US 9710866 W US9710866 W US 9710866W WO 9800539 A3 WO9800539 A3 WO 9800539A3
Authority
WO
WIPO (PCT)
Prior art keywords
kinase
mip
mkk3
protein
mitogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/010866
Other languages
French (fr)
Other versions
WO1998000539A2 (en
Inventor
Venkatakrishna Shyamala
Michael W Kavanaugh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Priority to AU43260/97A priority Critical patent/AU4326097A/en
Publication of WO1998000539A2 publication Critical patent/WO1998000539A2/en
Publication of WO1998000539A3 publication Critical patent/WO1998000539A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A novel human gene encoding a protein termed MKK3-Interacting Protein (MIP) is disclosed. MIP expression is indicative of a tissue selected from the group of consisting of brain, kidney, liver, lung, pancreas, and spleen. MIP binds to a dominant interfering mutant of MAPK kinase-3 (MKK3) and may be involved in the transduction of extracellular signals into the nucleus which result in the activation of p38 kinase.
PCT/US1997/010866 1996-07-03 1997-07-02 (mitogen-activated protein kinase) kinase-3 (mkk3) interacting protein (mip) Ceased WO1998000539A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU43260/97A AU4326097A (en) 1996-07-03 1997-07-02 (mitogen-activated protein kinase) kinase-3 (mkk3) interacting protein (mip)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US2122496P 1996-07-03 1996-07-03
US60/021,224 1996-07-03
US2164196P 1996-07-12 1996-07-12
US60/021,641 1996-07-12
US88657297A 1997-07-01 1997-07-01
US08/886,572 1997-07-01

Publications (2)

Publication Number Publication Date
WO1998000539A2 WO1998000539A2 (en) 1998-01-08
WO1998000539A3 true WO1998000539A3 (en) 1998-03-26

Family

ID=27361599

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/010866 Ceased WO1998000539A2 (en) 1996-07-03 1997-07-02 (mitogen-activated protein kinase) kinase-3 (mkk3) interacting protein (mip)

Country Status (2)

Country Link
AU (1) AU4326097A (en)
WO (1) WO1998000539A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756332A (en) * 1996-12-26 1998-05-26 Incyte Pharmaceuticals, Inc. Guanosine monophosphate reductase
US6372473B1 (en) 1997-05-28 2002-04-16 Human Genome Sciences, Inc. Tissue plasminogen activator-like protease
US6165461A (en) * 1998-04-14 2000-12-26 Board Of Regents, University Of Texas System Tao protein kinases and methods of use therefor
JP2004521892A (en) 2000-12-20 2004-07-22 メルク　エンド　カムパニー　インコーポレーテッド (Halo-benzocarbonyl) heterocyclic fused phenyl p38 kinase inhibitors

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
B. DÉRIJARD ET AL.: "Independent Human MAP kinase signal transduction pathways defined by MEK and MKK isoforms.", SCIENCE, vol. 267, 3 February 1995 (1995-02-03), pages 682 - 685, XP002054336 *
H. KANNO ET AL.: "Two structural genes on different chromosomes are required for encoding the major subunit of human cell glucose-6-phosphate dehydrogenase.", CELL, vol. 58, 11 August 1989 (1989-08-11), pages 595 - 606, XP002054262 *
S. HENIKOFF ET AL.: "The human mRNA that provides the N-terminus of chimeric G6PD encodes GMP reductase.", CELL, vol. 58, 22 September 1989 (1989-09-22), pages 1021 - 1022, XP002054263 *
T. KONDOH ET AL.: "Genomic structure and expression of human guanosine monophosphate reductase.", HUMAN GENETICS, vol. 88, 1991, pages 219 - 224, XP002054264 *
Z. XIA ET AL.: "Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis.", SCIENCE, vol. 270, 24 November 1995 (1995-11-24), pages 1326 - 1331, XP002054337 *

Also Published As

Publication number Publication date
WO1998000539A2 (en) 1998-01-08
AU4326097A (en) 1998-01-21

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