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WO1997031019B1 - Peptides antipathogenes et compositions les contenant - Google Patents

Peptides antipathogenes et compositions les contenant

Info

Publication number
WO1997031019B1
WO1997031019B1 PCT/IL1997/000066 IL9700066W WO9731019B1 WO 1997031019 B1 WO1997031019 B1 WO 1997031019B1 IL 9700066 W IL9700066 W IL 9700066W WO 9731019 B1 WO9731019 B1 WO 9731019B1
Authority
WO
WIPO (PCT)
Prior art keywords
leu
lys
amino acid
ile
ser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL1997/000066
Other languages
English (en)
Other versions
WO1997031019A3 (fr
WO1997031019A2 (fr
Filing date
Publication date
Priority claimed from IL11722396A external-priority patent/IL117223A0/xx
Priority to BR9707691A priority Critical patent/BR9707691A/pt
Priority to JP9529954A priority patent/JP2000506128A/ja
Priority to IL12573497A priority patent/IL125734A/xx
Priority to AU17319/97A priority patent/AU730069B2/en
Priority to US09/125,605 priority patent/US6172038B1/en
Priority to NZ331219A priority patent/NZ331219A/xx
Priority to EA199800754A priority patent/EA199800754A1/ru
Priority to EP97904561A priority patent/EP0904291A2/fr
Application filed filed Critical
Publication of WO1997031019A2 publication Critical patent/WO1997031019A2/fr
Publication of WO1997031019B1 publication Critical patent/WO1997031019B1/fr
Publication of WO1997031019A3 publication Critical patent/WO1997031019A3/fr
Priority to CA002281204A priority patent/CA2281204A1/fr
Priority to US09/367,714 priority patent/US7001983B1/en
Priority to JP53645398A priority patent/JP2001512475A/ja
Priority to AU60056/98A priority patent/AU6005698A/en
Priority to KR1019997007477A priority patent/KR20000071187A/ko
Priority to CN98804347A priority patent/CN1252808A/zh
Priority to PCT/IL1998/000081 priority patent/WO1998037090A1/fr
Priority to EA199900752A priority patent/EA199900752A1/ru
Priority to BR9807456-3A priority patent/BR9807456A/pt
Priority to EP98903286A priority patent/EP0977774A1/fr
Priority to IL13136898A priority patent/IL131368A0/xx
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

On a découvert que les peptides ayant une charge positive nette et ne présentant pas de configuration en hélice α ou une configuration en hélice α seulement partielle, ont une activité cytolytique sélective non hémolytique. Les peptides peuvent être dérivés de peptides naturels tels que la pardaxine et la mellitine et des fragments de celles-ci, dans lesquels les restes de L-aminoacides sont remplacés par des restes de D-aminoacides correspondants, et des dérivés cycliques de ces derniers, ou sont des diastéréoisomères de peptides linéaires à teneurs variables en au moins un acide aminé à charge positive et en au moins un acide aminé hydrophobe, et dans lesquels au moins un des restes d'aminoacides est un D-aminoacide, et de préférence au moins un tiers de la séquence se compose de restes de D-aminoacides. Des compositions pharmaceutiques comprenant les peptides cytolytiques non hémolytiques peuvent être utilisés pour le traitement de plusieurs maladies induites par des pathogènes dont les infections bactériennes, fongiques, virales, à mycoplasma et dues à des protozaires et pour le traitement du cancer.
PCT/IL1997/000066 1996-02-22 1997-02-20 Peptides antipathogenes et compositions les contenant Ceased WO1997031019A2 (fr)

Priority Applications (19)

Application Number Priority Date Filing Date Title
EP97904561A EP0904291A2 (fr) 1996-02-22 1997-02-20 Peptides antipathogenes et compositions les contenant
JP9529954A JP2000506128A (ja) 1996-02-22 1997-02-20 抗病原性ペプチドおよびこれらを含む組成物
BR9707691A BR9707691A (pt) 1996-02-22 1997-02-20 Peptídios antipatogênicos e composições que compreendem os mesmos
IL12573497A IL125734A (en) 1996-02-22 1997-02-20 Antipathogenic peptides and compositions comprising them
AU17319/97A AU730069B2 (en) 1996-02-22 1997-02-20 Antipathogenic peptides and compositions comprising them
US09/125,605 US6172038B1 (en) 1996-02-22 1997-02-20 Antipathogenic peptides and compositions comprising them
NZ331219A NZ331219A (en) 1996-02-22 1997-02-20 Antipathogenic peptides having a non-hemolytic selective cytolytic activity and compositions comprising them
EA199800754A EA199800754A1 (ru) 1996-02-22 1997-02-20 Противопатогенные пептиды и композиции, их включающие
IL13136898A IL131368A0 (en) 1997-02-20 1998-02-19 Antipathogenic synthetic peptides and compositions comprising them
EP98903286A EP0977774A1 (fr) 1997-02-20 1998-02-19 Peptides synthetiques antipathogenes et compositions les contenant
BR9807456-3A BR9807456A (pt) 1997-02-20 1998-02-19 Peptìdios antipatogênicos sintéticos e composições que compreendem os mesmos
CA002281204A CA2281204A1 (fr) 1997-02-20 1998-02-19 Peptides synthetiques antipathogenes et compositions les contenant
EA199900752A EA199900752A1 (ru) 1997-02-20 1998-02-19 Противопатогенные синтетические пептиды и композиции, их включающие
US09/367,714 US7001983B1 (en) 1997-02-20 1998-02-19 Antipathogenic synthetic peptides and compositions comprising them
JP53645398A JP2001512475A (ja) 1997-02-20 1998-02-19 抗病原性合成ペプチドおよびこれらを含む組成物
AU60056/98A AU6005698A (en) 1997-02-20 1998-02-19 Antipathogenic synthetic peptides and compositions comprising them
KR1019997007477A KR20000071187A (ko) 1996-02-22 1998-02-19 항병원성 합성 펩타이드와 그 구성물
CN98804347A CN1252808A (zh) 1997-02-20 1998-02-19 抗病原合成肽及包含该肽类的组合物
PCT/IL1998/000081 WO1998037090A1 (fr) 1997-02-20 1998-02-19 Peptides synthetiques antipathogenes et compositions les contenant

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL11722396A IL117223A0 (en) 1996-02-22 1996-02-22 Antipathogenic polypeptides and compositions comprising them
IL117223 1996-02-22

Publications (3)

Publication Number Publication Date
WO1997031019A2 WO1997031019A2 (fr) 1997-08-28
WO1997031019A3 WO1997031019A3 (fr) 1997-10-23
WO1997031019B1 true WO1997031019B1 (fr) 1997-10-23

Family

ID=11068576

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL1997/000066 Ceased WO1997031019A2 (fr) 1996-02-22 1997-02-20 Peptides antipathogenes et compositions les contenant

Country Status (13)

Country Link
US (1) US6172038B1 (fr)
EP (1) EP0904291A2 (fr)
JP (1) JP2000506128A (fr)
KR (2) KR19990087100A (fr)
CN (1) CN1216549A (fr)
AU (1) AU730069B2 (fr)
BR (1) BR9707691A (fr)
CA (1) CA2247025A1 (fr)
CZ (1) CZ264398A3 (fr)
EA (1) EA199800754A1 (fr)
IL (2) IL117223A0 (fr)
NZ (1) NZ331219A (fr)
WO (1) WO1997031019A2 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1252808A (zh) * 1997-02-20 2000-05-10 耶达研究及发展有限公司 抗病原合成肽及包含该肽类的组合物
US6818213B1 (en) 1998-07-13 2004-11-16 Board Of Regents, The University Of Texas System Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
AU750414B2 (en) 1998-07-13 2002-07-18 Board Of Regents, The University Of Texas System Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids
US7488590B2 (en) 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
SI1783222T1 (en) 1998-10-23 2012-09-28 Kirin Amgen Inc Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity.
GB0005703D0 (en) 2000-03-09 2000-05-03 Alpharma As Compounds
IL139720A0 (en) * 2000-11-16 2002-02-10 Yeda Res & Dev Diastereomeric peptides and pharmaceutical compositions comprising them
AU2004246909B2 (en) * 2003-06-19 2010-08-19 Yeda Research & Development Co. Ltd. Antimicrobial and anticancer lipopeptides
CA2572765C (fr) 2004-07-08 2013-05-21 Amgen Inc. Peptides therapeutiques
EP1797127B1 (fr) 2004-09-24 2017-06-14 Amgen Inc. Molecules fc modifiees
AU2005319578A1 (en) * 2004-11-24 2006-06-29 Neopro Labs, Llc Methods and compositions for treating conditions
WO2006128289A1 (fr) * 2005-06-02 2006-12-07 University Of Manitoba Utilisation de brevinin-2r dans le traitement du cancer
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
AU2006329535A1 (en) * 2005-12-27 2007-07-05 Yeda Research And Development Co. Ltd. Histidine-containing diastereomeric peptides and uses thereof
CA2637221A1 (fr) 2006-02-10 2007-08-16 Dermagen Ab Nouveaux peptides antimicrobiens et leur utilisation
US9283260B2 (en) 2006-04-21 2016-03-15 Amgen Inc. Lyophilized therapeutic peptibody formulations
WO2014038004A1 (fr) * 2012-09-05 2014-03-13 株式会社メニコン Lentille ophtalmique à libération de médicament lente et son procédé de fabrication
JP6093528B2 (ja) * 2012-09-19 2017-03-08 株式会社ミルボン スクリーニング方法
WO2017134661A1 (fr) 2016-02-04 2017-08-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Procédés de destruction de biofilms
GB2557654A (en) * 2016-12-14 2018-06-27 Uea Enterprises Ltd Method for nucleic acid depletion
CN113528600A (zh) * 2021-07-08 2021-10-22 石河子大学 一种利用沙门氏菌诱导蝇蛆制备抗菌肽的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5258454A (en) * 1988-09-01 1993-11-02 Riso National Laboratory Peptide synthesis method and solid support for use in the method

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