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EA199800179A1 - Process for preparing solid dosage forms of very low-dose drugs - Google Patents

Process for preparing solid dosage forms of very low-dose drugs

Info

Publication number
EA199800179A1
EA199800179A1 EA199800179A EA199800179A EA199800179A1 EA 199800179 A1 EA199800179 A1 EA 199800179A1 EA 199800179 A EA199800179 A EA 199800179A EA 199800179 A EA199800179 A EA 199800179A EA 199800179 A1 EA199800179 A1 EA 199800179A1
Authority
EA
Eurasian Patent Office
Prior art keywords
low
dosage forms
solid dosage
preparing solid
dose drugs
Prior art date
Application number
EA199800179A
Other languages
Russian (ru)
Other versions
EA000740B1 (en
Inventor
Джеймс Альберт Нэппер
Нил Мортимер
Карен Триона О'Браен
Султан Джеймс Манек
Раджиндер Кумар
Майкл Сидней Джордж Кларк
Джулия Мэри Лоудон
Original Assignee
Смитклайн Бичам Плс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9515624.6A external-priority patent/GB9515624D0/en
Priority claimed from GBGB9606684.0A external-priority patent/GB9606684D0/en
Application filed by Смитклайн Бичам Плс filed Critical Смитклайн Бичам Плс
Publication of EA199800179A1 publication Critical patent/EA199800179A1/en
Publication of EA000740B1 publication Critical patent/EA000740B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Способ изготовления лекарственного средства, который включает смешивание частиц носителя с водным раствором лекарственного вещества в количестве 1-3% раствора от общего веса смеси, и способ лечения и/или профилактики деменции, который включает введение пациенту [R-(Z)]-α-(метоксиимино)-α-(1-азабицикло[2,2,2]окт-3-ил)ацетонитрила моногидрохлорида в суточной дозе менее 0,01 мг/кг, а также фармацевтические композиции, используемые в этих способах.Международная заявка была опубликована вместе с отчетом о международном поиске.A method of manufacturing a medicinal product, which includes mixing particles of a carrier with an aqueous solution of a medicinal substance in an amount of 1-3% solution of the total weight of the mixture, and a method for treating and / or preventing dementia, which comprises administering to the patient [R- (Z)] - α- (methoxyimino) -α- (1-azabicyclo [2.2.2] oct-3-yl) acetonitrile monohydrochloride in a daily dose of less than 0.01 mg / kg, as well as pharmaceutical compositions used in these methods. An international application has been published. along with an international search report.

EA199800179A 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs and a pharmaceutical obtained therein EA000740B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9515624.6A GB9515624D0 (en) 1995-07-29 1995-07-29 Novel process
GBGB9606684.0A GB9606684D0 (en) 1996-03-29 1996-03-29 Novel process
PCT/EP1996/003326 WO1997004750A2 (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs

Publications (2)

Publication Number Publication Date
EA199800179A1 true EA199800179A1 (en) 1998-10-29
EA000740B1 EA000740B1 (en) 2000-02-28

Family

ID=26307485

Family Applications (2)

Application Number Title Priority Date Filing Date
EA199901055A EA199901055A1 (en) 1995-07-29 1996-07-29 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT AND / OR PREVENTION OF DEMENTIA
EA199800179A EA000740B1 (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs and a pharmaceutical obtained therein

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA199901055A EA199901055A1 (en) 1995-07-29 1996-07-29 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT AND / OR PREVENTION OF DEMENTIA

Country Status (25)

Country Link
EP (1) EP0841902A2 (en)
JP (1) JPH11510493A (en)
KR (1) KR19990035972A (en)
CN (1) CN1196677A (en)
AP (1) AP858A (en)
AR (1) AR004178A1 (en)
AU (1) AU716961B2 (en)
BG (1) BG102266A (en)
BR (1) BR9609804A (en)
CA (1) CA2228048A1 (en)
CZ (1) CZ24798A3 (en)
DZ (1) DZ2077A1 (en)
EA (2) EA199901055A1 (en)
HU (1) HUP9900521A3 (en)
IL (1) IL122897A0 (en)
MA (1) MA23953A1 (en)
MX (1) MX9800809A (en)
NO (1) NO980384L (en)
NZ (1) NZ315632A (en)
OA (1) OA10659A (en)
PL (1) PL325242A1 (en)
SK (1) SK11098A3 (en)
TR (1) TR199800156T1 (en)
UY (1) UY24297A1 (en)
WO (1) WO1997004750A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9619074D0 (en) * 1996-09-12 1996-10-23 Smithkline Beecham Plc Composition
CA2323177A1 (en) * 1998-03-11 1999-09-16 Susan Marie Milosovich Composition
FR2796840B1 (en) * 1999-07-26 2003-06-20 Ethypharm Lab Prod Ethiques LOW-DOSE TABLETS AND METHOD OF PREPARATION
ATE307591T1 (en) 2000-12-14 2005-11-15 Ortho Mcneil Pharm Inc PREPARATIONS CONTAINING A STEROID HORMONE AND A STABILIZING AGENT IN NON-CRYSTALLINE FORM
US20070202179A1 (en) * 2004-04-09 2007-08-30 FAULKNER Patrick Low Dose Pharmaceutical Products
WO2026018155A1 (en) 2024-07-16 2026-01-22 Syremis Therapeutics Ltd. Combinations of sabcomeline with long-acting non-cns penetrant muscarinic antagonists
WO2026018154A1 (en) 2024-07-16 2026-01-22 Syremis Therapeutics Ltd. Combinations of sabcomeline with non-cns penetrant muscarinic antagonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4489026A (en) * 1982-09-07 1984-12-18 The Upjohn Company Process for preparing solid unit dosage forms of ultra-low dose drugs
JPS5970614A (en) * 1982-10-14 1984-04-21 Asahi Chem Ind Co Ltd Wet solid pharmaceutical preparation of very small amount of main drug
US4898736A (en) * 1988-03-09 1990-02-06 Merck & Co., Inc. Method for tablet preparation
DE69034146T2 (en) * 1989-04-13 2005-07-14 Beecham Group P.L.C., Brentford Chemical compounds
ZA939565B (en) * 1993-12-21 1994-08-11 Applied Analytical Ind Inc Method for preparing low dose pharmaceutical products.

Also Published As

Publication number Publication date
UY24297A1 (en) 1997-01-23
CN1196677A (en) 1998-10-21
WO1997004750A3 (en) 1997-03-27
KR19990035972A (en) 1999-05-25
CA2228048A1 (en) 1997-02-13
HUP9900521A2 (en) 1999-06-28
MX9800809A (en) 1998-04-30
EA000740B1 (en) 2000-02-28
SK11098A3 (en) 1998-07-08
EA199901055A1 (en) 2000-06-26
AR004178A1 (en) 1998-11-04
EP0841902A2 (en) 1998-05-20
JPH11510493A (en) 1999-09-14
CZ24798A3 (en) 1998-06-17
WO1997004750A2 (en) 1997-02-13
NO980384L (en) 1998-03-26
TR199800156T1 (en) 1998-04-21
AP858A (en) 2000-07-12
BG102266A (en) 1998-10-30
NZ315632A (en) 1999-11-29
MA23953A1 (en) 1997-04-01
AU6738496A (en) 1997-02-26
IL122897A0 (en) 1998-08-16
HUP9900521A3 (en) 2001-04-28
NO980384D0 (en) 1998-01-28
OA10659A (en) 2002-09-18
DZ2077A1 (en) 2002-07-22
AP9801170A0 (en) 1998-01-31
BR9609804A (en) 1999-07-06
AU716961B2 (en) 2000-03-09
PL325242A1 (en) 1998-07-06

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU