[go: up one dir, main page]

WO1996039101B1 - Compositions et procedes relatifs a une matrice extracellulaire secretee naturellement - Google Patents

Compositions et procedes relatifs a une matrice extracellulaire secretee naturellement

Info

Publication number
WO1996039101B1
WO1996039101B1 PCT/US1996/009482 US9609482W WO9639101B1 WO 1996039101 B1 WO1996039101 B1 WO 1996039101B1 US 9609482 W US9609482 W US 9609482W WO 9639101 B1 WO9639101 B1 WO 9639101B1
Authority
WO
WIPO (PCT)
Prior art keywords
extracellular matrix
cells
naturally secreted
framework
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1996/009482
Other languages
English (en)
Other versions
WO1996039101A1 (fr
Filing date
Publication date
Priority claimed from US08/470,101 external-priority patent/US5830708A/en
Application filed filed Critical
Priority to JP50179097A priority Critical patent/JP3709487B2/ja
Priority to NZ311313A priority patent/NZ311313A/xx
Priority to EP96921369A priority patent/EP0967934B1/fr
Priority to DE69634454T priority patent/DE69634454T2/de
Priority to AU62609/96A priority patent/AU708090B2/en
Priority to AT96921369T priority patent/ATE290350T1/de
Publication of WO1996039101A1 publication Critical patent/WO1996039101A1/fr
Publication of WO1996039101B1 publication Critical patent/WO1996039101B1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

L'invention concerne des compositions contenant des matrices extracellulaires humaines sécrétées naturellement, leurs procédés de fabrication et d'utilisation. On obtient une matrice extracellulaire selon l'invention en mettant des cellules en culture dans une structure de support tridimensionnelle de sorte que ces dernières sécrètent une matrice extracellulaire. On tue ensuite les cellules et on les retire de la structure de support pour n'y laisser que la matrice extracellulaire, après quoi on peut enlever cette dernière du support, la combiner avec un véhicule approprié pharmacologiquement acceptable et l'injecter dans une zone tissulaire anormale de la peau d'un patient.
PCT/US1996/009482 1995-06-06 1996-06-06 Compositions et procedes relatifs a une matrice extracellulaire secretee naturellement Ceased WO1996039101A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP50179097A JP3709487B2 (ja) 1995-06-06 1996-06-06 自然分泌細胞外マトリックスのための組成物及び方法
NZ311313A NZ311313A (en) 1995-06-06 1996-06-06 Composition and method for making compositions for treatment of wrinkles and scars using human extracellular matrix
EP96921369A EP0967934B1 (fr) 1995-06-06 1996-06-06 Compositions et procedes relatifs a une matrice extracellulaire secretee naturellement
DE69634454T DE69634454T2 (de) 1995-06-06 1996-06-06 Zusammensetzungen und Verfahren mit Bezug auf eine auf natürliche Weise sekretierte Matrix
AU62609/96A AU708090B2 (en) 1995-06-06 1996-06-06 Compositions and methods for naturally secreted extracellular matrix
AT96921369T ATE290350T1 (de) 1995-06-06 1996-06-06 Zusammensetzungen und verfahren mit bezug auf eine auf natürliche weise sekretierte matrix

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/470,101 US5830708A (en) 1995-06-06 1995-06-06 Methods for production of a naturally secreted extracellular matrix
US470,101 1995-06-06

Publications (2)

Publication Number Publication Date
WO1996039101A1 WO1996039101A1 (fr) 1996-12-12
WO1996039101B1 true WO1996039101B1 (fr) 1997-01-09

Family

ID=23866272

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/009482 Ceased WO1996039101A1 (fr) 1995-06-06 1996-06-06 Compositions et procedes relatifs a une matrice extracellulaire secretee naturellement

Country Status (11)

Country Link
US (1) US5830708A (fr)
EP (1) EP0967934B1 (fr)
JP (1) JP3709487B2 (fr)
KR (1) KR19990022216A (fr)
AT (1) ATE290350T1 (fr)
AU (1) AU708090B2 (fr)
CA (1) CA2223892A1 (fr)
DE (1) DE69634454T2 (fr)
ES (1) ES2238076T3 (fr)
NZ (1) NZ311313A (fr)
WO (1) WO1996039101A1 (fr)

Families Citing this family (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6974571B2 (en) * 1995-03-28 2005-12-13 Thomas Jefferson University Isolated stromal cells and methods of using the same
US6284284B1 (en) 1995-06-06 2001-09-04 Advanced Tissue Sciences, Inc. Compositions and methods for production and use of an injectable naturally secreted extracellular matrix
US7767452B2 (en) 1997-02-20 2010-08-03 Kleinsek Don A Tissue treatments with adipocyte cells
WO1998036705A1 (fr) * 1997-02-20 1998-08-27 Keller Gregory S Reparation de defauts tissulaire au niveau du derme, de l'hypoderme et des cordes vocales et augmentation des tissus
GB9720987D0 (en) * 1997-10-01 1997-12-03 Biocure Ltd A multicellular in vitro assay of angiogenesis
US6225118B1 (en) 1997-10-01 2001-05-01 Biocure Limited Multicellular in vitro assay of angiogenesis
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
WO1999047186A1 (fr) * 1998-03-18 1999-09-23 University Of Pittsburgh Matieres composites a base de chitosane contenant du glycosaminoglycane pour la reparation du cartilage
US6378527B1 (en) * 1998-04-08 2002-04-30 Chondros, Inc. Cell-culture and polymer constructs
US6428978B1 (en) * 1998-05-08 2002-08-06 Cohesion Technologies, Inc. Methods for the production of gelatin and full-length triple helical collagen in recombinant cells
DK1131410T3 (da) * 1998-11-19 2005-10-31 Organogenesis Inc Gensplejsede vævskonstruktioner og fremgangsmåde til fremstilling og anvendelse deraf
US7615373B2 (en) 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
US6662805B2 (en) 1999-03-24 2003-12-16 The Johns Hopkins University Method for composite cell-based implants
US20030007954A1 (en) * 1999-04-12 2003-01-09 Gail K. Naughton Methods for using a three-dimensional stromal tissue to promote angiogenesis
US6372494B1 (en) 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
EP1196206A1 (fr) * 1999-07-09 2002-04-17 Advanced Tissue Sciences, Inc. Appareil revetu d'une matrice extracellulaire naturellement secretee par l'homme
CA2383398C (fr) * 1999-08-23 2013-06-11 Organogenesis, Inc. Compositions et traitements pour soins cutanes
US20090074729A2 (en) * 1999-11-05 2009-03-19 Donald Kleinsek Augmentation and repair of spincter defects with cells including fibroblasts
WO2001032129A2 (fr) * 1999-11-05 2001-05-10 Gerigene Medical Corporation Augmentation et reparation des imperfections des tissus mous lies a l'age
US20080286242A2 (en) * 1999-11-05 2008-11-20 Donald Kleinsek Augmentation and repair of spincter defects with cells including mesenchymal cells
US20080267923A2 (en) * 1999-11-05 2008-10-30 Donald Kleinsek Hair undifferentiated cells
US7799325B2 (en) * 1999-11-05 2010-09-21 Kleinsek Donald A Removal of hypertrophic scars
AU2001250018A1 (en) 2000-03-02 2001-09-12 University Of Rochester Ex vivo generation of functional leukemia cells in a three-dimensional bioreactor
AU2001249221A1 (en) 2000-03-20 2001-10-03 Biosphere Medical, Inc. Injectable and swellable microspheres for tissue bulking
AU2001247507A1 (en) 2000-03-20 2001-10-03 Biosphere Medical, Inc. Injectable microspheres for tissue construction
US6436424B1 (en) * 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
US7338657B2 (en) * 2001-03-15 2008-03-04 Biosphere Medical, Inc. Injectable microspheres for tissue construction
US6638312B2 (en) 2000-08-04 2003-10-28 Depuy Orthopaedics, Inc. Reinforced small intestinal submucosa (SIS)
US8366787B2 (en) * 2000-08-04 2013-02-05 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
DE60121450T2 (de) * 2000-08-16 2007-02-15 Duke University Mittels gewebetechnologie hergestellte dezellularisierte gegenstände und gewebe
JP2004508305A (ja) 2000-09-01 2004-03-18 ヴァージニア　コモンウェルス　ユニバーシティ　インテレクチュアル　プロパティー　ファンデーション 電気処理されたフィブリンをベースとするマトリックスおよび組織
US20090130066A1 (en) * 2000-11-06 2009-05-21 Gerigene Medical Corporation Augmentation and repair of sphincter defects with cells including muscle cells
AU2002225700A1 (en) * 2000-11-17 2002-05-27 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen
US7311905B2 (en) 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
DK1349918T3 (da) 2000-12-06 2014-11-10 Anthrogenesis Corp Fremgangsmåde til indsamling af stamceller fra moderkagen
US7041868B2 (en) 2000-12-29 2006-05-09 Kimberly-Clark Worldwide, Inc. Bioabsorbable wound dressing
KR101132545B1 (ko) 2001-02-14 2012-04-02 안트로제네시스 코포레이션 산후 포유류의 태반, 이의 용도 및 태반 줄기세포
EP1362095B1 (fr) 2001-02-14 2015-05-27 Anthrogenesis Corporation Placenta post-gravidique de mammifere, son utilisation et cellules souches placentaires correspondantes
US8337537B2 (en) 2001-07-16 2012-12-25 Depuy Products, Inc. Device from naturally occurring biologically derived materials
WO2003007786A2 (fr) 2001-07-16 2003-01-30 Depuy Products, Inc. Echafaudage a distribution poreuse t procede correspondant
JP4294474B2 (ja) 2001-07-16 2009-07-15 デピュイ・プロダクツ・インコーポレイテッド 半月板再生装置
ATE499908T1 (de) * 2001-07-16 2011-03-15 Depuy Products Inc Gerät zur reparatur von knorpelmaterial
EP1416886A4 (fr) * 2001-07-16 2007-04-18 Depuy Products Inc Structure de support et methode de reparation et de regeneration de cartilage
JP4302515B2 (ja) 2001-07-16 2009-07-29 デピュイ・プロダクツ・インコーポレイテッド 単体型外科装置および方法
EP1416874A4 (fr) 2001-07-16 2007-04-18 Depuy Products Inc Echafaudages de matrice extracellulaire poreux hybrides biologique/synthetique
US8025896B2 (en) 2001-07-16 2011-09-27 Depuy Products, Inc. Porous extracellular matrix scaffold and method
US7819918B2 (en) * 2001-07-16 2010-10-26 Depuy Products, Inc. Implantable tissue repair device
EP2292091A1 (fr) 2002-02-13 2011-03-09 Anthrogenesis Corporation Cellules souches de type embryonnaire dérivées de placenta mammalien post-partum, utilisations, et procédés de traitement à base de cellules de ce type
WO2003072128A2 (fr) * 2002-02-22 2003-09-04 Ebi, L.P. Procedes et composes destines a traiter des defauts osseux ou du cartilage
US7498171B2 (en) 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
KR100527623B1 (ko) * 2002-06-01 2005-11-15 라이프코드인터내셔날 주식회사 세포외기질을 포함하는 인공장기 제조용 생분해성 고분자기질 및 그의 제조방법
CA2505534A1 (fr) 2002-11-26 2004-06-10 Anthrogenesis Corporation Agents cytotherapeutiques, unites cytotherapeutiques et procedes de traitement dans lesquels ils interviennent
IL156945A0 (en) * 2003-07-15 2004-02-08 Itzhak Tavori Device and a method for orthopedic delivery of bone reconstruction medium
US7326571B2 (en) * 2003-07-17 2008-02-05 Boston Scientific Scimed, Inc. Decellularized bone marrow extracellular matrix
JP2005211099A (ja) * 2004-01-27 2005-08-11 Olympus Corp 人工臓器構成材および人工臓器構成体の製造方法および人工臓器
US7569233B2 (en) 2004-05-04 2009-08-04 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
EP1748744A4 (fr) * 2004-05-11 2011-08-03 Synthasome Inc Tricot tissulaire
US20070190108A1 (en) * 2004-05-17 2007-08-16 Arindam Datta High performance reticulated elastomeric matrix preparation, properties, reinforcement, and use in surgical devices, tissue augmentation and/or tissue repair
WO2006026730A2 (fr) * 2004-08-30 2006-03-09 Iken Tissue Therapeutics, Inc. Tissus tridimensionnels de culture et utilisations de ceux-ci
US20080226604A9 (en) * 2005-06-17 2008-09-18 Theregen Company Methods for treating ischemic tissue
US7513866B2 (en) 2004-10-29 2009-04-07 Depuy Products, Inc. Intestine processing device and associated method
US7354627B2 (en) 2004-12-22 2008-04-08 Depuy Products, Inc. Method for organizing the assembly of collagen fibers and compositions formed therefrom
US7595062B2 (en) 2005-07-28 2009-09-29 Depuy Products, Inc. Joint resurfacing orthopaedic implant and associated method
US20070065415A1 (en) * 2005-09-16 2007-03-22 Kleinsek Donald A Compositions and methods for the augmentation and repair of defects in tissue
EP2530145A1 (fr) 2005-10-13 2012-12-05 Anthrogenesis Corporation Immunomodulation utilisant des cellules souches de placenta
JP5409009B2 (ja) * 2005-12-01 2014-02-05 エイジェンシー フォー サイエンス，テクノロジー アンド リサーチ 組織工学の足場としての三次元再構成細胞外マトリクス
KR20200123283A (ko) 2005-12-29 2020-10-28 안트로제네시스 코포레이션 태반 줄기 세포 집단
US8455250B2 (en) 2005-12-29 2013-06-04 Anthrogenesis Corporation Co-culture of placental stem cells and stem cells from a second source
US20070178137A1 (en) * 2006-02-01 2007-08-02 Toby Freyman Local control of inflammation
EP3483263A1 (fr) 2006-10-23 2019-05-15 Celularity, Inc. Procédés et compositions pour le traitement de déficits osseux au moyen de populations de cellules placentaires
US7871440B2 (en) 2006-12-11 2011-01-18 Depuy Products, Inc. Unitary surgical device and method
CA2677397C (fr) 2007-02-12 2016-04-05 Anthrogenesis Corporation Traitement des maladies inflammatoires au moyen de cellules souches placentaires
US10494607B2 (en) 2007-02-12 2019-12-03 Celularity, Inc. CD34+,CD45−placental stem cell-enriched cell populations
US9200253B1 (en) 2007-08-06 2015-12-01 Anthrogenesis Corporation Method of producing erythrocytes
KR20190132556A (ko) 2007-09-28 2019-11-27 안트로제네시스 코포레이션 인간 태반 관류액 및 인간 태반-유래 중간체 천연 킬러 세포를 사용한 종양 억제 방법
CN101909694A (zh) 2007-11-07 2010-12-08 人类起源公司 脐带血在治疗早产并发症中的用途
CN101801352B (zh) 2007-11-30 2013-04-03 Rnl生物技术株式会社 用于治疗小便失禁的含有来自蜕膜或脂肪的干细胞的细胞治疗剂
US10702554B2 (en) * 2007-12-03 2020-07-07 Sanbio, Inc. Extracellular matrix from pluripotent cells
CN102066558B (zh) 2008-01-30 2017-02-08 希斯托金公司 胞外基质组合物
WO2010003104A2 (fr) * 2008-07-02 2010-01-07 Allergan, Inc. Compositions et procédés de remplissage et de régénération tissulaires
RU2662676C1 (ru) 2008-08-20 2018-07-26 Антродженезис Корпорейшн Улучшенная клеточная композиция и способы ее получения
JP5916388B2 (ja) 2008-11-14 2016-05-11 ヒストジェン インコーポレイテッド がんの処置のための細胞外マトリックス組成物
CN102282252B (zh) 2008-11-19 2017-07-04 人类起源公司 羊膜来源的贴壁细胞
PL2451964T3 (pl) 2009-07-10 2018-08-31 Histogen, Inc. Kompozycje kondycjonowanego podłoża i macierzy zewnątrzkomórkowej z komórek hodowanych w warunkach hipoksji
CA2786400C (fr) 2010-01-05 2018-11-27 Cell Constructs, Inc. Biomateriaux fabriques a partir de cheveux humains
DK3284818T3 (da) 2010-01-26 2022-06-20 Celularity Inc Behandling af knoglerelateret kræft ved hjælp af placenta stamceller
CN102933703A (zh) 2010-04-07 2013-02-13 人类起源公司 使用胎盘干细胞的血管生成
NZ605505A (en) 2010-07-13 2015-02-27 Anthrogenesis Corp Methods of generating natural killer cells
EP2799078A1 (fr) 2010-11-12 2014-11-05 Allergan, Inc. Milieu de culture conditionné métabolisé et procédés d'utilisation
WO2012092480A1 (fr) 2010-12-30 2012-07-05 Anthirogenesis Corporation Compositions comprenant des cellules adhérentes dérivées d'amnion et du plasma riche en plaquettes
AR084754A1 (es) 2010-12-30 2013-06-05 Anthrogenesis Corp Composiciones que comprenden celulas madre de placenta y plasma rico en plaquetas, y sus metodos de uso
US8969315B2 (en) 2010-12-31 2015-03-03 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory RNA molecules
US9556414B2 (en) 2011-01-06 2017-01-31 Humacyte Tissue-engineered constructs
DK2714059T3 (en) 2011-06-01 2019-01-21 Celularity Inc TREATMENT OF PAIN WHEN USING PLACENT STAM CELLS
JP2014531908A (ja) 2011-10-14 2014-12-04 プレジデント アンド フェローズ オブ ハーバード カレッジ 構造アッセンブリによる配列決定
ES2991004T3 (es) 2011-12-22 2024-12-02 Harvard College Métodos para la detección de analitos
EP4108782B1 (fr) 2011-12-22 2023-06-07 President and Fellows of Harvard College Compositions et procédés de détection d'analyte
CN104303186B (zh) * 2012-05-09 2018-12-11 皇家飞利浦有限公司 介入信息代理医学追踪接口
US9914967B2 (en) 2012-06-05 2018-03-13 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using DNA origami probes
AU2014215458A1 (en) 2013-02-05 2015-08-13 Anthrogenesis Corporation Natural killer cells from placenta
US10138509B2 (en) 2013-03-12 2018-11-27 President And Fellows Of Harvard College Method for generating a three-dimensional nucleic acid containing matrix
AU2014274939B2 (en) 2013-06-04 2020-03-19 President And Fellows Of Harvard College RNA-guideded transcriptional regulation
US10179932B2 (en) 2014-07-11 2019-01-15 President And Fellows Of Harvard College Methods for high-throughput labelling and detection of biological features in situ using microscopy
AU2016349288A1 (en) 2015-11-03 2018-05-31 President And Fellows Of Harvard College Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix
CN109415761B (zh) 2016-04-25 2022-09-20 哈佛学院董事及会员团体 用于原位分子检测的杂交链反应方法
CN105920679B (zh) * 2016-04-26 2018-10-19 青岛大学 一种具有三维梯度孔结构的皮肤支架材料的制备方法
CN118853848A (zh) 2016-08-31 2024-10-29 哈佛学院董事及会员团体 将生物分子的检测组合到使用荧光原位测序的单个试验的方法
CN118389650A (zh) 2016-08-31 2024-07-26 哈佛学院董事及会员团体 生成用于通过荧光原位测序检测的核酸序列文库的方法
KR20190140906A (ko) 2017-04-14 2019-12-20 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 세포-유래 마이크로필라멘트 네트워크의 생성 방법
US11718829B2 (en) 2017-07-28 2023-08-08 Breakthrough Tech Llc Methods and compositions for manufacturing extracellular matrix
WO2019152522A1 (fr) 2018-01-30 2019-08-08 Histogen, Inc. Vésicules extracellulaires issues de cellules cultivées dans des conditions hypoxiques et leurs utilisations
SG11202101934SA (en) 2018-07-30 2021-03-30 Readcoor Llc Methods and systems for sample processing or analysis
WO2020076976A1 (fr) 2018-10-10 2020-04-16 Readcoor, Inc. Indexation moléculaire spatiale tridimensionnelle
CN111084788A (zh) * 2018-10-22 2020-05-01 上海蓝盎电子科技发展有限公司 人工细胞间质
US12077780B2 (en) 2020-02-14 2024-09-03 Allergan Sales, Llc Conditioned medium from cells cultured under hypoxic conditions and uses thereof
US20220049303A1 (en) 2020-08-17 2022-02-17 Readcoor, Llc Methods and systems for spatial mapping of genetic variants
EP4395796A4 (fr) 2021-09-01 2024-12-25 Shanghai Qisheng Biological Preparation Co., Ltd. Régénération de cartilage à l'aide de compositions de collagène injectables polymérisables in situ contenant des chondrocytes ou des cellules souches
EP4457266A4 (fr) 2021-12-28 2025-10-22 Shanghai Qisheng Biological Preparation Co Ltd Compositions de copolymère d'acide hyaluronique-collagène et leurs applications médicales
CN115006597B (zh) * 2022-06-02 2024-01-19 上海威高医疗技术发展有限公司 一种口腔修复膜及其制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3949073A (en) * 1974-11-18 1976-04-06 The Board Of Trustees Of Leland Stanford Junior University Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution
US4424208A (en) * 1982-01-11 1984-01-03 Collagen Corporation Collagen implant material and method for augmenting soft tissue
US4582640A (en) * 1982-03-08 1986-04-15 Collagen Corporation Injectable cross-linked collagen implant material
US4837285A (en) * 1984-03-27 1989-06-06 Medimatrix Collagen matrix beads for soft tissue repair
US5288617A (en) * 1984-10-31 1994-02-22 Commonwealth Scientific And Industrial Research Organization Method of producing an antigenic preparation
US5266480A (en) * 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US4963489A (en) * 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5460939A (en) * 1986-04-18 1995-10-24 Advanced Tissue Sciences, Inc. Temporary living skin replacement
US5032508A (en) * 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5160490A (en) * 1986-04-18 1992-11-03 Marrow-Tech Incorporated Three-dimensional cell and tissue culture apparatus
US4721096A (en) * 1986-04-18 1988-01-26 Marrow-Tech Incorporated Process for replicating bone marrow in vitro and using the same
US4803075A (en) * 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
JPH041118Y2 (fr) * 1986-07-31 1992-01-14
GB8708009D0 (en) * 1987-04-03 1987-05-07 Clayton Found Res Injectable soft tissue augmentation materials
US5342765A (en) * 1991-08-01 1994-08-30 Occidental Chemical Corporation Method of producing extracellular products from aerobic microorganisms
US5204382A (en) * 1992-02-28 1993-04-20 Collagen Corporation Injectable ceramic compositions and methods for their preparation and use
US5478739A (en) * 1992-10-23 1995-12-26 Advanced Tissue Sciences, Inc. Three-dimensional stromal cell and tissue culture system
US5541106A (en) * 1993-04-05 1996-07-30 Desmos, Inc. Cell matrix stimulated attachment and hemidesmosome assembly
US5397352A (en) * 1993-08-27 1995-03-14 Burres; Steven Method of recollagenation
US5516532A (en) * 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation

Similar Documents

Publication Publication Date Title
WO1996039101B1 (fr) Compositions et procedes relatifs a une matrice extracellulaire secretee naturellement
DE69634454T2 (de) Zusammensetzungen und Verfahren mit Bezug auf eine auf natürliche Weise sekretierte Matrix
DE69531638T2 (de) Biomatrix für geweberegenaration
DE69626035T2 (de) Ein biologisches material, das eine wirksame kultur von knochenmarkstammzellen, die teilweise oder vollständing in bindegewebszellen differenziert sind, enthält, und eine dreidimensionale, bioverträgliche und biologische abbaubare matrix, die aus einen hyaluronsäurederivat besteht
US6284284B1 (en) Compositions and methods for production and use of an injectable naturally secreted extracellular matrix
US8864844B2 (en) Tissue scaffold
DE3751843T2 (de) Herstellung von körperorganen durch kontroliertes zellwachstum auf künstlicher matrix
DE60022075T2 (de) Mechanische herzklappe und ihr herstellungsverfahren
DE69219613T2 (de) Vorvaskularisierte polymerimplantate für organtransplantation
DE69724275T2 (de) Biopolymerschäume zur gewebeerneurung und -rekonstruktion
DE69028524T2 (de) In vivo-neomorphogenese von knorpel aus zellkulturen
DE69017820T2 (de) Implantaten für grosse mengen von zellen auf polymerische matrizen.
DE60018576T2 (de) In vitro heilung von knochen- und/oder knorpelschäden
US5665391A (en) Cultured, full-thickness integument substitutes based on three-dimensional matrix membranes
Yannas et al. Surface biology of collagen scaffold explains blocking of wound contraction and regeneration of skin and peripheral nerves
DE69803065T2 (de) Zellkulturmatrix und biologisch abbaubare dreidimensionale matrix auf hyaluronsäurederivatbasis
CN101998862A (zh) 人胶原产品和制备人胶原产品的方法
US20190216984A1 (en) Vascularized full thickness tissue-engineered skin assembled by hydrogel, nanofibrous scaffolds and skin cell layers and preparation method thereof
AU2009212946A1 (en) Autologous cells on a support matrix for tissue repair
DE69913543T3 (de) Dermales Gerüst auf der Grundlage eines neutralisierten Chitosan-Schwammes oder eines neutralisierten gemischten Chitosan-Kollagen-Schwammes
DE112012005018T5 (de) Verfahren zur Herstellung von aurikulärem Knorpelgewebe und aurikuläres Knorpelgewebe
WO2001003750A1 (fr) Appareil revetu d'une matrice extracellulaire naturellement secretee par l'homme
DE10041468C1 (de) Hautmatrix zur Abdeckung und Regenerierung verletzter Hautpartien sowie Verfahren zu ihrer Herstellung
CN1201825C (zh) 一种制备人工子宫内膜的方法
JP2005211480A (ja) 皮膚の分離無細胞化方法、無細胞化真皮マトリックス及びその製造方法並びに無細胞化真皮マトリックスを用いた複合培養皮膚