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WO1996037605A3 - OLIGONUCLEOTIDES ANTISENS POUR BLOQUER LA SYNTHESE DU RECEPTEUR DE L'IgE - Google Patents

OLIGONUCLEOTIDES ANTISENS POUR BLOQUER LA SYNTHESE DU RECEPTEUR DE L'IgE Download PDF

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Publication number
WO1996037605A3
WO1996037605A3 PCT/FR1996/000785 FR9600785W WO9637605A3 WO 1996037605 A3 WO1996037605 A3 WO 1996037605A3 FR 9600785 W FR9600785 W FR 9600785W WO 9637605 A3 WO9637605 A3 WO 9637605A3
Authority
WO
WIPO (PCT)
Prior art keywords
sense oligonucleotides
ige receptor
anti sense
receptor synthesis
blocking ige
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR1996/000785
Other languages
English (en)
Other versions
WO1996037605A2 (fr
Inventor
Eduardo Pirotzky
Soudhir Colote
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority to US08/952,597 priority Critical patent/US5892023A/en
Priority to AU60082/96A priority patent/AU6008296A/en
Priority to EP96917549A priority patent/EP0828827A2/fr
Publication of WO1996037605A2 publication Critical patent/WO1996037605A2/fr
Publication of WO1996037605A3 publication Critical patent/WO1996037605A3/fr
Priority to NO975423A priority patent/NO975423D0/no
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/337—Chemical structure of the base in alpha-anomeric form
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des oligonucléotides antisens qui hybrident sélectivement avec un ou plusieurs gènes nécessaires à bloquer la synthèse du récepteur de l'IgE, des compositions pharmaceutiques les contenant et leur utilisation pour la préparation de médicaments pour le traitement d'allergies.
PCT/FR1996/000785 1995-05-26 1996-05-24 OLIGONUCLEOTIDES ANTISENS POUR BLOQUER LA SYNTHESE DU RECEPTEUR DE L'IgE Ceased WO1996037605A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US08/952,597 US5892023A (en) 1995-05-26 1996-05-24 Anti sense oligonucleotides for blocking IgE receptor synthesis
AU60082/96A AU6008296A (en) 1995-05-26 1996-05-24 Anti sense oligonucleotides for blocking ige receptor synthe sis
EP96917549A EP0828827A2 (fr) 1995-05-26 1996-05-24 OLIGONUCLEOTIDES ANTISENS POUR BLOQUER LA SYNTHESE DU RECEPTEUR DE L'IgE
NO975423A NO975423D0 (no) 1995-05-26 1997-11-25 Anti-sense oligonukleotider for blokkering av IgE-reseptorsyntese

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9510718.1 1995-05-26
GBGB9510718.1A GB9510718D0 (en) 1995-05-26 1995-05-26 Antisense oligonucleotides

Publications (2)

Publication Number Publication Date
WO1996037605A2 WO1996037605A2 (fr) 1996-11-28
WO1996037605A3 true WO1996037605A3 (fr) 1996-12-27

Family

ID=10775100

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1996/000785 Ceased WO1996037605A2 (fr) 1995-05-26 1996-05-24 OLIGONUCLEOTIDES ANTISENS POUR BLOQUER LA SYNTHESE DU RECEPTEUR DE L'IgE

Country Status (7)

Country Link
US (1) US5892023A (fr)
EP (1) EP0828827A2 (fr)
AU (1) AU6008296A (fr)
CA (1) CA2222197A1 (fr)
GB (1) GB9510718D0 (fr)
NO (1) NO975423D0 (fr)
WO (1) WO1996037605A2 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1282699B1 (fr) 2000-05-04 2012-11-21 Sarepta Therapeutics, Inc. Composition anti-sens a region d'epissage et methode associee
CA2499073C (fr) * 2002-09-16 2013-07-23 Commvault Systems, Inc. Systeme et methode de copie auxiliaire a flux combine
US20080311556A1 (en) * 2003-08-07 2008-12-18 Iversen Patrick L Sense Antiviral Compound and Method for Treating Ssrna Viral Infection
US20050222068A1 (en) * 2003-10-23 2005-10-06 Mourich Dan V Method and antisense composition for selective inhibition of HIV infection in hematopoietic cells
US20050171044A1 (en) * 2003-12-24 2005-08-04 Stein David A. Oligonucleotide compound and method for treating nidovirus infections
CA2553104A1 (fr) * 2004-01-23 2005-08-11 Avi Biopharma, Inc. Oligomeres antisens et methodes destinees a induire la tolerance immunitaire et l'immunosuppression
US20060058255A1 (en) * 2004-03-01 2006-03-16 Jianzhu Chen RNAi-based therapeutics for allergic rhinitis and asthma
USRE48960E1 (en) 2004-06-28 2022-03-08 The University Of Western Australia Antisense oligonucleotides for inducing exon skipping and methods of use thereof
EP2500430B1 (fr) 2004-06-28 2017-03-08 The University Of Western Australia Oligonucléotides antisens permettant d'induire un saut d'exon et leurs procédés d'utilisation
CA2571593C (fr) * 2004-07-02 2015-04-21 Avi Biopharma, Inc. Technique et compose antibacterien antisens
US8129352B2 (en) * 2004-09-16 2012-03-06 Avi Biopharma, Inc. Antisense antiviral compound and method for treating ssRNA viral infection
US8357664B2 (en) 2004-10-26 2013-01-22 Avi Biopharma, Inc. Antisense antiviral compound and method for treating influenza viral infection
US7524829B2 (en) * 2004-11-01 2009-04-28 Avi Biopharma, Inc. Antisense antiviral compounds and methods for treating a filovirus infection
US20060240032A1 (en) * 2005-03-31 2006-10-26 Hinrichs David J Immunomodulating compositions and methods for use in the treatment of human autoimmune diseases
US8067571B2 (en) * 2005-07-13 2011-11-29 Avi Biopharma, Inc. Antibacterial antisense oligonucleotide and method
US8524676B2 (en) * 2005-09-08 2013-09-03 Sarepta Therapeutics, Inc. Method for treating enterovirus or rhinovirus infection using antisense antiviral compounds
WO2007030576A2 (fr) * 2005-09-08 2007-03-15 Avi Biopharma, Inc. Compose antisens antiviral et procede de traitement d'infection picornavirale
US8501704B2 (en) 2005-11-08 2013-08-06 Sarepta Therapeutics, Inc. Immunosuppression compound and treatment method
PL2735568T3 (pl) 2006-05-10 2018-02-28 Sarepta Therapeutics, Inc. Analogi oligonukleotydowe mające kationowe połączenia pomiędzy podjednostkami
US8785407B2 (en) * 2006-05-10 2014-07-22 Sarepta Therapeutics, Inc. Antisense antiviral agent and method for treating ssRNA viral infection
CA2710013A1 (fr) * 2007-12-28 2009-07-09 Avi Biopharma, Inc. Agents immunomodulatoires et procedes d'utilisation
KR20230025924A (ko) 2008-10-24 2023-02-23 사렙타 쎄러퓨틱스 인코퍼레이티드 Dmd를 위한 다중 엑손 스키핑 조성물
CA2746508A1 (fr) * 2008-12-17 2010-07-15 Avi Biopharma, Inc. Compositions antisens et methodes de modulation de l'hypersensibilite de contact ou de la dermatite de contact
TR201816523T4 (tr) 2009-11-12 2018-11-21 Univ Western Australia Patolojilerin tedavisine yönelik antisens moleküller ve yöntemler.
WO2011060320A1 (fr) 2009-11-13 2011-05-19 Avi Biopharma, Inc. Composé antiviral antisens et méthode de traitement d'une infection par le virus grippal
AU2011257980B2 (en) 2010-05-28 2016-06-30 Sarepta Therapeutics, Inc. Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups
US8198429B2 (en) 2010-08-09 2012-06-12 Avi Biopharma, Inc. Antisense antiviral compounds and methods for treating a filovirus infection
US10017763B2 (en) 2010-09-03 2018-07-10 Sarepta Therapeutics, Inc. dsRNA molecules comprising oligonucleotide analogs having modified intersubunit linkages and/or terminal groups
HK1202111A1 (en) 2011-11-18 2015-09-18 Sarepta Therapeutics, Inc. Functionally-modified oligonucleotides and subunits thereof
MX366485B (es) 2013-03-14 2019-07-10 Sarepta Therapeutics Inc Composiciones para el salto de exón para tratamiento de distrofia muscular.
MX373959B (es) 2013-03-15 2020-07-13 Sarepta Therapeutics Inc Composición para usarse en el tratamiento de la distrofia muscular de duchenne (dmd).
WO2016196897A1 (fr) 2015-06-04 2016-12-08 Sarepta Therapeutics, Inc. Procédés et composés pour le traitement de maladies et d'états pathologiques associés aux lymphocytes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993021317A1 (fr) * 1992-04-16 1993-10-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services ISOLATION, CARACTERISATION ET UTILISATION DE LA SOUS-UNITE HUMAINE β DU RECEPTEUR DE HAUTE AFFINITE POUR L'IMMUNOGLOBULINE E
WO1995009002A1 (fr) * 1993-09-30 1995-04-06 University Of Pennsylvania Methode d'inhibition de la phagocytose

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993021317A1 (fr) * 1992-04-16 1993-10-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services ISOLATION, CARACTERISATION ET UTILISATION DE LA SOUS-UNITE HUMAINE β DU RECEPTEUR DE HAUTE AFFINITE POUR L'IMMUNOGLOBULINE E
WO1995009002A1 (fr) * 1993-09-30 1995-04-06 University Of Pennsylvania Methode d'inhibition de la phagocytose

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BHATTI, L. ET AL.: "Inhibition of B cell proliferation by antisense DNA to both alpha and beta forms of Fc epsilon R II.", CELL IMMUNOL, (1992 OCT 1) 144 (1) 117-30, XP000561855 *
FOURNIER, S. ET AL.: "Role for low-affinity receptor for IgE (CD23) in normal and leukemic B-cell proliferation.", BLOOD, (1994 SEP 15) 84 (6) 1881-6., XP000609085 *
FU-TONG, LIU ET AL.: "CDNA HETEROGENEITY SUGGESTS STRUCTURAL VARIANTS RELATED TO THE HIGH-AFFINITY IGE RECEPTOR", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 85, no. 15, pages 5639 - 5643, XP000005253 *
ZON, G.: "Oligonucleotide analogues as potential chemotherapeutic agents", PHARMACEUTICAL RESEARCH, VOL. 5 (1988); 539 - 549, XP002008915 *

Also Published As

Publication number Publication date
NO975423L (no) 1997-11-25
WO1996037605A2 (fr) 1996-11-28
AU6008296A (en) 1996-12-11
CA2222197A1 (fr) 1996-11-28
EP0828827A2 (fr) 1998-03-18
NO975423D0 (no) 1997-11-25
US5892023A (en) 1999-04-06
GB9510718D0 (en) 1995-07-19

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